Derek Mann
@damann1.bsky.social
Scientist, mentor, husband, father, grandfather, rugby fan, Man Utd supporter, cook, grateful cancer survivor researching cancer immunology.
Very proud of our latest review on the challenges of surgical treatments for hepatocellular carcinoma
New online! Improving surgical treatments for hepatocellular carcinoma
Improving surgical treatments for hepatocellular carcinoma
Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01143-yThis Review examines how advances in tumour biology, immunogenomics and graft preservation are redefining surgical management of hepatocellular carcinoma. Malik et al. describe the shift from anatomical to biology-informed paradigms to individualize surgical decision-making.
www.nature.com
November 18, 2025 at 1:35 AM
Very proud of our latest review on the challenges of surgical treatments for hepatocellular carcinoma
As Newcastle University’s Professor of Hepatology, I am honoured and extremely proud to be a contributor to its world top 10 ranking in Gastroenterology and Hepatology 👊
July 6, 2025 at 3:26 PM
As Newcastle University’s Professor of Hepatology, I am honoured and extremely proud to be a contributor to its world top 10 ranking in Gastroenterology and Hepatology 👊
Reposted by Derek Mann
The NU Conference was a big success with a superb plenary from Ram DasGupta (CRUK Scotland). Prizes for talks - J Dishington (1st) and H Stewart; flash talks - E Woodward (1st), L Taylor (2nd); posters - E Hackney (1st), K Papa (2nd). Congrats and to all presenters for giving us a memorable day!
June 16, 2025 at 2:26 PM
The NU Conference was a big success with a superb plenary from Ram DasGupta (CRUK Scotland). Prizes for talks - J Dishington (1st) and H Stewart; flash talks - E Woodward (1st), L Taylor (2nd); posters - E Hackney (1st), K Papa (2nd). Congrats and to all presenters for giving us a memorable day!
Spectacular 3 days in Singapore. Everyone should visit
April 22, 2025 at 2:15 PM
Spectacular 3 days in Singapore. Everyone should visit
Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease
March 27, 2025 at 1:29 PM
Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease
Our latest paper, published today in FEBS Letters is a chemical biology study on development of drugs selectively targeting HDAC6 with demonstration of efficacy in a human model of liver fibrosis. febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic ....
febs.onlinelibrary.wiley.com
March 14, 2025 at 7:14 PM
Our latest paper, published today in FEBS Letters is a chemical biology study on development of drugs selectively targeting HDAC6 with demonstration of efficacy in a human model of liver fibrosis. febs.onlinelibrary.wiley.com/doi/10.1111/...
Wow, phenomenal work. 75% of pancreatic cancer patients alive 3 years after receiving a personalised mRNA vaccine. Durable CD8+ T cell responses underlying the therapeutic benefit. Congrats to the authors 👊👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature
In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked lo...
www.nature.com
February 27, 2025 at 10:39 PM
Wow, phenomenal work. 75% of pancreatic cancer patients alive 3 years after receiving a personalised mRNA vaccine. Durable CD8+ T cell responses underlying the therapeutic benefit. Congrats to the authors 👊👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dr Amy Collins from our group and @nucancer.bsky.social selected for early career researcher oral presentation of her poster on use of a complex human tissue culture model of liver cancer for drug development.
February 21, 2025 at 2:31 PM
Dr Amy Collins from our group and @nucancer.bsky.social selected for early career researcher oral presentation of her poster on use of a complex human tissue culture model of liver cancer for drug development.
Next up, our talented PhD student Keara, who was super busy at her poster on development of a tumour slice screening platform for discovery of liver cancer drug targets.
February 20, 2025 at 3:06 PM
Next up, our talented PhD student Keara, who was super busy at her poster on development of a tumour slice screening platform for discovery of liver cancer drug targets.
Dr Amy Collins is busy at her poster on modelling hepatocellular carcinoma at the 2025 EASL Liver Cancer Summit in Paris. Funding for her work from Cancer Research U.K.
February 20, 2025 at 12:28 PM
Dr Amy Collins is busy at her poster on modelling hepatocellular carcinoma at the 2025 EASL Liver Cancer Summit in Paris. Funding for her work from Cancer Research U.K.
Reposted by Derek Mann
An important new study on the genetics of liver cancer published today in Nature led by Prof Tom Bird of Edinburgh University with contributions from @damann1.bsky.social, @jleslie1.bsky.social and others of @nucancer.bsky.social.
Human-correlated genetic models identify precision therapy for liver cancer - Nature
As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in ...
www.nature.com
February 19, 2025 at 7:18 PM
An important new study on the genetics of liver cancer published today in Nature led by Prof Tom Bird of Edinburgh University with contributions from @damann1.bsky.social, @jleslie1.bsky.social and others of @nucancer.bsky.social.
Well done Keara, very proud of you!
Our talented PhD student Keara wins a regional prize for her work on developing a 96-well scale model of liver cancer tumour microenvironment. Congratulations Keara!
February 11, 2025 at 11:38 PM
Well done Keara, very proud of you!
The Cure. Somber, Sad, Glorious (and oh that bass!) 😊
THE CURE It Can Never Be The Same @ Meltdown Festival, London 6/24/18
YouTube video by citizenborland
youtu.be
February 4, 2025 at 10:37 PM
The Cure. Somber, Sad, Glorious (and oh that bass!) 😊
On World Cancer Day we welcome Dr Abdullah Malik to our liver cancer team. Abdullah is a talented surgeon who has won a prestigious Medical Research Council clinician scientist training fellowship to research the basis of recurrence of cancer following surgical removal of a patient’s tumour.
February 4, 2025 at 6:36 PM
On World Cancer Day we welcome Dr Abdullah Malik to our liver cancer team. Abdullah is a talented surgeon who has won a prestigious Medical Research Council clinician scientist training fellowship to research the basis of recurrence of cancer following surgical removal of a patient’s tumour.
Reposted by Derek Mann
Today is World Cancer Day. At the NU Centre for Cancer we are dedicated to working towards more effective and gentler treatments for cancer patients.
February 4, 2025 at 9:03 AM
Today is World Cancer Day. At the NU Centre for Cancer we are dedicated to working towards more effective and gentler treatments for cancer patients.
The graph is reporting a decline in published works. That is not the same as leaving a research career.
January 11, 2025 at 5:52 PM
The graph is reporting a decline in published works. That is not the same as leaving a research career.
Others have said the same. Maybe a new career move if and when the funding dries up 🤣
January 10, 2025 at 11:51 PM
Others have said the same. Maybe a new career move if and when the funding dries up 🤣
In addition to my trials and tribulations with bowel cancer I also suffer from pre-cancerous lesions on the skin around my eyes. So now have a new pair of wraparound prescription shades to offer a better degree of protection. Not sure if I look more like The Terminator or a character from The Matrix
January 10, 2025 at 8:44 PM
In addition to my trials and tribulations with bowel cancer I also suffer from pre-cancerous lesions on the skin around my eyes. So now have a new pair of wraparound prescription shades to offer a better degree of protection. Not sure if I look more like The Terminator or a character from The Matrix
Reposted by Derek Mann
We are very proud that our very own Professor Christine Harrison has been deservedly recognised with an OBE for her work on improving the scientific knowledge and care of childhood leukaemia. bloodcancer.org.uk/news/blood-c...
Blood Cancer UK | Blood cancer researcher recognised in King’s New Years Honours
The King’s New Years Honours list has been announced with Blood Cancer UK's trustee awarded an OBE for services to children.
bloodcancer.org.uk
January 2, 2025 at 1:29 AM
We are very proud that our very own Professor Christine Harrison has been deservedly recognised with an OBE for her work on improving the scientific knowledge and care of childhood leukaemia. bloodcancer.org.uk/news/blood-c...
Hmmm yes, Dylan may have have some genius moments but he is obviously a bit of a knob
December 29, 2024 at 7:44 PM
Hmmm yes, Dylan may have have some genius moments but he is obviously a bit of a knob
Keep going and wishing you happy holidays and good health in 2025
December 24, 2024 at 11:22 PM
Keep going and wishing you happy holidays and good health in 2025