Linda Sinclair
@lindavsinclair.bsky.social
Immunologist, working with Cantrell Lab. Interested in LOTS - focused on nutrient and metabolic control of the immune system. (opinions are my own)
Pinned
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
www.nature.com
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Reposted by Linda Sinclair
2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Iron and the immune system - Nature Reviews Immunology
Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...
www.nature.com
June 23, 2025 at 4:10 PM
2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Linda Sinclair
Reposted by Linda Sinclair
Special issue Immunometabolism and Beyond: from Liver to Brain!
European Journal of Immunology
Article types: reviews and research articles
Submission deadline 1 November 2025
Thanks to Nadja, Matteo and Bin for this wonderful opportunity!
#immunometabolism #EJI #CRC1292 #CRC355 #CRC156 #FZI
European Journal of Immunology
Article types: reviews and research articles
Submission deadline 1 November 2025
Thanks to Nadja, Matteo and Bin for this wonderful opportunity!
#immunometabolism #EJI #CRC1292 #CRC355 #CRC156 #FZI
May 26, 2025 at 11:39 AM
Reposted by Linda Sinclair
🚨Last week's #immunometabolism findings
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
June 15, 2025 at 1:25 AM
🚨Last week's #immunometabolism findings
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
Reposted by Linda Sinclair
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells - Nature Communications
Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that asp...
www.nature.com
June 20, 2025 at 4:46 PM
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Linda Sinclair
So cool to start the afternoon session with @plantophagy.bsky.social !! Here in the @autophagyuk and @UK_proteostasis meeting
June 4, 2025 at 1:18 PM
So cool to start the afternoon session with @plantophagy.bsky.social !! Here in the @autophagyuk and @UK_proteostasis meeting
Reposted by Linda Sinclair
What if Tregs are not a separate lineage, but part of spontaneously activated T cells?
In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.🧵(1/4)
academic.oup.com/discovimmuno...
In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.🧵(1/4)
academic.oup.com/discovimmuno...
Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1
Summary. Despite extensive regulatory T cell (Treg) research, fundamental questions on in vivo dynamics remain to be answered. The current study aims to di
academic.oup.com
April 26, 2025 at 12:22 PM
What if Tregs are not a separate lineage, but part of spontaneously activated T cells?
In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.🧵(1/4)
academic.oup.com/discovimmuno...
In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.🧵(1/4)
academic.oup.com/discovimmuno...
Reposted by Linda Sinclair
Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...
April 26, 2025 at 3:42 AM
Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...
Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells
www.annualreviews.org/content/jour...
Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells
www.annualreviews.org/content/jour...
Protein Synthesis and Metabolism in T Cells | Annual Reviews
T lymphocytes are essential for immune responses to pathogens and tumors. Their ability to rapidly clonally expand and differentiate to effector cells following infection, and then to curb effector fu...
www.annualreviews.org
April 26, 2025 at 7:59 AM
Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells
www.annualreviews.org/content/jour...
Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells
www.annualreviews.org/content/jour...
Reposted by Linda Sinclair
Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease
March 27, 2025 at 1:29 PM
Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease
Reposted by Linda Sinclair
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
March 14, 2025 at 3:25 PM
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
A lovely News and Views on Samantha Pretto/Max Mazzone’s “ #Elov1 and #CD8s and #tumour paper “ - check it out! www.nature.com/articles/s42...
Disrupting cholesterol homeostasis in T cells boosts antitumour responses - Nature Metabolism
A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1-dep...
www.nature.com
March 27, 2025 at 7:24 AM
A lovely News and Views on Samantha Pretto/Max Mazzone’s “ #Elov1 and #CD8s and #tumour paper “ - check it out! www.nature.com/articles/s42...
Reposted by Linda Sinclair
📢 A new episode of the podcast is out!
We chat with Dr. Luke O’Neill (@lukeanthonyoneill.bsky.social) at Trinity College Dublin (@tcddublin.bsky.social) about the metabolic regulation of immune cell function and the innate #ImmuneSystem.
🎧 Listen now: bit.ly/3QybMBq
We chat with Dr. Luke O’Neill (@lukeanthonyoneill.bsky.social) at Trinity College Dublin (@tcddublin.bsky.social) about the metabolic regulation of immune cell function and the innate #ImmuneSystem.
🎧 Listen now: bit.ly/3QybMBq
February 25, 2025 at 9:11 PM
📢 A new episode of the podcast is out!
We chat with Dr. Luke O’Neill (@lukeanthonyoneill.bsky.social) at Trinity College Dublin (@tcddublin.bsky.social) about the metabolic regulation of immune cell function and the innate #ImmuneSystem.
🎧 Listen now: bit.ly/3QybMBq
We chat with Dr. Luke O’Neill (@lukeanthonyoneill.bsky.social) at Trinity College Dublin (@tcddublin.bsky.social) about the metabolic regulation of immune cell function and the innate #ImmuneSystem.
🎧 Listen now: bit.ly/3QybMBq
Reposted by Linda Sinclair
Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!
Interested in microbial #metabolism, #mucosalbiology and #UTI? Then check out the open postdoctoral position in the Mucosal Immunology Group at ETH Zurich! NB: All applications must go via the ETH job portal:
www.jobs.ethz.ch/job/view/JOP...
Closing date: 24th Feburary
🧪🧫🔬
www.jobs.ethz.ch/job/view/JOP...
Closing date: 24th Feburary
🧪🧫🔬
Postdoctoral researcher –Understanding bacterial metabolism in the urinary tract
www.jobs.ethz.ch
February 10, 2025 at 8:13 PM
Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!
Reposted by Linda Sinclair
I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.
March 3, 2025 at 8:46 AM
I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.
Reposted by Linda Sinclair
Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...
Hallmarks and metabolic regulation of type 2 activated human lung macrophages
Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Ou...
www.biorxiv.org
March 3, 2025 at 3:42 PM
Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...
Reposted by Linda Sinclair
Okey dokey here goes! First real post - please reshare if appropriate 🙏
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
January 7, 2025 at 5:13 PM
Okey dokey here goes! First real post - please reshare if appropriate 🙏
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
www.nature.com
March 1, 2025 at 11:18 AM
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Reposted by Linda Sinclair
📢 Still time to be part of SIGNET 2025!
We're accepting late-breaking abstracts until Monday. Share your latest discoveries with the immunology community in Scotland on Thursday 27 March 🔬
Don't miss this final chance! Submit here: bit.ly/4euIWLO
We're accepting late-breaking abstracts until Monday. Share your latest discoveries with the immunology community in Scotland on Thursday 27 March 🔬
Don't miss this final chance! Submit here: bit.ly/4euIWLO
February 28, 2025 at 12:33 PM
📢 Still time to be part of SIGNET 2025!
We're accepting late-breaking abstracts until Monday. Share your latest discoveries with the immunology community in Scotland on Thursday 27 March 🔬
Don't miss this final chance! Submit here: bit.ly/4euIWLO
We're accepting late-breaking abstracts until Monday. Share your latest discoveries with the immunology community in Scotland on Thursday 27 March 🔬
Don't miss this final chance! Submit here: bit.ly/4euIWLO
Reposted by Linda Sinclair
Fine-tuning tumor immunogenicity with mitochondrial complex I
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
www.nature.com
January 17, 2025 at 3:43 PM
Fine-tuning tumor immunogenicity with mitochondrial complex I
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
Reposted by Linda Sinclair
Delighted to have had the opportunity to write this spotlight with @juanquintana.bsky.social and the lab, on the recent @lydialynch.bsky.social paper, showing rhythmicity of IL-17 expression in adipose! Fascinating paper, which raises loads of cool questions #immunosky www.cell.com/immunity/ful...
Interleukin-17 and fat: Timing is everything
Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a
recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent
expression of interleukin-17 b...
www.cell.com
January 14, 2025 at 4:12 PM
Delighted to have had the opportunity to write this spotlight with @juanquintana.bsky.social and the lab, on the recent @lydialynch.bsky.social paper, showing rhythmicity of IL-17 expression in adipose! Fascinating paper, which raises loads of cool questions #immunosky www.cell.com/immunity/ful...
Reposted by Linda Sinclair
Our Communication and Engagement Grant is open to all BSI members who want to take part in #PublicEngagement 🌟
Share your passion, build skills, and make a difference to the world of #immunology 💪
Application deadline: 1 Feb 2025 🗓️
Apply now 👉 bit.ly/3Y9j8gm
Share your passion, build skills, and make a difference to the world of #immunology 💪
Application deadline: 1 Feb 2025 🗓️
Apply now 👉 bit.ly/3Y9j8gm
January 16, 2025 at 3:49 PM
Our Communication and Engagement Grant is open to all BSI members who want to take part in #PublicEngagement 🌟
Share your passion, build skills, and make a difference to the world of #immunology 💪
Application deadline: 1 Feb 2025 🗓️
Apply now 👉 bit.ly/3Y9j8gm
Share your passion, build skills, and make a difference to the world of #immunology 💪
Application deadline: 1 Feb 2025 🗓️
Apply now 👉 bit.ly/3Y9j8gm
Reposted by Linda Sinclair
Elegant work by Jason Cyster's group
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.
www.cell.com
January 5, 2025 at 4:02 PM
Elegant work by Jason Cyster's group
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky
Reposted by Linda Sinclair
Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....
Identification of the mammalian VPS4A as a selective lipophagy receptor
www.tandfonline.com
January 5, 2025 at 9:13 PM
Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....
Reposted by Linda Sinclair
Michael J Fox has had tremendous influence on people with Parkinson's Disease (PD), their carers, families and those working on PD. He is a shining example of what a single person is capable of.
Well deserved recognition.
Well deserved recognition.
Michael J. Fox receiving the Presidential Medal of Freedom from Joe Biden….why is it so dusty in here now….I’m not crying, you’re crying 🥹🙏
January 5, 2025 at 9:32 PM
Michael J Fox has had tremendous influence on people with Parkinson's Disease (PD), their carers, families and those working on PD. He is a shining example of what a single person is capable of.
Well deserved recognition.
Well deserved recognition.