Young-Pearse Lab
@typlab.bsky.social
The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and neurodevelopmental disorders. Account run by lab members.
Find us at: youngpearselab.bwh.harvard.edu
Find us at: youngpearselab.bwh.harvard.edu
We're excited to share our new pre-print, where @gizemterzioglu.bsky.social et al. identify SHIP1, the protein encoded by the Alzheimer's disease risk gene INPP5D, as a regulator of endo-lysosome function and selective phagocytosis in human iPSC-derived microglia! www.biorxiv.org/content/10.1...
INPP5D/SHIP1 is a dual regulator of endo-lysosome function and selective phagocytosis in human microglia
INPP5D, the gene encoding SHIP1, is genetically associated with Alzheimer’s disease (AD) risk and plays a central role in regulating immune function. Here, we aimed to elucidate the mechanism by which...
www.biorxiv.org
November 4, 2025 at 10:11 PM
We're excited to share our new pre-print, where @gizemterzioglu.bsky.social et al. identify SHIP1, the protein encoded by the Alzheimer's disease risk gene INPP5D, as a regulator of endo-lysosome function and selective phagocytosis in human iPSC-derived microglia! www.biorxiv.org/content/10.1...
Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!
October 18, 2025 at 3:18 PM
Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
link.springer.com
October 15, 2025 at 2:08 PM
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications
Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...
link.springer.com
September 8, 2025 at 2:13 PM
New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Best of luck today to @alexlish.bsky.social on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!
August 25, 2025 at 9:41 PM
Best of luck today to @alexlish.bsky.social on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!
Honored to have our work featured!Huge thanks for highlighting our triculture Alzheimer’s model!
I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reconstructing Alzheimer’s disease one cell type at a time using in vitro tricultures
In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…
www.sciencedirect.com
July 31, 2025 at 11:49 AM
Honored to have our work featured!Huge thanks for highlighting our triculture Alzheimer’s model!
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
July 10, 2025 at 9:48 PM
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.
June 13, 2025 at 6:26 PM
Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.
🧠 New study led by our talented graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13. Check it out here in Brain: academic.oup.com/brain/articl...
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academic.oup.com
June 13, 2025 at 10:43 AM
🧠 New study led by our talented graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13. Check it out here in Brain: academic.oup.com/brain/articl...
Highlights from our lab at the @keystonesymposia.bsky.social Neurodegeneration meeting!
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
June 12, 2025 at 9:15 PM
Highlights from our lab at the @keystonesymposia.bsky.social Neurodegeneration meeting!
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes,
and neurons to investigate intercellular communication across different environmental
and genetic contexts. Transcr...
www.cell.com
June 5, 2025 at 12:49 AM
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Proud of our amazing postdoc @heuerwego.bsky.social 👏 who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!
June 4, 2025 at 10:03 PM
Proud of our amazing postdoc @heuerwego.bsky.social 👏 who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!
We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!
June 4, 2025 at 2:09 AM
We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!
Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! 🏆📖 We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! 🎉🍽️
June 3, 2025 at 12:29 AM
Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! 🏆📖 We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! 🎉🍽️
🎓Congratulations to our incredible grads! 🎉
Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂
We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish.bsky.social
Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂
We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish.bsky.social
May 31, 2025 at 3:45 PM
🎓Congratulations to our incredible grads! 🎉
Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂
We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish.bsky.social
Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂
We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish.bsky.social
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
GBM-Masterpreis - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
gbm-online.de
May 30, 2025 at 11:06 AM
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Reposted by Young-Pearse Lab
With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD.
Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.
Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.
May 21, 2025 at 6:12 PM
With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD.
Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.
Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.
Big shoutout to our lab at the annual ROSMAP meeting in Chicago!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
May 21, 2025 at 8:20 PM
Big shoutout to our lab at the annual ROSMAP meeting in Chicago!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
Excited to see our recent study featured on Alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read the full story here!
Alzheimer’s Risk Variants Leave Astrocytes CLUless | ALZFORUM
nam04.safelinks.protection.outlook.com
May 15, 2025 at 9:45 AM
Excited to see our recent study featured on Alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read the full story here!
A big day for the TYP lab! Master's student Emma successfully defended her incredible thesis work today where she's been working with @gizemterzioglu.bsky.social on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!
May 14, 2025 at 11:19 PM
A big day for the TYP lab! Master's student Emma successfully defended her incredible thesis work today where she's been working with @gizemterzioglu.bsky.social on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!
Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!
May 14, 2025 at 10:00 PM
Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!
Tracy gave a great presentation at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete! Huge thanks to Peter St. George-Hyslop, Li-Huei Tsai & Riqiang Yan for an incredible meeting. So many inspiring talks! #TargetAD25
May 10, 2025 at 7:55 PM
Tracy gave a great presentation at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete! Huge thanks to Peter St. George-Hyslop, Li-Huei Tsai & Riqiang Yan for an incredible meeting. So many inspiring talks! #TargetAD25
Reposted by Young-Pearse Lab
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
www.sciencedirect.com
April 30, 2025 at 3:51 PM
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response
to accumulated neuropathology, thereby dampening inflammatory signaling between microglia
and astrocytes. Using s...
www.cell.com
April 30, 2025 at 3:56 PM
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
April 11, 2025 at 11:50 PM
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!