Kero Guynes
@kguynes.bsky.social
Postdoc at Blizard Institute (Branco Lab) | Alumnus of @IMBA_Vienna (Burga Lab), @Martin-Duran Lab (QMUL), and Partridge Lab (IHA, UCL)
Surreal to finally see Žižek live! Fortunate to have had a short, fulfilling exchange with him.
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
November 10, 2025 at 10:01 PM
Surreal to finally see Žižek live! Fortunate to have had a short, fulfilling exchange with him.
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
Reposted by Kero Guynes
Want to automate workflows in #FIJI?
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Batch Processing with the ImageJ Macro Language
The ImageJ wiki is a community-edited knowledge base on topics relating to ImageJ, a public domain program for processing and analyzing scientific images, and its ecosystem of derivatives and variants...
imagej.github.io
October 23, 2025 at 4:32 PM
Want to automate workflows in #FIJI?
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Transposon addiction unseating ancestral mechanism is my favourite bit
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 23, 2025 at 3:01 PM
Transposon addiction unseating ancestral mechanism is my favourite bit
Reposted by Kero Guynes
another fascinating collaboration with the Turco lab @fmiscience.bsky.social www.biorxiv.org/content/10.1...
A model of apical-out human first trimester trophoblast organoids to study regeneration after syncytial damage
The villous syncytiotrophoblast in humans is the interface between maternal blood and the placenta and its functions are essential for a successful pregnancy. The syncytium can be damaged in vivo foca...
www.biorxiv.org
October 23, 2025 at 6:45 AM
another fascinating collaboration with the Turco lab @fmiscience.bsky.social www.biorxiv.org/content/10.1...
Reposted by Kero Guynes
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins
Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...
www.biorxiv.org
October 23, 2025 at 12:50 PM
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
The histone code at a crossroads: history, context, and new approaches: Trends in Genetics www.cell.com/trends/genet...
The histone code at a crossroads: history, context, and new approaches
Recent studies have reported that catalytically dead histone-modifying enzymes can
rescue the function of their null alleles. Histone ‘replacement’ experiments have
similarly found a lack of phenotype...
www.cell.com
October 14, 2025 at 2:48 PM
The histone code at a crossroads: history, context, and new approaches: Trends in Genetics www.cell.com/trends/genet...
Reposted by Kero Guynes
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
October 10, 2025 at 12:57 PM
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
Reposted by Kero Guynes
Naked mole-rat workers may have specific roles, such as cleaning the toilet chamber or transporting waste, rather than being generalist helpers. The findings suggest their colonies are even more complex than we thought. 🧪 #animals #zoology #nature
www.livescience.com/animals/land...
www.livescience.com/animals/land...
Some naked mole rats are designated toilet cleaners, study suggests
Naked mole rats may have specific roles, such as cleaning the toilet chamber or transporting waste, rather than being generalist helpers. The findings suggest naked-mole-rat colonies are even more com...
www.livescience.com
October 9, 2025 at 6:00 AM
Naked mole-rat workers may have specific roles, such as cleaning the toilet chamber or transporting waste, rather than being generalist helpers. The findings suggest their colonies are even more complex than we thought. 🧪 #animals #zoology #nature
www.livescience.com/animals/land...
www.livescience.com/animals/land...
Reposted by Kero Guynes
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
2026 PhD recruitment is now open.
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
PhD student recruitment
PhD recruitment information.
www.crick.ac.uk
October 7, 2025 at 4:43 PM
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
Excellent resource - thank you!
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
October 9, 2025 at 5:27 PM
Excellent resource - thank you!
Reposted by Kero Guynes
I really love this experimental study on emergence of plasmid stability by @daganlab.bsky.social
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance - Nature Communications
It is expected that plasmids are costly and therefore that selection is required to maintain them within bacterial populations. Here, Wein et al. show that plasmid stability can emerge even in the absence of positive selection and that loss may be determined by transcription-replication conflict.
www.nature.com
October 3, 2025 at 9:44 AM
I really love this experimental study on emergence of plasmid stability by @daganlab.bsky.social
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
Reposted by Kero Guynes
#TEsky Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera) doi.org/10.1038/s415...
Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera) - Scientific Reports
Scientific Reports - Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera)
doi.org
October 4, 2025 at 5:12 PM
#TEsky Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera) doi.org/10.1038/s415...
Reposted by Kero Guynes
The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.02.679314v1
October 3, 2025 at 7:34 AM
The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.02.679314v1
Sad loss, but will continue to inspire many more generations
JUST IN: Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.
Jane Goodall, legendary primatologist, has died at age 91
Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.
n.pr
October 1, 2025 at 7:18 PM
Sad loss, but will continue to inspire many more generations
Reposted by Kero Guynes
UPDATE: The 2025-2026 list of faculty and postdoc positions in ecology and evolutionary biology is out! Be sure to check out this active and helpful community run resources! docs.google.com/spreadsheets...
ecoevojobs.net 2025-26
docs.google.com
September 19, 2025 at 9:47 PM
UPDATE: The 2025-2026 list of faculty and postdoc positions in ecology and evolutionary biology is out! Be sure to check out this active and helpful community run resources! docs.google.com/spreadsheets...
Reposted by Kero Guynes
PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
September 17, 2025 at 10:39 AM
PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
Reposted by Kero Guynes
🎵WHY DO ENHANCER!
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
Distal enhancers loop to proximal enhancers, not to promoters - Nature Reviews Molecular Cell Biology
This Comment posits that enhancers stimulate the transcription machinery only through short-range interactions and, therefore, that enhancer activity at a distance is mediated by chromatin loops betwe...
www.nature.com
September 9, 2025 at 5:42 PM
🎵WHY DO ENHANCER!
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
Reposted by Kero Guynes
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 12:19 PM
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Reposted by Kero Guynes
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...
www.nature.com
May 7, 2025 at 3:23 PM
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Reposted by Kero Guynes
Save the Date!
Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment.
📅7 - 9 Sep 2026
📍University of Warwick, UK
Register your interest for #HumanDev26: www.biologists.com/meetings/dev...
Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment.
📅7 - 9 Sep 2026
📍University of Warwick, UK
Register your interest for #HumanDev26: www.biologists.com/meetings/dev...
September 13, 2025 at 1:12 PM
Save the Date!
Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment.
📅7 - 9 Sep 2026
📍University of Warwick, UK
Register your interest for #HumanDev26: www.biologists.com/meetings/dev...
Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment.
📅7 - 9 Sep 2026
📍University of Warwick, UK
Register your interest for #HumanDev26: www.biologists.com/meetings/dev...
Reposted by Kero Guynes
#TEsky Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes doi.org/10.1002/advs...
Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes
By integrating phylogenetic relationships derived from nuclear DNA with population genetic analyses across ten pufferfish species, the genetic differentiation mechanisms underpinning the radiative sp....
doi.org
September 11, 2025 at 1:23 PM
#TEsky Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes doi.org/10.1002/advs...
Reposted by Kero Guynes
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
Reposted by Kero Guynes
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Reposted by Kero Guynes
"Honey, wake up. New CUT protocol just dropped" www.biorxiv.org/content/10.1...
CUT&TIME captures the history of open chromatin in developing neurons
Chromatin structure plays a central role in defining cell identity by regulating gene expression. During development, shifts in chromatin structure facilitate changes in gene expression needed to spec...
www.biorxiv.org
September 1, 2025 at 9:19 AM
"Honey, wake up. New CUT protocol just dropped" www.biorxiv.org/content/10.1...