Moritz Hunkeler
@moritzhunkeler.bsky.social
Instrument Specialist at BioEM lab, Biozentrum, University of Basel
Every day I’m wafflin’ 🎶
November 18, 2025 at 9:08 AM
Every day I’m wafflin’ 🎶
Carboxylases are the best 🥰
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
October 31, 2025 at 7:14 AM
Carboxylases are the best 🥰
Reposted by Moritz Hunkeler
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
September 30, 2025 at 9:52 AM
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
What is the weight of an EM grid? 🤔
October 1, 2025 at 3:25 PM
What is the weight of an EM grid? 🤔
New toy installed 💥🧊
September 29, 2025 at 6:30 AM
New toy installed 💥🧊
Amazing, I wonder how many people are now sprinting back to some of their old data sets of small particles that they could never successfully process.. err, i have to go 🏃♂️💨
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 14, 2025 at 6:58 PM
Amazing, I wonder how many people are now sprinting back to some of their old data sets of small particles that they could never successfully process.. err, i have to go 🏃♂️💨
Yes great, new grid boxes that have no space to write on. With lids that no standard tool can open. 👍
May 15, 2025 at 6:41 PM
Yes great, new grid boxes that have no space to write on. With lids that no standard tool can open. 👍
Received program for amazing cryo-EM symposium 👍 It’s on a Saturday, 9-5 🤦🏻♂️
January 3, 2025 at 3:08 PM
Received program for amazing cryo-EM symposium 👍 It’s on a Saturday, 9-5 🤦🏻♂️
Reposted by Moritz Hunkeler
Indulged in the popular German New Years Eve tradition of watching Dinner for One - you may wish to indulge, or not
youtu.be/2pbJlHMpUlU?...
youtu.be/2pbJlHMpUlU?...
Dinner for One - The Original
YouTube video by Photography and Me
youtu.be
December 31, 2024 at 10:27 PM
Indulged in the popular German New Years Eve tradition of watching Dinner for One - you may wish to indulge, or not
youtu.be/2pbJlHMpUlU?...
youtu.be/2pbJlHMpUlU?...
Woohoo congrats!
Thrilled to share that I have been selected as one of this year's new EMBO Young Investigators. I look forward to meeting many of the other Young Investigators in the coming years, and I am most grateful to the members of my laboratory at the ICR who made this possible.
www.embo.org/press-releas...
www.embo.org/press-releas...
Twenty-seven scientists become EMBO Young Investigators – Press releases – EMBO
The group leaders join an international network of nearly 800 life scientists and receive financial support
www.embo.org
December 3, 2024 at 6:16 PM
Woohoo congrats!
My UBR4, despite being very active, always looked like garbage on the grids. Need to dig in here to find the secret sauce! Congrats to @micharapelab.bsky.social lab et al
The molecular basis of integrated stress response silencing https://www.biorxiv.org/content/10.1101/2024.12.02.626349v1
The molecular basis of integrated stress response silencing https://www.biorxiv.org/content/10.1101/2024.12.02.626349v1
Chronic stress response activation impairs cell survival and causes devastating degenerative disease
www.biorxiv.org
December 3, 2024 at 6:40 AM
My UBR4, despite being very active, always looked like garbage on the grids. Need to dig in here to find the secret sauce! Congrats to @micharapelab.bsky.social lab et al
Nice 🥳
This one was delayed for a while… apologies to the musicians. Collab with Matt, Will and Lorna (over on Twitter). And a great dev effort from Lorenz @lorenzlamm.bsky.social. Ofc @cellarchlab.com team. Comment if you want to help. #teamthylakoid
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular architecture of thylakoid membranes within intact spinach chloroplasts
Thylakoid membranes coordinate the light reactions of photosynthesis across multiple scales, coupling the architecture of an elaborate membrane network to the spatial organization of individual protei...
www.biorxiv.org
November 27, 2024 at 6:44 PM
Nice 🥳
Reposted by Moritz Hunkeler
New #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1
Homologous to E6AP C-Terminus (HECT) ubiquitin ligases play key roles in essential pathways such as DNA repair, cell cycle control or protein quality control. Tom1 is one of five HECT ubiquitin E3 lig...
www.biorxiv.org
November 27, 2024 at 1:00 PM
New #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
When are there too many starter packs? 🤔
November 20, 2024 at 8:39 AM
When are there too many starter packs? 🤔
Hello @subAngstrom, where art thou?
November 14, 2024 at 7:15 PM
Hello @subAngstrom, where art thou?
No answer on the other platform, so I ask here again: Is the 3DFSC server working for anybody?
November 13, 2024 at 7:14 AM
No answer on the other platform, so I ask here again: Is the 3DFSC server working for anybody?
Reposted by Moritz Hunkeler
Over 4 years in the making, I am extremely happy to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells: www.biorxiv.org/content/10.1...
February 24, 2024 at 9:37 AM
Over 4 years in the making, I am extremely happy to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells: www.biorxiv.org/content/10.1...
Stuff’s glowing..
November 12, 2024 at 11:59 AM
Stuff’s glowing..
Reposted by Moritz Hunkeler
November 8, 2024 at 10:01 PM
Did I miss something?
November 11, 2024 at 6:22 AM
Did I miss something?
Reposted by Moritz Hunkeler
Opening for an awesome group leader to join our community on the 5th/6th floor of the @biozentrum. We're looking for someone who brings an exiting biological program using a combo of structural biology, cellular imaging, and biophysics.
Come join us!!🧪🧶🧬🔬👩🔬
www.biozentrum.unibas.ch/open-positio...
Come join us!!🧪🧶🧬🔬👩🔬
www.biozentrum.unibas.ch/open-positio...
Assistant/Associate Professor in Structural Biology, Biological Imaging or Biophysics
www.biozentrum.unibas.ch
July 19, 2024 at 8:30 AM
Opening for an awesome group leader to join our community on the 5th/6th floor of the @biozentrum. We're looking for someone who brings an exiting biological program using a combo of structural biology, cellular imaging, and biophysics.
Come join us!!🧪🧶🧬🔬👩🔬
www.biozentrum.unibas.ch/open-positio...
Come join us!!🧪🧶🧬🔬👩🔬
www.biozentrum.unibas.ch/open-positio...
Interesting 👍🏻
I think the ideal is creating these during submission (which is doable) and having authors sign off on them just as they sign off that the PDF created from the Word file is OK
November 18, 2023 at 8:46 PM
Interesting 👍🏻
Reposted by Moritz Hunkeler
Read tomorrow's Nature to find out what we think 7 years of solving #cryoEM structures of brain-derived #amyloids has taught us about neurodegeneration, and where to go from here. With Michel Goedert and Ben Ryskeldi-Falcon, and very grateful to present and past group members.
rdcu.be/dnaXd
rdcu.be/dnaXd
September 27, 2023 at 4:11 PM
Read tomorrow's Nature to find out what we think 7 years of solving #cryoEM structures of brain-derived #amyloids has taught us about neurodegeneration, and where to go from here. With Michel Goedert and Ben Ryskeldi-Falcon, and very grateful to present and past group members.
rdcu.be/dnaXd
rdcu.be/dnaXd
So how does this work?
September 20, 2023 at 6:04 PM
So how does this work?