Celeste Karch
@karchlab.bsky.social
Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her.
www.karchlab.wustl.edu
www.karchlab.wustl.edu
!["[c]learly Rosy had to go or be put in her place”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:an2lkmy3huazryrvir2strds/bafkreieh3gaaje45rowrtp3xg5x6kmnzz4ewpaayv4kteikj5uwyvkvk74@jpeg)
Reposted by Celeste Karch
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
Reposted by Celeste Karch
Our first Family Social Hour is today at 8PM! Join us to meet other #MAPTFTD families ❤️
#cureMAPTFTD #FTD
us06web.zoom.us/meeting/regi...
#cureMAPTFTD #FTD
us06web.zoom.us/meeting/regi...
October 26, 2025 at 10:59 PM
Our first Family Social Hour is today at 8PM! Join us to meet other #MAPTFTD families ❤️
#cureMAPTFTD #FTD
us06web.zoom.us/meeting/regi...
#cureMAPTFTD #FTD
us06web.zoom.us/meeting/regi...
Reposted by Celeste Karch
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
October 22, 2025 at 6:28 PM
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau - Molecular Psychiatry
Molecular Psychiatry - Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
www.nature.com
October 21, 2025 at 9:22 PM
Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
October 21, 2025 at 1:06 AM
Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?
June 6, 2025 at 9:22 PM
Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?
Reposted by Celeste Karch
Reposted by Celeste Karch
Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!
https://ucl.ac.uk/work-at-ucl/se…
May 9, 2025 at 8:33 AM
Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!
Reposted by Celeste Karch
LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data
LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data https://www.biorxiv.org/content/10.1101/2025.04.28.650893v1
May 1, 2025 at 6:55 PM
LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data
Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...
URGENT ACTION ALERT: Historic Threat to SNAP – Keep The Pressure On
secure.everyaction.com
May 1, 2025 at 3:59 PM
Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...
Reposted by Celeste Karch
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response
to accumulated neuropathology, thereby dampening inflammatory signaling between microglia
and astrocytes. Using s...
www.cell.com
April 30, 2025 at 3:56 PM
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Great article featuring pioneering work from the Frost lab along with promising clinical trial data @bessfrost.bsky.social
Could blocking ‘jumping genes’ help fight disease and aging?
The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own
www.science.org
April 18, 2025 at 1:52 AM
Great article featuring pioneering work from the Frost lab along with promising clinical trial data @bessfrost.bsky.social
Reposted by Celeste Karch
Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
April 17, 2025 at 10:25 PM
Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
Reposted by Celeste Karch
Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration
Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.
Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.
us02web.zoom.us
April 10, 2025 at 3:43 PM
Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration
Reposted by Celeste Karch
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
doi.org
April 11, 2025 at 2:00 PM
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
Reposted by Celeste Karch
Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social
March 20, 2025 at 1:38 AM
Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social
When educators, students, families, and community members come together, there is nothing we cannot achieve. Join us to protect students and families on March 19 by attending or hosting a “walk-in” at your local school: nea.org/March19
March 19 Participant Toolkit | NEA
On Wednesday, March 19, our communities will walk into our schools together to show elected leaders that we are united in support for the programs and protections our communities need to thrive.
nea.org
March 19, 2025 at 1:54 AM
When educators, students, families, and community members come together, there is nothing we cannot achieve. Join us to protect students and families on March 19 by attending or hosting a “walk-in” at your local school: nea.org/March19