The Interactive Fly
@interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
Epiney, D. G., Chaya, G. M., Dillon, N. R., Lai, S. L., Doe, C. Q. (2025). Single nuclei RNA-sequencing of adult brain neurons derived from type 2 neuroblasts reveals transcriptional complexity in the insect central complex. Elife, 14 elifesciences.org/articles/105...
November 8, 2025 at 12:47 AM
Epiney, D. G., Chaya, G. M., Dillon, N. R., Lai, S. L., Doe, C. Q. (2025). Single nuclei RNA-sequencing of adult brain neurons derived from type 2 neuroblasts reveals transcriptional complexity in the insect central complex. Elife, 14 elifesciences.org/articles/105...
Deng, X., Suito, T., Tominaga, M., Sokabe, T. (2025). Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila. Commun Biol, 8(1):765 www.nature.com/articles/s42...
Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila - Communications Biology
A lipid enzyme is involved in the thermal responsiveness of neurons by regulating ionotropic receptor expression, thereby maintaining the cool temperature avoidance of Drosophila larvae.
www.nature.com
November 8, 2025 at 12:45 AM
Deng, X., Suito, T., Tominaga, M., Sokabe, T. (2025). Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila. Commun Biol, 8(1):765 www.nature.com/articles/s42...
Chai, C. M., Morrow, C. M., Parikh, D. D., Von Reyn, C. R., Leonardo, A., Card, G. M. (2025). Shorter-duration escapes driven by Drosophila giant interneurons promote survival during predation. Proc Biol Sci, 292(2047):20241724 royalsocietypublishing.org/doi/10.1098/...
November 8, 2025 at 12:44 AM
Chai, C. M., Morrow, C. M., Parikh, D. D., Von Reyn, C. R., Leonardo, A., Card, G. M. (2025). Shorter-duration escapes driven by Drosophila giant interneurons promote survival during predation. Proc Biol Sci, 292(2047):20241724 royalsocietypublishing.org/doi/10.1098/...
Benton, R., Mermet, J., Jang, A., Endo, K., Cruchet, S., Menuz, K. (2025). An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system. EMBO Rep, 26(12):3204-3225 www.embopress.org/doi/full/10....
An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system | EMBO reports
imageimageIdentification of a new antennal Or and an unusual hybrid Or/Ir neuron “complete”
the olfactory map in Drosophila melanogaster. Numerous features of this species’ olfactory system are synthe...
www.embopress.org
November 8, 2025 at 12:43 AM
Benton, R., Mermet, J., Jang, A., Endo, K., Cruchet, S., Menuz, K. (2025). An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system. EMBO Rep, 26(12):3204-3225 www.embopress.org/doi/full/10....
Guerrero, C. Y. P., Cusick, M. R., ..., Cavanaugh, D. J. (2025). The cell-intrinsic circadian clock is dispensable for lateral posterior clock neuron regulation of Drosophila rest-activity rhythms. Neurobiol Sleep Circadian Rhythms, 18:100124 www.sciencedirect.com/science/arti...
November 8, 2025 at 12:41 AM
Guerrero, C. Y. P., Cusick, M. R., ..., Cavanaugh, D. J. (2025). The cell-intrinsic circadian clock is dispensable for lateral posterior clock neuron regulation of Drosophila rest-activity rhythms. Neurobiol Sleep Circadian Rhythms, 18:100124 www.sciencedirect.com/science/arti...
Currier, T. A., Clandinin, T. R. (2025). Infrequent strong connections constrain connectomic predictions of neuronal function. Cell www.cell.com/cell/abstrac...
Infrequent strong connections constrain connectomic predictions of neuronal function
Extensive measurements of visual selectivity in the fly optic lobe enable a broad
assessment of connectome-based functional predictions. Strong connections possess
an outsized share of the connectome’...
www.cell.com
November 8, 2025 at 12:40 AM
Currier, T. A., Clandinin, T. R. (2025). Infrequent strong connections constrain connectomic predictions of neuronal function. Cell www.cell.com/cell/abstrac...
Lushchak, O., Strilbytska, O., Petakh, P., Kamyshnyi, O., Koliada, O., Semaniuk, U. (2025). Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila. Biogerontology, 26(3):116 link.springer.com/article/10.1...
Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila - Biogerontology
Varied factors and interventions were shown to extend the lifespan. An understanding of the mechanisms behind the beneficial effects might extend our understanding of how interventions work. However, ...
link.springer.com
November 7, 2025 at 12:40 AM
Lushchak, O., Strilbytska, O., Petakh, P., Kamyshnyi, O., Koliada, O., Semaniuk, U. (2025). Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila. Biogerontology, 26(3):116 link.springer.com/article/10.1...
Abolaji, A. O., Adedara, A. O., ...., B., Whitworth, A. J., Aschner, M. (2025). Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila alpha-synuclein model of Parkinson's disease. Sci Rep, 15(1):17769 www.nature.com/articles/s41...
Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson’s disease - Scientific Reports
Scientific Reports - Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson’s disease
www.nature.com
November 7, 2025 at 12:39 AM
Abolaji, A. O., Adedara, A. O., ...., B., Whitworth, A. J., Aschner, M. (2025). Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila alpha-synuclein model of Parkinson's disease. Sci Rep, 15(1):17769 www.nature.com/articles/s41...
Cong, F., Bao, H., Wang, X., Tang, Y., Bao, Y., Poulton, J. S., Liu, X., Wong, A. C., Ji, X., Deng, W. M. (2025). Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage. Embo j, 44(13):3586-3613 www.embopress.org/doi/full/10....
November 7, 2025 at 12:36 AM
Cong, F., Bao, H., Wang, X., Tang, Y., Bao, Y., Poulton, J. S., Liu, X., Wong, A. C., Ji, X., Deng, W. M. (2025). Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage. Embo j, 44(13):3586-3613 www.embopress.org/doi/full/10....
Leventhal, M. J., Zanella, C. A., Kang, B., ,,,,., Scherzer, C. R., Feany, M. B., Fraenkel, E. (2025). An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration. Nat Commun, 16(1):4441 www.nature.com/articles/s41...
An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration - Nature Communications
In this study, Leventhal et al. integrate multi-omic data from human and Drosophila models of Alzheimer’s disease to define regulators of age-associated neurodegeneration in Alzheimer’s disease and th...
www.nature.com
November 7, 2025 at 12:35 AM
Leventhal, M. J., Zanella, C. A., Kang, B., ,,,,., Scherzer, C. R., Feany, M. B., Fraenkel, E. (2025). An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration. Nat Commun, 16(1):4441 www.nature.com/articles/s41...
Choi, B., Cho, K. S. (2025). Role of neuronal fabp in autophagy and amyloid-β pathology in a Drosophila model of Alzheimer disease.. Autophagy Rep, 4(1):2466120 www.tandfonline.com/doi/full/10....
November 7, 2025 at 12:33 AM
Choi, B., Cho, K. S. (2025). Role of neuronal fabp in autophagy and amyloid-β pathology in a Drosophila model of Alzheimer disease.. Autophagy Rep, 4(1):2466120 www.tandfonline.com/doi/full/10....
White, M. A., Crowley, L., Massenzio, F., Li, X., Niblock, M., Coleman, M. P., Barmada, S. J., Sreedharan, J. (2025). Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependent manner. Res Sq, www.researchsquare.com/article/rs-6...
November 7, 2025 at 12:32 AM
White, M. A., Crowley, L., Massenzio, F., Li, X., Niblock, M., Coleman, M. P., Barmada, S. J., Sreedharan, J. (2025). Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependent manner. Res Sq, www.researchsquare.com/article/rs-6...
Reposted by The Interactive Fly
By comparing differently tuned glomeruli, this work shows that the brain uses different circuit layouts for specialised vs general smells, offering new insight into how odour meaning is encoded.
buff.ly/XDmo4Ue
buff.ly/XDmo4Ue
November 6, 2025 at 11:28 PM
By comparing differently tuned glomeruli, this work shows that the brain uses different circuit layouts for specialised vs general smells, offering new insight into how odour meaning is encoded.
buff.ly/XDmo4Ue
buff.ly/XDmo4Ue
Cerny, J., Krishnan, N., Prokupkova, N., Sterbova, H., Kodrik, D. (2025). Elimination of certain honeybee venom activities by adipokinetic hormone. Sci Rep, 15(1):18638 www.nature.com/articles/s41...
Elimination of certain honeybee venom activities by adipokinetic hormone - Scientific Reports
Scientific Reports - Elimination of certain honeybee venom activities by adipokinetic hormone
www.nature.com
November 6, 2025 at 12:58 AM
Cerny, J., Krishnan, N., Prokupkova, N., Sterbova, H., Kodrik, D. (2025). Elimination of certain honeybee venom activities by adipokinetic hormone. Sci Rep, 15(1):18638 www.nature.com/articles/s41...
Azmin, M. R., Habibie, H., Filmaharani, F., ...., N. P., Mudjahid, M., Yuliana, D., Nainu, F. (2025). Aspirin-Mediated Reduction of Glucose Level and Inflammation in Drosophila melanogaster. ACS Omega, 10(18):18622-18628. pubs.acs.org/doi/10.1021/...
Aspirin-Mediated Reduction of Glucose Level and Inflammation in Drosophila melanogaster
Diabetes mellitus (DM), particularly type 2 diabetes mellitus (T2DM), is a global health challenge marked by chronic hyperglycemia and inflammation, which contributes to both metabolic dysregulation a...
pubs.acs.org
November 6, 2025 at 12:57 AM
Azmin, M. R., Habibie, H., Filmaharani, F., ...., N. P., Mudjahid, M., Yuliana, D., Nainu, F. (2025). Aspirin-Mediated Reduction of Glucose Level and Inflammation in Drosophila melanogaster. ACS Omega, 10(18):18622-18628. pubs.acs.org/doi/10.1021/...
Musachio, E., Almeida, F. P., Poetini, M. R., Janner, D. E., Alves, D., Guerra, G., Prigol, M. (2025). 7-chloro-4-(phenylselanyl)quinoline exerts protective effect on neurotoxicity in Drosophila. Comp Biochem Physiol C Toxicol Pharmacol, 296:110257 www.sciencedirect.com/science/arti...
7-chloro-4-(phenylselanyl)quinoline exerts protective effect on acrylamide-induced neurotoxicity in the fly Drosophila melanogaster through modulation of acetylcholinesterase and oxidative stress
This study aimed to evaluate the neuroprotective action of 7-chloro-4-(phenylselanyl)quinoline (4-PSQ) through the activity of the enzyme acetylcholin…
www.sciencedirect.com
November 6, 2025 at 12:55 AM
Musachio, E., Almeida, F. P., Poetini, M. R., Janner, D. E., Alves, D., Guerra, G., Prigol, M. (2025). 7-chloro-4-(phenylselanyl)quinoline exerts protective effect on neurotoxicity in Drosophila. Comp Biochem Physiol C Toxicol Pharmacol, 296:110257 www.sciencedirect.com/science/arti...
Price, D. K., West, K., Cevallos-Zea, M., Cahan, S. H., Nunez, J. C. B., Longman, E. K., Yew, J. Y., Mederios, M. J. (2025). Microbiome composition shapes temperature tolerance in a Hawaiian picture-winged Drosophila. bioRxiv, www.biorxiv.org/content/10.1...
November 6, 2025 at 12:51 AM
Price, D. K., West, K., Cevallos-Zea, M., Cahan, S. H., Nunez, J. C. B., Longman, E. K., Yew, J. Y., Mederios, M. J. (2025). Microbiome composition shapes temperature tolerance in a Hawaiian picture-winged Drosophila. bioRxiv, www.biorxiv.org/content/10.1...
Alassaf, M., Madan, A., Ranganathan, S., Marschall, S., Wong, J. J., Goldberg, Z. H., Brent, A. E., Rajan, A. (2025). Adipocyte metabolic state regulates glial phagocytic function. Cell Rep, 44(5):115704 www.cell.com/cell-reports...
Adipocyte metabolic state regulates glial phagocytic function
An obesogenic diet alters lipid metabolism in Drosophila adipocytes, remotely disrupting
glial phagocytic function. Alassaf et al. identify adipocyte-derived ApoB and receptor
LpR1 as crucial regulato...
www.cell.com
November 6, 2025 at 12:49 AM
Alassaf, M., Madan, A., Ranganathan, S., Marschall, S., Wong, J. J., Goldberg, Z. H., Brent, A. E., Rajan, A. (2025). Adipocyte metabolic state regulates glial phagocytic function. Cell Rep, 44(5):115704 www.cell.com/cell-reports...
Sheng, Y., Xu, Z., Li, Y., Chen, J., ...., Wang, Y., Chen, X., Shen, X. X., Huang, J. (2025). Fruit flies exploit behavioral fever as a defense strategy against parasitic insects. Sci Adv, 11(24):eadw0191 www.science.org/doi/10.1126/...
Fruit flies exploit behavioral fever as a defense strategy against parasitic insects
Fruit flies use behavioral fever to combat parasitoid wasps and boost survival.
www.science.org
November 6, 2025 at 12:48 AM
Sheng, Y., Xu, Z., Li, Y., Chen, J., ...., Wang, Y., Chen, X., Shen, X. X., Huang, J. (2025). Fruit flies exploit behavioral fever as a defense strategy against parasitic insects. Sci Adv, 11(24):eadw0191 www.science.org/doi/10.1126/...
Kim, H. S., Santana, G. M., Sancer, G., Emonet, T., Jeanne, J. M. (2025). Divergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit. Curr Biol, 35(13):3146-3162. www.cell.com/current-biol...
Divergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit
Kim et al. investigate how the Drosophila olfactory system dynamically transforms
odor information. They discover that distinct synaptic dynamics from individual projection
neurons underlie different ...
www.cell.com
November 4, 2025 at 7:45 PM
Kim, H. S., Santana, G. M., Sancer, G., Emonet, T., Jeanne, J. M. (2025). Divergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit. Curr Biol, 35(13):3146-3162. www.cell.com/current-biol...
Patel, A. A., Cardona, A., Cox, D. N. (2025). Neural substrates of cold nociception in Drosophila larva. Elife, 12 elifesciences.org/articles/91582
November 4, 2025 at 7:44 PM
Patel, A. A., Cardona, A., Cox, D. N. (2025). Neural substrates of cold nociception in Drosophila larva. Elife, 12 elifesciences.org/articles/91582
Patel, A. A., Cardona, A., Cox, D. N. (2025). Neural substrates of cold nociception in Drosophila larva. Elife, 12 elifesciences.org/articles/91582
November 4, 2025 at 7:43 PM
Patel, A. A., Cardona, A., Cox, D. N. (2025). Neural substrates of cold nociception in Drosophila larva. Elife, 12 elifesciences.org/articles/91582
Richter, V., Rist, A., Kislinger, G., Laumann, M., Schoofs, A., Miroschnikow, A., Pankratz, M. J., Cardona, A., Thum, A. S. (2025). Morphology and ultrastructure of external sense organs of Drosophila larvae. Elife, 12 elifesciences.org/articles/91155
November 4, 2025 at 7:42 PM
Richter, V., Rist, A., Kislinger, G., Laumann, M., Schoofs, A., Miroschnikow, A., Pankratz, M. J., Cardona, A., Thum, A. S. (2025). Morphology and ultrastructure of external sense organs of Drosophila larvae. Elife, 12 elifesciences.org/articles/91155
Andersen, M. K., Robertson, R. M., MacMillan, H. A. (2025). Temperature sensitivity of spreading depolarization in the CNS of Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol, 329(1):R134-r149 journals.physiology.org/doi/full/10....
November 4, 2025 at 7:40 PM
Andersen, M. K., Robertson, R. M., MacMillan, H. A. (2025). Temperature sensitivity of spreading depolarization in the CNS of Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol, 329(1):R134-r149 journals.physiology.org/doi/full/10....
Cheng, L. S., Charng, C. C., Chen, R. H., Feng, K. L., Chiang, A. S., Lo, C. C., Lee, T. K. (2025). Hybrid neural networks in the mushroom body drive olfactory preference in Drosophila. Sci Adv, 11(22):eadq9893 www.science.org/doi/10.1126/...
Hybrid neural networks in the mushroom body drive olfactory preference in Drosophila
An L-shaped hybrid network orchestrates differential olfactory coding for learning in flies, unveiling sensory-to-behavior links.
www.science.org
November 4, 2025 at 7:39 PM
Cheng, L. S., Charng, C. C., Chen, R. H., Feng, K. L., Chiang, A. S., Lo, C. C., Lee, T. K. (2025). Hybrid neural networks in the mushroom body drive olfactory preference in Drosophila. Sci Adv, 11(22):eadq9893 www.science.org/doi/10.1126/...