Shutt Lab
@mitomorph.bsky.social
Associate Professor at University of Calgary studying mitochondria.
Reposted by Shutt Lab
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Reposted by Shutt Lab
We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv: www.biorxiv.org/content/10.1...
Hyper-proliferation of Adipose Progenitors During Developmental Adipogenesis Programs Higher Adipocyte Number and Early-onset Obesity in Offspring Born to Obese Dams
Being born to a mother who was obese during pregnancy is one of the strongest predictors of early onset obesity and metabolic syndrome. To identify the developmental mechanism linking maternal obesity...
www.biorxiv.org
September 18, 2025 at 3:45 PM
We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv: www.biorxiv.org/content/10.1...
Reposted by Shutt Lab
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1
June 27, 2025 at 2:33 PM
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1
Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.
New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...
www.biorxiv.org
June 27, 2025 at 4:20 PM
Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.
Congrats to ShuttLab PhD student Mashiat Zaman @mashiatzaman.bsky.social on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa
June 3, 2025 at 9:54 PM
Congrats to ShuttLab PhD student Mashiat Zaman @mashiatzaman.bsky.social on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa
Reposted by Shutt Lab
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications
Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...
www.nature.com
June 1, 2025 at 1:16 AM
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Reposted by Shutt Lab
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mitochondrial presequences harbor variable strengths to maintain organellar function
Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...
www.biorxiv.org
May 29, 2025 at 9:18 PM
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Shutt Lab
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell
great work by Martin Picard
www.scientificamerican.com/article/why-...
great work by Martin Picard
www.scientificamerican.com/article/why-...
The Hidden Social Lives of Mitochondria
When these energy-giving organelles thrive, so do we
www.scientificamerican.com
May 22, 2025 at 4:41 AM
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell
great work by Martin Picard
www.scientificamerican.com/article/why-...
great work by Martin Picard
www.scientificamerican.com/article/why-...
Reposted by Shutt Lab
Our Special Issue: Cell Biology of Mitochondria is complete.
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
May 15, 2025 at 2:32 PM
Our Special Issue: Cell Biology of Mitochondria is complete.
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Happy to see this fun piece finally out. Congrats to Laurie for bringing this all together and thanks to Martin for his contributions.
In their Opinion article, Laurie Lee-Glover, Martin Picard and Timothy Shutt @mitomorph.bsky.social argue that mitochondria should be considered as the ‘Chief Executive Organelle’ – the CEO – of the cell. #JCSMitoSI #Mitochondria
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
May 13, 2025 at 6:41 PM
Happy to see this fun piece finally out. Congrats to Laurie for bringing this all together and thanks to Martin for his contributions.
Reposted by Shutt Lab
🚨New preprint!🚨 #teamtomo
We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles.
Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science
We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles.
Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science
Surface morphometrics reveals local membrane thickness variation in organellar subcompartments https://www.biorxiv.org/content/10.1101/2025.04.30.651574v1
May 1, 2025 at 7:42 PM
🚨New preprint!🚨 #teamtomo
We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles.
Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science
We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles.
Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science
Reposted by Shutt Lab
Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover:
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
Inter-organelle Stress Communication in Inflammation & Disease Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
bit.ly
April 27, 2025 at 1:10 PM
Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover:
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
Reposted by Shutt Lab
This work characterizes the Q367H variant in MFN2, identified in a patient with myopathy but no peripheral, and shows a novel way in which MFN2 dysfunction causes disease by promoting mtDNA release and subsequent inflammation @mitomorph.bsky.social www.life-science-alliance.org/content/8/6/...
April 11, 2025 at 8:34 PM
This work characterizes the Q367H variant in MFN2, identified in a patient with myopathy but no peripheral, and shows a novel way in which MFN2 dysfunction causes disease by promoting mtDNA release and subsequent inflammation @mitomorph.bsky.social www.life-science-alliance.org/content/8/6/...
Reposted by Shutt Lab
I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
Our April issue is here! rupress.org/jcb/issue/22...
The cover shows a segmented model of cytoplasmic #ribosomes associated with mitochondrial membrane in a Saccharomyces cerevisiae cell. From Ya-Ting Chang, @nanigrotjahn.bsky.social and colleagues (doi.org/10.1083/jcb....)
The cover shows a segmented model of cytoplasmic #ribosomes associated with mitochondrial membrane in a Saccharomyces cerevisiae cell. From Ya-Ting Chang, @nanigrotjahn.bsky.social and colleagues (doi.org/10.1083/jcb....)
April 9, 2025 at 10:35 PM
I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
Reposted by Shutt Lab
New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
April 4, 2025 at 5:38 PM
New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
Reposted by Shutt Lab
Are u tired of reading about tariffs? Then take a look to our last work! @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:07 PM
Are u tired of reading about tariffs? Then take a look to our last work! @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Shutt Lab
A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation
Pathogenic variants in the mitochondrial protein MFN2 are typically associated with a peripheral neuropathy phenotype, but can also cause a variety of additional pathologies including myopathy. Here, ...
www.life-science-alliance.org
April 3, 2025 at 6:46 AM
A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
Our paper describing a novel MFN2 variant linked to mtDNA-mediated inflammation is now published at Life Science Alliance @lsajournal.org.
doi.org/10.26508/lsa...
doi.org/10.26508/lsa...
April 3, 2025 at 6:26 PM
Our paper describing a novel MFN2 variant linked to mtDNA-mediated inflammation is now published at Life Science Alliance @lsajournal.org.
doi.org/10.26508/lsa...
doi.org/10.26508/lsa...
Reposted by Shutt Lab
MITOtalks this week
April 1, 2025 at 4:10 PM
MITOtalks this week
Great chance for Canadian researchers to attend a great scientific meeting in Canada!
Missed the deadline for the abstract submission for the CSMB meeting on Protein Homeostasis – From Basic Science to Human Health?
Well the deadline was extended until April 15th!
event.fourwaves.com/csmb-prince-...
Well the deadline was extended until April 15th!
event.fourwaves.com/csmb-prince-...
2025 CSMB-PRinCE Joint Conference
Fourwaves - 2025 CSMB-PRinCE Joint Conference
event.fourwaves.com
April 1, 2025 at 3:48 PM
Great chance for Canadian researchers to attend a great scientific meeting in Canada!
Reposted by Shutt Lab
I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt
A robustly rooted tree of eukaryotes reveals their excavate ancestry - Nature
The root of the eukaryote Tree of Life is estimated from a new, larger dataset of mitochondrial proteins including all known eukaryotic supergroups, showing it lies between two multi-supergroup assemb...
doi.org
March 14, 2025 at 11:38 AM
I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt
Reposted by Shutt Lab
Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658
Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...
www.nature.com
March 3, 2025 at 11:44 AM
Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Shutt Lab
The 12th Canadian Developmental Biology Conference will take place in the beautiful city of Kelowna, British Columbia, Canada, in May 25-28, 2025. The registration is still open. event.fourwaves.com/12cdb/pages
February 27, 2025 at 1:17 AM
The 12th Canadian Developmental Biology Conference will take place in the beautiful city of Kelowna, British Columbia, Canada, in May 25-28, 2025. The registration is still open. event.fourwaves.com/12cdb/pages
Reposted by Shutt Lab
I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing @jmacuada.bsky.social
Available in @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
#mito #mitochondria
Available in @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
#mito #mitochondria
How are mitochondrial nucleoids trafficked?
Mitochondria harbor their own DNA (mtDNA), which codifies essential proteins of the
oxidative phosphorylation (OXPHOS) system and locally feeds them to their surrounding
inner mitochondrial membrane (...
www.cell.com
February 21, 2025 at 1:31 PM
I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing @jmacuada.bsky.social
Available in @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
#mito #mitochondria
Available in @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
#mito #mitochondria
New update on our preprint of the mt-HI-NESS reporter for imaging mtDNA nucleoids
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A novel genetic fluorescent reporter to visualize mitochondrial nucleoids
Mitochondria have their own genome (mtDNA), which is present in hundreds of copies per cell and organized into nucleoid structures that are distributed throughout the dynamic mitochondrial network. Be...
www.biorxiv.org
January 24, 2025 at 5:47 PM
New update on our preprint of the mt-HI-NESS reporter for imaging mtDNA nucleoids
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...