Garvin SUMO Biology Lab
@garvinlab.bsky.social
Research Lab in the School of Molecular and Cellular Biology, University of Leeds. Focusing on all things weird and wonderful concerning SUMOylation.
Reposted by Garvin SUMO Biology Lab
The Royal Society's Newton International Fellowships are now open for applications, aimed at non-UK early career scientists who wish to conduct research in the UK. Find out more and apply by 11 March: #RSGrants https://royalsociety.org/grants/newton-international/
January 15, 2026 at 3:56 PM
The Royal Society's Newton International Fellowships are now open for applications, aimed at non-UK early career scientists who wish to conduct research in the UK. Find out more and apply by 11 March: #RSGrants https://royalsociety.org/grants/newton-international/
Reposted by Garvin SUMO Biology Lab
The final version of our article on XPF-ERCC1-SLX4 complexes has now been published (the link below still works). I am happy to report that the rendering of our DNA gels has now been corrected. 😉
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 15, 2026 at 11:48 AM
The final version of our article on XPF-ERCC1-SLX4 complexes has now been published (the link below still works). I am happy to report that the rendering of our DNA gels has now been corrected. 😉
Reposted by Garvin SUMO Biology Lab
Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳
January 14, 2026 at 8:43 PM
Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳
Reposted by Garvin SUMO Biology Lab
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
January 15, 2026 at 7:45 AM
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
Reposted by Garvin SUMO Biology Lab
Check out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...
2026 DNA Damage, Mutation and Cancer Conference GRC
The 2026 Gordon Research Conference on DNA Damage, Mutation and Cancer will be held in Ventura, California. Apply today to reserve your spot.
www.grc.org
January 15, 2026 at 12:08 AM
Check out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...
Reposted by Garvin SUMO Biology Lab
Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Client Challenge
link.springer.com
January 9, 2026 at 1:06 PM
Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Garvin SUMO Biology Lab
New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
IFI16 senses and protects stalled replication forks
Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…
www.sciencedirect.com
January 8, 2026 at 4:07 PM
New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Garvin SUMO Biology Lab
Congratulations to the 2025 Policy Impact and Public Engagement Awards winners! 🎉
Meet them at www.nottingham.ac.uk/policyengage... #WeAreUoN
Meet them at www.nottingham.ac.uk/policyengage... #WeAreUoN
The 2025 Policy Impact and Public Engagement Awards winners
The Institute is proud to announce the winners of this year
www.nottingham.ac.uk
April 29, 2025 at 12:53 PM
Congratulations to the 2025 Policy Impact and Public Engagement Awards winners! 🎉
Meet them at www.nottingham.ac.uk/policyengage... #WeAreUoN
Meet them at www.nottingham.ac.uk/policyengage... #WeAreUoN
Reposted by Garvin SUMO Biology Lab
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic
academic.oup.com
July 10, 2025 at 2:55 PM
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
Reposted by Garvin SUMO Biology Lab
Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 18, 2025 at 3:04 PM
Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Garvin SUMO Biology Lab
Deadline to apply for MRC fully funded 4-year PhD studentships is approaching on *9 Jan 2026*!
Join world-class researchers across
@unibirmingham.bsky.social ,
@uniofleicester.bsky.social and @uniofnottingham.bsky.social
👉See more.bham.ac.uk/mrc-aim/phd-...
Join world-class researchers across
@unibirmingham.bsky.social ,
@uniofleicester.bsky.social and @uniofnottingham.bsky.social
👉See more.bham.ac.uk/mrc-aim/phd-...
a cartoon drawing of a clock with a face and arms and legs
Alt: a cartoon drawing of a clock with a face and arms and legs
media.tenor.com
December 18, 2025 at 2:19 PM
Deadline to apply for MRC fully funded 4-year PhD studentships is approaching on *9 Jan 2026*!
Join world-class researchers across
@unibirmingham.bsky.social ,
@uniofleicester.bsky.social and @uniofnottingham.bsky.social
👉See more.bham.ac.uk/mrc-aim/phd-...
Join world-class researchers across
@unibirmingham.bsky.social ,
@uniofleicester.bsky.social and @uniofnottingham.bsky.social
👉See more.bham.ac.uk/mrc-aim/phd-...
Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...
DNA double strand break repair: a model of specificity and complexity in SUMO signalling
Among the ubiquitin-like superfamily, small ubiquitin-like modifiers (SUMOs) are the most well-understood. However, in comparison with the prototypical small modifier ubiquitin, our understanding of t...
portlandpress.com
December 17, 2025 at 9:10 AM
Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...
Reposted by Garvin SUMO Biology Lab
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com
PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
December 15, 2025 at 12:15 PM
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Reposted by Garvin SUMO Biology Lab
Leeds researchers have secured two major Wellcome Trust Discovery Awards.
The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease.
🔗Full story: bit.ly/4oW3D99
@astburycentre.bsky.social @universityofleeds.bsky.social
The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease.
🔗Full story: bit.ly/4oW3D99
@astburycentre.bsky.social @universityofleeds.bsky.social
Two more Wellcome Discovery Awards reinforce Leeds as leader in biological research
Some of Leeds’ top biological researchers have received two new Wellcome Discovery Awards, confirming the university’s status as a centre of excellence in biological research.
bit.ly
November 6, 2025 at 2:44 PM
Leeds researchers have secured two major Wellcome Trust Discovery Awards.
The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease.
🔗Full story: bit.ly/4oW3D99
@astburycentre.bsky.social @universityofleeds.bsky.social
The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease.
🔗Full story: bit.ly/4oW3D99
@astburycentre.bsky.social @universityofleeds.bsky.social
Reposted by Garvin SUMO Biology Lab
Our review article on recent RNase H2 in replciation stress and cancer has been published in @jcellsci.bsky.social! Thank you for the invitation Journal of Cell Science @jcellsci.bsky.social and Company of Biologists @biologists.bsky.social.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer
Summary: Control of RNA:DNA hybrids by RNase H2 helps protect genome stability. Recent insights into RNase H2 molecular functions and alterations in cancer shed new light on mechanisms of human diseas...
journals.biologists.com
December 10, 2025 at 10:57 AM
Our review article on recent RNase H2 in replciation stress and cancer has been published in @jcellsci.bsky.social! Thank you for the invitation Journal of Cell Science @jcellsci.bsky.social and Company of Biologists @biologists.bsky.social.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Garvin SUMO Biology Lab
Our @costerlab.bsky.social review is out!
It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!
www.sciencedirect.com/science/arti...
@adityasethi.bsky.social @billiedelpino.bsky.social
It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!
www.sciencedirect.com/science/arti...
@adityasethi.bsky.social @billiedelpino.bsky.social
How DNA secondary structures drive replication fork instability
DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…
www.sciencedirect.com
December 10, 2025 at 11:53 AM
Our @costerlab.bsky.social review is out!
It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!
www.sciencedirect.com/science/arti...
@adityasethi.bsky.social @billiedelpino.bsky.social
It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!
www.sciencedirect.com/science/arti...
@adityasethi.bsky.social @billiedelpino.bsky.social
Reposted by Garvin SUMO Biology Lab
🎉 Congrats to the faculty's Dr Jonathan Machin who has been awarded the British Biophysical Society's 2026 Kendrew Doctoral Thesis Prize, for his outstanding research on outer membrane proteins.
Read more here: britishbiophysics.org/awards/
Read more here: britishbiophysics.org/awards/
BBS Awards
BBS Awards The BBS Kendrew Doctoral Thesis Prize was established in 2019 and will be awarded every two years for an outstanding PhD thesis in biophysics for which the principal work has been carried o...
britishbiophysics.org
December 10, 2025 at 3:17 PM
🎉 Congrats to the faculty's Dr Jonathan Machin who has been awarded the British Biophysical Society's 2026 Kendrew Doctoral Thesis Prize, for his outstanding research on outer membrane proteins.
Read more here: britishbiophysics.org/awards/
Read more here: britishbiophysics.org/awards/
Reposted by Garvin SUMO Biology Lab
🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications
Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...
www.nature.com
December 10, 2025 at 12:11 PM
🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
Reposted by Garvin SUMO Biology Lab
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...
rdcu.be
December 9, 2025 at 1:21 PM
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
Reposted by Garvin SUMO Biology Lab
You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation???
Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!
Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!
Thanks @kfeijszaja.bsky.social and team for the excellent Spotlight on our collaborative work with @jnpruneda.bsky.social: Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells: Trends in Biochemical Sciences www.cell.com/trends/bioch...
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells
Ubiquitination and ADP-ribosylation are protein post-translational modifications (PTMs)
which influence diverse protein properties. In vitro work has indicated that ubiquitin
can be ADP-ribosylated an...
www.cell.com
April 25, 2025 at 8:16 AM
You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation???
Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!
Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!
Reposted by Garvin SUMO Biology Lab
New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)
For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...
DUCs are C2 domain containing plant-specific deubiquitinases stabilizing endocytic cargo at the plasma membrane
Deubiquitinases (DUBs) remove ubiquitin modifications from proteins in a substrate- or linkage-selective manner and regulate numerous cell-biological processes, including endocytosis. By performing ho...
www.biorxiv.org
December 8, 2025 at 12:49 PM
New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)
Reposted by Garvin SUMO Biology Lab
The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.
Non-covalent SUMO interactions with ligases and effectors: SUMO-interacting motifs and beyond
SUMOylation, a protein post-translational modification (PTM) involving the covalent attachment of small ubiquitin-like modifier (SUMO), regulates a wide range of cellular processes. The key hallmark o...
portlandpress.com
November 24, 2025 at 9:06 PM
The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.
Reposted by Garvin SUMO Biology Lab
📢 Last days to apply! 📢
Fully funded PhD position, starting Oct 2026.
Deadline Nov 16th.
We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.
Project details: tinyurl.com/CosterPhD
Apply: tinyurl.com/ApplyICR
The lab: CosterLab.com
Fully funded PhD position, starting Oct 2026.
Deadline Nov 16th.
We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.
Project details: tinyurl.com/CosterPhD
Apply: tinyurl.com/ApplyICR
The lab: CosterLab.com
Typos in the genome: Defining the molecular mechanism of replication slippage
Typos in the genome: Defining the molecular mechanism of replication slippage
tinyurl.com
November 14, 2025 at 1:04 PM
📢 Last days to apply! 📢
Fully funded PhD position, starting Oct 2026.
Deadline Nov 16th.
We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.
Project details: tinyurl.com/CosterPhD
Apply: tinyurl.com/ApplyICR
The lab: CosterLab.com
Fully funded PhD position, starting Oct 2026.
Deadline Nov 16th.
We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.
Project details: tinyurl.com/CosterPhD
Apply: tinyurl.com/ApplyICR
The lab: CosterLab.com
Reposted by Garvin SUMO Biology Lab
Join us in a highly collaborative environment. At the IMP everything is possible.
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 11, 2025 at 9:56 AM
Join us in a highly collaborative environment. At the IMP everything is possible.
Reposted by Garvin SUMO Biology Lab
Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects.
If you’re at the conference, come say hi before it wraps up!! 👋
If you’re at the conference, come say hi before it wraps up!! 👋
November 11, 2025 at 11:13 AM
Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects.
If you’re at the conference, come say hi before it wraps up!! 👋
If you’re at the conference, come say hi before it wraps up!! 👋