Antoni Wrobel
@agwrobel.bsky.social
Structural biologist and group leader at the Oxford Biochemistry Department. Interested in principles and molecular mechanisms underlying viral evolution and host changes.
Reposted by Antoni Wrobel
Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology
Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.
www.nature.com
September 26, 2025 at 3:29 PM
Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great stuff!
Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for
>4,400 viruses, allowing mapping of form and function across the human and animal
virosphere. Viro3D i...
doi.org
September 26, 2025 at 8:19 PM
Great stuff!
Reposted by Antoni Wrobel
Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
September 16, 2025 at 5:32 AM
Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
September 8, 2025 at 3:16 PM
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Reposted by Antoni Wrobel
Running Phenix and stuck?
Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program.
Big thanks to Tom Willinger for making this happen!
Try it out: phenix-online.org/version_docs...
Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program.
Big thanks to Tom Willinger for making this happen!
Try it out: phenix-online.org/version_docs...
June 23, 2025 at 5:15 AM
Running Phenix and stuck?
Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program.
Big thanks to Tom Willinger for making this happen!
Try it out: phenix-online.org/version_docs...
Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program.
Big thanks to Tom Willinger for making this happen!
Try it out: phenix-online.org/version_docs...
Reposted by Antoni Wrobel
Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...
RePOWER: Returning to Postgraduate Study in the Life and Environmental Sciences
iles.web.ox.ac.uk
May 19, 2025 at 1:55 PM
Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...
Reposted by Antoni Wrobel
Congratulations! @jansenlab.bsky.social
@oxfordbiochemistry.bsky.social
www.nature.com/articles/s41...
@oxfordbiochemistry.bsky.social
www.nature.com/articles/s41...
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling - Nature Structural & Molecular Biology
Mikulski et al. identify a distinct chromatin structure at clustered GBP innate immune genes that preserves a mitotically heritable memory of prior priming by interferon-γ.
www.nature.com
May 7, 2025 at 9:45 AM
We are currently seeking an ambitious, motivated, and hard-working scientist to join my lab (wrobel-lab.org) at the Department of Biochemistry of the University of Oxford as a Postdoctoral Research Associate. If interested, please go here directly: tinyurl.com/postdoc-wrob... or read more below.
Wrobel lab | Explore Mechanisms of Viral Infection studied at Oxford Biochemistry Department
Discover our research on viral evolution and host interactions. Join our team and stay updated with the latest lab news and publications.
wrobel-lab.org
May 6, 2025 at 2:57 PM
We are currently seeking an ambitious, motivated, and hard-working scientist to join my lab (wrobel-lab.org) at the Department of Biochemistry of the University of Oxford as a Postdoctoral Research Associate. If interested, please go here directly: tinyurl.com/postdoc-wrob... or read more below.
Congrats @msuskiewicz.bsky.social and @mvstaller.bsky.social ! And thanks for all your work and inviting me to contribute - looking very much forward to working together!
I'm happy (if somewhat uneasy, given the times are uncertain for many) to have been selected for an @hfspo.bsky.social HFSP Research Grant Early Career, with great partners: @mvstaller.bsky.social & @agwrobel.bsky.social . We will study filament formation by transcription factors.
April 1, 2025 at 1:16 PM
Congrats @msuskiewicz.bsky.social and @mvstaller.bsky.social ! And thanks for all your work and inviting me to contribute - looking very much forward to working together!
Reposted by Antoni Wrobel
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 10:37 PM
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
An amazing new fully-funded DPhil/PhD opportunity at Oxford and beyond: with great learning opportunities and a lot of supervisors from various disciplines (including myself). Please apply and share with those potentially interested!
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
How to Apply and Funding
iles.web.ox.ac.uk
January 17, 2025 at 12:35 AM
An amazing new fully-funded DPhil/PhD opportunity at Oxford and beyond: with great learning opportunities and a lot of supervisors from various disciplines (including myself). Please apply and share with those potentially interested!
Reposted by Antoni Wrobel
We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!
January 7, 2025 at 10:13 AM
We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!
Reposted by Antoni Wrobel
Check out the magnificent #baculovirus structure! The unique virion architecture and structural atlas of hallmark proteins place baculo-like viruses into a separate new realm. Many insights into baculo biology and evolution. Collab with the group of Fasséli Coulibaly. www.science.org/doi/10.1126/...
December 23, 2024 at 7:23 PM
Check out the magnificent #baculovirus structure! The unique virion architecture and structural atlas of hallmark proteins place baculo-like viruses into a separate new realm. Many insights into baculo biology and evolution. Collab with the group of Fasséli Coulibaly. www.science.org/doi/10.1126/...
Reposted by Antoni Wrobel
RNA virologists, check out "The protein structurome of Orthornavirae and its dark matter" by Pascal Mutz, Valerian Dolja, Eugene Koonin et al (including @simrouxvirus.bsky.social, @apcamargo.bsky.social, @urineri.bsky.social, @anamarijabutkovic.bsky.social)
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
The protein structurome of Orthornavirae and its dark matter | mBio
Advanced methods for protein structure prediction, such as AlphaFold2, greatly expand
our capability to identify protein domains and infer their likely functions and evolutionary
relationships. This i...
journals.asm.org
December 30, 2024 at 6:49 PM
RNA virologists, check out "The protein structurome of Orthornavirae and its dark matter" by Pascal Mutz, Valerian Dolja, Eugene Koonin et al (including @simrouxvirus.bsky.social, @apcamargo.bsky.social, @urineri.bsky.social, @anamarijabutkovic.bsky.social)
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Antoni Wrobel
A starter pack for all virologists out there on the blue side ! Might be missing some people but it’s a good start ! go.bsky.app/DmphBCT
November 17, 2024 at 10:05 AM
A starter pack for all virologists out there on the blue side ! Might be missing some people but it’s a good start ! go.bsky.app/DmphBCT
Reposted by Antoni Wrobel
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU
November 10, 2024 at 2:43 PM
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU
Reposted by Antoni Wrobel
Big news! We're looking for a new Professor (or Associate Professor) in Infection and/or Immunity! Come work with us in @cambridgebiosci.bsky.social, it's a collaborative and supportive environment with great resources, students and colleagues!
www.jobs.cam.ac.uk/job/49381/
Deadline 26/1/25 (Pls RT)
www.jobs.cam.ac.uk/job/49381/
Deadline 26/1/25 (Pls RT)
Associate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of Cambridge
Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
November 29, 2024 at 3:39 PM
Big news! We're looking for a new Professor (or Associate Professor) in Infection and/or Immunity! Come work with us in @cambridgebiosci.bsky.social, it's a collaborative and supportive environment with great resources, students and colleagues!
www.jobs.cam.ac.uk/job/49381/
Deadline 26/1/25 (Pls RT)
www.jobs.cam.ac.uk/job/49381/
Deadline 26/1/25 (Pls RT)
Can't recommend enough!
We are still considering postdoc candidates for the post advertised below. A 2-year contract beginning in 2025 to work on protein SUMO E3 ligases and the nucleosome.
November 30, 2024 at 2:02 AM
Can't recommend enough!
Reposted by Antoni Wrobel
My half-hearted attempt to start a structural virology starter pack. Could be useful for conference organisation in the future! 😀
go.bsky.app/Qxv95BL
Comment below if you'd like me to add you, or anyone you recommend!
#virology #cryoEM
go.bsky.app/Qxv95BL
Comment below if you'd like me to add you, or anyone you recommend!
#virology #cryoEM
November 13, 2024 at 9:21 PM
My half-hearted attempt to start a structural virology starter pack. Could be useful for conference organisation in the future! 😀
go.bsky.app/Qxv95BL
Comment below if you'd like me to add you, or anyone you recommend!
#virology #cryoEM
go.bsky.app/Qxv95BL
Comment below if you'd like me to add you, or anyone you recommend!
#virology #cryoEM