NDimmuno
@ndimmuno.bsky.social
Passionate about research and education. Curious immunologist finding my spot in the world. Studying monogenic inflammatory disorders in India.
Pinned
NDimmuno
@ndimmuno.bsky.social
· Dec 1
We've made a starter pack to bring together individuals working on primary immunodeficiency and immune dysregulation (a.k.a. Inborn errors of immunity).
Our community is slowly growing here! Let me know if you want to be added. And do tag profiles I've missed!
#PID #IEI
go.bsky.app/3D5Ew75
Our community is slowly growing here! Let me know if you want to be added. And do tag profiles I've missed!
#PID #IEI
go.bsky.app/3D5Ew75
Reposted by NDimmuno
This year's JEM #Immunology collection highlights recent findings in the field of B cells, CD8+ T cell stemness, priming and differentiation, CD4+ T cell heterogeneity, autoimmunity, lymphatic immunophysiology and innate immune signaling. 👉 rupress.org/jem/collecti...
#AAI2025
#AAI2025
April 29, 2025 at 2:16 PM
This year's JEM #Immunology collection highlights recent findings in the field of B cells, CD8+ T cell stemness, priming and differentiation, CD4+ T cell heterogeneity, autoimmunity, lymphatic immunophysiology and innate immune signaling. 👉 rupress.org/jem/collecti...
#AAI2025
#AAI2025
Reposted by NDimmuno
ARAP2 regulates responses to interferon-gamma by restricting SOCS1 https://www.biorxiv.org/content/10.1101/2025.04.28.650977v1
April 29, 2025 at 4:30 PM
ARAP2 regulates responses to interferon-gamma by restricting SOCS1 https://www.biorxiv.org/content/10.1101/2025.04.28.650977v1
Reposted by NDimmuno
Review @annualreviews.bsky.social
Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases
www.annualreviews.org/content/jour...
Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases
www.annualreviews.org/content/jour...
April 26, 2025 at 3:40 AM
Review @annualreviews.bsky.social
Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases
www.annualreviews.org/content/jour...
Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases
www.annualreviews.org/content/jour...
Reposted by NDimmuno
Of course: www.statnews.com/2025/02/14/t...
Texas measles outbreak rises to 48 cases. It's the state's worst in nearly 30 years
The ongoing measles outbreak in West Texas has doubled in size to 48 cases, mostly in children and teens, making it the state's worst in nearly 30 years.
www.statnews.com
February 15, 2025 at 12:53 AM
Of course: www.statnews.com/2025/02/14/t...
Reposted by NDimmuno
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
rdcu.be/d9iRG
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...
rdcu.be
February 11, 2025 at 9:57 AM
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
rdcu.be/d9iRG
Reposted by NDimmuno
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.
www.cuimc.columbia.edu
January 1, 2025 at 5:45 PM
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
Reposted by NDimmuno
Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
December 29, 2024 at 10:31 PM
Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Reposted by NDimmuno
#WeekendRead! #EveryCellisAnImmuneCell! Park, Ahn & Barber show @sciimmunology.bsky.social that DNA-damaged cells activate cGAS-STING secreting factors & induce endosomal vesicles that activate in antigen-presenting cells cGAS-STING inducing immune activation! www.science.org/doi/10.1126/...
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells
Both cytosolic DNA species and innate immune STING signaling are required for stressed cells to activate phagocytes.
www.science.org
December 22, 2024 at 4:27 PM
#WeekendRead! #EveryCellisAnImmuneCell! Park, Ahn & Barber show @sciimmunology.bsky.social that DNA-damaged cells activate cGAS-STING secreting factors & induce endosomal vesicles that activate in antigen-presenting cells cGAS-STING inducing immune activation! www.science.org/doi/10.1126/...
Reposted by NDimmuno
#Immunology by First release now @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
December 19, 2024 at 8:08 PM
#Immunology by First release now @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Reposted by NDimmuno
#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus - Nature Reviews Rheumatology
This Review provides a comprehensive update on dysregulated type I interferon production and signalling in autoinflammatory interferonopathies, monogenic systemic lupus erythematosus and conditio...
bit.ly
December 20, 2024 at 9:22 AM
#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Reposted by NDimmuno
Now online - research briefing from @inflammasomelab.bsky.social Mercedes Monteleone on our recent @natimmunol.bsky.social publication on how pyroptotic cell corpses signal to dendritic cells from beyond the grave! #inflammasomes #pyroptosis #CellDeath #CLEC9A
Link: rdcu.be/d30EL
Link: rdcu.be/d30EL
December 19, 2024 at 3:53 AM
Now online - research briefing from @inflammasomelab.bsky.social Mercedes Monteleone on our recent @natimmunol.bsky.social publication on how pyroptotic cell corpses signal to dendritic cells from beyond the grave! #inflammasomes #pyroptosis #CellDeath #CLEC9A
Link: rdcu.be/d30EL
Link: rdcu.be/d30EL
Interesting read. I wonder if we see more Mtb infections or more severe/disseminated infections in patients with monogenic interferonopathies? Esp. from Mtb endemic regions? #autoinflammation #IDsky #immunosky
Interesting review by Russell Vance
"The major difference, for which we lack a satisfying explanation, is that innate immunity is able to sterilize a dose of 10^6 Legionella within a few days, whereas innate immunity fails to eliminate even a single bacillus of Mtb" #ImmunoSky
"The major difference, for which we lack a satisfying explanation, is that innate immunity is able to sterilize a dose of 10^6 Legionella within a few days, whereas innate immunity fails to eliminate even a single bacillus of Mtb" #ImmunoSky
Tuberculosis as an unconventional interferonopathy
Tuberculosis is caused by Mycobacterium tuberculosis, a bacterium that accounts for more human mortality than any other. Evidence is accumulating for …
www.sciencedirect.com
December 18, 2024 at 1:31 PM
Interesting read. I wonder if we see more Mtb infections or more severe/disseminated infections in patients with monogenic interferonopathies? Esp. from Mtb endemic regions? #autoinflammation #IDsky #immunosky
Reposted by NDimmuno
1/ We are excited to share our new paper in @jexpmed.bsky.social about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem....).
A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity | Journal of Experimental Medicine | Rockefeller University Press
This study identifies 11 IFNAR1 alleles impairing IFN-α/ω responses but sparing IFN-β, including an allele common in Southern China (P335del). Heterozygous
doi.org
December 17, 2024 at 3:11 PM
1/ We are excited to share our new paper in @jexpmed.bsky.social about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem....).
Reposted by NDimmuno
CD19-CAR-T decrease autoantibody levels, thus reducing functional immune complexes that contribute to systemic sclerosis pathogenesis via activation of FcγRIIIA+ NK cells
doi.org/10.1186/s130...
doi.org/10.1186/s130...
December 16, 2024 at 3:48 AM
CD19-CAR-T decrease autoantibody levels, thus reducing functional immune complexes that contribute to systemic sclerosis pathogenesis via activation of FcγRIIIA+ NK cells
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Reposted by NDimmuno
Had great fun talking all things immunological to Lara and Vyanka on their ImmunoTea Podcast.
open.spotify.com/episode/2YqS...
open.spotify.com/episode/2YqS...
ImmunoTea Episode 24 - Innate Immunity and Immunometabolism
ImmunoTea: Your Immunology Podcast · Episode
open.spotify.com
December 16, 2024 at 12:20 PM
Had great fun talking all things immunological to Lara and Vyanka on their ImmunoTea Podcast.
open.spotify.com/episode/2YqS...
open.spotify.com/episode/2YqS...
Reposted by NDimmuno
There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...
December 16, 2024 at 9:25 AM
There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...
Reposted by NDimmuno
Very cool story! A good example of how chasing the weird thing you see in sequencing data can lead to exciting new discoveries.
#RNASky #RNABiology #ImmunoSky
#RNASky #RNABiology #ImmunoSky
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 13, 2024 at 11:11 AM
Very cool story! A good example of how chasing the weird thing you see in sequencing data can lead to exciting new discoveries.
#RNASky #RNABiology #ImmunoSky
#RNASky #RNABiology #ImmunoSky
This sounds like science fiction!
Sharing here a new commentary in Science Policy Forum that provides new analysis on risks related to the potential future creation of mirror bacteria — synthetic organisms in which all molecules have reversed chirality (i.e. are ‘mirrored’). 1/x
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Confronting risks of mirror life
Broad discussion is needed to chart a path forward.
www.science.org
December 13, 2024 at 3:20 PM
This sounds like science fiction!
Reposted by NDimmuno
A starter pack for anyone interested in #autoinflammation and #autoinflammatory diseases.
Please let me know if you’d like to be added.
go.bsky.app/5M6obrp
Please let me know if you’d like to be added.
go.bsky.app/5M6obrp
December 7, 2024 at 2:10 AM
A starter pack for anyone interested in #autoinflammation and #autoinflammatory diseases.
Please let me know if you’d like to be added.
go.bsky.app/5M6obrp
Please let me know if you’d like to be added.
go.bsky.app/5M6obrp
Reposted by NDimmuno
A lipid made by tumour cells reprograms immune cells
www.nature.com/articles/d41...
this is the N&V for:
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
this is the N&V for:
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
www.nature.com/articles/s41...
A lipid made by tumour cells reprograms immune cells
Insights into how cancer cells become unresponsive to therapy.
www.nature.com
December 13, 2024 at 1:55 PM
A lipid made by tumour cells reprograms immune cells
www.nature.com/articles/d41...
this is the N&V for:
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
this is the N&V for:
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
www.nature.com/articles/s41...
So cytokines orchestrate cellular rewiring to regulate translational processes like epigenetic markers regulate transcription. Biology is so intricate!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
P-stalk ribosomes act as master regulators of cytokine-mediated processes
Cytokines remodel the ribosome to incorporate the P-stalk, therefore altering the translation of mRNAs involved in cytokine responses.
www.cell.com
December 12, 2024 at 3:12 PM
So cytokines orchestrate cellular rewiring to regulate translational processes like epigenetic markers regulate transcription. Biology is so intricate!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by NDimmuno
Immunologists, time to embrace your inner neuroscientist 🧠🧪
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
www.nature.com
December 11, 2024 at 12:00 PM
Immunologists, time to embrace your inner neuroscientist 🧠🧪
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Reposted by NDimmuno
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
December 9, 2024 at 1:39 AM
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Reposted by NDimmuno
#paperoftheweek
F-actin-rich filopodia crown pyroptotic corpses and bind to DNGR-1, to activate dendritic cells & drive immunity! 🦠
Huge congrats @inflammasomelab.bsky.social & all co-authors 👏🏻
@natimmunol.bsky.social
www.nature.com/articles/s41...
F-actin-rich filopodia crown pyroptotic corpses and bind to DNGR-1, to activate dendritic cells & drive immunity! 🦠
Huge congrats @inflammasomelab.bsky.social & all co-authors 👏🏻
@natimmunol.bsky.social
www.nature.com/articles/s41...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
www.nature.com
December 8, 2024 at 11:45 AM
#paperoftheweek
F-actin-rich filopodia crown pyroptotic corpses and bind to DNGR-1, to activate dendritic cells & drive immunity! 🦠
Huge congrats @inflammasomelab.bsky.social & all co-authors 👏🏻
@natimmunol.bsky.social
www.nature.com/articles/s41...
F-actin-rich filopodia crown pyroptotic corpses and bind to DNGR-1, to activate dendritic cells & drive immunity! 🦠
Huge congrats @inflammasomelab.bsky.social & all co-authors 👏🏻
@natimmunol.bsky.social
www.nature.com/articles/s41...
Reposted by NDimmuno
A starter pack for PhD students and Postdocs in Immunology to connect 🔽
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
December 4, 2024 at 7:14 AM
A starter pack for PhD students and Postdocs in Immunology to connect 🔽
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4