Hamadoun Touré
@htoure.bsky.social
Postdoc @fredhutch.bsky.social
Neonatal immunity | Mucosal immunology | Host/Pathogen interactions
⚽️🏃🏾🥘📖
Neonatal immunity | Mucosal immunology | Host/Pathogen interactions
⚽️🏃🏾🥘📖
Reposted by Hamadoun Touré
Dr. Steven Henikoff receives the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research.
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
Brandeis University honors Fred Hutch molecular biologist
Dr. Steven Henikoff, a molecular biologist at Fred Hutch Cancer Center, has won the prestigious Rosenstiel Award for Distinguished Work in Basic Medical Research from Brandeis University recognizing h...
www.fredhutch.org
October 31, 2025 at 12:48 AM
Dr. Steven Henikoff receives the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research.
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
Reposted by Hamadoun Touré
Bizarre that our 2020 #Drosophila #AMP review already feels out of date.
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
October 24, 2025 at 12:05 PM
Bizarre that our 2020 #Drosophila #AMP review already feels out of date.
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
Reposted by Hamadoun Touré
Dr. Meghan Koch from @fredhutch.org has discovered a biological mechanism sprung in the first week of life that trains a mouse pup’s #ImmuneSystem to tolerate harmless gut bugs and new foods.
⚗️ Abstract: https://bit.ly/4nt6qGh
📰 Press release: https://bit.ly/46N7vBY
⚗️ Abstract: https://bit.ly/4nt6qGh
📰 Press release: https://bit.ly/46N7vBY
October 1, 2025 at 8:15 PM
Dr. Meghan Koch from @fredhutch.org has discovered a biological mechanism sprung in the first week of life that trains a mouse pup’s #ImmuneSystem to tolerate harmless gut bugs and new foods.
⚗️ Abstract: https://bit.ly/4nt6qGh
📰 Press release: https://bit.ly/46N7vBY
⚗️ Abstract: https://bit.ly/4nt6qGh
📰 Press release: https://bit.ly/46N7vBY
Reposted by Hamadoun Touré
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen,
highlighting the urgent need for novel therapies. A deeper under...
www.pnas.org
September 23, 2025 at 3:32 AM
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Reposted by Hamadoun Touré
Hello everyone! I am a postdoc in mucosal immunology and I am looking for new postdoc position in Europe! I know a lot about gut mast cells, but also CD4 T cells and type 2/3 immunity in general. I've worked with single cell sequencing and neuroimmune interactions. Feel free to share! Thank you! ♥️🥼👩🔬
September 24, 2025 at 8:07 PM
Hello everyone! I am a postdoc in mucosal immunology and I am looking for new postdoc position in Europe! I know a lot about gut mast cells, but also CD4 T cells and type 2/3 immunity in general. I've worked with single cell sequencing and neuroimmune interactions. Feel free to share! Thank you! ♥️🥼👩🔬
Reposted by Hamadoun Touré
Outstanding work outlined here demonstrating the importance of maternal breast milk antibodies for immune development from my @fredhutch.bsky.social colleague Meghan Koch.
Interaction between breast milk antibodies and gut microbes shape immune responses during weaning @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 15, 2025 at 3:20 AM
Outstanding work outlined here demonstrating the importance of maternal breast milk antibodies for immune development from my @fredhutch.bsky.social colleague Meghan Koch.
Reposted by Hamadoun Touré
Happy #Obliteride weekend! We had a blast kicking off year 13 of #fredhutch Obliteride tonight, an event that brings together a global community with one goal: fueling lifesaving cancer research!
See ya tomorrow at the start line, #Obliteriders! 🚴♀️🏃
See ya tomorrow at the start line, #Obliteriders! 🚴♀️🏃
August 9, 2025 at 3:46 AM
Happy #Obliteride weekend! We had a blast kicking off year 13 of #fredhutch Obliteride tonight, an event that brings together a global community with one goal: fueling lifesaving cancer research!
See ya tomorrow at the start line, #Obliteriders! 🚴♀️🏃
See ya tomorrow at the start line, #Obliteriders! 🚴♀️🏃
Reposted by Hamadoun Touré
ⓅⒶⓇⒶⒹⒾⒼⓂ ⓈⒽⒾⒻⓉ
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
www.cell.com
July 18, 2025 at 12:34 AM
ⓅⒶⓇⒶⒹⒾⒼⓂ ⓈⒽⒾⒻⓉ
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Reposted by Hamadoun Touré
The countdown is on ... 4 days left to submit your abstract and apply for student/post-doc member travel grants for #Cytokines2025. The deadline is Monday, June 30.
seattle.cytokinesociety.org
seattle.cytokinesociety.org
June 26, 2025 at 11:21 PM
The countdown is on ... 4 days left to submit your abstract and apply for student/post-doc member travel grants for #Cytokines2025. The deadline is Monday, June 30.
seattle.cytokinesociety.org
seattle.cytokinesociety.org
Reposted by Hamadoun Touré
New commentary co-authored w/ collaborators Liat Shenhav & Mike Silverman 🧪🤱🏻
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
June 13, 2025 at 12:41 AM
New commentary co-authored w/ collaborators Liat Shenhav & Mike Silverman 🧪🤱🏻
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
Reposted by Hamadoun Touré
Congrats, @immunojake.bsky.social & Erica Culberson DeshmukhLab @cincyresearch.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns
Stevens et al. reveal that antibiotic-induced microbiome disruption impairs infant
antiviral immunity by reducing inosine levels, which disturbs CD8+ T cell programming.
Remarkably, Bifidobacterium co...
www.cell.com
June 11, 2025 at 12:35 AM
Congrats, @immunojake.bsky.social & Erica Culberson DeshmukhLab @cincyresearch.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Reposted by Hamadoun Touré
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM
wwwfbm.unil.ch
June 10, 2025 at 1:53 PM
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
Reposted by Hamadoun Touré
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
June 5, 2025 at 2:28 PM
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Hamadoun Touré
We are happy to annouce that we have deposited at @VDRC
(ViennaDrosophila Resource Center) a list of isogenized @Drosophila immunity mutants affecting all major immune modules and effectors. We hope these strains will be useful to the community.
epfl.ch/labs/lemaitr...
(ViennaDrosophila Resource Center) a list of isogenized @Drosophila immunity mutants affecting all major immune modules and effectors. We hope these strains will be useful to the community.
epfl.ch/labs/lemaitr...
May 28, 2025 at 2:43 PM
We are happy to annouce that we have deposited at @VDRC
(ViennaDrosophila Resource Center) a list of isogenized @Drosophila immunity mutants affecting all major immune modules and effectors. We hope these strains will be useful to the community.
epfl.ch/labs/lemaitr...
(ViennaDrosophila Resource Center) a list of isogenized @Drosophila immunity mutants affecting all major immune modules and effectors. We hope these strains will be useful to the community.
epfl.ch/labs/lemaitr...
I am delighted share our latest paper from my PhD work.
Context: Cystic fibrosis (CF) is caused by mutations affecting CFTR functions, leading to increased activity of the epithelial sodium channel (ENaC). CF favors infections by Mycobacterium abscessus and some other specific microbes.
(1/3)
Context: Cystic fibrosis (CF) is caused by mutations affecting CFTR functions, leading to increased activity of the epithelial sodium channel (ENaC). CF favors infections by Mycobacterium abscessus and some other specific microbes.
(1/3)
Epithelial sodium channel ENaC hyperactivity impairs the ability of Drosophila to mount an efficient humoral immune response against M. abscessus in cystic fibrosis, and inhibition of ENaC was sufficient to rescue hyper-sensitivity to pathogens. www.nature.com/articles/s42...
@htoure.bsky.social
@htoure.bsky.social
April 28, 2025 at 6:54 PM
I am delighted share our latest paper from my PhD work.
Context: Cystic fibrosis (CF) is caused by mutations affecting CFTR functions, leading to increased activity of the epithelial sodium channel (ENaC). CF favors infections by Mycobacterium abscessus and some other specific microbes.
(1/3)
Context: Cystic fibrosis (CF) is caused by mutations affecting CFTR functions, leading to increased activity of the epithelial sodium channel (ENaC). CF favors infections by Mycobacterium abscessus and some other specific microbes.
(1/3)
Reposted by Hamadoun Touré
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
March 13, 2025 at 6:43 AM
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
Reposted by Hamadoun Touré
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
Reposted by Hamadoun Touré
My weekend with immunologists devising new strategies to treat cancer, allergy, Alzheimer’s, autoimmunity and infection. The WH has just paused peer-reviewed NIH funding that pays for these studies. If you care about human life, write your representatives. Demand that NIH funding is restored asap.
January 28, 2025 at 5:27 AM
My weekend with immunologists devising new strategies to treat cancer, allergy, Alzheimer’s, autoimmunity and infection. The WH has just paused peer-reviewed NIH funding that pays for these studies. If you care about human life, write your representatives. Demand that NIH funding is restored asap.
Reposted by Hamadoun Touré
🎉Thrilled to announce the 10th anniversary of the
@ipbstoulouse.bsky.social Student Symposium in Toulouse, Nov. 4-5! Honored to welcome stellar keynote speakers Y. Belkaid, @mblokesch.bsky.social, F. Mechta-Grigoriou, and B. Küster - A celebration of science & discovery!
www.ipbs.fr/agenda/event...
@ipbstoulouse.bsky.social Student Symposium in Toulouse, Nov. 4-5! Honored to welcome stellar keynote speakers Y. Belkaid, @mblokesch.bsky.social, F. Mechta-Grigoriou, and B. Küster - A celebration of science & discovery!
www.ipbs.fr/agenda/event...
January 13, 2025 at 4:51 PM
🎉Thrilled to announce the 10th anniversary of the
@ipbstoulouse.bsky.social Student Symposium in Toulouse, Nov. 4-5! Honored to welcome stellar keynote speakers Y. Belkaid, @mblokesch.bsky.social, F. Mechta-Grigoriou, and B. Küster - A celebration of science & discovery!
www.ipbs.fr/agenda/event...
@ipbstoulouse.bsky.social Student Symposium in Toulouse, Nov. 4-5! Honored to welcome stellar keynote speakers Y. Belkaid, @mblokesch.bsky.social, F. Mechta-Grigoriou, and B. Küster - A celebration of science & discovery!
www.ipbs.fr/agenda/event...
Reposted by Hamadoun Touré
Gives me great pleasure to share with the world the labs latest paper, reviewing the nascent but growing area of endogenous thymic regeneration. Great to work with the marvelous trainees David and Dante on this. www.nature.com/articles/s41...
Endogenous thymic regeneration: restoring T cell production following injury - Nature Reviews Immunology
This Review discusses recent advances in our understanding of the biology of endogenous tissue regeneration in the thymus, highlighting the clinical implications of poor thymic recovery.
www.nature.com
January 6, 2025 at 6:02 PM
Gives me great pleasure to share with the world the labs latest paper, reviewing the nascent but growing area of endogenous thymic regeneration. Great to work with the marvelous trainees David and Dante on this. www.nature.com/articles/s41...
I am happy to share our latest story on the pathogenesis of #Mycobacterium abscessus infections.
We show that the infected #Drosophila professional phagocytes, through production of the cytokines Upd2 and 3, remotely activate the JAK/STAT pathway in the intestinal stem cells.
👇
We show that the infected #Drosophila professional phagocytes, through production of the cytokines Upd2 and 3, remotely activate the JAK/STAT pathway in the intestinal stem cells.
👇
December 28, 2024 at 2:40 AM
I am happy to share our latest story on the pathogenesis of #Mycobacterium abscessus infections.
We show that the infected #Drosophila professional phagocytes, through production of the cytokines Upd2 and 3, remotely activate the JAK/STAT pathway in the intestinal stem cells.
👇
We show that the infected #Drosophila professional phagocytes, through production of the cytokines Upd2 and 3, remotely activate the JAK/STAT pathway in the intestinal stem cells.
👇
Reposted by Hamadoun Touré
Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH | mBio
Despite the availability of antibiotic treatment, M. tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major infectious disease
killer worldwide. A better understanding of the en...
journals.asm.org
December 3, 2024 at 3:00 PM
Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Hamadoun Touré
Exciting times! Our latest preprint is now live 🤩!
After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n
www.biorxiv.org/content/10.1...
After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n
www.biorxiv.org/content/10.1...
Diverse phage defence systems define West African South American pandemic Vibrio cholerae
Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. Interestingly, two unique genetic signatures define the West ...
www.biorxiv.org
November 25, 2024 at 2:27 PM
Exciting times! Our latest preprint is now live 🤩!
After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n
www.biorxiv.org/content/10.1...
After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n
www.biorxiv.org/content/10.1...
Reposted by Hamadoun Touré
go.bsky.app/7zMmwNY
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍
November 20, 2024 at 9:51 AM
go.bsky.app/7zMmwNY
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍