High-pressure freezer. Vitrifies samples that are too thick for standard plunge-freezing 👌

Checked with Thermo, the plan 4 does take standard cassettes from standard nanocabs. The only thing that is (obviously) not compatible is the optional vacuum nanocab and the plan 3 autoloader (but it can be upgraded). The tomogrids are compatible with both autoloaders

“Existing instruments
equipped with an Autoloader can be retrofitted to be
compatible with both standard capsules and the
Vacuum Capsule.” This implies a system can take both types of capsules

Yeah that’s if you want to use the new vacuum nanocab on the older systems.. but what about using the normal nanocab on the new autoloader?

Unless i misunderstand this somewhat hazy documentation, which is entirely possible 😅

I don’t think the plan 3 and plan 4 autoloaders are per se not compatible.. the plan 4 does still take the normal cassettes, right? You’re only referring to the new TomoGrids for which you need the plan 4

Fair enough, but I normally have other plans in the night 🤔💤

Exciting! Can you let us know here 🦋 how install and benchmarking is going?

No raw micrograph or processing figure?? Could you please add this during peer review ?@micharapelab.bsky.social

A Brave New World

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