Milka Kostic
@milkakostic.bsky.social
chemical biology enthusiast & strategist; I make impossible things possible - all before breakfast!
New paper from Will Gibson's lab showcases how induced proximity can be used to induce targeted protein mislocalization as a strategy to trigger cancer cell death.
Interesting, very interesting!!!!!
www.nature.com/articles/s41...
Interesting, very interesting!!!!!
www.nature.com/articles/s41...
Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs - Nature Chemical Biology
Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while ...
www.nature.com
November 4, 2025 at 2:26 PM
New paper from Will Gibson's lab showcases how induced proximity can be used to induce targeted protein mislocalization as a strategy to trigger cancer cell death.
Interesting, very interesting!!!!!
www.nature.com/articles/s41...
Interesting, very interesting!!!!!
www.nature.com/articles/s41...
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Assistant/Associate Professor, Chemical Biology job
careers.dana-farber.org
June 30, 2025 at 7:30 PM
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
New paper from @nickpolizzi.bsky.social, Bill Degrado and Bobo Dang showing that de novo designed small molecule binding proteins can bind to the drug and clear it from the circulation in vivo. Read in Nature Biomedical Engineering!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants - Nature Biomedical Engineering
Cyclic and mirror-image variants of de novo-designed proteins effectively bind and clear small-molecule drugs in vivo in less than 30 min, highlighting the applicability of computational tools to prod...
www.nature.com
June 6, 2025 at 11:52 AM
New paper from @nickpolizzi.bsky.social, Bill Degrado and Bobo Dang showing that de novo designed small molecule binding proteins can bind to the drug and clear it from the circulation in vivo. Read in Nature Biomedical Engineering!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Milka Kostic
⏳ Only 4 days left to submit your abstract and secure the #ChemBioParis2025 early bird rate!
Deadline: June 10 🗓️
Don’t miss keynotes, awards & the trainee symposium in Paris 🇫🇷
🔗 chembioparis2025.com
#ChemBioEvent #ICBS2025 #ECBS2025
Deadline: June 10 🗓️
Don’t miss keynotes, awards & the trainee symposium in Paris 🇫🇷
🔗 chembioparis2025.com
#ChemBioEvent #ICBS2025 #ECBS2025
June 6, 2025 at 11:19 AM
⏳ Only 4 days left to submit your abstract and secure the #ChemBioParis2025 early bird rate!
Deadline: June 10 🗓️
Don’t miss keynotes, awards & the trainee symposium in Paris 🇫🇷
🔗 chembioparis2025.com
#ChemBioEvent #ICBS2025 #ECBS2025
Deadline: June 10 🗓️
Don’t miss keynotes, awards & the trainee symposium in Paris 🇫🇷
🔗 chembioparis2025.com
#ChemBioEvent #ICBS2025 #ECBS2025
Reposted by Milka Kostic
#ChemRxiv would love your help! Give us your thoughts on preprints in a brief survey (americanchemical.co1.qualtrics.com/jfe/form/SV_...), whether or not you've ever posted a #preprint before. Your feedback will help us focus on the best possible ways to support open science in chemistry.
ChemRxiv Community Survey
ChemRxiv is conducting a survey to better understand your views on preprints. Your input will be invaluable in helping us shape new features, understand your questions or concerns about preprints, and...
americanchemical.co1.qualtrics.com
June 5, 2025 at 1:35 PM
#ChemRxiv would love your help! Give us your thoughts on preprints in a brief survey (americanchemical.co1.qualtrics.com/jfe/form/SV_...), whether or not you've ever posted a #preprint before. Your feedback will help us focus on the best possible ways to support open science in chemistry.
Reposted by Milka Kostic
🌍 Be part of the global spotlight at #ChemBioParis2025 — the premier Chemical Biology event of 2025 at Sorbonne Université, Paris.
💼 Sponsorship starts at just €300. Showcase your brand to world-leading scientists!
📩 Get our partnership kit: chembioparis2025.com
#ICBS2025 #ECBS2025 #ChemBio
💼 Sponsorship starts at just €300. Showcase your brand to world-leading scientists!
📩 Get our partnership kit: chembioparis2025.com
#ICBS2025 #ECBS2025 #ChemBio
May 12, 2025 at 11:20 AM
🌍 Be part of the global spotlight at #ChemBioParis2025 — the premier Chemical Biology event of 2025 at Sorbonne Université, Paris.
💼 Sponsorship starts at just €300. Showcase your brand to world-leading scientists!
📩 Get our partnership kit: chembioparis2025.com
#ICBS2025 #ECBS2025 #ChemBio
💼 Sponsorship starts at just €300. Showcase your brand to world-leading scientists!
📩 Get our partnership kit: chembioparis2025.com
#ICBS2025 #ECBS2025 #ChemBio
Reposted by Milka Kostic
Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID
Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID
Here we describe ProtacID, a flexible BioID (proximity-dependent biotinylation)-based approach to identify PROTAC-proximal proteins in living cells. ProtacID analysis of VHL- and CRBN-recruiting PROTA...
www.biorxiv.org
May 12, 2025 at 10:57 AM
Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID
Reposted by Milka Kostic
BIG NEWS - for the first time ever, we're running a Bioimage Analysis Beginnings Bootcamp. Learn #bioimageanalysis from awesome folks, and gain familiarity with some new tools as well as how to pick the right tool in the first place. Aug 4th-8th - apply here (soon!) forms.gle/d2fCXsrWHVP8...
May 1, 2025 at 9:22 PM
BIG NEWS - for the first time ever, we're running a Bioimage Analysis Beginnings Bootcamp. Learn #bioimageanalysis from awesome folks, and gain familiarity with some new tools as well as how to pick the right tool in the first place. Aug 4th-8th - apply here (soon!) forms.gle/d2fCXsrWHVP8...
Reposted by Milka Kostic
The cryo-em core at kumc is looking for a lab manager. This is an exciting opportunity to join a growing facility. kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
May 8, 2025 at 4:04 PM
The cryo-em core at kumc is looking for a lab manager. This is an exciting opportunity to join a growing facility. kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
NEW PREPRINT ALERT: Buhrlage lab in collaboration with @irinabezsonova.bsky.social has developed a new class of USP7 activators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been assoc...
www.biorxiv.org
May 8, 2025 at 4:27 PM
NEW PREPRINT ALERT: Buhrlage lab in collaboration with @irinabezsonova.bsky.social has developed a new class of USP7 activators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Milka Kostic
Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1...
🧵🧪
🧵🧪
Zero-shot design of drug-binding proteins via neural selection-expansion
Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...
www.biorxiv.org
April 28, 2025 at 3:22 PM
Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1...
🧵🧪
🧵🧪
Reposted by Milka Kostic
We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅
🔗 Supplementary material: ars.els-cdn.com/content/imag...
#ChemicalProbes #DrugDiscovery #ChemicalBiology
🔗 Supplementary material: ars.els-cdn.com/content/imag...
#ChemicalProbes #DrugDiscovery #ChemicalBiology
ars.els-cdn.com
March 2, 2025 at 9:14 AM
We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅
🔗 Supplementary material: ars.els-cdn.com/content/imag...
#ChemicalProbes #DrugDiscovery #ChemicalBiology
🔗 Supplementary material: ars.els-cdn.com/content/imag...
#ChemicalProbes #DrugDiscovery #ChemicalBiology
Reposted by Milka Kostic
Review @cp-cellchembiol.bsky.social @volkerhaucke-lab.bsky.social
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Mechanisms and functions of lysosomal lipid homeostasis
In this review Ebner et al. summarize and discuss the rapidly increasing knowledge
regarding the mechanisms of lysosomal lipid turnover and export as well as the pathways
for the homeostatic control a...
www.cell.com
March 7, 2025 at 6:20 PM
Review @cp-cellchembiol.bsky.social @volkerhaucke-lab.bsky.social
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Reposted by Milka Kostic
Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free.
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
March 5, 2025 at 5:12 PM
Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free.
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
Potential explanation for the results of the most recent elections?
Seems like H. sapiens can't fight biology? "Both male and female mice exhibit female preference (under normal conditions) but shift to male preference when confronted with survival threats."
www.science.org/doi/10.1126/...
Seems like H. sapiens can't fight biology? "Both male and female mice exhibit female preference (under normal conditions) but shift to male preference when confronted with survival threats."
www.science.org/doi/10.1126/...
Sexually dimorphic dopaminergic circuits determine sex preference
Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and femal...
www.science.org
February 4, 2025 at 12:19 PM
Potential explanation for the results of the most recent elections?
Seems like H. sapiens can't fight biology? "Both male and female mice exhibit female preference (under normal conditions) but shift to male preference when confronted with survival threats."
www.science.org/doi/10.1126/...
Seems like H. sapiens can't fight biology? "Both male and female mice exhibit female preference (under normal conditions) but shift to male preference when confronted with survival threats."
www.science.org/doi/10.1126/...
What do you get when you put @aledmedwards.bsky.social and me in front of a microphone? You get a great conversation about #openscience, #ChemicalProbes, and a crazy goal about creating tool compounds and probes for every protein in the human proteome by 2035. creators.spotify.com/pod/show/tar...
Episode 2: Why Open Science with Aled Edwards? by Target 2035 Podcast series
What if the greatest breakthroughs in research were locked away, inaccessible to the world? For Aled Edwards, this wasn’t just a hypothetical but a reality he encountered early in his career. In this ...
creators.spotify.com
January 22, 2025 at 5:30 PM
What do you get when you put @aledmedwards.bsky.social and me in front of a microphone? You get a great conversation about #openscience, #ChemicalProbes, and a crazy goal about creating tool compounds and probes for every protein in the human proteome by 2035. creators.spotify.com/pod/show/tar...
Our upcoming #TPD webinar features an intriguing talk "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways" by Itay Koren (Bar-Ilan University). Tomorrow at noon EST - www.danafarbertargetedproteindegradation.org
Upcoming Speakers | Targeted Protein Degradation Webinar Series
www.danafarbertargetedproteindegradation.org
January 22, 2025 at 5:25 PM
Our upcoming #TPD webinar features an intriguing talk "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways" by Itay Koren (Bar-Ilan University). Tomorrow at noon EST - www.danafarbertargetedproteindegradation.org
Reposted by Milka Kostic
An in-cell approach to evaluate E3 ligases for use in targeted protein degradation. https://www.biorxiv.org/content/10.1101/2024.12.19.629291v1
December 21, 2024 at 2:30 PM
An in-cell approach to evaluate E3 ligases for use in targeted protein degradation. https://www.biorxiv.org/content/10.1101/2024.12.19.629291v1
Reposted by Milka Kostic
In a study published today in @jclinical-invest.bsky.social, @behnamnabet.bsky.social and collaborators describe how they used targeted protein degradation in mice to rapidly destroy lung and pancreas tumors caused by a variant of a commonly mutated, cancer-driving gene.
Tricking cells into trashing cancer
In a study published today in the Journal of Clinical Investigation, Fred Hutch Cancer Center cancer chemical biologist Behnam Nabet and his collaborators describe how they used targeted protein degra...
www.fredhutch.org
January 9, 2025 at 7:29 PM
In a study published today in @jclinical-invest.bsky.social, @behnamnabet.bsky.social and collaborators describe how they used targeted protein degradation in mice to rapidly destroy lung and pancreas tumors caused by a variant of a commonly mutated, cancer-driving gene.
Reposted by Milka Kostic
Ever wonder where Nobel Prize-winning AlphaFold got its training data? Read how pioneering crystallographer Helen Berman helped build the Protein Data Bank as a home for more than 200,000 protein structures that would come to shape AI and protein prediction ➡️
The huge protein database that spawned AlphaFold and biology’s AI revolution
Pioneering crystallographer Helen Berman helped to set up the massive collection of protein structures that underpins the Nobel-prize-winning tool’s success.
buff.ly
January 20, 2025 at 8:12 PM
Ever wonder where Nobel Prize-winning AlphaFold got its training data? Read how pioneering crystallographer Helen Berman helped build the Protein Data Bank as a home for more than 200,000 protein structures that would come to shape AI and protein prediction ➡️
Reposted by Milka Kostic
Excited to share this beast of a review on the potential of protein-based degraders from trainees who are all not on the Sky! Herein we cover choice of binders, selection strategies, E3 ligases, and DELIVERY! pubs.acs.org/doi/10.1021/...
Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics
The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due to the ability of degrader molecules to selectively modulate disease-relevant proteins. A key limitation to ...
pubs.acs.org
January 18, 2025 at 1:07 AM
Excited to share this beast of a review on the potential of protein-based degraders from trainees who are all not on the Sky! Herein we cover choice of binders, selection strategies, E3 ligases, and DELIVERY! pubs.acs.org/doi/10.1021/...
Reposted by Milka Kostic
We've a postdoc opening for our lab at the Broad: Cambridge MA!
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
December 18, 2024 at 3:50 PM
We've a postdoc opening for our lab at the Broad: Cambridge MA!
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Reposted by Milka Kostic
The Young Scientist Award of @gdchbiochem.bsky.social of @gdch.bsky.social is open for nominations. If you know an excellent candidate, who defended their PhD or had a publication in 2024 in the field of biochemistry (or related), strongly consider nominating them. en.gdch.de/network-stru...
December 13, 2024 at 12:43 PM
The Young Scientist Award of @gdchbiochem.bsky.social of @gdch.bsky.social is open for nominations. If you know an excellent candidate, who defended their PhD or had a publication in 2024 in the field of biochemistry (or related), strongly consider nominating them. en.gdch.de/network-stru...