Vinko Palada
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drvinkopalada.bsky.social
Vinko Palada
@drvinkopalada.bsky.social
Neuroscientist 🧠 PI and Docent @helsinki.fi Pain Chronotherapies | Effects of analgesics on sleep and circadian rhythms I Neuropathic pain and associated comorbidities 🌅⏰💊
https://www.linkedin.com/in/vinkopalada
🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology!

Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.

pubmed.ncbi.nlm.nih.gov/40802988/
Differential Effects of Pregabalin and Morphine on the Sleep-Wake Cycle and Circadian Rhythms in Mice with Neuropathic Pain - PubMed
Pregabalin, unlike morphine, restores SNI-disrupted sleep architecture, circadian rhythms, and spinal circadian gene expression.
pubmed.ncbi.nlm.nih.gov
August 26, 2025 at 8:39 AM
I am pleased to share our new paper that explores the effects of painful nerve injury on temporal changes in transcriptome in pain-regulating sensory tissues.

Read more here:
www.sciencedirect.com/science/arti...
Circadian disruption upon painful peripheral nerve injury in mice: Temporal effects on transcriptome in pain-regulating sensory tissues
Neuropathic pain (NP) resulting from nerve damage shows diurnal fluctuation of intensity in patients, indicating circadian regulation. However, mechan…
www.sciencedirect.com
July 24, 2025 at 5:10 PM