Nature Reviews Molecular Cell Biology, Published online: 02 January 2026; doi:10.1038/s41580-025-00933-1Cohesin complexes regulate genome architecture through DNA loop extrusion and sister chromatid cohesion. The Review discusses how these two cohesin activities mediate the organization of replicated chromosomes and their segregation in mitosis and meiosis, DNA break repair, and age-related aneuploidy in oocytes.

We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,

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The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA

For decades, the 5' to 3' direction of translation has been a central dogma of molecular biology. Here we present evidence that eukaryotic circular RNAs (circRNAs) can serve as templates for 3' to 5' ...

The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...