A. Phillip West
@westlabmito.bsky.social
Associate Professor @jacksonlab researching how mitochondria shape innate immune and inflammatory responses in disease and aging.
Just wrapped our @Fusion_Conf on Inter-organelle Communication in Inflammation and Disease. 4 days of outstanding science! Thanks to all speakers, poster presenters, and other attendees for making it a great meeting. (Photo of some of us on excursion to Marsaxlokk village).
October 13, 2025 at 1:25 PM
Just wrapped our @Fusion_Conf on Inter-organelle Communication in Inflammation and Disease. 4 days of outstanding science! Thanks to all speakers, poster presenters, and other attendees for making it a great meeting. (Photo of some of us on excursion to Marsaxlokk village).
About two months to go until the Fusion Inter-Organelle Communication in Inflammation and Disease Conference in Malta. Short talk slots and travel scholarships still available. We'd love to see you at #IOSCD25 so please apply!
@fusionconf.bsky.social
@fusionconf.bsky.social
August 4, 2025 at 1:38 PM
About two months to go until the Fusion Inter-Organelle Communication in Inflammation and Disease Conference in Malta. Short talk slots and travel scholarships still available. We'd love to see you at #IOSCD25 so please apply!
@fusionconf.bsky.social
@fusionconf.bsky.social
Reposted by A. Phillip West
A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC Oligomerization Inhibitor https://www.biorxiv.org/content/10.1101/2025.06.30.661942v1
July 3, 2025 at 11:45 PM
A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC Oligomerization Inhibitor https://www.biorxiv.org/content/10.1101/2025.06.30.661942v1
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications
Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...
www.nature.com
June 1, 2025 at 1:16 AM
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Reposted by A. Phillip West
⏰Register & Submit by 02 June 2025⏰
Join discussions around organelle stress communication mechanisms in homeostatic & pathological settings including cancer, metabolic & neurologic diseases, & aging at #IOSCD25!
Find out more: bit.ly/42VGAmD
@westlabmito.bsky.social
Join discussions around organelle stress communication mechanisms in homeostatic & pathological settings including cancer, metabolic & neurologic diseases, & aging at #IOSCD25!
Find out more: bit.ly/42VGAmD
@westlabmito.bsky.social
If you are interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you!
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
May 27, 2025 at 10:54 AM
⏰Register & Submit by 02 June 2025⏰
Join discussions around organelle stress communication mechanisms in homeostatic & pathological settings including cancer, metabolic & neurologic diseases, & aging at #IOSCD25!
Find out more: bit.ly/42VGAmD
@westlabmito.bsky.social
Join discussions around organelle stress communication mechanisms in homeostatic & pathological settings including cancer, metabolic & neurologic diseases, & aging at #IOSCD25!
Find out more: bit.ly/42VGAmD
@westlabmito.bsky.social
If you are interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you!
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
May 10, 2025 at 9:15 PM
If you are interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you!
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover:
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
Inter-organelle Stress Communication in Inflammation & Disease Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
bit.ly
April 27, 2025 at 1:10 PM
Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover:
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social
Reposted by A. Phillip West
📢1 WEEK TO GO📢
Have you registered for #IOSCD25 yet? Early bird & talk submission close next week!
📄Programme now live
💰Grants available
📆Application deadline: 01 May 2025
Find out more: bit.ly/4jI458f
Have you registered for #IOSCD25 yet? Early bird & talk submission close next week!
📄Programme now live
💰Grants available
📆Application deadline: 01 May 2025
Find out more: bit.ly/4jI458f
April 23, 2025 at 11:48 AM
📢1 WEEK TO GO📢
Have you registered for #IOSCD25 yet? Early bird & talk submission close next week!
📄Programme now live
💰Grants available
📆Application deadline: 01 May 2025
Find out more: bit.ly/4jI458f
Have you registered for #IOSCD25 yet? Early bird & talk submission close next week!
📄Programme now live
💰Grants available
📆Application deadline: 01 May 2025
Find out more: bit.ly/4jI458f
Congrats to Omkar Shinde and Pingwei Li for resolving the cryo-EM structures of free and cGAMP-bound ABCC1. This paper follows on the great work from Dan Stetson's lab revealing ABCC1 as a cGAMP exporter. www.sciencedirect.com/science/arti...
Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export
Cyclic nucleotide GMP-AMP (cGAMP) plays a critical role in mediating the innate immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator …
www.sciencedirect.com
January 15, 2025 at 5:54 PM
Congrats to Omkar Shinde and Pingwei Li for resolving the cryo-EM structures of free and cGAMP-bound ABCC1. This paper follows on the great work from Dan Stetson's lab revealing ABCC1 as a cGAMP exporter. www.sciencedirect.com/science/arti...