The Interactive Fly
@interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
Huang, Y. C., Costa, C. A. M., Ruiz, N. V., Wang, X., Jevitt, A., Breneman, C. M., Han, C., Deng, W. M. (2025). Polyploidy promotes transformation of epithelial cells into non-professional phagocytes. bioRxiv, www.biorxiv.org/content/10.1...
January 28, 2026 at 7:17 PM
Huang, Y. C., Costa, C. A. M., Ruiz, N. V., Wang, X., Jevitt, A., Breneman, C. M., Han, C., Deng, W. M. (2025). Polyploidy promotes transformation of epithelial cells into non-professional phagocytes. bioRxiv, www.biorxiv.org/content/10.1...
Singh, J., Verma, D., Sarkar, B., Paul, M., Mutsuddi, M., Mukherjee, A. (2025). Notch and LIM-homeodomain protein Arrowhead regulate each other in a feedback mechanism to play a role in wing and neuronal development in Drosophila. Open Biol, 15(4):240247 royalsocietypublishing.org/rsob/article...
January 28, 2026 at 7:10 PM
Singh, J., Verma, D., Sarkar, B., Paul, M., Mutsuddi, M., Mukherjee, A. (2025). Notch and LIM-homeodomain protein Arrowhead regulate each other in a feedback mechanism to play a role in wing and neuronal development in Drosophila. Open Biol, 15(4):240247 royalsocietypublishing.org/rsob/article...
Fujinaga, D., Nolan, C., Yamanaka, N. (2025). Functional characterization of eicosanoid signaling in Drosophila development. PLoS Genet, 21(5):e1011705 journals.plos.org/plosgenetics...
Functional characterization of eicosanoid signaling in Drosophila development
Author summary There are numerous bioactive lipids that control animal physiology, and some of them are commonly observed in both humans and insects. Well-studied insects such as fruit flies can there...
journals.plos.org
January 28, 2026 at 7:07 PM
Fujinaga, D., Nolan, C., Yamanaka, N. (2025). Functional characterization of eicosanoid signaling in Drosophila development. PLoS Genet, 21(5):e1011705 journals.plos.org/plosgenetics...
Zhao, Y., Alexandre, C., Kelly, G., Vincent, J. P., Perez-Mockus, G. (2025). HIF-1alpha-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development. Nat Commun, www.nature.com/articles/s41...
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development - Nature Communications
During normal development, growing fly wing precursors become hypoxic, triggering HIF-1α-mediated negative feedback on TOR signalling and growth deceleration. Without this feedback, the mismatch betwe...
www.nature.com
January 28, 2026 at 7:05 PM
Zhao, Y., Alexandre, C., Kelly, G., Vincent, J. P., Perez-Mockus, G. (2025). HIF-1alpha-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development. Nat Commun, www.nature.com/articles/s41...
Medina, A. B., Perochon, J., Tian, Y., Johnson, C. T., Holcombe, J., Ramesh, P., Polcownuk, S., Yu, Y., Cordero, J. B. (2025). Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila. Dev Cell, 60(22):3085-3101 www.cell.com/developmenta...
Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila
Adult intestinal plasticity and tissue repair involves complex and reciprocal multicellular
interactions. Medina, Perochon, et al. report a signaling axis between hormone-producing
cells in the intest...
www.cell.com
January 28, 2026 at 7:04 PM
Medina, A. B., Perochon, J., Tian, Y., Johnson, C. T., Holcombe, J., Ramesh, P., Polcownuk, S., Yu, Y., Cordero, J. B. (2025). Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila. Dev Cell, 60(22):3085-3101 www.cell.com/developmenta...
Ahrentlov, N., Kubrak, O., Lassen, M., ...., Nagy, S., Imig, C., Richter, E. A., Texada, M. J., Rewitz, K. (2025). Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan. Nat Metab, 7(6):1223-1245 www.nature.com/articles/s42...
Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan - Nature Metabolism
The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.
www.nature.com
January 28, 2026 at 7:02 PM
Ahrentlov, N., Kubrak, O., Lassen, M., ...., Nagy, S., Imig, C., Richter, E. A., Texada, M. J., Rewitz, K. (2025). Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan. Nat Metab, 7(6):1223-1245 www.nature.com/articles/s42...
Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 pubmed.ncbi.nlm.nih.gov/40178596/
January 28, 2026 at 12:06 PM
Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 pubmed.ncbi.nlm.nih.gov/40178596/
Hey, J., Pavinato, V. A. C. (2025). Isolating selective from non-selective forces using site frequency ratios. PLoS Genet, 21(4):e1011427 journals.plos.org/plosgenetics...
Isolating selective from non-selective forces using site frequency ratios
Author summary A new statistical method is presented for estimating the distribution of strengths of natural selection acting on mutations in natural populations using the distribution of polymorphic ...
journals.plos.org
January 28, 2026 at 11:37 AM
Hey, J., Pavinato, V. A. C. (2025). Isolating selective from non-selective forces using site frequency ratios. PLoS Genet, 21(4):e1011427 journals.plos.org/plosgenetics...
Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 link.springer.com/article/10.1...
Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution - Journal of Molecular Evolution
The protein encoded by the Drosophila melanogaster gene bag of marbles (bam) plays an essential role in early gametogenesis by complexing with the gene product of benign gonial cell neoplasm (bgcn) to...
link.springer.com
January 28, 2026 at 11:35 AM
Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 link.springer.com/article/10.1...
Lai, W. Y., Hsu, S. K., Futschik, A., Schlotterer, C. (2025). Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation. Elife, 13 elifesciences.org/articles/102...
January 28, 2026 at 7:24 AM
Lai, W. Y., Hsu, S. K., Futschik, A., Schlotterer, C. (2025). Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation. Elife, 13 elifesciences.org/articles/102...
Glaser-Schmitt, A., Lebherz, M., Saydam, E., Bornberg-Bauer, E., Parsch, J. (2025). Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster onlinelibrary.wiley.com/doi/10.1002/...
Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster
We show that newly-evolved, expressed open reading frames (neORFs) identified in a set of inbred Drosophila melanogaster lines are also expressed in multiple tissues and developmental stages of poole...
onlinelibrary.wiley.com
January 28, 2026 at 7:22 AM
Glaser-Schmitt, A., Lebherz, M., Saydam, E., Bornberg-Bauer, E., Parsch, J. (2025). Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster onlinelibrary.wiley.com/doi/10.1002/...
Hey, J., Pavinato, V. A. C. (2025). Isolating selective from non-selective forces using site frequency ratios. PLoS Genet, 21(4):e1011427 journals.plos.org/plosgenetics...
Isolating selective from non-selective forces using site frequency ratios
Author summary A new statistical method is presented for estimating the distribution of strengths of natural selection acting on mutations in natural populations using the distribution of polymorphic ...
journals.plos.org
January 28, 2026 at 7:16 AM
Hey, J., Pavinato, V. A. C. (2025). Isolating selective from non-selective forces using site frequency ratios. PLoS Genet, 21(4):e1011427 journals.plos.org/plosgenetics...
Audet, T., Wilson, A., Dukas, R., Dworkin, I. (2025). he role of resource defensibility in facilitating sexually-selected weapon evolution: An experimental evolution test. Evolution, academic.oup.com/evolut/artic...
The role of resource defensibility in facilitating sexually selected weapon evolution: an experimental evolution test
Abstract. Animal weapons have evolved multiple times, primarily for battling for access to mates. Despite intra-sexual selection being common, exaggerated
academic.oup.com
January 28, 2026 at 7:14 AM
Audet, T., Wilson, A., Dukas, R., Dworkin, I. (2025). he role of resource defensibility in facilitating sexually-selected weapon evolution: An experimental evolution test. Evolution, academic.oup.com/evolut/artic...
Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). omparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 link.springer.com/article/10.1...
Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution - Journal of Molecular Evolution
The protein encoded by the Drosophila melanogaster gene bag of marbles (bam) plays an essential role in early gametogenesis by complexing with the gene product of benign gonial cell neoplasm (bgcn) to...
link.springer.com
January 28, 2026 at 7:11 AM
Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). omparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 link.springer.com/article/10.1...
Reposted by The Interactive Fly
Huang, Y. C., Costa, C. A. M., Ruiz, N. V., Wang, X., Jevitt, A., Breneman, C. M., Han, C., Deng, W. M. (2025). Polyploidy promotes transformation of epithelial cells into non-professional phagocytes. bioRxiv, www.biorxiv.org/content/10.1...
January 24, 2026 at 8:39 PM
Huang, Y. C., Costa, C. A. M., Ruiz, N. V., Wang, X., Jevitt, A., Breneman, C. M., Han, C., Deng, W. M. (2025). Polyploidy promotes transformation of epithelial cells into non-professional phagocytes. bioRxiv, www.biorxiv.org/content/10.1...
Singh, J., Verma, D., Sarkar, B., Paul, M., Mutsuddi, M., Mukherjee, A. (2025). Notch and LIM-homeodomain protein Arrowhead regulate each other in a feedback mechanism to play a role in wing and neuronal development in Drosophila. Open Biol, 15(4):240247 royalsocietypublishing.org/rsob/article...
January 24, 2026 at 8:38 PM
Singh, J., Verma, D., Sarkar, B., Paul, M., Mutsuddi, M., Mukherjee, A. (2025). Notch and LIM-homeodomain protein Arrowhead regulate each other in a feedback mechanism to play a role in wing and neuronal development in Drosophila. Open Biol, 15(4):240247 royalsocietypublishing.org/rsob/article...
Fujinaga, D., Nolan, C., Yamanaka, N. (2025). Functional characterization of eicosanoid signaling in Drosophila development. PLoS Genet, 21(5):e1011705 journals.plos.org/plosgenetics...
Functional characterization of eicosanoid signaling in Drosophila development
Author summary There are numerous bioactive lipids that control animal physiology, and some of them are commonly observed in both humans and insects. Well-studied insects such as fruit flies can there...
journals.plos.org
January 24, 2026 at 8:35 PM
Fujinaga, D., Nolan, C., Yamanaka, N. (2025). Functional characterization of eicosanoid signaling in Drosophila development. PLoS Genet, 21(5):e1011705 journals.plos.org/plosgenetics...
Medina, A. B., Perochon, J., Tian, Y., Johnson, C. T., Holcombe, J., Ramesh, P., Polcownuk, S., Yu, Y., Cordero, J. B. (2025). Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila. Dev Cell, 60(22):3085-3101 www.cell.com/developmenta...
Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila
Adult intestinal plasticity and tissue repair involves complex and reciprocal multicellular
interactions. Medina, Perochon, et al. report a signaling axis between hormone-producing
cells in the intest...
www.cell.com
January 24, 2026 at 8:31 PM
Medina, A. B., Perochon, J., Tian, Y., Johnson, C. T., Holcombe, J., Ramesh, P., Polcownuk, S., Yu, Y., Cordero, J. B. (2025). Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila. Dev Cell, 60(22):3085-3101 www.cell.com/developmenta...
Ahrentlov, N., Kubrak, O., Lassen, M., Malita, A., Koyama, T., ...., Nagy, S., Imig, C., Richter, E. A., Texada, M. J., Rewitz, K. (2025). Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan. Nat Metab, 7(6):1223-1245 www.nature.com/articles/s42...
Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan - Nature Metabolism
The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.
www.nature.com
January 24, 2026 at 8:29 PM
Ahrentlov, N., Kubrak, O., Lassen, M., Malita, A., Koyama, T., ...., Nagy, S., Imig, C., Richter, E. A., Texada, M. J., Rewitz, K. (2025). Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan. Nat Metab, 7(6):1223-1245 www.nature.com/articles/s42...
Evdokimova, A. A., Kolesnikova, T. D., Mazina, M. Y., ...., Vorobyeva, N. E. (2025). Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation. Nucleic Acids Res, 53(7) pmc.ncbi.nlm.nih.gov/articles/PMC...
January 21, 2026 at 8:37 PM
Evdokimova, A. A., Kolesnikova, T. D., Mazina, M. Y., ...., Vorobyeva, N. E. (2025). Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation. Nucleic Acids Res, 53(7) pmc.ncbi.nlm.nih.gov/articles/PMC...
Evdokimova, A. A., Kolesnikova, T. D., Mazina, M. Y., ...., Vorobyeva, N. E. (2025). Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation. Nucleic Acids Res, 53(7) pmc.ncbi.nlm.nih.gov/articles/PMC...
January 21, 2026 at 8:36 PM
Evdokimova, A. A., Kolesnikova, T. D., Mazina, M. Y., ...., Vorobyeva, N. E. (2025). Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation. Nucleic Acids Res, 53(7) pmc.ncbi.nlm.nih.gov/articles/PMC...
Dahn, S., Wagner, A. E. (2025). Drosophila melanogaster as a model organism to investigate sex specific differences. Sci Rep, 15(1):19648 www.nature.com/articles/s41...
Drosophila melanogaster as a model organism to investigate sex specific differences - Scientific Reports
Scientific Reports - Drosophila melanogaster as a model organism to investigate sex specific differences
www.nature.com
January 21, 2026 at 8:32 PM
Dahn, S., Wagner, A. E. (2025). Drosophila melanogaster as a model organism to investigate sex specific differences. Sci Rep, 15(1):19648 www.nature.com/articles/s41...
Sun, Y., Shui, K., Li, Q., Liu, C., Jin, W., Ni, J. Q., Lu, J., Zhang, L. (2025). Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythms and sleep. PLoS Biol, 23(5):e3003173 journals.plos.org/plosbiology/...
Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythms and sleep
Oscillations of core clock genes, including Clock (Clk), are essential for the generation of circadian rhythms. This study reveals that upstream open reading frames are enriched in Drosophila circadia...
journals.plos.org
January 21, 2026 at 8:30 PM
Sun, Y., Shui, K., Li, Q., Liu, C., Jin, W., Ni, J. Q., Lu, J., Zhang, L. (2025). Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythms and sleep. PLoS Biol, 23(5):e3003173 journals.plos.org/plosbiology/...
Fallacaro, S., Mukherjee, A., Turner, M. A., Garcia, H. G., Mir, M. (2025). Transcription factor hubs exhibit gene-specific properties that tune expression. bioRxiv, www.biorxiv.org/content/10.1...
January 21, 2026 at 8:29 PM
Fallacaro, S., Mukherjee, A., Turner, M. A., Garcia, H. G., Mir, M. (2025). Transcription factor hubs exhibit gene-specific properties that tune expression. bioRxiv, www.biorxiv.org/content/10.1...