Siri Leknes
@sirileknes.bsky.social
Professor, LAB lab, University of Oslo 🇳🇴
Pleasure, pain, stress, reward. Opioids.
Affective Brains.
Currently on sabbatical @anatajadura’s lab in Madrid
Twin mum.
www.affectivebrains.com
Pleasure, pain, stress, reward. Opioids.
Affective Brains.
Currently on sabbatical @anatajadura’s lab in Madrid
Twin mum.
www.affectivebrains.com
Pinned
Siri Leknes
@sirileknes.bsky.social
· Dec 3
Today it’s official:
my ERC CoG proposal on the full spectrum of opioid effects was funded 💃🤩💃
(Short description found here: affectivebrains.com/portfolio/spectro/)
Thrilled to be celebrating this & other wins of 2024 with this wonderful group of colleagues
my ERC CoG proposal on the full spectrum of opioid effects was funded 💃🤩💃
(Short description found here: affectivebrains.com/portfolio/spectro/)
Thrilled to be celebrating this & other wins of 2024 with this wonderful group of colleagues
⬆️avoidance learning / negative reinforcement in opioid-treated patients (26 chronic pain, 24 OUD)
Cool project
🤔
Are opioids the common factor, or another vulnerability?
Chronic pain, depression, anxiety, fatigue, addiction ... All comorbid & w/ same predictors
jamanetwork.com/journals/jam...
Cool project
🤔
Are opioids the common factor, or another vulnerability?
Chronic pain, depression, anxiety, fatigue, addiction ... All comorbid & w/ same predictors
jamanetwork.com/journals/jam...
Increased Avoidance Learning in Chronic Opioid Users
This case-control study determines whether opioid addiction is characterized by increased avoidance learning and whether this is also observed in individuals with chronic nonaddicted opioid use.
jamanetwork.com
November 9, 2025 at 4:33 PM
⬆️avoidance learning / negative reinforcement in opioid-treated patients (26 chronic pain, 24 OUD)
Cool project
🤔
Are opioids the common factor, or another vulnerability?
Chronic pain, depression, anxiety, fatigue, addiction ... All comorbid & w/ same predictors
jamanetwork.com/journals/jam...
Cool project
🤔
Are opioids the common factor, or another vulnerability?
Chronic pain, depression, anxiety, fatigue, addiction ... All comorbid & w/ same predictors
jamanetwork.com/journals/jam...
Reposted by Siri Leknes
Another key aspect of stopping the new information tech (radio) from ruining democracy 100 years ago was gov’t regulation.
Amongst many other regulatory tools, we regulated radio ownership. We also created public media to serve the public interest. The BBC came from the same motivation.
Amongst many other regulatory tools, we regulated radio ownership. We also created public media to serve the public interest. The BBC came from the same motivation.
November 9, 2025 at 2:55 PM
Another key aspect of stopping the new information tech (radio) from ruining democracy 100 years ago was gov’t regulation.
Amongst many other regulatory tools, we regulated radio ownership. We also created public media to serve the public interest. The BBC came from the same motivation.
Amongst many other regulatory tools, we regulated radio ownership. We also created public media to serve the public interest. The BBC came from the same motivation.
Reposted by Siri Leknes
Citation impact and actual impact are not the same thing. What is the prototypical paper from the social-behavioral sciences that had both a huge citation impact and a huge actual (by your definition) impact?
Vote by naming a paper or liking someone else's nomination. One box filled per day.
Vote by naming a paper or liking someone else's nomination. One box filled per day.
November 5, 2025 at 2:33 PM
Citation impact and actual impact are not the same thing. What is the prototypical paper from the social-behavioral sciences that had both a huge citation impact and a huge actual (by your definition) impact?
Vote by naming a paper or liking someone else's nomination. One box filled per day.
Vote by naming a paper or liking someone else's nomination. One box filled per day.
This is great, keep on adding suggestions everyone 😆
Science friends: Anyone have a memorable, pithy quote about how important it is the unlearn or let go of cherished but incorrect scientific hypotheses/models e.g. DA=Rew; 5-HTTLPR and Amyg (or interacting w NLEs to promote MDEs); WM-related PFC=storage
November 7, 2025 at 1:36 PM
This is great, keep on adding suggestions everyone 😆
Funding wise, this seems to be my year 💪🤩
Now setting up an interdisciplinary convergence environment to figure out mechanisms of OPRM1 mutation & importance for addiction
Co-PIs @koenvervaeke @deopandey @osmangani
www.uio.no/english/rese...
Now setting up an interdisciplinary convergence environment to figure out mechanisms of OPRM1 mutation & importance for addiction
Co-PIs @koenvervaeke @deopandey @osmangani
www.uio.no/english/rese...
www.uio.no
November 5, 2025 at 11:58 AM
Funding wise, this seems to be my year 💪🤩
Now setting up an interdisciplinary convergence environment to figure out mechanisms of OPRM1 mutation & importance for addiction
Co-PIs @koenvervaeke @deopandey @osmangani
www.uio.no/english/rese...
Now setting up an interdisciplinary convergence environment to figure out mechanisms of OPRM1 mutation & importance for addiction
Co-PIs @koenvervaeke @deopandey @osmangani
www.uio.no/english/rese...
Reposted by Siri Leknes
The hard problem is solved - Thanks @naddenmark.bsky.social !
November 3, 2025 at 6:55 PM
The hard problem is solved - Thanks @naddenmark.bsky.social !
Great thread
There still seems to be a lot of confusion about significance testing in psych. No, p-values *don’t* become useless at large N. This flawed point also used to be framed as "too much power". But power isn't the problem – it's 1) unbalanced error rates and 2) the (lack of a) SESOI. 1/ >
But here's, the thing, p values and significance become useless at such large sample sizes. When you're dividing the coefficient by the SE and the sample size is in the tens of thousands, EVERYTHING IS SIGNIFICANT. All you're testing is whether the coefficient is different than zero.
November 2, 2025 at 12:23 PM
Great thread
Hi early career researchers
I know job interviews can feel a bit like exams
But having done six in the last week, let me tell you
Chances are you’ve blown the minds of the interviewing panel 🤩🤩🤩
I know job interviews can feel a bit like exams
But having done six in the last week, let me tell you
Chances are you’ve blown the minds of the interviewing panel 🤩🤩🤩
October 28, 2025 at 8:09 PM
Hi early career researchers
I know job interviews can feel a bit like exams
But having done six in the last week, let me tell you
Chances are you’ve blown the minds of the interviewing panel 🤩🤩🤩
I know job interviews can feel a bit like exams
But having done six in the last week, let me tell you
Chances are you’ve blown the minds of the interviewing panel 🤩🤩🤩
Valladolid pain conference crowd pretending to master social media (pouting) garden 😁 😂😂😂
October 17, 2025 at 12:49 PM
Valladolid pain conference crowd pretending to master social media (pouting) garden 😁 😂😂😂
Reposted by Siri Leknes
Here are two "I can't believe these are free" online stats texts books that cover both underlying principles and practical applications in R that I regularly refer to.
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
October 17, 2025 at 8:43 AM
Here are two "I can't believe these are free" online stats texts books that cover both underlying principles and practical applications in R that I regularly refer to.
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
Seriously word?
I have long complained about the absence of ‘interoception’ from Microsoft Word’s internal dictionary, but today I would also -shockingly- like to highlight the absence of ‘orgasm’. New paper (with many unrecognized words) coming soon.
October 16, 2025 at 10:01 PM
Seriously word?
Been working a lot on own & colleagues’ grants recently
Many great proposals define the problem so narrowly that it leads directly to the solution the project offers
Eg 1/
Many great proposals define the problem so narrowly that it leads directly to the solution the project offers
Eg 1/
a man and a woman are looking at each other with the words there was just one small hiccup though
ALT: a man and a woman are looking at each other with the words there was just one small hiccup though
media.tenor.com
October 15, 2025 at 4:53 PM
Been working a lot on own & colleagues’ grants recently
Many great proposals define the problem so narrowly that it leads directly to the solution the project offers
Eg 1/
Many great proposals define the problem so narrowly that it leads directly to the solution the project offers
Eg 1/
Reposted by Siri Leknes
When I was an undergrad, I saw a talk by Oliver Sacks about music. During the Q&A, someone asked Sacks if he thought science would reveal the deepest mysteries of art. Sacks (a rare humanist among scientists) said that he doubted it, at which Eric Kandel (the host) leaped up and grabbed the mic.
October 15, 2025 at 9:27 AM
When I was an undergrad, I saw a talk by Oliver Sacks about music. During the Q&A, someone asked Sacks if he thought science would reveal the deepest mysteries of art. Sacks (a rare humanist among scientists) said that he doubted it, at which Eric Kandel (the host) leaped up and grabbed the mic.
Reposted by Siri Leknes
Our systematic review and meta-analysis is now published in Neurobiology of Stress 🍾
Main takeaway: glucose increases cortisol stress reactivity (robust, small effect), but effects of progesterone and estradiol are weak and rather inconsistent. Read more about it here 👇🏻
Main takeaway: glucose increases cortisol stress reactivity (robust, small effect), but effects of progesterone and estradiol are weak and rather inconsistent. Read more about it here 👇🏻
📣 Excited to share that my first paper is now published!
📄"Metabolic state shapes cortisol reactivity to acute stress: A systematic review and meta-analysis of metabolic and hormonal modulators"
You can find the full paper here:
doi.org/10.1016/j.yn...
📄"Metabolic state shapes cortisol reactivity to acute stress: A systematic review and meta-analysis of metabolic and hormonal modulators"
You can find the full paper here:
doi.org/10.1016/j.yn...
Redirecting
doi.org
October 15, 2025 at 1:00 PM
Our systematic review and meta-analysis is now published in Neurobiology of Stress 🍾
Main takeaway: glucose increases cortisol stress reactivity (robust, small effect), but effects of progesterone and estradiol are weak and rather inconsistent. Read more about it here 👇🏻
Main takeaway: glucose increases cortisol stress reactivity (robust, small effect), but effects of progesterone and estradiol are weak and rather inconsistent. Read more about it here 👇🏻
Reposted by Siri Leknes
Great advice on universities at risk of accepting the Compact: "Really all you need to do is get your campus to hand this issue over to a very, very slow committee!"
We now enter the most dangerous phase, but also the one with the greatest opportunity. The U.S. has thousands of colleges, some run by red state governments, so it's too much to hope that NONE sign up for this federal takeover.
But it matters WHO signs up. The administration is taking a risk.
But it matters WHO signs up. The administration is taking a risk.
After getting zero firm commitments to this point from the first nine invitees, the Trump administration is extending its proposed compact to all colleges. Expect some red-state publics to say yes.
October 14, 2025 at 3:26 PM
Great advice on universities at risk of accepting the Compact: "Really all you need to do is get your campus to hand this issue over to a very, very slow committee!"
Point of view, Norwegian time optimist
Optimal arrival for 6 pm dinner: 6.10
Earliest polite: 6
Latest polite:6.20? With message, 6.35 🤷♀️
Optimal arrival for 6 pm dinner: 6.10
Earliest polite: 6
Latest polite:6.20? With message, 6.35 🤷♀️
If you are invited to someone’s house for dinner (say, at 6:00), what’s the earliest you might arrive and the latest and still be considered polite?
(Bonus q: what’s the *optimally* polite time?)
I’m curious how this varies culturally/regionally/generationally.
(Bonus q: what’s the *optimally* polite time?)
I’m curious how this varies culturally/regionally/generationally.
a man in a suit and tie is saying " do not test my politeness "
ALT: a man in a suit and tie is saying " do not test my politeness "
media.tenor.com
October 13, 2025 at 11:07 AM
Point of view, Norwegian time optimist
Optimal arrival for 6 pm dinner: 6.10
Earliest polite: 6
Latest polite:6.20? With message, 6.35 🤷♀️
Optimal arrival for 6 pm dinner: 6.10
Earliest polite: 6
Latest polite:6.20? With message, 6.35 🤷♀️
Reposted by Siri Leknes
Interesting how companies and the financial world is racing to spend mindboggling amounts of money to build the infrastructure to train computers. But we are leaving the infrastructure to train and educate humans crumbling. The question is who will train who?
a man in a suit is holding a jacket and a cigarette .
ALT: a man in a suit is holding a jacket and a cigarette .
media.tenor.com
October 8, 2025 at 5:15 PM
Interesting how companies and the financial world is racing to spend mindboggling amounts of money to build the infrastructure to train computers. But we are leaving the infrastructure to train and educate humans crumbling. The question is who will train who?
Reposted by Siri Leknes
Norway!!! ❤️ ❤️ ❤️
'When authoritarians seize power, it is crucial to recognize courageous defenders of freedom who rise and resist,' the Norwegian Nobel Committee said as it announced Maria Corina Machado as the winner of the 2025 Nobel Peace Prize
October 10, 2025 at 1:07 PM
Norway!!! ❤️ ❤️ ❤️
Reposted by Siri Leknes
The Cognitive Science Society is looking for new members for its Student Committee!
Open to current members enrolled in MA or PhD programs (any country 🌍)
Apply by November 14!
cognitivesciencesociety.org/get-involved/
Open to current members enrolled in MA or PhD programs (any country 🌍)
Apply by November 14!
cognitivesciencesociety.org/get-involved/
October 10, 2025 at 1:42 PM
The Cognitive Science Society is looking for new members for its Student Committee!
Open to current members enrolled in MA or PhD programs (any country 🌍)
Apply by November 14!
cognitivesciencesociety.org/get-involved/
Open to current members enrolled in MA or PhD programs (any country 🌍)
Apply by November 14!
cognitivesciencesociety.org/get-involved/
Can I trust nature research assistant by springer??
October 8, 2025 at 2:04 PM
Can I trust nature research assistant by springer??
Reposted by Siri Leknes
The Nobel Prizes, 5 of 6 having so far gone to US based scientists, are a reminder of why we must stand up for science against this horrid administration. Here are some great Scientist Activists to follow.
go.bsky.app/14W5Rdk
go.bsky.app/14W5Rdk
October 8, 2025 at 1:16 AM
The Nobel Prizes, 5 of 6 having so far gone to US based scientists, are a reminder of why we must stand up for science against this horrid administration. Here are some great Scientist Activists to follow.
go.bsky.app/14W5Rdk
go.bsky.app/14W5Rdk
Reposted by Siri Leknes
It has been an amazing experience to be President of @improvingpsych.org for the past year. There aren't many societies that would engage early career researchers in leadership, but SIPS is very special 🧡✨
October 7, 2025 at 8:14 AM
It has been an amazing experience to be President of @improvingpsych.org for the past year. There aren't many societies that would engage early career researchers in leadership, but SIPS is very special 🧡✨
One week left to apply!
Please RT
2 new positions in the lab as postdoc & PhD!
Interested in stress, pain, or reward? This project has it all!
We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶
www.jobbnorge.no/en/available...
2 new positions in the lab as postdoc & PhD!
Interested in stress, pain, or reward? This project has it all!
We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶
www.jobbnorge.no/en/available...
Postdoctoral Research Fellowship (286516) | University of Oslo
Job title: Postdoctoral Research Fellowship (286516), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
October 7, 2025 at 7:36 AM
One week left to apply!
Brilliant thread summarising this field - perfect for those in other fields 🙏
🧩Learning to talk & read isn’t just about effort or teaching—it’s shaped by biology, experience & context
🧠Our new review links genetics, neuroscience, psychology & education to show why some children find language or reading easier.
📖 doi.org/10.31234/osf...
🖼️genes→brain→cognition→behaviour 🧵👇
🧠Our new review links genetics, neuroscience, psychology & education to show why some children find language or reading easier.
📖 doi.org/10.31234/osf...
🖼️genes→brain→cognition→behaviour 🧵👇
October 6, 2025 at 10:46 AM
Brilliant thread summarising this field - perfect for those in other fields 🙏
Reposted by Siri Leknes
“Added value” 🙄
September 26, 2025 at 9:38 AM
“Added value” 🙄