Garvin SUMO Biology Lab
@garvinlab.bsky.social
Research Lab in the School of Molecular and Cellular Biology, University of Leeds. Focusing on all things weird and wonderful concerning SUMOylation.
Reposted by Garvin SUMO Biology Lab
Join us in a highly collaborative environment. At the IMP everything is possible.
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 11, 2025 at 9:56 AM
Join us in a highly collaborative environment. At the IMP everything is possible.
Reposted by Garvin SUMO Biology Lab
Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects.
If you’re at the conference, come say hi before it wraps up!! 👋
If you’re at the conference, come say hi before it wraps up!! 👋
November 11, 2025 at 11:13 AM
Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects.
If you’re at the conference, come say hi before it wraps up!! 👋
If you’re at the conference, come say hi before it wraps up!! 👋
Reposted by Garvin SUMO Biology Lab
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 12, 2025 at 3:55 AM
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
Reposted by Garvin SUMO Biology Lab
We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!
Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds on FindAPhD.com
PhD Project - Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 10, 2025 at 10:11 AM
We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!
Reposted by Garvin SUMO Biology Lab
Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD!
Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!
Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!
ICYMI: New Online! Decoding ubiquitin signals inside cells
Decoding ubiquitin signals inside cells
Nature Reviews Molecular Cell Biology, Published online: 31 October 2025; doi:10.1038/s41580-025-00919-zIn this Tools of the Trade article, Kiss (Schulman lab) discusses the development of UbiREAD, a method that delivers in vitro-ubiquitinated protein reporters into cells to systematically assess how different ubiquitin chain configurations affect protein stability and degradation.
bit.ly
November 4, 2025 at 10:04 AM
Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD!
Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!
Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!
Reposted by Garvin SUMO Biology Lab
If you are working on Genome stability and repair pathways and you're looking for a tenure track professorship, check out this opportunity at The Max Perutz Labs at the University of Vienna: jobs.zeit.de/jobs/tenure-...
Tenure-Track Professorship in Genome Biology - Universität Wien
Universität Wien bietet Stelle als Tenure-Track Professorship in Genome Biology in Wien - jetzt bewerben!
jobs.zeit.de
October 30, 2025 at 2:18 PM
If you are working on Genome stability and repair pathways and you're looking for a tenure track professorship, check out this opportunity at The Max Perutz Labs at the University of Vienna: jobs.zeit.de/jobs/tenure-...
Reposted by Garvin SUMO Biology Lab
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Reposted by Garvin SUMO Biology Lab
Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.
September 11, 2025 at 4:34 PM
Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.
Reposted by Garvin SUMO Biology Lab
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Reposted by Garvin SUMO Biology Lab
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 7, 2025 at 8:51 AM
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Reposted by Garvin SUMO Biology Lab
3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries
lnkd.in/etU3yydb
lnkd.in/etU3yydb
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
October 7, 2025 at 8:52 AM
3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries
lnkd.in/etU3yydb
lnkd.in/etU3yydb
Reposted by Garvin SUMO Biology Lab
Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊
Histone Recycling Promotes PARP Inhibitor Resistance
Major Finding: PARP inhibition induces eviction of histones, and the chaperone NASP is required to recycle these histones to prevent DNA damage and promote resistance. Concept: Histone recycling repre...
aacrjournals.org
September 15, 2025 at 8:15 AM
Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊
Reposted by Garvin SUMO Biology Lab
Xingzhi Xu, Shunichi Takeda and collaborators show that UFL1-dependent #UFMylation of MCM5 promotes CMG replicative helicase formation and replication fork progression
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
September 15, 2025 at 8:54 AM
Xingzhi Xu, Shunichi Takeda and collaborators show that UFL1-dependent #UFMylation of MCM5 promotes CMG replicative helicase formation and replication fork progression
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Garvin SUMO Biology Lab
🔬 What are plasmodesmata, and why are they important?
In this new case study, discover how the Faculty's Professor Yoselin Benitez-Alfonso's research into microscopic plant pores could help tackle climate change and global food insecurity.
bit.ly/4pocNvX
@researchleeds.bsky.social
In this new case study, discover how the Faculty's Professor Yoselin Benitez-Alfonso's research into microscopic plant pores could help tackle climate change and global food insecurity.
bit.ly/4pocNvX
@researchleeds.bsky.social
September 15, 2025 at 9:14 AM
🔬 What are plasmodesmata, and why are they important?
In this new case study, discover how the Faculty's Professor Yoselin Benitez-Alfonso's research into microscopic plant pores could help tackle climate change and global food insecurity.
bit.ly/4pocNvX
@researchleeds.bsky.social
In this new case study, discover how the Faculty's Professor Yoselin Benitez-Alfonso's research into microscopic plant pores could help tackle climate change and global food insecurity.
bit.ly/4pocNvX
@researchleeds.bsky.social
Reposted by Garvin SUMO Biology Lab
Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
September 16, 2025 at 5:32 AM
Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.
Reposted by Garvin SUMO Biology Lab
Looking forward to another great day at Ribosome biogenesis meeting @embo.org Great conversations yesterday and lively to catch up with colleagues!
September 10, 2025 at 7:59 AM
Looking forward to another great day at Ribosome biogenesis meeting @embo.org Great conversations yesterday and lively to catch up with colleagues!
Reposted by Garvin SUMO Biology Lab
We’re happy to share that our labs first #ALS and #FTD study “A stress-dependent TDP-43 SUMOylation program preserves neuronal function” is now online at Molecular Neurodegeneration! doi.org/10.1186/s130...
A stress-dependent TDP-43 SUMOylation program preserves neuronal function - Molecular Neurodegeneration
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exo...
doi.org
March 28, 2025 at 2:53 PM
We’re happy to share that our labs first #ALS and #FTD study “A stress-dependent TDP-43 SUMOylation program preserves neuronal function” is now online at Molecular Neurodegeneration! doi.org/10.1186/s130...
Reposted by Garvin SUMO Biology Lab
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
Reposted by Garvin SUMO Biology Lab
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...
rdcu.be
September 2, 2025 at 11:55 AM
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Reposted by Garvin SUMO Biology Lab
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Pharmacologic interrogation of USP28 cellular function in p53 signaling
Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28
probe, alongside a control compound and an inhibitor-resistant mutant. They show that
USP28 inhibition mimics p53 path...
www.cell.com
September 2, 2025 at 5:04 PM
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Reposted by Garvin SUMO Biology Lab
What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
August 26, 2025 at 12:49 PM
What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
Reposted by Garvin SUMO Biology Lab
Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!
What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
September 2, 2025 at 2:00 PM
Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!
Reposted by Garvin SUMO Biology Lab
We are happy to have contributed a protocol to a book on SUMO methods (work mainly by postdoc El Hadji Cisse and engineer Stéphane Goffinont): link.springer.com/protocol/10....
Production and Purification of SUMO-UBC9 and SUMO-RANGAP1CTD
SUMOylation is a post-translational modification catalyzed by a multi-step enzymatic cascade. To gain structural biology insights into the last step of this process, where SUMO is transferred from a S...
link.springer.com
September 1, 2025 at 11:53 AM
We are happy to have contributed a protocol to a book on SUMO methods (work mainly by postdoc El Hadji Cisse and engineer Stéphane Goffinont): link.springer.com/protocol/10....
Reposted by Garvin SUMO Biology Lab
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
August 28, 2025 at 5:35 PM
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Reposted by Garvin SUMO Biology Lab
Opening a "Decision on your Manuscript" email
August 29, 2025 at 8:22 AM
Opening a "Decision on your Manuscript" email