Logan Grosenick, PhD
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logangrosenick.bsky.social
Logan Grosenick, PhD
@logangrosenick.bsky.social
AI/Psychiatry/Neuroscience • PI of Grosenick Lab @ Cornell

Previously invented fiber photometry and developed light field microscopy in the Deisseroth Lab; then subtyping for depression/autism.

Engineering better treatments using AI @ grosenicklab.org
New preprint from the lab, accepted at @neuripsconf.bsky.social NeurIPS 2025!

lnkd.in/eKVNGVNU

Most AI models treat all inputs the same.

We show how to adaptively route each sample across modalities and tasks, boosting performance, interpretability, and clinical impact for heterogenous data.
October 7, 2025 at 3:54 PM
Reposted by Logan Grosenick, PhD
"JAMA enthusiastically launches JAMA+ Women’s Health as a curated source of trusted clinical information to help clinicians advance health care for women worldwide."

🔗 Read this Editorial to learn more: ja.ma/46kacf7

📌 Explore JAMA+ Women’s Health: ja.ma/42ifhSF
September 5, 2025 at 6:15 PM
Reposted by Logan Grosenick, PhD
Launched in 2023, Imaging Neuroscience is now firmly established, with full indexing (PubMed, etc.) and 700 papers to date.

We're very happy to announce that we are able to reduce the APC to $1400.

Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.
September 5, 2025 at 2:59 AM
Reposted by Logan Grosenick, PhD
🤖🧠 Paper out in Nature Communications! 🧠🤖

Bayesian models can learn rapidly. Neural networks can handle messy, naturalistic data. How can we combine these strengths?

Our answer: Use meta-learning to distill Bayesian priors into a neural network!

www.nature.com/articles/s41...

1/n
May 20, 2025 at 7:04 PM
Reposted by Logan Grosenick, PhD
1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Learning produces an orthogonalized state machine in the hippocampus
YouTube video by Weinan Sun
www.youtube.com
February 12, 2025 at 7:36 PM
Reposted by Logan Grosenick, PhD
Now that the first Advisory Council meeting will be announced in the Federal Register tomorrow (National Institute for Complementary and Integrative Health) tomorrow, I want to clarify something that has been happening for at least the past 30 days.

1/n
a woman sitting on a couch with the words " wanna know a fun fact " on her face
ALT: a woman sitting on a couch with the words " wanna know a fun fact " on her face
media.tenor.com
March 19, 2025 at 3:05 PM
Reposted by Logan Grosenick, PhD
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience
The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...
onlinelibrary.wiley.com
March 14, 2025 at 10:25 AM
Reposted by Logan Grosenick, PhD
Re the Tononi paper: Both Tononi’s IIT (phi) and Friston’s FEP start from fundamental, axiomatic, and debatable assumptions. These assumptions are generally made without any humility. This logic allows them to make exceptionally broad claims. Which contributes to my unease about them.
March 12, 2025 at 4:01 PM
Reposted by Logan Grosenick, PhD
Reposted by Logan Grosenick, PhD
⚡️ Excited to introduce ZAPBench, our #ICLR2025 spotlight: The Zebrafish Activity Prediction Benchmark measures progress in predicting neural activity within an entire vertebrate brain (70k+ neurons!)

Explore interactive visualizations, datasets, code + paper: google-research.github.io/zapbench

🧠🧪
ZAPBench
ZAPBench evaluates how well different models can predict the activity of over 70,000 neurons in a novel larval zebrafish dataset.
google-research.github.io
March 4, 2025 at 3:22 PM
Reposted by Logan Grosenick, PhD
Can we use brain scans to identify biologically distinct "autisms"? And If so, how?

In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions!

Find out more here 👇👇
www.biorxiv.org/content/10.1...

Thread below 🧵 1/n
March 6, 2025 at 11:18 AM
Reposted by Logan Grosenick, PhD
One of the NIMH PIs whose name is the termination list: Sooyhun Lee, whose lab just published this beautiful @nature.com paper (that has received too little press because comms at NIH are down). Read! Cite!

www.nature.com/articles/s41...
March 6, 2025 at 7:04 PM
Reposted by Logan Grosenick, PhD
Should you stick to your goal, try something else, or give up? Your median raphe nucleus in the brainstem knows and will decide for you 😉. First foray of my lab into foraging, behavioural strategies and exploration. Amazing work from the one and only Mehran Ahmadlou: www.nature.com/articles/s41...
A subcortical switchboard for perseverative, exploratory and disengaged states - Nature
Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary function...
www.nature.com
March 5, 2025 at 8:27 PM
Reposted by Logan Grosenick, PhD
The Society for Neuroscience selected the paper on this tool for an upcoming webinar on FlexRig and open-source tools in general. The webinar will be on March 25 from 11:45 am – 1 pm ET. Here is the registration page for this webinar: neuronline.sfn.org/scientific-r....
An Open-Source 3D Printable Platform for Testing Head-Fixed Cognitive Flexibility in Rodents
<p>Join this interactive session as Tim Spellman discusses his paper, “An Open-Source 3D-Printable Platform for Testing Head-Fixed Cognitive Flexibility in Rodents”, with eNeuro Reviewing Editor Mark ...
neuronline.sfn.org
February 28, 2025 at 8:21 PM
Reposted by Logan Grosenick, PhD
Nice story on fabulous new work from @dingliu.bsky.social in my lab, just out today!...
February 26, 2025 at 5:08 PM
Reposted by Logan Grosenick, PhD
New work accepted to #AISTATS2025

We developed a new explainable AI method to better understand time-series data.

We can map back inputs (neurons) to their latent space. Basically merging #CEBRA with measuring the individual neurons contribution over time

arxiv.org/abs/2502.12977
February 20, 2025 at 5:35 AM
Reposted by Logan Grosenick, PhD
Evo 2 Can Design Entire Genomes https://www.asimov.press/p/evo-2 🧬🖥️🧪
February 19, 2025 at 4:19 PM
Reposted by Logan Grosenick, PhD
Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊

Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.

Paper here 👇
www.nature.com/articles/s41...
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression - Nature Communications
A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...
www.nature.com
February 13, 2025 at 3:51 PM
Reposted by Logan Grosenick, PhD
Cells in the hippocampus encode not only information about a fellow bat’s position, but also its identity and distinct social features.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/social-behav...
January 30, 2025 at 7:05 PM
Reposted by Logan Grosenick, PhD
delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab

www.nature.com/articles/s41...
Atypical hippocampal excitatory neurons express and govern object memory - Nature Communications
Pyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene ex...
www.nature.com
February 13, 2025 at 6:38 PM
Reposted by Logan Grosenick, PhD
Two cool papers on the HPC out today in @nature.com:

1. Replay during non-REM sleep switches between prioritizing recent versus remote memories:

www.nature.com/articles/s41...

2. All optical obs. of synaptic plasticity rules during place field formation:

www.nature.com/articles/s41...

🧠📈 🧪
Sleep microstructure organizes memory replay - Nature
The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.
www.nature.com
January 30, 2025 at 4:32 PM
Reposted by Logan Grosenick, PhD
Congratulations @kaidikang.bsky.social et al on their paper in Nature.

Also proud of the team at #MIDB in the support! @tervoclemmensb.bsky.social @bart-larsen.bsky.social and more!

If you are interested in optimizing study designs, take a look, it's a great read!

www.nature.com/articles/s41...
Study design features increase replicability in brain-wide association studies - Nature
Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide association ...
www.nature.com
November 27, 2024 at 11:31 PM
Reposted by Logan Grosenick, PhD
Together with some friends we built an optical Brain Machine Interface to see if cortical activity (PPC) can control behaviour in real time, without animals having to learn to use it. Here's what happened:

www.biorxiv.org/content/10.1...
www.biorxiv.org
December 3, 2024 at 11:03 AM
Reposted by Logan Grosenick, PhD
Stellar new work lead by the inimitable James Whittington in Neuron that develops a new theory unifying episodic and working memory and explains diverse hippocampal and prefrontal data: www.cell.com/neuron/fullt... w/Will Dorrell, @behrenstimb.bsky.social Mohamedy El Gaby
A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps
The algorithm of the prefrontal working memory system on sequence memory tasks is not well understood, whereas it is well understood for the hippocampal episodic memory system. This work shows a mathematical duality between working and episodic sequence memory. This leads to a computational understanding of sequence working memory—as structured activity slots. This theory algorithmically explains recurrent neural network (RNN) and prefrontal representations during sequence memory tasks.
www.cell.com
December 6, 2024 at 6:47 PM
Reposted by Logan Grosenick, PhD
Exciting news from the lab! In collaboration with our #EU-Nanobrigth partners, we’ve developed and tested a new probe for vibrational fiber photometry, enabling minimally invasive Raman spectroscopy deep into the 🧠. www.nature.com/articles/s41... @naturemethods.bsky.social
Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain - Nature Methods
Vibrational fiber photometry enables Raman spectroscopy in the mouse brain with low impact, owing to the use of tapered fibers.
www.nature.com
December 31, 2024 at 10:49 AM