Elizabeth Rideout
@ejrideout.bsky.social
My lab studies sex differences in metabolism and metabolic disease in flies and mice. #sexdifferences #Drosophila #lipid #insulin #betacell
Reposted by Elizabeth Rideout
We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.
December 15, 2025 at 9:42 PM
We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.
Reposted by Elizabeth Rideout
Now published as version of record at @elife.bsky.social !
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
November 28, 2025 at 9:34 PM
Now published as version of record at @elife.bsky.social !
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
Reposted by Elizabeth Rideout
✨A gut feeling you’ll love this one 🐛 The anterior midgut of a Drosophila melanogaster 🪰larva puts on a confocal glow show! 🟢 Adult midgut progenitors 🔴 Actin 🔵 Nuclei 📸Image by Sapna Krishnakumar #FluorescenceFriday #Microscopy #DevBio
November 28, 2025 at 11:07 PM
✨A gut feeling you’ll love this one 🐛 The anterior midgut of a Drosophila melanogaster 🪰larva puts on a confocal glow show! 🟢 Adult midgut progenitors 🔴 Actin 🔵 Nuclei 📸Image by Sapna Krishnakumar #FluorescenceFriday #Microscopy #DevBio
Reposted by Elizabeth Rideout
Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social
November 26, 2025 at 3:45 AM
Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social
Reposted by Elizabeth Rideout
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
tinyurl.com
October 29, 2025 at 12:31 PM
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Reposted by Elizabeth Rideout
📣Tomorrow is International #DayoftheGirl
& 30 years since the Beijing Declaration on advancing equity, development & peace for all women & girls
📈We must scale investment in girls — including through research, health, education & empowerment-
-a commitment we make in our lab
#GenerationEquality
& 30 years since the Beijing Declaration on advancing equity, development & peace for all women & girls
📈We must scale investment in girls — including through research, health, education & empowerment-
-a commitment we make in our lab
#GenerationEquality
October 10, 2025 at 1:08 PM
📣Tomorrow is International #DayoftheGirl
& 30 years since the Beijing Declaration on advancing equity, development & peace for all women & girls
📈We must scale investment in girls — including through research, health, education & empowerment-
-a commitment we make in our lab
#GenerationEquality
& 30 years since the Beijing Declaration on advancing equity, development & peace for all women & girls
📈We must scale investment in girls — including through research, health, education & empowerment-
-a commitment we make in our lab
#GenerationEquality
Reposted by Elizabeth Rideout
Burgmer, S., Meyer Zu Altenschildesche, F., Gyenis, A., Lee, H., Vilchez, D., Giavalisco, P., Fichant, A., Uhlirova, M., Storelli, G. (2025). Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Rep, 44(6):115811 www.cell.com/cell-reports...
Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling
Burgmer et al. show that the pattern recognition receptors (PRRs) PGRP-LC and PGRP-LE
repress key metabolic functions in the Drosophila midgut. These regulations occur
independently of canonical immun...
www.cell.com
October 6, 2025 at 10:39 PM
Burgmer, S., Meyer Zu Altenschildesche, F., Gyenis, A., Lee, H., Vilchez, D., Giavalisco, P., Fichant, A., Uhlirova, M., Storelli, G. (2025). Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Rep, 44(6):115811 www.cell.com/cell-reports...
Another amazing achievement from the fly community 🤩
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
October 6, 2025 at 1:23 AM
Another amazing achievement from the fly community 🤩
Reposted by Elizabeth Rideout
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
bit.ly/4gX6njF
Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology
Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly
October 4, 2025 at 2:32 PM
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
bit.ly/4gX6njF
Reposted by Elizabeth Rideout
🪰 More than 750 scientists from 40+ countries gathered in Alicante for the XXVIII European Drosophila Research Conference #EDRC2025.
For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏
@edrc2025.bsky.social
@csic.es @dicv.csic.es @umh.es
For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏
@edrc2025.bsky.social
@csic.es @dicv.csic.es @umh.es
September 29, 2025 at 4:57 PM
🪰 More than 750 scientists from 40+ countries gathered in Alicante for the XXVIII European Drosophila Research Conference #EDRC2025.
For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏
@edrc2025.bsky.social
@csic.es @dicv.csic.es @umh.es
For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏
@edrc2025.bsky.social
@csic.es @dicv.csic.es @umh.es
Reposted by Elizabeth Rideout
Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027
September 28, 2025 at 4:00 PM
Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027
Reposted by Elizabeth Rideout
#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!
September 27, 2025 at 11:46 AM
#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!
Beautiful location, fabulous science, and wonderful people 🤩 Thanks to the organizers for all your hard work in bringing us together!
We are on day 3 of #EDRC2025 continuing with excellent #Drosophila science
September 28, 2025 at 7:30 AM
Beautiful location, fabulous science, and wonderful people 🤩 Thanks to the organizers for all your hard work in bringing us together!
Reposted by Elizabeth Rideout
Interesting episode of short wave about the origin of endometriosis. I really appreciate that they end with how uncertainty in NIH funding affects the future of their work.
www.npr.org/2025/09/26/n...
www.npr.org/2025/09/26/n...
What causes endometriosis? Scientists are closer to finding out : Short Wave
Since the age of nine or ten, Katie Burns has had debilitating pain from endometriosis, a condition where tissue resembling the uterine lining grows outside the uterus. For years, Katie was in the dar...
www.npr.org
September 27, 2025 at 9:30 AM
Interesting episode of short wave about the origin of endometriosis. I really appreciate that they end with how uncertainty in NIH funding affects the future of their work.
www.npr.org/2025/09/26/n...
www.npr.org/2025/09/26/n...
Not going to lie…I have gotten very distracted by this feature before 😂
September 24, 2025 at 2:35 PM
Not going to lie…I have gotten very distracted by this feature before 😂
Reposted by Elizabeth Rideout
2nd paper outta my PhD is NOW PUBLISHED😭
🧬🖥️ 🦑Here we show how comparative #genomics 🧬 is a powerful tool to detect putative #SexDetermination genes: Dmrt1L & SoxH from #bivalves 🦪 share evolutionary patterns with Sry from #mammals 🐗 but not with genes from
#drosophila 🪰
doi.org/10.1111/mec....
🧬🖥️ 🦑Here we show how comparative #genomics 🧬 is a powerful tool to detect putative #SexDetermination genes: Dmrt1L & SoxH from #bivalves 🦪 share evolutionary patterns with Sry from #mammals 🐗 but not with genes from
#drosophila 🪰
doi.org/10.1111/mec....
September 22, 2025 at 3:11 PM
2nd paper outta my PhD is NOW PUBLISHED😭
🧬🖥️ 🦑Here we show how comparative #genomics 🧬 is a powerful tool to detect putative #SexDetermination genes: Dmrt1L & SoxH from #bivalves 🦪 share evolutionary patterns with Sry from #mammals 🐗 but not with genes from
#drosophila 🪰
doi.org/10.1111/mec....
🧬🖥️ 🦑Here we show how comparative #genomics 🧬 is a powerful tool to detect putative #SexDetermination genes: Dmrt1L & SoxH from #bivalves 🦪 share evolutionary patterns with Sry from #mammals 🐗 but not with genes from
#drosophila 🪰
doi.org/10.1111/mec....
Taking in my favorite part of Vancouver airport on the way to EDRC in Alicante - excited to see folks there for all things Drosophila!
September 23, 2025 at 11:45 PM
Taking in my favorite part of Vancouver airport on the way to EDRC in Alicante - excited to see folks there for all things Drosophila!
Reposted by Elizabeth Rideout
Studies of prohormone convertase knockouts in mouse islets reveal plasticity in proglucagon processing to support intra-islet α cell-to-β cell communication, normally dominated by glucagon secretion www.science.org/doi/10.1126/...
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion
α cells can generate and secrete both glucagon and GLP-1 with distinct processing enzymes to control metabolism.
www.science.org
September 20, 2025 at 11:44 AM
Studies of prohormone convertase knockouts in mouse islets reveal plasticity in proglucagon processing to support intra-islet α cell-to-β cell communication, normally dominated by glucagon secretion www.science.org/doi/10.1126/...
Feeling fortunate to have contributed data to this effort led by Dr Soumitra Pal, Dr Teresa Przytycka, Dr Brian Oliver, along with Dr George Vogler and Dr Frank Schnorrer. Puja in the lab also produced data on fat body cell counts.
September 20, 2025 at 2:24 PM
Feeling fortunate to have contributed data to this effort led by Dr Soumitra Pal, Dr Teresa Przytycka, Dr Brian Oliver, along with Dr George Vogler and Dr Frank Schnorrer. Puja in the lab also produced data on fat body cell counts.
Very proud of Celena Cherian in the lab, who contributed data to www.biorxiv.org/content/10.1... Briefly, Celena showed female fat body cells have higher ribosomal protein expression and more protein synthesis than males. This difference persists even after cell size is accounted for!
Cell type specific allometry controls sex-differences in Drosophila body size
Species and sex-specific differences in organ size are fundamental features of animal biology, yet the mechanisms that drive these differences remain debated. Adult female Drosophila are larger than m...
www.biorxiv.org
September 20, 2025 at 2:24 PM
Very proud of Celena Cherian in the lab, who contributed data to www.biorxiv.org/content/10.1... Briefly, Celena showed female fat body cells have higher ribosomal protein expression and more protein synthesis than males. This difference persists even after cell size is accounted for!
Supporting and extending these data, Dr Kim Rewitz’s lab has posted a beautiful paper on this topic www.biorxiv.org/content/10.1... We were fortunate to have lots of great discussions about these data!
Gut hormone signaling drives sex differences in metabolism and behavior
Males and females have different physiological and reproductive demands, and consequently exhibit widespread differences in metabolism and behavior. One of the most consistent differences across anima...
www.biorxiv.org
September 20, 2025 at 2:07 PM
Supporting and extending these data, Dr Kim Rewitz’s lab has posted a beautiful paper on this topic www.biorxiv.org/content/10.1... We were fortunate to have lots of great discussions about these data!
There are lots of interesting questions left from this work, but we were excited to report such a strong sex difference in these cells.
September 20, 2025 at 2:07 PM
There are lots of interesting questions left from this work, but we were excited to report such a strong sex difference in these cells.