Jason Plemel
@jrplemel.bsky.social
Husband, Father, and Associate Prof
@UAlberta_FoMD. Studying in all things glia. Hoping to #endMS. jrplemel@ualberta.ca
@UAlberta_FoMD. Studying in all things glia. Hoping to #endMS. jrplemel@ualberta.ca
Excited that the work from the talented Dr. Sameera Zia is now out. Blood, sweat, and tears went into this one. An amazing job. rdcu.be/ePyQm
Age-impaired remyelination is associated with dysregulated microglial transitions
Nature Communications - Microglial states throughout remyelination are incompletely understood. Here, the authors show that microglia form several states during the early stages of remyelination...
rdcu.be
November 12, 2025 at 2:46 PM
Excited that the work from the talented Dr. Sameera Zia is now out. Blood, sweat, and tears went into this one. An amazing job. rdcu.be/ePyQm
Looking forward to this:
Our first Invited Speaker to present at GIA2025 is Dr. Jason Plemel (@jrplemel.bsky.social), a Canada Research Chair in Glial Neuroimmunology and Associate Professor in the UofA Department of Medicine Neurology Division. Dr. Plemel will talk on Microglia and glycome alterations during demyelination.
October 30, 2025 at 11:56 PM
Looking forward to this:
Reposted by Jason Plemel
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
October 17, 2025 at 12:18 PM
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Reposted by Jason Plemel
🧪
My amazing Department of Chemistry and Biochemistry at @ulethbridge.ca is seeking a motivated & talented candidate for a tenure-track Assistant Professor position in the area of experimental chemistry.
We encourage you to apply or help spread the word!
uleth.peopleadmin.ca/postings/8541
We encourage you to apply or help spread the word!
uleth.peopleadmin.ca/postings/8541
Faculty of Arts & Science - Assistant Professor (Chemistry and Biochemistry)
The Department of Chemistry and Biochemistry at the University of Lethbridge invites applications for a tenure-track position in any area of experimental chemistry. This appointment will be at the ran...
uleth.peopleadmin.ca
August 1, 2025 at 7:53 PM
🧪
Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner
June 26, 2025 at 4:32 PM
Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner
Reposted by Jason Plemel
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Read this Research Article from our special issue on lifelong development #LifelongDevSI, by Brady Hammond, @jrplemel.bsky.social & co.:
journals.biologists.com/dev/article/...
Read this Research Article from our special issue on lifelong development #LifelongDevSI, by Brady Hammond, @jrplemel.bsky.social & co.:
journals.biologists.com/dev/article/...
June 17, 2025 at 3:29 PM
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Read this Research Article from our special issue on lifelong development #LifelongDevSI, by Brady Hammond, @jrplemel.bsky.social & co.:
journals.biologists.com/dev/article/...
Read this Research Article from our special issue on lifelong development #LifelongDevSI, by Brady Hammond, @jrplemel.bsky.social & co.:
journals.biologists.com/dev/article/...
Excited to get going for the 2025 #endMS_SummerSchool !
It takes a village! Look at all the welcome packages for those who make this event happen
It takes a village! Look at all the welcome packages for those who make this event happen
June 17, 2025 at 3:11 PM
Excited to get going for the 2025 #endMS_SummerSchool !
It takes a village! Look at all the welcome packages for those who make this event happen
It takes a village! Look at all the welcome packages for those who make this event happen
Two in one week! An amazing MSc Defence for Rebecca John, co-supervised by Karim Fouad and myself.
June 13, 2025 at 10:44 PM
Two in one week! An amazing MSc Defence for Rebecca John, co-supervised by Karim Fouad and myself.
Super proud of Brady Hammond for successfully defending his PhD today. Well done Brady!
June 12, 2025 at 2:46 AM
Super proud of Brady Hammond for successfully defending his PhD today. Well done Brady!
Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...
journals.biologists.com
June 3, 2025 at 4:14 PM
Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Amazing work by @iammadho.bsky.social 👇
Check it out
Check it out
Ecstatic to post my 1st first author review!
Ever wondered about the immune cell perspective on sex differences within the PNS under pain? Do I have news for you 📝🗯️🦠🔬🤕
Read it here: doi.org/10.1016/j.bb...
So grateful to write this under the labs of @bradleykerr.bsky.social @jrplemel.bsky.social
Ever wondered about the immune cell perspective on sex differences within the PNS under pain? Do I have news for you 📝🗯️🦠🔬🤕
Read it here: doi.org/10.1016/j.bb...
So grateful to write this under the labs of @bradleykerr.bsky.social @jrplemel.bsky.social
June 2, 2025 at 9:09 PM
Amazing work by @iammadho.bsky.social 👇
Check it out
Check it out
Reposted by Jason Plemel
Graduate student and post-doc (Neuroimmunology & High-Throughput Immunometabolic Profiling in MS) positions available in Dr. Deepak Kaushik's laboratory at Memorial University #neurojobs can-acn.org/msc-phd-posi... can-acn.org/postdoctoral...
MSc/PhD Position at the Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada – Canadian Association for Neuroscience
Dr. Deepak Kaushik, Assistant Professor at the Faculty of Medicine, Memorial University of Newfoundland (MUN, St. John’s, Canada), is currently recruiting MSc/PhD fellows to join a CIHR-funded…
can-acn.org
May 1, 2025 at 6:34 PM
Graduate student and post-doc (Neuroimmunology & High-Throughput Immunometabolic Profiling in MS) positions available in Dr. Deepak Kaushik's laboratory at Memorial University #neurojobs can-acn.org/msc-phd-posi... can-acn.org/postdoctoral...
Reposted by Jason Plemel
Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
sciencedirect.com
April 18, 2025 at 3:03 PM
Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
Reposted by Jason Plemel
Congratulations to all accepted SS & SPRINT applicants. The application quality was outstanding but sadly we are unable to accept everyone. A truly national🍁program. Can't wait to meet you in Edmonton. @ualberta.bsky.social, @jrplemel.bsky.social, @rimuhc.bsky.social, @healthsciences.mcgill.ca
Excited to share this month's #endMS newsletter unveiling the list of successful #endMS_SummerSchool and #endMS_SPRINT applicants, achievements, publications and more! View the full issue here: bit.ly/endMS_Newsle...
April 2025 endMS Bits and Pieces Newsletter
bit.ly
April 15, 2025 at 7:16 PM
Congratulations to all accepted SS & SPRINT applicants. The application quality was outstanding but sadly we are unable to accept everyone. A truly national🍁program. Can't wait to meet you in Edmonton. @ualberta.bsky.social, @jrplemel.bsky.social, @rimuhc.bsky.social, @healthsciences.mcgill.ca
Check out this exciting work by @philgrossphd.bsky.social in the @jkhuang.bsky.social lab! Thanks for asking us to be a part of it
Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...
1/3
1/3
Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications
The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...
www.nature.com
March 7, 2025 at 2:24 PM
Check out this exciting work by @philgrossphd.bsky.social in the @jkhuang.bsky.social lab! Thanks for asking us to be a part of it
Reposted by Jason Plemel
March 5, 2025 at 8:47 PM
Reposted by Jason Plemel
Reposted by Jason Plemel
I knew this would happen, but it's still surreal to hear another nation's leader talk to us in a televised address the way US presidents have historically spoken to the citizens of countries led by dictators and despots.
Trudeau: "I want to speak first directly to the American people. We don't want this. We want to work with you as a friend and ally. We don't want to see you hurt either. But your government has chosen to do this to you. As of this morning, markets are down and inflation is set to rise dramatically."
March 4, 2025 at 4:58 PM
I knew this would happen, but it's still surreal to hear another nation's leader talk to us in a televised address the way US presidents have historically spoken to the citizens of countries led by dictators and despots.
Reposted by Jason Plemel
I hope you haven’t missed this awesome new study by
@caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰
@caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience
The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...
www.nature.com
March 1, 2025 at 1:52 AM
I hope you haven’t missed this awesome new study by
@caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰
@caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰
Check out a recent paper by Karim Fouad and my groups examining how reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states
February 28, 2025 at 6:55 PM
Check out a recent paper by Karim Fouad and my groups examining how reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states
Reposted by Jason Plemel
Oligodendrocyte precursor cells facilitate neuronal lysosome release
Oligodendrocyte precursor cells facilitate neuronal lysosome release - Nature Communications
Oligodendrocyte precursor cells (OPCs) play a multifaceted role in the brain. Here, the authors show that OPCs regulate neuronal metabolism by forming contacts with neuronal somata, facilitating lysos...
www.nature.com
January 30, 2025 at 10:34 PM
Oligodendrocyte precursor cells facilitate neuronal lysosome release
Reposted by Jason Plemel
Wise words from another Nobel laureate.
Take a look at this passage from the autobiography of Van Essen from the same SfN series
January 18, 2025 at 2:57 PM
Wise words from another Nobel laureate.
Reposted by Jason Plemel
Cool new manuscript from the Huang lab!!
Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1
January 12, 2025 at 3:42 AM
Cool new manuscript from the Huang lab!!
Reposted by Jason Plemel
Old article but poignant as ever.
Success in science is far more than science alone.
Success in science is far more than science alone.
The discoverer of GFP gene for a glowing protein
was driving a van for a car dealership in Huntsville, Alabama, when he learned that former colleagues
had won science's greatest honor.
www.discovermagazine.com/mind/how-bad...
www.discovermagazine.com/mind/how-bad...
How Bad Luck & Bad Networking Cost Douglas Prasher a Nobel Prize
The discoverer of a gene for a glowing protein
was driving a van for a car dealership in Huntsville, Alabama, when he learned that former colleagues
had won science's greatest honor.
www.discovermagazine.com
December 29, 2024 at 1:59 PM
Old article but poignant as ever.
Success in science is far more than science alone.
Success in science is far more than science alone.
Reposted by Jason Plemel
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/full/10....
www.science.org/doi/full/10....
December 23, 2024 at 2:36 PM
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/full/10....
www.science.org/doi/full/10....