Congrats Wendy, Olivier & Team! 👏🏿👏🏿

- ENaC hyperactivity per se impacts flies ability to produce a vitamin D-related hormone, and consequently to produce protective AMPs.

I know Drosophila doesn’t have lungs 🫁 😉 to fully model CF pulmonary infections … but here we provide the mechanistic consequences of ENaC hyperactivity.

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Take homes:

-CFTR-deficient flies and ENaC-overexpressing flies are both highly susceptible to infection by CF-related pathogens

- ENaC blockade in CFTR-deficient flies is sufficient to rescue their survival, suggesting that ENaC hyperactivity drives at least partially susceptibility.

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Thanks Marion!

Thank you @marionbrunck.bsky.social !