Reposted
At the end of the day, if you're constantly on the pointy end of the breakdown of society, you're going to get kind of effed up. This is one reason that pretty much every large municipality needs drastically more cops.
One of the reasons police officers are the way they are is we expect them to deal with the absolute worst of humanity day in and day out. We have to be rotating these people more.
this is a through-line on a number of jobs that we ask mostly-men to do: they are catastrophically bad for mental health, and we know this, and we do not make sufficient provision for care for it.
not gonna be a popular take but “cop” is one of those jobs
not gonna be a popular take but “cop” is one of those jobs
December 1, 2025 at 7:21 PM
At the end of the day, if you're constantly on the pointy end of the breakdown of society, you're going to get kind of effed up. This is one reason that pretty much every large municipality needs drastically more cops.
Reposted
The 1-2 punch of "gangs provide identity and create financial, social *and emotional* support where it is otherwise absent" and "cops are indistinguishable from gangs" does lead to some in-hindsight obvious conclusions about secondary, unspoken motivations cops have for closing ranks when questioned
December 1, 2025 at 5:39 PM
The 1-2 punch of "gangs provide identity and create financial, social *and emotional* support where it is otherwise absent" and "cops are indistinguishable from gangs" does lead to some in-hindsight obvious conclusions about secondary, unspoken motivations cops have for closing ranks when questioned
Reposted
like. fundamentally, at deep deep bedrock, rationalism as it currently exists is path-dependent on *not* asking questions about who is paying for what, who is manipulating you, and whose power you are contributing to
August 22, 2025 at 4:59 PM
like. fundamentally, at deep deep bedrock, rationalism as it currently exists is path-dependent on *not* asking questions about who is paying for what, who is manipulating you, and whose power you are contributing to
kinda worried that freddie deboer might be having a manic episode rn, he's being unusually aggressive on substack
i guess he probably has a better support system now but he also has a new baby...concerning
i guess he probably has a better support system now but he also has a new baby...concerning
July 29, 2025 at 8:12 PM
kinda worried that freddie deboer might be having a manic episode rn, he's being unusually aggressive on substack
i guess he probably has a better support system now but he also has a new baby...concerning
i guess he probably has a better support system now but he also has a new baby...concerning
Reposted
Mainline Protestantism has a tons and tons of churches that won't chase you out for who you are and they, we, are *dying* by the numbers. So I think the larger problem is not pushing people out, but our ability to draw people in in the first place.
June 23, 2025 at 4:16 PM
Mainline Protestantism has a tons and tons of churches that won't chase you out for who you are and they, we, are *dying* by the numbers. So I think the larger problem is not pushing people out, but our ability to draw people in in the first place.
Reposted
We shouldn't make people feel unwelcome unnecessarily. Christianity is, among other things, a project of universal fraternity*. But we can't operate just on selecting *against* things. We have to believe in something. We might as well start with God.
June 23, 2025 at 4:28 PM
We shouldn't make people feel unwelcome unnecessarily. Christianity is, among other things, a project of universal fraternity*. But we can't operate just on selecting *against* things. We have to believe in something. We might as well start with God.
Reposted
Church is expensive. It takes time, money, and emotional energy. It's not enough for churches to just not abuse people, we need to provide value. Meaningful work, not just a flavor of charity to give to. Meaningful connection, not just "a community". Make Big Asks. Worship the living God.
June 23, 2025 at 4:22 PM
Church is expensive. It takes time, money, and emotional energy. It's not enough for churches to just not abuse people, we need to provide value. Meaningful work, not just a flavor of charity to give to. Meaningful connection, not just "a community". Make Big Asks. Worship the living God.
Reposted
want to see a super weird hallucination? i fed it a somewhat oblique SCP to see if it could pick the actual story out of a collection of documents -- basically, an early "reader test" for a genre which can fail if readers can't read between the lines -- and it started producing nonsense science.
May 23, 2025 at 8:38 PM
want to see a super weird hallucination? i fed it a somewhat oblique SCP to see if it could pick the actual story out of a collection of documents -- basically, an early "reader test" for a genre which can fail if readers can't read between the lines -- and it started producing nonsense science.
Reposted
Combine this video tech with the “grandma they arrested me in Tijuana” scam and every Nana’s bank account nationwide will be empty within a month
May 21, 2025 at 12:28 AM
Combine this video tech with the “grandma they arrested me in Tijuana” scam and every Nana’s bank account nationwide will be empty within a month
Reposted
Apparently the root cause of this article is that the judge in one of the antitrust lawsuits thought these numbers were small instead of big. (They're big.)
May 12, 2025 at 1:05 AM
Apparently the root cause of this article is that the judge in one of the antitrust lawsuits thought these numbers were small instead of big. (They're big.)
Reposted
This isn't true. I'm the person who ran the experiments this is BSing about. When search results are worse, people attempt fewer tasks. When they're better they attempt more.
May 12, 2025 at 1:05 AM
This isn't true. I'm the person who ran the experiments this is BSing about. When search results are worse, people attempt fewer tasks. When they're better they attempt more.
Reposted
It's a cyanobacteria on the outside, fungus on the inside.
Well, sort of. The fungus lives in the extracellular sheath produced by the Cyanobacteria, and therefore are not really true endophytes. But the cyanos do create the external structure.
Well, sort of. The fungus lives in the extracellular sheath produced by the Cyanobacteria, and therefore are not really true endophytes. But the cyanos do create the external structure.
February 15, 2025 at 6:29 PM
It's a cyanobacteria on the outside, fungus on the inside.
Well, sort of. The fungus lives in the extracellular sheath produced by the Cyanobacteria, and therefore are not really true endophytes. But the cyanos do create the external structure.
Well, sort of. The fungus lives in the extracellular sheath produced by the Cyanobacteria, and therefore are not really true endophytes. But the cyanos do create the external structure.
Reposted
It is such an intuitive way of approaching the problem, that anyone who believes in 'individual level selection' on animals, plants, or unicellular eukaryotes absolutely believes in group selection, as these individuals are, in fact, groups.
February 6, 2025 at 2:56 PM
It is such an intuitive way of approaching the problem, that anyone who believes in 'individual level selection' on animals, plants, or unicellular eukaryotes absolutely believes in group selection, as these individuals are, in fact, groups.
Reposted
eRA commons access via login dot gov is down again. Different error page this time.
February 3, 2025 at 7:58 PM
eRA commons access via login dot gov is down again. Different error page this time.
Reposted
"You know the neopolitan mathematician Borelli used bioanchors to examine with great niceity the proposition of heavier than air flight, but was totally wrong?"
January 29, 2025 at 3:34 PM
"You know the neopolitan mathematician Borelli used bioanchors to examine with great niceity the proposition of heavier than air flight, but was totally wrong?"
need to read, but if it holds up i think this is the first direct evidence that capsid formation is important for an Arc-mediated phenotype
1/ I cannot think of a better first post in the fresh blue sky to introduce the Caron lab than a thread about 👾Arc👾 and our newest preprint. So, buckle up science butterflies!🦋🧞♂️ #neuroscience #Drosophila #ArcGenes #WomenInSTEM
a bunch of butterflies flying in a blue sky with the words sci-universe below them
ALT: a bunch of butterflies flying in a blue sky with the words sci-universe below them
media.tenor.com
November 11, 2024 at 4:22 AM
need to read, but if it holds up i think this is the first direct evidence that capsid formation is important for an Arc-mediated phenotype
Reposted
Doing good science is 90% finding a science buddy to constantly talk to about the project.
November 9, 2024 at 10:53 PM
Doing good science is 90% finding a science buddy to constantly talk to about the project.
Reposted
IMO the best near-term application for recent de novo protein design methods is to replace antibodies as experimental reagents. mAbs & pAbs are a pain to work with & are prone to reproducibility problems. Yet for some reason we only hear de novo designed proteins discussed as potential therapeutics
'In an analysis published in eLife last year, the YCharOS team used this method to assess 614 commercial antibodies, targeting a total of 65 neuroscience-related proteins2. Two-thirds of them did not work as recommended by manufacturers.'
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com
November 10, 2024 at 11:28 AM
IMO the best near-term application for recent de novo protein design methods is to replace antibodies as experimental reagents. mAbs & pAbs are a pain to work with & are prone to reproducibility problems. Yet for some reason we only hear de novo designed proteins discussed as potential therapeutics
what's the smallest possible endogenously fluorescent peptide possible, I wonder?
November 8, 2024 at 10:44 PM
what's the smallest possible endogenously fluorescent peptide possible, I wonder?
in retrospect it makes sense that high inflation would have worse consequences for the incumbent than high unemployment
high inflation affects everyone, high unemployment is mostly salient to the unemployed, which is...not everyone
high inflation affects everyone, high unemployment is mostly salient to the unemployed, which is...not everyone
November 8, 2024 at 6:53 PM
in retrospect it makes sense that high inflation would have worse consequences for the incumbent than high unemployment
high inflation affects everyone, high unemployment is mostly salient to the unemployed, which is...not everyone
high inflation affects everyone, high unemployment is mostly salient to the unemployed, which is...not everyone
lmao apparently you cant put ebola sequences into af3
November 7, 2024 at 7:41 PM
lmao apparently you cant put ebola sequences into af3
if we have trees cilia could they grow taller
November 5, 2024 at 3:15 PM
if we have trees cilia could they grow taller
ok but tucker's kinda right about nukes ngl
November 4, 2024 at 8:46 PM
ok but tucker's kinda right about nukes ngl