Indigo V.L. Rose
@ivlrose.bsky.social
Uses functional genomics to study astrocyte & neuron states in neurodegenerative disease 🧪. Neuroscience PhD candidate at UCSF (Kampmann Lab). He/him 🏳️🌈
Reposted by Indigo V.L. Rose
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 4:43 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Reposted by Indigo V.L. Rose
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Reposted by Indigo V.L. Rose
Glia gang, this is for you!
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
November 3, 2025 at 3:47 PM
Glia gang, this is for you!
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
RIP Kit-Kat 💔
Nearly a week after a self-driving Waymo taxi struck and killed KitKat, the “Mayor of 16th Street,” San Francisco’s Mission District is still mourning.
A week after a Waymo self-driving car killed a beloved cat, San Francisco still mourns
Nearly a week after a self-driving Waymo taxi struck and killed KitKat, the “Mayor of 16th Street,” San Francisco’s Mission District is still mourning.
bit.ly
November 2, 2025 at 5:58 PM
RIP Kit-Kat 💔
Reposted by Indigo V.L. Rose
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Indigo V.L. Rose
We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Check out our latest Oligo investigation led by @pryprk.bsky.social !
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:40 PM
We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Reposted by Indigo V.L. Rose
uv makes installing and using Python *so* easy! It works on pretty much any computer and it's lightning fast. 🔭☄️ #astrocode
If you're still using conda, pyenv, or... basically any other tool, then I can *highly* recommend switching:
If you're still using conda, pyenv, or... basically any other tool, then I can *highly* recommend switching:
uv is the best thing to happen to the Python ecosystem in a decade - Blog - Dr. Emily L. Hunt
Released in 2024, uv is hands-down the best tool for managing Python installations and dependencies. Here's why.
emily.space
October 24, 2025 at 1:03 PM
uv makes installing and using Python *so* easy! It works on pretty much any computer and it's lightning fast. 🔭☄️ #astrocode
If you're still using conda, pyenv, or... basically any other tool, then I can *highly* recommend switching:
If you're still using conda, pyenv, or... basically any other tool, then I can *highly* recommend switching:
Reposted by Indigo V.L. Rose
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
October 22, 2025 at 6:28 PM
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Reposted by Indigo V.L. Rose
Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau - Molecular Psychiatry
Molecular Psychiatry - Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
www.nature.com
October 21, 2025 at 9:22 PM
Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Indigo V.L. Rose
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
October 15, 2025 at 4:11 PM
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
Reposted by Indigo V.L. Rose
In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 24, 2025 at 12:41 PM
In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
Wow now that was an earthquake! Never been shaken awake before
September 22, 2025 at 10:01 AM
Wow now that was an earthquake! Never been shaken awake before
Reposted by Indigo V.L. Rose
Rust 1.90.0 is out! blog.rust-lang.org/2025/09/18/R...
Major features:
* lld as the default linker on x86_64-unknown-linux-gnu
* cargo workspace publishing support built into cargo
* more const context APIs, and stabilization of new useful APIs
Major features:
* lld as the default linker on x86_64-unknown-linux-gnu
* cargo workspace publishing support built into cargo
* more const context APIs, and stabilization of new useful APIs
Announcing Rust 1.90.0 | Rust Blog
Empowering everyone to build reliable and efficient software.
blog.rust-lang.org
September 18, 2025 at 2:17 PM
Rust 1.90.0 is out! blog.rust-lang.org/2025/09/18/R...
Major features:
* lld as the default linker on x86_64-unknown-linux-gnu
* cargo workspace publishing support built into cargo
* more const context APIs, and stabilization of new useful APIs
Major features:
* lld as the default linker on x86_64-unknown-linux-gnu
* cargo workspace publishing support built into cargo
* more const context APIs, and stabilization of new useful APIs
Reposted by Indigo V.L. Rose
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 5:38 PM
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
Reposted by Indigo V.L. Rose
Most neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPR activation for SCN2A-related neurodevelopmental disorders | Nature
www.nature.com
September 17, 2025 at 3:13 PM
Most neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Indigo V.L. Rose
Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling @cellcellpress.bsky.social @travisfaust.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
September 11, 2025 at 3:32 PM
Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling @cellcellpress.bsky.social @travisfaust.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Indigo V.L. Rose
![Comic. [Building with large sign in front of it[ SIGN: Welcome to the *Biology Department* It has been [changeable sign: 3] days since we discovered something existentially horrifying about bugs that makes you question your whole reality](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreigvmzverlrjgqp4mazbkhm43fpvv2hdbkd2t2646dhihozrwdcy24@jpeg)
September 11, 2025 at 9:24 PM
Reposted by Indigo V.L. Rose
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 7, 2025 at 9:20 PM
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
Getting a breathtaking view of the Golden Gate Bridge! Perfect conditions this weekend.
September 7, 2025 at 8:11 PM
Getting a breathtaking view of the Golden Gate Bridge! Perfect conditions this weekend.
Thanks Nat Neuro for posting about our recent paper! This project goes to show that you can have a really wacky idea and occasionally biology will throw you a bone and it will actually work!
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
@kampmann.bsky.social @ivlrose.bsky.social
www.nature.com/articles/s41...
@kampmann.bsky.social @ivlrose.bsky.social
www.nature.com/articles/s41...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
September 5, 2025 at 6:05 PM
Thanks Nat Neuro for posting about our recent paper! This project goes to show that you can have a really wacky idea and occasionally biology will throw you a bone and it will actually work!
I love this cover art so much!
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
September 4, 2025 at 3:45 PM
I love this cover art so much!
Reposted by Indigo V.L. Rose
Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
Astrocyte networks span large swaths of brain
The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.
www.thetransmitter.org
September 3, 2025 at 1:57 PM
Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
Ever wanted to do a CRISPR screen directly in the mammalian brain? While perturbing thousands of genes in parallel? All while targeting specific cell types? Check out our latest paper describing CrAAVe-seq, a powerful new functional genomics tool for massively parallel neuroscience research
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
August 23, 2025 at 6:06 AM
Ever wanted to do a CRISPR screen directly in the mammalian brain? While perturbing thousands of genes in parallel? All while targeting specific cell types? Check out our latest paper describing CrAAVe-seq, a powerful new functional genomics tool for massively parallel neuroscience research
Reposted by Indigo V.L. Rose
This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.
August 18, 2025 at 1:39 AM
This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.
Reposted by Indigo V.L. Rose
Cool astrocyte paper!
Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals - Nature Neuroscience
The relative contribution of intrinsic and extrinsic factors to astrocyte heterogeneity is unknown. Using heterotropic transplantation of septal astrocytes with distinct lineage origins, we show that ...
www.nature.com
July 29, 2025 at 4:40 PM
Cool astrocyte paper!