Mar Hernández Secorún
@marhsecorun.bsky.social
PhD Health Science. Moving from clinic to basic science. Translational rules 🤟🏽🤟🏽
Pain and neuropathies are my combo ❤️🧠
Pain and neuropathies are my combo ❤️🧠
Reposted by Mar Hernández Secorún
finally some real data on this. nicely done. love the phantom.
February 13, 2026 at 12:09 AM
finally some real data on this. nicely done. love the phantom.
Amazing new findings for a future analgesic! THC exerts direct inhibition of peripheral nociceptors via modulation of NaV1.7 and NaV1.8 at the local anaesthetic binding site.
Science is so beautiful!
www.nature.com/articles/s41...
Science is so beautiful!
www.nature.com/articles/s41...
The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaV1.7 and NaV1.8 nociceptive sodium channels - Neuropsychopharmacology
Neuropsychopharmacology - The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaV1.7 and NaV1.8 nociceptive sodium channels
www.nature.com
January 28, 2026 at 9:06 AM
Amazing new findings for a future analgesic! THC exerts direct inhibition of peripheral nociceptors via modulation of NaV1.7 and NaV1.8 at the local anaesthetic binding site.
Science is so beautiful!
www.nature.com/articles/s41...
Science is so beautiful!
www.nature.com/articles/s41...
Reposted by Mar Hernández Secorún
Both paper and thread are worth a read 👇
I agree.
For me, at first, Academia was very much an identity and a calling.
Years later, after some experience of terrible university management, it is "a job".
Some other reflections (which turned out to be about workload management, and ways of working)
For me, at first, Academia was very much an identity and a calling.
Years later, after some experience of terrible university management, it is "a job".
Some other reflections (which turned out to be about workload management, and ways of working)
December 8, 2025 at 9:10 AM
Both paper and thread are worth a read 👇
Reposted by Mar Hernández Secorún
Have you been wondering what the role is of non-neuronal cells in modulating sensory neuron activity? Check out this review from @psalmotoxin.bsky.social et al. in @sfnjournals.bsky.social’s #JNeurosci, one of this week’s #EditorsPick papers chosen by @rpseal.bsky.social bit.ly/3XEp2rE #PRF
November 26, 2025 at 1:00 PM
Have you been wondering what the role is of non-neuronal cells in modulating sensory neuron activity? Check out this review from @psalmotoxin.bsky.social et al. in @sfnjournals.bsky.social’s #JNeurosci, one of this week’s #EditorsPick papers chosen by @rpseal.bsky.social bit.ly/3XEp2rE #PRF
Reposted by Mar Hernández Secorún
Have you heard of MDFIC2, the newly identified sensory neuron-enriched modulator of PIEZO channels? Check out Habib et al. in @pnas.org, one of this week’s #EditorsPick papers chosen by @rpseal.bsky.social bit.ly/4renN08 #PRF
November 26, 2025 at 2:00 PM
Have you heard of MDFIC2, the newly identified sensory neuron-enriched modulator of PIEZO channels? Check out Habib et al. in @pnas.org, one of this week’s #EditorsPick papers chosen by @rpseal.bsky.social bit.ly/4renN08 #PRF
Reposted by Mar Hernández Secorún
Huerta et al. find that standard analgesics reliably reduce spontaneous neuropathic pain in preclinical models, mirroring clinical efficacy and highlighting the value of assessing non-evoked pain. Learn more in #PAIN bit.ly/4hHOvJU
November 25, 2025 at 9:00 PM
Huerta et al. find that standard analgesics reliably reduce spontaneous neuropathic pain in preclinical models, mirroring clinical efficacy and highlighting the value of assessing non-evoked pain. Learn more in #PAIN bit.ly/4hHOvJU
Reposted by Mar Hernández Secorún
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Here's our accompanying review!
www.jneurosci.org/content/45/4...
November 12, 2025 at 6:19 PM
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Reposted by Mar Hernández Secorún
Brask-Thomsen et al. find that in diabetic polyneuropathy and type 2 diabetes, development of and relief from neuropathic pain was common over a 5-year period. Associated factors were investigated. Learn more in #PAIN bit.ly/3WGJYOu
November 10, 2025 at 1:00 PM
Brask-Thomsen et al. find that in diabetic polyneuropathy and type 2 diabetes, development of and relief from neuropathic pain was common over a 5-year period. Associated factors were investigated. Learn more in #PAIN bit.ly/3WGJYOu
Reposted by Mar Hernández Secorún
Beisswanger et al. use microneurography to reveal C-nociceptor dysfunction beyond conventional testing, offering insights into the role of C-nociceptors in ongoing neuropathic pain. Learn more in #PAIN bit.ly/4nqvWMG
October 23, 2025 at 12:00 PM
Beisswanger et al. use microneurography to reveal C-nociceptor dysfunction beyond conventional testing, offering insights into the role of C-nociceptors in ongoing neuropathic pain. Learn more in #PAIN bit.ly/4nqvWMG
Reposted by Mar Hernández Secorún
A test of nerves in diabetic peripheral neuropathy
@dianatavf.bsky.social @tedpricethepainguy.bsky.social & team identify regenerative and degenerative pathways and highlight axonal mRNA transport as a new mechanism in DPN:
www.jci.org/articles/vie...
@dianatavf.bsky.social @tedpricethepainguy.bsky.social & team identify regenerative and degenerative pathways and highlight axonal mRNA transport as a new mechanism in DPN:
www.jci.org/articles/vie...
October 21, 2025 at 4:15 PM
A test of nerves in diabetic peripheral neuropathy
@dianatavf.bsky.social @tedpricethepainguy.bsky.social & team identify regenerative and degenerative pathways and highlight axonal mRNA transport as a new mechanism in DPN:
www.jci.org/articles/vie...
@dianatavf.bsky.social @tedpricethepainguy.bsky.social & team identify regenerative and degenerative pathways and highlight axonal mRNA transport as a new mechanism in DPN:
www.jci.org/articles/vie...
Reposted by Mar Hernández Secorún
Thanks to @massih.bsky.social for inviting me to co-author this commentary @science.org Mapping the anatomy of placebo analgesia | Science www.science.org/doi/10.1126/...
Mapping the anatomy of placebo analgesia
The identification of somatotopy in brainstem pain modulatory pathways could help treat chronic pain
www.science.org
August 28, 2025 at 11:18 PM
Thanks to @massih.bsky.social for inviting me to co-author this commentary @science.org Mapping the anatomy of placebo analgesia | Science www.science.org/doi/10.1126/...
A really interesting paper from @drvinkopalada.bsky.social and colleagues for figuring out where to focus our intervention. If my patients mostly have nocturnal symptoms, which one would you use?
🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology!
Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.
pubmed.ncbi.nlm.nih.gov/40802988/
Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.
pubmed.ncbi.nlm.nih.gov/40802988/
Differential Effects of Pregabalin and Morphine on the Sleep-Wake Cycle and Circadian Rhythms in Mice with Neuropathic Pain - PubMed
Pregabalin, unlike morphine, restores SNI-disrupted sleep architecture, circadian rhythms, and spinal circadian gene expression.
pubmed.ncbi.nlm.nih.gov
August 27, 2025 at 8:02 AM
A really interesting paper from @drvinkopalada.bsky.social and colleagues for figuring out where to focus our intervention. If my patients mostly have nocturnal symptoms, which one would you use?
Reposted by Mar Hernández Secorún
🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology!
Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.
pubmed.ncbi.nlm.nih.gov/40802988/
Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.
pubmed.ncbi.nlm.nih.gov/40802988/
Differential Effects of Pregabalin and Morphine on the Sleep-Wake Cycle and Circadian Rhythms in Mice with Neuropathic Pain - PubMed
Pregabalin, unlike morphine, restores SNI-disrupted sleep architecture, circadian rhythms, and spinal circadian gene expression.
pubmed.ncbi.nlm.nih.gov
August 26, 2025 at 8:39 AM
🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology!
Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.
pubmed.ncbi.nlm.nih.gov/40802988/
Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.
pubmed.ncbi.nlm.nih.gov/40802988/
Reposted by Mar Hernández Secorún
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
August 24, 2025 at 1:08 PM
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Reposted by Mar Hernández Secorún
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI -
Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy
www.jci.org
August 19, 2025 at 4:55 PM
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
Reposted by Mar Hernández Secorún
Time pressure gets in the way of ideas. Nature Careers spoke with researchers about making space for creativity by developing ‘creative oases’ and small grants for risky ideas to encourage innovative thinking in science. #Academicsky 🧪
Can creativity in science be learnt? These researchers think so
Time pressure gets in the way of ideas. Developing ‘creative oases’ and small grants for risky ideas can encourage innovative thinking in science.
go.nature.com
August 17, 2025 at 1:18 PM
Time pressure gets in the way of ideas. Nature Careers spoke with researchers about making space for creativity by developing ‘creative oases’ and small grants for risky ideas to encourage innovative thinking in science. #Academicsky 🧪
Reposted by Mar Hernández Secorún
Lin et al. find that structural brain alterations are linked to neuropathic pain in peripheral neuropathy, including thinning, gyral flattening, and altered topographic organization in pain-related cortices. Learn more in #PAIN bit.ly/3Hnqzhi
August 14, 2025 at 12:00 PM
Lin et al. find that structural brain alterations are linked to neuropathic pain in peripheral neuropathy, including thinning, gyral flattening, and altered topographic organization in pain-related cortices. Learn more in #PAIN bit.ly/3Hnqzhi
Reposted by Mar Hernández Secorún
A study in Nature Communications identifies a neural circuit in mice that transmits cool sensation from the skin to the brain, revealing a dedicated pathway for detecting innocuous cool temperatures. go.nature.com/45Brumv 🧪
August 13, 2025 at 1:17 PM
A study in Nature Communications identifies a neural circuit in mice that transmits cool sensation from the skin to the brain, revealing a dedicated pathway for detecting innocuous cool temperatures. go.nature.com/45Brumv 🧪
Reposted by Mar Hernández Secorún
What do you think Lee et al.’s findings in @natcomms.nature.com of a feedforward amplification circuit for cool sensation, as well as a modality-specific spinal pathway for thermal processing, do for our understanding of thermosensation? bit.ly/3JlS8rS #PRF
August 13, 2025 at 2:00 PM
What do you think Lee et al.’s findings in @natcomms.nature.com of a feedforward amplification circuit for cool sensation, as well as a modality-specific spinal pathway for thermal processing, do for our understanding of thermosensation? bit.ly/3JlS8rS #PRF
Reposted by Mar Hernández Secorún
A feature in Nature explores how research into developing ways to probe layers of consciousness in the human brain could inform how scientists search for awareness in all its possible forms. 🧪
How to detect consciousness in people, animals and maybe even AI
Insights from human brains could inform how scientists search for awareness in all its possible forms.
go.nature.com
August 8, 2025 at 1:22 AM
A feature in Nature explores how research into developing ways to probe layers of consciousness in the human brain could inform how scientists search for awareness in all its possible forms. 🧪
After completing my PhD, I'm embarked on a new journey of learning and growth. I'm eager to dive into the basic science and solidify my foundation as a future translational researcher. Since July, spending a few months at KU Leuven for that! We are continuing the active search for a PostDoc!
August 6, 2025 at 12:59 PM
After completing my PhD, I'm embarked on a new journey of learning and growth. I'm eager to dive into the basic science and solidify my foundation as a future translational researcher. Since July, spending a few months at KU Leuven for that! We are continuing the active search for a PostDoc!
Reposted by Mar Hernández Secorún
Nuestro último trabajo eBioMedicine Lancet: efectos x ejercicio 🏃🏻♀️ en cerebro 🧠 muestran perfil hormético (mejora cognición y neurogénesis si es moderado, inútil si extenuante) causado por cambios en microbiota 🦠 y después de trasplante fecal @CSICdivulga @SENC_ @institutocajal.bsky.social
August 6, 2025 at 8:57 AM
Nuestro último trabajo eBioMedicine Lancet: efectos x ejercicio 🏃🏻♀️ en cerebro 🧠 muestran perfil hormético (mejora cognición y neurogénesis si es moderado, inútil si extenuante) causado por cambios en microbiota 🦠 y después de trasplante fecal @CSICdivulga @SENC_ @institutocajal.bsky.social
Reposted by Mar Hernández Secorún
Llimós-Aubach et al. identify the potassium channel TRESK, which regulates the excitability of specific nonhistaminergic pruriceptors and modulates acute and chronic itch, as a potential target for antipruritic pharmacological compounds. #PAIN bit.ly/3U4kolf
August 4, 2025 at 12:00 PM
Llimós-Aubach et al. identify the potassium channel TRESK, which regulates the excitability of specific nonhistaminergic pruriceptors and modulates acute and chronic itch, as a potential target for antipruritic pharmacological compounds. #PAIN bit.ly/3U4kolf
Revisiting the updated NeuPSIG guideline, I’m struck by how often efficacy is isolated from harm. With poor AE reporting and short follow-ups, NNHs fall short. RCTs must improve how harms are measured to truly guide neuropathic pain care. www.thelancet.com/action/showP...
www.thelancet.com
July 30, 2025 at 7:35 AM
Revisiting the updated NeuPSIG guideline, I’m struck by how often efficacy is isolated from harm. With poor AE reporting and short follow-ups, NNHs fall short. RCTs must improve how harms are measured to truly guide neuropathic pain care. www.thelancet.com/action/showP...
Reposted by Mar Hernández Secorún
Dear Bsky Friends, physical activity as a central pillar of #lifestyle modification in the management of chronic #musculoskeletal #pain & its effects on pain modulation & #sleep, #stress regulation, #diet & #smoking behavior: tinyurl.com/2ntkuda3
June 25, 2025 at 2:50 PM
Dear Bsky Friends, physical activity as a central pillar of #lifestyle modification in the management of chronic #musculoskeletal #pain & its effects on pain modulation & #sleep, #stress regulation, #diet & #smoking behavior: tinyurl.com/2ntkuda3