Wiseman Lab
@wisemanlab.bsky.social
Official BlueSky Account of Luke Wiseman's Lab at Scripps Research. For our research interests please visit our website @ http://wiseman.scripps.edu. Posts by Luke.
Reposted by Wiseman Lab
Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling https://www.biorxiv.org/content/10.64898/2026.02.17.706344v1
February 18, 2026 at 1:30 PM
Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling https://www.biorxiv.org/content/10.64898/2026.02.17.706344v1
Reposted by Wiseman Lab
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis https://www.biorxiv.org/content/10.64898/2026.02.01.703113v1
February 3, 2026 at 5:30 PM
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis https://www.biorxiv.org/content/10.64898/2026.02.01.703113v1
New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 18, 2026 at 3:18 PM
New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Wiseman Lab
One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org
www.embo.org/people/revie...
www.embo.org/people/revie...
Review Commons: rethinking peer review – Features – EMBO
A conversation with Thomas Lemberger, lead of the Review Commons initiative and Head of Open Science Implementation at EMBO.
www.embo.org
December 11, 2025 at 8:52 AM
One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org
www.embo.org/people/revie...
www.embo.org/people/revie...
Reposted by Wiseman Lab
De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response https://www.biorxiv.org/content/10.64898/2025.12.22.695711v1
December 23, 2025 at 2:45 PM
De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response https://www.biorxiv.org/content/10.64898/2025.12.22.695711v1
Reposted by Wiseman Lab
JCB’s Cover of the Year voting is open!
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
December 22, 2025 at 8:03 PM
JCB’s Cover of the Year voting is open!
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
Reposted by Wiseman Lab
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 18, 2025 at 8:36 PM
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Reposted by Wiseman Lab
In collaboration with @enginlab.bsky.social, Khahani Eynullazada, a grad student from @sroyyors.bsky.social Lab identified gene regulatory networks capturing shared and perturbation-specific stress pathways in Type 1 diabetes using GRN inference tools on scRNA-seq data from in vivo mouse models.
How disabling one gene protects mice against Type 1 diabetes
UW–Madison researchers have discovered a mechanism that could one day help people at risk of developing the metabolic disease.
news.wisc.edu
December 17, 2025 at 6:34 PM
In collaboration with @enginlab.bsky.social, Khahani Eynullazada, a grad student from @sroyyors.bsky.social Lab identified gene regulatory networks capturing shared and perturbation-specific stress pathways in Type 1 diabetes using GRN inference tools on scRNA-seq data from in vivo mouse models.
Reposted by Wiseman Lab
If you're at #CellBio2025, please join us tomorrow at 9AM in Room 122 for a fantastic speaker lineup at the #EndoplasmicReticulum Minisymposium!
Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz!
@ascbiology.bsky.social
Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz!
@ascbiology.bsky.social
December 10, 2025 at 1:51 AM
If you're at #CellBio2025, please join us tomorrow at 9AM in Room 122 for a fantastic speaker lineup at the #EndoplasmicReticulum Minisymposium!
Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz!
@ascbiology.bsky.social
Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz!
@ascbiology.bsky.social
Reposted by Wiseman Lab
Just one week away until #CellBio2025!
Please plan to join us for a sUPeR speakER lineup at the #EndoplasmicReticulum Minisymposium!
Dec 10 at 9 AM
@ascbiology.bsky.social
Please plan to join us for a sUPeR speakER lineup at the #EndoplasmicReticulum Minisymposium!
Dec 10 at 9 AM
@ascbiology.bsky.social
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
December 6, 2025 at 12:46 PM
Reposted by Wiseman Lab
Postdoc position available in my lab in Jena (Germany.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
Postdoc (m/f/x)
Our Research Group led by Janine Kirstein, Professorin at Friedrich-Schiller-University Jena, is looking for a highly motivated and talented Postdoctoral Researcher (m/f/x) to join a research project ...
jobs.leibniz-fli.de
November 4, 2025 at 7:39 AM
Postdoc position available in my lab in Jena (Germany.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 2, 2025 at 4:33 PM
Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756
Reposted by Wiseman Lab
🚨 #teamtomo!🚨
Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??
Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??
August 20, 2025 at 12:18 AM
🚨 #teamtomo!🚨
Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??
Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??
Reposted by Wiseman Lab
Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!
July 29, 2025 at 11:33 PM
Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!
New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...
www.biorxiv.org
June 27, 2025 at 3:52 PM
New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Wiseman Lab
TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5
April 14, 2025 at 8:05 AM
TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5
Reposted by Wiseman Lab
I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
Our April issue is here! rupress.org/jcb/issue/22...
The cover shows a segmented model of cytoplasmic #ribosomes associated with mitochondrial membrane in a Saccharomyces cerevisiae cell. From Ya-Ting Chang, @nanigrotjahn.bsky.social and colleagues (doi.org/10.1083/jcb....)
The cover shows a segmented model of cytoplasmic #ribosomes associated with mitochondrial membrane in a Saccharomyces cerevisiae cell. From Ya-Ting Chang, @nanigrotjahn.bsky.social and colleagues (doi.org/10.1083/jcb....)
April 9, 2025 at 10:35 PM
I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
@zidlab.bsky.social @tomo.science @hamid13r.bsky.social
Reposted by Wiseman Lab
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 11:30 AM
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Reposted by Wiseman Lab
🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast!
Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social
#FASEB2025 #ERSRC
Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social
#FASEB2025 #ERSRC
🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking.
Check out the program and register here 👇
events.faseb.org/event/endoplasmic-reticulum-function-disease
Check out the program and register here 👇
events.faseb.org/event/endoplasmic-reticulum-function-disease
Endoplasmic Reticulum
events.faseb.org
April 2, 2025 at 4:43 AM
🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast!
Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social
#FASEB2025 #ERSRC
Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social
#FASEB2025 #ERSRC
Reposted by Wiseman Lab
New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
April 4, 2025 at 5:38 PM
New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
Reposted by Wiseman Lab
Fantastic article from Linda Hendershot—an incredible scientist and one of the most supportive and inspiring researchers I've had the pleasure of meeting.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A BiP-centric view of endoplasmic reticulum functions and of my career
After completing my post-doctoral training at the University of Alabama, Birmingham and a brief period on the faculty there, I joined the Department o…
www.sciencedirect.com
March 9, 2025 at 6:43 PM
Fantastic article from Linda Hendershot—an incredible scientist and one of the most supportive and inspiring researchers I've had the pleasure of meeting.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Wiseman Lab
OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs."
www.sandiegouniontribune.com/2025/02/25/o...
www.sandiegouniontribune.com/2025/02/25/o...
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
www.sandiegouniontribune.com
February 25, 2025 at 7:57 PM
OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs."
www.sandiegouniontribune.com/2025/02/25/o...
www.sandiegouniontribune.com/2025/02/25/o...
Reposted by Wiseman Lab
Past few weeks of Unfolded Protein Response papers! #ERStress @biomednews.bsky.social
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
February 23, 2025 at 2:25 PM
Past few weeks of Unfolded Protein Response papers! #ERStress @biomednews.bsky.social
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
Reposted by Wiseman Lab
Very happy to share the latest preprint from my lab led by Kaylee Vosbigian @kaylee-vosbigian.bsky.social ! We found that Anaplasma activates the ATF6 branch of the unfolded protein response in Ixodes ticks to facilitate cholesterol uptake for growth and survival. #MicroSky #Anaplasma #ticks
ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics https://www.biorxiv.org/content/10.1101/2025.01.08.632023v1
January 10, 2025 at 10:05 PM
Very happy to share the latest preprint from my lab led by Kaylee Vosbigian @kaylee-vosbigian.bsky.social ! We found that Anaplasma activates the ATF6 branch of the unfolded protein response in Ixodes ticks to facilitate cholesterol uptake for growth and survival. #MicroSky #Anaplasma #ticks
Excited to be involved in this cool project led by @yananchenlab.bsky.social and her team showing protection afforded by the ATF6 activator AA147 in a mouse model of multiple sclerosis. Check it out! 👇
I'm excited to share that our preprint is out on bioRxiv!
In this study, we explore the therapeutic potential of a pharmacologic ATF6 activator in a multiple sclerosis mouse model and its underlying mechanisms. #MultipleSclerosis #Neuroscience
biorxiv.org/cgi/content/...
In this study, we explore the therapeutic potential of a pharmacologic ATF6 activator in a multiple sclerosis mouse model and its underlying mechanisms. #MultipleSclerosis #Neuroscience
biorxiv.org/cgi/content/...
January 2, 2025 at 11:35 PM
Excited to be involved in this cool project led by @yananchenlab.bsky.social and her team showing protection afforded by the ATF6 activator AA147 in a mouse model of multiple sclerosis. Check it out! 👇
