Nicholas Mancuso
@nmancuso.bsky.social
Associate Professor at USC. Genetics/Stats/ML. Husband and father. GA➡️CA. He/him. Views are mine.
www.mancusolab.com
www.mancusolab.com
Pinned
Nicholas Mancuso
@nmancuso.bsky.social
· Nov 17
a cartoon character with a skull on his face
ALT: a cartoon character with a skull on his face
media.tenor.com
Who dares to disturb my slumber
I wish I could be a curling rock.
February 17, 2026 at 5:56 AM
I wish I could be a curling rock.
Reposted by Nicholas Mancuso
It is not a massive phenomenon, it is a tiny slice of a subset of one specific geographic area, it signifies nothing other than addiction and mental illness presents in many forms, and What This All Means is absolutely nothing for 99.9% of the population
February 15, 2026 at 8:41 PM
It is not a massive phenomenon, it is a tiny slice of a subset of one specific geographic area, it signifies nothing other than addiction and mental illness presents in many forms, and What This All Means is absolutely nothing for 99.9% of the population
Reposted by Nicholas Mancuso
In @nytopinion.nytimes.com
The Trump administration is “using detention to inflict pain on anyone — immigrant or citizen — caught in its grasp,” our columnist Jamelle Bouie writes.
The Trump administration is “using detention to inflict pain on anyone — immigrant or citizen — caught in its grasp,” our columnist Jamelle Bouie writes.
Opinion | The Depravity of Trump’s Immigrant Detention
The president’s immigration dragnet is vicious but not surprising.
nyti.ms
February 15, 2026 at 2:10 AM
In @nytopinion.nytimes.com
The Trump administration is “using detention to inflict pain on anyone — immigrant or citizen — caught in its grasp,” our columnist Jamelle Bouie writes.
The Trump administration is “using detention to inflict pain on anyone — immigrant or citizen — caught in its grasp,” our columnist Jamelle Bouie writes.
My name is Ozymandias, King of Kings;
Look on my Works, ye Mighty, and despair!
Look on my Works, ye Mighty, and despair!
February 14, 2026 at 10:39 PM
My name is Ozymandias, King of Kings;
Look on my Works, ye Mighty, and despair!
Look on my Works, ye Mighty, and despair!
Just a reminder tmw is valentines day, for folks who uh need a reminder lol
February 14, 2026 at 3:32 AM
Just a reminder tmw is valentines day, for folks who uh need a reminder lol
Reposted by Nicholas Mancuso
Might be interesting to ask Tapper “So, as you understand it, was Manzanar a concentration camp?”
Because a lot of people (maybe Tapper) think it’s only a “concentration camp” if it comes from the Todeslager region of Germany, otherwise it’s just sparkling relocation.
Because a lot of people (maybe Tapper) think it’s only a “concentration camp” if it comes from the Todeslager region of Germany, otherwise it’s just sparkling relocation.
February 13, 2026 at 2:12 AM
Might be interesting to ask Tapper “So, as you understand it, was Manzanar a concentration camp?”
Because a lot of people (maybe Tapper) think it’s only a “concentration camp” if it comes from the Todeslager region of Germany, otherwise it’s just sparkling relocation.
Because a lot of people (maybe Tapper) think it’s only a “concentration camp” if it comes from the Todeslager region of Germany, otherwise it’s just sparkling relocation.
Reposted by Nicholas Mancuso
Gave Codex an old R simulation I had lying around and it very adeptly turned it into an interactive web app with tunable parameters and visualizations.
sashagusev.github.io/Stabilizing-...
sashagusev.github.io/Stabilizing-...
Stabilizing Selection Dashboard
sashagusev.github.io
February 13, 2026 at 2:58 PM
Gave Codex an old R simulation I had lying around and it very adeptly turned it into an interactive web app with tunable parameters and visualizations.
sashagusev.github.io/Stabilizing-...
sashagusev.github.io/Stabilizing-...
Reposted by Nicholas Mancuso
"disinclination to be accountable to laypeople"
tyler threename harper is a professor
/touches earpiece
sorry, WAS
tyler threename harper is a professor
/touches earpiece
sorry, WAS
People on X are praising this article as good and honest journalism, but it’s just garbage. It’s a gussied up opinions column with Free Press level journalistic integrity. Not one prof agreeing with Harper’s view went on the record and he spoke to a whopping 20 out of approximately 130K in the US.
February 13, 2026 at 2:39 AM
"disinclination to be accountable to laypeople"
tyler threename harper is a professor
/touches earpiece
sorry, WAS
tyler threename harper is a professor
/touches earpiece
sorry, WAS
Reposted by Nicholas Mancuso
Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n
news.cuanschutz.edu/dbmi/cu-ansc...
news.cuanschutz.edu/dbmi/cu-ansc...
CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative
CU Anschutz welcomes Alice Soragni to launch a Functional Personalized Medicine Initiative using rapid tumor organoid testing to guide treatment decisions.
news.cuanschutz.edu
February 10, 2026 at 9:32 PM
Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n
news.cuanschutz.edu/dbmi/cu-ansc...
news.cuanschutz.edu/dbmi/cu-ansc...
For folks that have tried both codex (5.3-codex) and claude, what are your thoughts? I've been using codex with some success, but it seems very limited compared to the subagent and plugin capability that claude has.
February 12, 2026 at 11:02 PM
For folks that have tried both codex (5.3-codex) and claude, what are your thoughts? I've been using codex with some success, but it seems very limited compared to the subagent and plugin capability that claude has.
Reposted by Nicholas Mancuso
The actor James Van Der Beek, who died on Wednesday at 48, was among a growing number of adults under 50 diagnosed with colorectal cancer. The disease is now the leading cause of cancer-related death in adults in this age group, surpassing lung and breast cancer.
James Van Der Beek’s Death Underscores Early-Onset Colorectal Cancers
The actor James Van Der Beek, who died on Wednesday at 48, was among a growing number of adults under 50 diagnosed with the disease.
nyti.ms
February 12, 2026 at 10:10 PM
The actor James Van Der Beek, who died on Wednesday at 48, was among a growing number of adults under 50 diagnosed with colorectal cancer. The disease is now the leading cause of cancer-related death in adults in this age group, surpassing lung and breast cancer.
I used my JAX-based skills for codex to port the excellent Python3 LDSC spec to JAX and Polars.
My intent here was to stress test my JAX skill definitions and find how I could improve rules and contexts--NOT to develop a replacement github.com/mancusolab/j...
My intent here was to stress test my JAX skill definitions and find how I could improve rules and contexts--NOT to develop a replacement github.com/mancusolab/j...
GitHub - mancusolab/jax_ldsc
Contribute to mancusolab/jax_ldsc development by creating an account on GitHub.
github.com
February 11, 2026 at 9:02 PM
I used my JAX-based skills for codex to port the excellent Python3 LDSC spec to JAX and Polars.
My intent here was to stress test my JAX skill definitions and find how I could improve rules and contexts--NOT to develop a replacement github.com/mancusolab/j...
My intent here was to stress test my JAX skill definitions and find how I could improve rules and contexts--NOT to develop a replacement github.com/mancusolab/j...
Please for the love of god, let Yahya Abdul-Mateen II and Ben Kingsley do whatever roles they want together from here on out. Wonderman is brilliant
February 11, 2026 at 6:51 AM
Please for the love of god, let Yahya Abdul-Mateen II and Ben Kingsley do whatever roles they want together from here on out. Wonderman is brilliant
Reposted by Nicholas Mancuso
Rep. Jamie Raskin tells Axios that when he searched Trump's name in the unredacted Epstein files, it came up "more than a million times." www.axios.com/2026/02/10/t...
Trump is in the unredacted Epstein files "more than a million times," Raskin alleges
One document recounts that Trump said he "never" asked Epstein to leave Mar-a-Lago.
www.axios.com
February 11, 2026 at 2:40 AM
Rep. Jamie Raskin tells Axios that when he searched Trump's name in the unredacted Epstein files, it came up "more than a million times." www.axios.com/2026/02/10/t...
Reposted by Nicholas Mancuso
I think it's important that everyone in this chain of command hang.
This is the 38th time that the U.S. military has unlawfully killed civilians on the orders of Pete Hegseth and Donald Trump. At least 130 people — never charged with crimes, their identities unknown to their executioners — are now dead.
We are murdering people and it is basically just background noise at this point. www.nytimes.com/2026/02/09/u...
February 10, 2026 at 4:18 PM
I think it's important that everyone in this chain of command hang.
Reposted by Nicholas Mancuso
Another Claude project: a static site that pulls in GWAS SNP data from ensemble, multiple public biobanks, open targets, gtex, eqtl catalog, and OMIM.
sashagusev.github.io/gwas_lookup/
sashagusev.github.io/gwas_lookup/
February 9, 2026 at 6:50 PM
Another Claude project: a static site that pulls in GWAS SNP data from ensemble, multiple public biobanks, open targets, gtex, eqtl catalog, and OMIM.
sashagusev.github.io/gwas_lookup/
sashagusev.github.io/gwas_lookup/
Birria sliders whew
February 9, 2026 at 1:51 AM
Birria sliders whew
Reposted by Nicholas Mancuso
The person Will is responding to literally has a profile pic mocking Will Stancil, whose "last account got banned"
These people are deranged! This is a level of brain poisoning similar to QAnon except it's targeted harassment of ONE person.
They should all be ip banned!
These people are deranged! This is a level of brain poisoning similar to QAnon except it's targeted harassment of ONE person.
They should all be ip banned!
It’s a good lesson, I guess - the fringe left will never care what you do, how much you put on the line, it will sell you out in a heartbeat for not being the exact same kind of communist as they are.
February 7, 2026 at 11:32 PM
The person Will is responding to literally has a profile pic mocking Will Stancil, whose "last account got banned"
These people are deranged! This is a level of brain poisoning similar to QAnon except it's targeted harassment of ONE person.
They should all be ip banned!
These people are deranged! This is a level of brain poisoning similar to QAnon except it's targeted harassment of ONE person.
They should all be ip banned!
Reposted by Nicholas Mancuso
High treason.
SCOOP: The NSA detected a phone call between foreign intelligence and a person close to Trump last spring.
Whistleblower says that Tulsi Gabbard blocked agency from sharing report and delivered it to White House chief of staff.
www.theguardian.com/us-news/2026...
Whistleblower says that Tulsi Gabbard blocked agency from sharing report and delivered it to White House chief of staff.
www.theguardian.com/us-news/2026...
NSA detected phone call between foreign intelligence and a person close to Trump
Whistleblower says that Tulsi Gabbard blocked agency from sharing report and delivered it to White House chief of staff
www.theguardian.com
February 7, 2026 at 5:56 PM
High treason.
Reposted by Nicholas Mancuso
My response...
2/2
2/2
February 7, 2026 at 2:16 PM
My response...
2/2
2/2
Reposted by Nicholas Mancuso
We are watching in real time who some scientists are willing to sacrifice in favor of access to funding: early career researchers, trainees, scientists from historically excluded groups and immigrants.
February 7, 2026 at 5:18 PM
We are watching in real time who some scientists are willing to sacrifice in favor of access to funding: early career researchers, trainees, scientists from historically excluded groups and immigrants.
Reposted by Nicholas Mancuso
Interesting, but of course: "It’s worth noting that a C compiler is a near-ideal task for semi-autonomous AI model coding: The specification is decades old and well-defined, comprehensive test suites already exist, and there’s a known-good reference compiler to check against."
February 6, 2026 at 11:46 PM
Interesting, but of course: "It’s worth noting that a C compiler is a near-ideal task for semi-autonomous AI model coding: The specification is decades old and well-defined, comprehensive test suites already exist, and there’s a known-good reference compiler to check against."
Reposted by Nicholas Mancuso
Polygenic scores are useful for early detection, but also early prevention!
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
Preventing premature deaths through polygenic risk scores - Nature Communications
Via an integrative modelling approach that combines population and clinical trial data, the authors find that polygenic risk score-based screening would reduce premature mortality across seven commonl...
doi.org
February 6, 2026 at 5:34 PM
Polygenic scores are useful for early detection, but also early prevention!
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
Reposted by Nicholas Mancuso
Pour one out for every professional political pundit, writer, consultant whatever that has spent the last decade trying to pretend that the Trump phenomenon was about trade or opiates and not a big chunk of white america losing its mind over having a black president bsky.app/profile/kyle...
A screenshot from a video posted on Trump's Truth Social account: truthsocial.com/@realDonaldT...
February 6, 2026 at 9:28 AM
Pour one out for every professional political pundit, writer, consultant whatever that has spent the last decade trying to pretend that the Trump phenomenon was about trade or opiates and not a big chunk of white america losing its mind over having a black president bsky.app/profile/kyle...