Mike Lacy
@mlacyphd.bsky.social
#OpenScience supporter, I work @Addgene.bsky.social curating DNA and web content. Previously worked at ASCB, publishing, Yale Biophysics PhD. He/him
Pinned
Mike Lacy
@mlacyphd.bsky.social
· Nov 12
👋 Intro for new folks:
I'm a scientific curator at @addgene.bsky.social. You might see my blog posts or get emails from me about depositing plasmids. Our team mainly works behind the scenes cleaning up data, making/updating webpages, and more. I'm always on the lookout for cool new science to share!
I'm a scientific curator at @addgene.bsky.social. You might see my blog posts or get emails from me about depositing plasmids. Our team mainly works behind the scenes cleaning up data, making/updating webpages, and more. I'm always on the lookout for cool new science to share!
Reposted by Mike Lacy
Are you presenting research at #SfN25 that uses materials available through Addgene?
Join our Addgene Ambassadors program!
Learn more: https://twp.ai/4ispwV
Join our Addgene Ambassadors program!
Learn more: https://twp.ai/4ispwV
November 6, 2025 at 5:00 PM
Are you presenting research at #SfN25 that uses materials available through Addgene?
Join our Addgene Ambassadors program!
Learn more: https://twp.ai/4ispwV
Join our Addgene Ambassadors program!
Learn more: https://twp.ai/4ispwV
Reposted by Mike Lacy
Newly released Stockholm Declaration recommends the following reforms to publishing:
1. Academia resumes control of publishing
2. Incentive systems to merit quality, not quantity
3. Independent fraud detection and prevention
4. Legislation and policies to protect science quality and integrity
1. Academia resumes control of publishing
2. Incentive systems to merit quality, not quantity
3. Independent fraud detection and prevention
4. Legislation and policies to protect science quality and integrity
Reformation of science publishing: the Stockholm Declaration | Royal Society Open Science
Science relies on integrity and trustworthiness. But scientists under career pressure
are lured to purchase fake publications from ‘paper mills’ that use AI-generated data,
text and image fabrication....
royalsocietypublishing.org
November 5, 2025 at 7:07 PM
Newly released Stockholm Declaration recommends the following reforms to publishing:
1. Academia resumes control of publishing
2. Incentive systems to merit quality, not quantity
3. Independent fraud detection and prevention
4. Legislation and policies to protect science quality and integrity
1. Academia resumes control of publishing
2. Incentive systems to merit quality, not quantity
3. Independent fraud detection and prevention
4. Legislation and policies to protect science quality and integrity
Reposted by Mike Lacy
🕰️In November 2000, Nikon launched MicroscopyU, an online educational hub aimed at inspiring microscope users worldwide.
🌐MicroscopyU continues to be a trusted source of learning and inspiration.
🔗Explore tutorials, techniques & insights: microscopyu.com
#NikonMicroscopy
🌐MicroscopyU continues to be a trusted source of learning and inspiration.
🔗Explore tutorials, techniques & insights: microscopyu.com
#NikonMicroscopy
November 5, 2025 at 8:04 AM
🕰️In November 2000, Nikon launched MicroscopyU, an online educational hub aimed at inspiring microscope users worldwide.
🌐MicroscopyU continues to be a trusted source of learning and inspiration.
🔗Explore tutorials, techniques & insights: microscopyu.com
#NikonMicroscopy
🌐MicroscopyU continues to be a trusted source of learning and inspiration.
🔗Explore tutorials, techniques & insights: microscopyu.com
#NikonMicroscopy
Reposted by Mike Lacy
"Science is being destroyed across many agencies" say federal researchers.
For my latest @nature.com piece, I spoke to 19 different scientists across EPA, NOAA, NIH, NASA, and USGS to document how science is being dismantled across US federal agencies.
For my latest @nature.com piece, I spoke to 19 different scientists across EPA, NOAA, NIH, NASA, and USGS to document how science is being dismantled across US federal agencies.
Dismantling of US federal agencies will ‘destroy science’
From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak out about the irreplaceable facilities, institutional knowledge and ...
www.nature.com
November 4, 2025 at 2:58 PM
"Science is being destroyed across many agencies" say federal researchers.
For my latest @nature.com piece, I spoke to 19 different scientists across EPA, NOAA, NIH, NASA, and USGS to document how science is being dismantled across US federal agencies.
For my latest @nature.com piece, I spoke to 19 different scientists across EPA, NOAA, NIH, NASA, and USGS to document how science is being dismantled across US federal agencies.
Reposted by Mike Lacy
A small 🧵 encouraging people to publish protocols.
Our #AutoSpectral release has made me reflect on how much the community tends to appreciate protocol papers. People rarely present protocols as their main achievements, but they are often the most impactful work.
www.biorxiv.org/content/10.1...
Our #AutoSpectral release has made me reflect on how much the community tends to appreciate protocol papers. People rarely present protocols as their main achievements, but they are often the most impactful work.
www.biorxiv.org/content/10.1...
AutoSpectral improves spectral flow cytometry accuracy through optimised spectral unmixing and autofluorescence-matching at the cellular level
The advent of spectral flow cytometry has seen a rapid rise in the complexity of flow cytometry experiments, allowing the construction of assays with at least 50 fluorescent parameters. To correctly d...
www.biorxiv.org
October 31, 2025 at 9:09 AM
A small 🧵 encouraging people to publish protocols.
Our #AutoSpectral release has made me reflect on how much the community tends to appreciate protocol papers. People rarely present protocols as their main achievements, but they are often the most impactful work.
www.biorxiv.org/content/10.1...
Our #AutoSpectral release has made me reflect on how much the community tends to appreciate protocol papers. People rarely present protocols as their main achievements, but they are often the most impactful work.
www.biorxiv.org/content/10.1...
To be clear, it's a very particular type of junk article (possibly completely fake), not "40% of all stroke research". But yeah, if you're doing a lit search on your gene of interest and come across papers that look like these, just say nope 🙅
40 Percent of Stroke Animal Studies May Have Problematic Images
Red flags during a literature review led to the discovery of over 200 papers on animal models of stroke with duplicated images, which is likely an underestimate.
www.the-scientist.com/40-percent-o...
Red flags during a literature review led to the discovery of over 200 papers on animal models of stroke with duplicated images, which is likely an underestimate.
www.the-scientist.com/40-percent-o...
40 Percent of Stroke Animal Studies May Have Problematic Images
Red flags during a literature review led to the discovery of over 200 papers on animal models of stroke with duplicated images, which is likely an underestimate.
www.the-scientist.com
October 31, 2025 at 9:48 AM
To be clear, it's a very particular type of junk article (possibly completely fake), not "40% of all stroke research". But yeah, if you're doing a lit search on your gene of interest and come across papers that look like these, just say nope 🙅
Reposted by Mike Lacy
Anyone have book recommendations for graduate students for scientific writing and/or presenting ?
October 30, 2025 at 3:53 PM
Anyone have book recommendations for graduate students for scientific writing and/or presenting ?
Reposted by Mike Lacy
Thinking we should make some monoclonal antibodies so wondering what experiences people have had with different companies, as it's not going to be cheap so want to get our moneys worth?
October 2, 2025 at 7:57 AM
Thinking we should make some monoclonal antibodies so wondering what experiences people have had with different companies, as it's not going to be cheap so want to get our moneys worth?
Reposted by Mike Lacy
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
October 30, 2025 at 11:44 AM
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
Reposted by Mike Lacy
Animals don't send emails.
Animals don't post rage bait on social media.
Vampire bats feed their friends.
Humpback whales make dinner together.
We can learn so much from animals.
Learn a new lesson from animals every month in the Love Notes from Nature 2026 calendar! Get one at squidfacts.net
Animals don't post rage bait on social media.
Vampire bats feed their friends.
Humpback whales make dinner together.
We can learn so much from animals.
Learn a new lesson from animals every month in the Love Notes from Nature 2026 calendar! Get one at squidfacts.net
October 27, 2025 at 4:05 PM
Animals don't send emails.
Animals don't post rage bait on social media.
Vampire bats feed their friends.
Humpback whales make dinner together.
We can learn so much from animals.
Learn a new lesson from animals every month in the Love Notes from Nature 2026 calendar! Get one at squidfacts.net
Animals don't post rage bait on social media.
Vampire bats feed their friends.
Humpback whales make dinner together.
We can learn so much from animals.
Learn a new lesson from animals every month in the Love Notes from Nature 2026 calendar! Get one at squidfacts.net
I love this series from @thetransmitter.bsky.social, and also remember having such a strong impression from reading this paper in grad school. Even tiny parts of the cell are wildly crowded and complex! www.cell.com/cell/fulltex...
October 27, 2025 at 10:40 AM
I love this series from @thetransmitter.bsky.social, and also remember having such a strong impression from reading this paper in grad school. Even tiny parts of the cell are wildly crowded and complex! www.cell.com/cell/fulltex...
Reposted by Mike Lacy
Very happy to share an expansion to the comparative gene editing toolkit: AAVs to reduce dopamine receptor levels that are functional in many rodent species. Fun collaboration with @malu-murugan.bsky.social, Elliott Albers and Frank Meye.
Comparative gene editing reduces dopamine receptor levels across rodent species
Translational challenges in neuroscience originate from species-specific differences that limit the generalizability of experimental findings. Comparative approaches can help distinguish conserved fro...
www.biorxiv.org
October 22, 2025 at 5:59 PM
Very happy to share an expansion to the comparative gene editing toolkit: AAVs to reduce dopamine receptor levels that are functional in many rodent species. Fun collaboration with @malu-murugan.bsky.social, Elliott Albers and Frank Meye.
Reposted by Mike Lacy
Bluesky, we need your help! Why does plain eGFP partially colocalize with actin filaments in cells? (No bleed-through, observed in multiple cell lines. Whole plasmid sequenced.) #FluorescenceFriday #Microscopy
October 24, 2025 at 1:11 PM
Bluesky, we need your help! Why does plain eGFP partially colocalize with actin filaments in cells? (No bleed-through, observed in multiple cell lines. Whole plasmid sequenced.) #FluorescenceFriday #Microscopy
Reposted by Mike Lacy
Developers, it’s live 👇
The Addgene Developers Portal gives you API access to plasmid + sequence data.
Query, integrate, and build with Addgene’s plasmid data.
Docs + access:
The Addgene Developers Portal gives you API access to plasmid + sequence data.
Query, integrate, and build with Addgene’s plasmid data.
Docs + access:
Addgene Developers Portal | Access Plasmid and Sequence Data via API
The Addgene Developers Portal provides API access to plasmid and sequence data.
twp.ai
October 23, 2025 at 9:00 AM
Developers, it’s live 👇
The Addgene Developers Portal gives you API access to plasmid + sequence data.
Query, integrate, and build with Addgene’s plasmid data.
Docs + access:
The Addgene Developers Portal gives you API access to plasmid + sequence data.
Query, integrate, and build with Addgene’s plasmid data.
Docs + access:
Reposted by Mike Lacy
🧠🥼🧬🧪🔬
Last year at @sfn.org I ran a workshop on "Opening the File Drawer" with Ben Kolber, Stacey Winham, Paul Sternberg, & Alex Freeman (@alexandrafreeman.bsky.social).
We've shared the resources that we compiled for that workshop in this new paper. ❤️
@comm4rigor.bsky.social @ummni.bsky.social
Last year at @sfn.org I ran a workshop on "Opening the File Drawer" with Ben Kolber, Stacey Winham, Paul Sternberg, & Alex Freeman (@alexandrafreeman.bsky.social).
We've shared the resources that we compiled for that workshop in this new paper. ❤️
@comm4rigor.bsky.social @ummni.bsky.social
Science projects are designed & funded on the scale of years, so what happens if you need to finish prematurely? @mhagenauer.bsky.social &co discuss solutions for quickly documenting partially finished projects & publishing ‘as you go’ in an uncertain environment @plosbiology.org 🧪 plos.io/4ovd1jH
October 22, 2025 at 7:50 PM
🧠🥼🧬🧪🔬
Last year at @sfn.org I ran a workshop on "Opening the File Drawer" with Ben Kolber, Stacey Winham, Paul Sternberg, & Alex Freeman (@alexandrafreeman.bsky.social).
We've shared the resources that we compiled for that workshop in this new paper. ❤️
@comm4rigor.bsky.social @ummni.bsky.social
Last year at @sfn.org I ran a workshop on "Opening the File Drawer" with Ben Kolber, Stacey Winham, Paul Sternberg, & Alex Freeman (@alexandrafreeman.bsky.social).
We've shared the resources that we compiled for that workshop in this new paper. ❤️
@comm4rigor.bsky.social @ummni.bsky.social
Reposted by Mike Lacy
Thanks for sharing your tools! 🧬🧑🔬 Find the plasmids here:
www.addgene.org/browse/artic...
www.addgene.org/browse/artic...
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
October 17, 2025 at 7:48 PM
Thanks for sharing your tools! 🧬🧑🔬 Find the plasmids here:
www.addgene.org/browse/artic...
www.addgene.org/browse/artic...
Reposted by Mike Lacy
🧪Hello friends! I'm working on a piece about putting together the best tenure/promotion package, and I'd love to hear from STEM folks who have recently done this or have experience evaluating these types of proposals. Please RT for reach, and feel free to reach out with any Qs!
October 13, 2025 at 8:16 PM
🧪Hello friends! I'm working on a piece about putting together the best tenure/promotion package, and I'd love to hear from STEM folks who have recently done this or have experience evaluating these types of proposals. Please RT for reach, and feel free to reach out with any Qs!
Reposted by Mike Lacy
We love sharing tools developed by @hhmijanelia.bsky.social GENIE Project! 🧠🔬🧬 Find their plasmids with biosensors for calcium, GABA, glutamate, and more: www.addgene.org/GENIE_Project/
October 14, 2025 at 3:46 PM
We love sharing tools developed by @hhmijanelia.bsky.social GENIE Project! 🧠🔬🧬 Find their plasmids with biosensors for calcium, GABA, glutamate, and more: www.addgene.org/GENIE_Project/
Reposted by Mike Lacy
🧞Like its namesake, Janelia’s GENIE Project Team makes wishes come true. Luckily for biologists, this genie doesn’t grant just 3 requests.
🧪Learn about how GENIE has accelerated the development of best-in-class sensors for measuring neuronal activity. https://hhmi.news/4gFqwKX
🧪Learn about how GENIE has accelerated the development of best-in-class sensors for measuring neuronal activity. https://hhmi.news/4gFqwKX
Unleashing the GENIE: Janelia's Project Team develops state-of-the-art sensors for biological research
For more than a decade, the GENIE Project Team at HHMI's Janelia Research Campus has collaborated with the research campus's tool developers and tool users to take innovative biological sensors from novel prototypes to widely used laboratory staples--a ...
hhmi.news
October 14, 2025 at 3:00 PM
🧞Like its namesake, Janelia’s GENIE Project Team makes wishes come true. Luckily for biologists, this genie doesn’t grant just 3 requests.
🧪Learn about how GENIE has accelerated the development of best-in-class sensors for measuring neuronal activity. https://hhmi.news/4gFqwKX
🧪Learn about how GENIE has accelerated the development of best-in-class sensors for measuring neuronal activity. https://hhmi.news/4gFqwKX
Reposted by Mike Lacy
Query from Slack: Looking for people with experience in proximity labelling in zebrafish? Considering using miniTurbo instead of BioID or APEX, what do the community think of it? Also looking for anybody that has experience with targeting labeling enzymes to the ER/secretory pathway? #AskZebrafish
October 9, 2025 at 4:35 PM
Query from Slack: Looking for people with experience in proximity labelling in zebrafish? Considering using miniTurbo instead of BioID or APEX, what do the community think of it? Also looking for anybody that has experience with targeting labeling enzymes to the ER/secretory pathway? #AskZebrafish
Reposted by Mike Lacy
Chonnettia Jones, Addgene’s President & Executive Director, is one of Endpoints News’ 2025 Top Women in Biopharma R&D! She is driving Addgene’s growth to enable more discovery and innovation, powered by the sharing of scientific resources.
🔗
🔗
endpoints.news
Meet 20 women reshaping biopharma, from early discovery to patient advocacy
twp.ai
October 8, 2025 at 3:00 PM
Chonnettia Jones, Addgene’s President & Executive Director, is one of Endpoints News’ 2025 Top Women in Biopharma R&D! She is driving Addgene’s growth to enable more discovery and innovation, powered by the sharing of scientific resources.
🔗
🔗
Reposted by Mike Lacy
New CRISPR libraries from the @johndoench.bsky.social and Root labs — Jacquere (human) and Julianna (mouse).
A perfect pairing for your next screen. 🍷🧀
https://twp.ai/9PX2kT
https://twp.ai/4irnYP
A perfect pairing for your next screen. 🍷🧀
https://twp.ai/9PX2kT
https://twp.ai/4irnYP
October 6, 2025 at 1:30 PM
New CRISPR libraries from the @johndoench.bsky.social and Root labs — Jacquere (human) and Julianna (mouse).
A perfect pairing for your next screen. 🍷🧀
https://twp.ai/9PX2kT
https://twp.ai/4irnYP
A perfect pairing for your next screen. 🍷🧀
https://twp.ai/9PX2kT
https://twp.ai/4irnYP
Reposted by Mike Lacy
There’s some things I disagree with here but this is absolutely on point: “Science moves faster when we write for each other rather than for gatekeepers...The transformation of scientific communication requires scientists willing to experiment and builders ready to support them.”
New Blog Post:
Scholarly Communication Is a Research Problem. This Means You.
pracheeac.substack.com/p/scholarly-...
Scholarly Communication Is a Research Problem. This Means You.
pracheeac.substack.com/p/scholarly-...
Scholarly Communication Is a Research Problem. This Means You.
Scholarly Communication Is a Research Problem.
pracheeac.substack.com
October 4, 2025 at 4:22 PM
There’s some things I disagree with here but this is absolutely on point: “Science moves faster when we write for each other rather than for gatekeepers...The transformation of scientific communication requires scientists willing to experiment and builders ready to support them.”
Reposted by Mike Lacy
🧪New from me for @nature.com: Nearly every model organism used in research has it's own database, called a MOD. These resources underpin decades of discovery, but they're collectively struggling amid funding cuts.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Model organism databases face budget cuts and closures
Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.
www.nature.com
October 2, 2025 at 3:54 PM
🧪New from me for @nature.com: Nearly every model organism used in research has it's own database, called a MOD. These resources underpin decades of discovery, but they're collectively struggling amid funding cuts.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Mike Lacy
These plasmids from @promegacorporation.bsky.social are exceptional new offerings from Addgene for a few reasons:
- Since there is no MTA, they are available to industry customers (joining an ever-growing catalog subset: www.addgene.org/industry/)
- They are available in a DNA format!
- Since there is no MTA, they are available to industry customers (joining an ever-growing catalog subset: www.addgene.org/industry/)
- They are available in a DNA format!
October 2, 2025 at 3:04 PM
These plasmids from @promegacorporation.bsky.social are exceptional new offerings from Addgene for a few reasons:
- Since there is no MTA, they are available to industry customers (joining an ever-growing catalog subset: www.addgene.org/industry/)
- They are available in a DNA format!
- Since there is no MTA, they are available to industry customers (joining an ever-growing catalog subset: www.addgene.org/industry/)
- They are available in a DNA format!