The Interactive Fly
@interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
Rousseau, C., Morand, T., Haas, G., Lauret, E., Kuhn, L., Chicher, J., Hammann, P., Meignin, C. (2025). In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster. PLoS Pathog, 21(5):e1013093 journals.plos.org/plospathogen...
In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster
Invertebrates rely mainly on RNA interference (RNAi) as a key defense mechanism against viral infections. The central protein of this process is an enzyme called Dicer-2, which senses and processes vi...
journals.plos.org
December 26, 2025 at 9:51 PM
Rousseau, C., Morand, T., Haas, G., Lauret, E., Kuhn, L., Chicher, J., Hammann, P., Meignin, C. (2025). In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster. PLoS Pathog, 21(5):e1013093 journals.plos.org/plospathogen...
Akulenko, N., Mikhaleva, E., Marfina, S., ...., Arapidi, G., Shender, V., Ryazansky, S. (2025). Insights into the target-directed miRNA degradation mechanism in Drosophila ovarian cell culture. Biochim Biophys Acta Gene Regul Mech, 1868(2):195092 www.sciencedirect.com/science/arti...
December 26, 2025 at 9:50 PM
Akulenko, N., Mikhaleva, E., Marfina, S., ...., Arapidi, G., Shender, V., Ryazansky, S. (2025). Insights into the target-directed miRNA degradation mechanism in Drosophila ovarian cell culture. Biochim Biophys Acta Gene Regul Mech, 1868(2):195092 www.sciencedirect.com/science/arti...
Tracy, L., Zhang, Z. Z. (2025). Safeguarding spermatogenesis from retrotransposon insertions by forming ecDNA. bioRxiv, www.biorxiv.org/content/10.1...
December 26, 2025 at 9:48 PM
Tracy, L., Zhang, Z. Z. (2025). Safeguarding spermatogenesis from retrotransposon insertions by forming ecDNA. bioRxiv, www.biorxiv.org/content/10.1...
xHwang, H. J., Sheard, K. M., Cox, R. T. (2025). Drosophila Clu ribonucleoprotein particle dynamics rely on the availability of functional Clu and translating ribosomes. J Cell Sci, 138(9) journals.biologists.com/jcs/article/...
Drosophila Clu ribonucleoprotein particle dynamics rely on the availability of functional Clu and translating ribosomes
Summary: The dynamics of Clu ribonucleoprotein particles are governed by its functional protein level and translating ribosomes, giving insight into how these unique particles regulate mitochondrial b...
journals.biologists.com
December 26, 2025 at 9:47 PM
xHwang, H. J., Sheard, K. M., Cox, R. T. (2025). Drosophila Clu ribonucleoprotein particle dynamics rely on the availability of functional Clu and translating ribosomes. J Cell Sci, 138(9) journals.biologists.com/jcs/article/...
Narbonne-Reveau, K., Erni, A., Eichner, N., Sankar, S., Kapoor, S., Meister, G., Cremer, H., Maurange, C., Beclin, C. (2025). In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors. PLoS Genet, 21(4):e1011680 journals.plos.org/plosgenetics...
In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors
MicroRNAs (miRNAs) are small RNAs that silence messenger RNAs (mRNAs) by binding to partially complementary sequences. They play a crucial role in cell type specification during development. Computati...
journals.plos.org
December 26, 2025 at 9:45 PM
Narbonne-Reveau, K., Erni, A., Eichner, N., Sankar, S., Kapoor, S., Meister, G., Cremer, H., Maurange, C., Beclin, C. (2025). In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors. PLoS Genet, 21(4):e1011680 journals.plos.org/plosgenetics...
Hayashi, M., Koga, Y., Kozono, Y., Kobayashi, S. (2025). Maternal ovo represses the expression of transposable elements in adult ovaries. Dev Biol, 523:111-114 www.sciencedirect.com/science/arti...
Maternal ovo represses the expression of transposable elements in adult ovaries
In germ cells, repressing transposable elements (TEs) is important to maintain genomic integrity. TE expression and transposition are repressed by PIW…
www.sciencedirect.com
December 26, 2025 at 9:44 PM
Hayashi, M., Koga, Y., Kozono, Y., Kobayashi, S. (2025). Maternal ovo represses the expression of transposable elements in adult ovaries. Dev Biol, 523:111-114 www.sciencedirect.com/science/arti...
Rethemeier, S., Fritzsche, S., Muhlen, D., Bucher, G., Hunnekuhl, V. S. (2025). Differences in size and number of embryonic type II neuroblast lineages correlate with divergent timing of central complex development between beetle and fly. Elife, 13 elifesciences.org/articles/99717
December 23, 2025 at 5:55 PM
Rethemeier, S., Fritzsche, S., Muhlen, D., Bucher, G., Hunnekuhl, V. S. (2025). Differences in size and number of embryonic type II neuroblast lineages correlate with divergent timing of central complex development between beetle and fly. Elife, 13 elifesciences.org/articles/99717
Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U., Andersen, P. (2025). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. Embo j, link.springer.com/article/10.1...
Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway - The EMBO Journal
Despite being essential for fertility, genome-defense-pathway genes often evolve rapidly. However, little is known about the molecular basis of this adaptation. Here, we characterized the evolution of...
link.springer.com
December 23, 2025 at 5:53 PM
Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U., Andersen, P. (2025). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. Embo j, link.springer.com/article/10.1...
Lee, D., Shahandeh, M. P., Abuin, L., Benton, R. (2025). Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation. PLoS Biol, 23(4):e3003120 journals.plos.org/plosbiology/...
Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation
How do diverse brain cells change over evolution? By comparing single-cell transcriptomic atlases from ecologically-distinct drosophilid species, this work identifies changes in the composition and ge...
journals.plos.org
December 23, 2025 at 5:52 PM
Lee, D., Shahandeh, M. P., Abuin, L., Benton, R. (2025). Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation. PLoS Biol, 23(4):e3003120 journals.plos.org/plosbiology/...
Keais, G. L., Saad-Roy, C. M., Gonzalez-Sqalli, E., ...., P., Wei, K. H., Loppin, B., Perlman, S. J. (2025). A selfish supergene causes meiotic drive through both sexes in Drosophila. Proc Natl Acad Sci U S A, 122(17):e2421185122 www.pnas.org/doi/10.1073/...
December 23, 2025 at 5:51 PM
Keais, G. L., Saad-Roy, C. M., Gonzalez-Sqalli, E., ...., P., Wei, K. H., Loppin, B., Perlman, S. J. (2025). A selfish supergene causes meiotic drive through both sexes in Drosophila. Proc Natl Acad Sci U S A, 122(17):e2421185122 www.pnas.org/doi/10.1073/...
Kao, J. A., Ewen-Campen, B., Extavour, C. G. (2025). Divergence of germ cell-less roles in germ line development across insect species. Dev Biol, 525:93-101 www.sciencedirect.com/science/arti...
Divergence of germ cell-less roles in germ line development across insect species
During development, sexually reproducing animals must specify and maintain the germ line, the lineage of cells that gives rise to the next generation …
www.sciencedirect.com
December 23, 2025 at 5:50 PM
Kao, J. A., Ewen-Campen, B., Extavour, C. G. (2025). Divergence of germ cell-less roles in germ line development across insect species. Dev Biol, 525:93-101 www.sciencedirect.com/science/arti...
Couto-Lima, C. A., Saari, S., Garcia, G. S., Rocha, G. H., Ten Hoeve, J., Dufour, E., Oliveira, M. T. (2025). Impairment of Muscle Function Causes Pupal Lethality in Flies Expressing the Mitochondrial Alternative Oxidase. Biomolecules, 15(4) pmc.ncbi.nlm.nih.gov/articles/PMC...
December 22, 2025 at 10:52 PM
Couto-Lima, C. A., Saari, S., Garcia, G. S., Rocha, G. H., Ten Hoeve, J., Dufour, E., Oliveira, M. T. (2025). Impairment of Muscle Function Causes Pupal Lethality in Flies Expressing the Mitochondrial Alternative Oxidase. Biomolecules, 15(4) pmc.ncbi.nlm.nih.gov/articles/PMC...
xKnop, M., Treitz, C., Bettendorf, S., ...., R. P., Baines, J. F., Tholey, A., Roeder, T. (2025). Mitochondrial sirtuin 4 shapes the intestinal microbiota of Drosophila by controlling lysozyme expression. Anim Microbiome link.springer.com/article/10.1...
Mitochondrial sirtuin 4 shapes the intestinal microbiota of Drosophila by controlling lysozyme expression - Animal Microbiome
Background Sirtuins are deacetylases that are highly conserved throughout the animal kingdom. They act as metabolic sensors that coordinate cellular responses, allowing an adapted response to various ...
link.springer.com
December 22, 2025 at 10:49 PM
xKnop, M., Treitz, C., Bettendorf, S., ...., R. P., Baines, J. F., Tholey, A., Roeder, T. (2025). Mitochondrial sirtuin 4 shapes the intestinal microbiota of Drosophila by controlling lysozyme expression. Anim Microbiome link.springer.com/article/10.1...
Zanco, B., Morimoto, J., Cockerell, F., Mirth, C., Sgro, C. M. (2025). Nutritional optima for life-history traits vary with temperature and across locally-adapted populations. J Insect Physiol, 163:104815 www.sciencedirect.com/science/arti...
Nutritional optima for life-history traits vary with temperature and across locally-adapted populations
As the climate changes, populations must overcome more frequent and more extreme exposure to a wide range of stressors. However, our knowledge of how …
www.sciencedirect.com
December 22, 2025 at 10:47 PM
Zanco, B., Morimoto, J., Cockerell, F., Mirth, C., Sgro, C. M. (2025). Nutritional optima for life-history traits vary with temperature and across locally-adapted populations. J Insect Physiol, 163:104815 www.sciencedirect.com/science/arti...
Zhao, Y., Alexandre, C., Kelly, G., Vincent, J. P., Perez-Mockus, G. (2025). HIF-1alpha-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development. Nat Commun www.nature.com/articles/s41...
December 22, 2025 at 10:46 PM
Zhao, Y., Alexandre, C., Kelly, G., Vincent, J. P., Perez-Mockus, G. (2025). HIF-1alpha-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development. Nat Commun www.nature.com/articles/s41...
Paul, B., Merta, H., Ugrankar-Banerjee, R., Hensley, M. R., Tran, S., ..., Font-Burgada, J., Mathews, T. P., Farber, S. A., Henne, W. M. (2025). Paraoxonase-like APMAP maintains endoplasmic-reticulum-associated lipid and lipoprotein homeostasis. Dev Cell www.cell.com/developmenta...
Paraoxonase-like APMAP maintains endoplasmic-reticulum-associated lipid and lipoprotein homeostasis
Here, Paul et al. show that APMAP is an ER-localized paraoxonase-like enzyme that
suppresses lipid oxidation and redox stress at the ER network. APMAP loss leads to
ER stress, redox disruption, phosph...
www.cell.com
December 22, 2025 at 10:44 PM
Paul, B., Merta, H., Ugrankar-Banerjee, R., Hensley, M. R., Tran, S., ..., Font-Burgada, J., Mathews, T. P., Farber, S. A., Henne, W. M. (2025). Paraoxonase-like APMAP maintains endoplasmic-reticulum-associated lipid and lipoprotein homeostasis. Dev Cell www.cell.com/developmenta...
Ghosh, K., Iyer, R. K., Sood, S., Islam, M. S., Labad, J. G., Khadilkar, R. J. (2025). Genetic perturbation of cellular homeostasis regulates integrated stress response signaling to control Drosophila hematopoiesis. Biol Open, 14(7) journals.biologists.com/bio/article/...
December 22, 2025 at 10:43 PM
Ghosh, K., Iyer, R. K., Sood, S., Islam, M. S., Labad, J. G., Khadilkar, R. J. (2025). Genetic perturbation of cellular homeostasis regulates integrated stress response signaling to control Drosophila hematopoiesis. Biol Open, 14(7) journals.biologists.com/bio/article/...
Zheng, C., Zheng, J., Wang, X., Zhang, Y., Ma, X., He, L. (2025). Two-pore-domain potassium channel Sandman regulates intestinal stem cell homeostasis and tumorigenesis in Drosophila melanogaster. J Genet Genomics, www.sciencedirect.com/science/arti...
December 19, 2025 at 5:48 PM
Zheng, C., Zheng, J., Wang, X., Zhang, Y., Ma, X., He, L. (2025). Two-pore-domain potassium channel Sandman regulates intestinal stem cell homeostasis and tumorigenesis in Drosophila melanogaster. J Genet Genomics, www.sciencedirect.com/science/arti...
Dominado, N., Ye, R., Casagranda, F., Heaney, J., Siddall, N. A., Abud, H. E., Hime, G. R. (2025). Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation. Cell Death Discov, 11(1):206 www.nature.com/articles/s41...
Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation - Cell Death Discovery
Cell Death Discovery - Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation
www.nature.com
December 19, 2025 at 5:46 PM
Dominado, N., Ye, R., Casagranda, F., Heaney, J., Siddall, N. A., Abud, H. E., Hime, G. R. (2025). Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation. Cell Death Discov, 11(1):206 www.nature.com/articles/s41...
Raz, A. A., Hassan, H., Yamashita, Y. M. (2025). Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation. bioRxiv, www.biorxiv.org/content/10.1...
December 19, 2025 at 5:45 PM
Raz, A. A., Hassan, H., Yamashita, Y. M. (2025). Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation. bioRxiv, www.biorxiv.org/content/10.1...
Knudsen, C., Moriya, A., Nakato, E., Gulati, R., Akiyama, T., Nakato, H. (2025). Chondroitin sulfate regulates proliferation of Drosophila intestinal stem cells. PLoS Genet, 21(5):e1011686 journals.plos.org/plosgenetics...
Chondroitin sulfate regulates proliferation of Drosophila intestinal stem cells
Author summary The control of stem cells is important to many areas of developmental and cell biology, including cancer, stem cell therapies, and tissue regeneration following injury. The Drosophila m...
journals.plos.org
December 19, 2025 at 5:43 PM
Knudsen, C., Moriya, A., Nakato, E., Gulati, R., Akiyama, T., Nakato, H. (2025). Chondroitin sulfate regulates proliferation of Drosophila intestinal stem cells. PLoS Genet, 21(5):e1011686 journals.plos.org/plosgenetics...
Chen, Y., Sun, L. V. (2025). alphaSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis. Sci Rep, 15(1):18989 www.nature.com/articles/s41...
αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis - Scientific Reports
Scientific Reports - αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis
www.nature.com
December 19, 2025 at 5:42 PM
Chen, Y., Sun, L. V. (2025). alphaSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis. Sci Rep, 15(1):18989 www.nature.com/articles/s41...
Chen, Y., Sun, L. V. (2025). alphaSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis. Sci Rep, 15(1):18989 www.nature.com/articles/s41...
αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis - Scientific Reports
Scientific Reports - αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis
www.nature.com
December 19, 2025 at 5:40 PM
Chen, Y., Sun, L. V. (2025). alphaSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis. Sci Rep, 15(1):18989 www.nature.com/articles/s41...
Zhang, Y., Ma, P., Wang, S., Chen, S., Deng, H. (2025). Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila. Nat Commun, 16(1):4909 www.nature.com/articles/s41...
Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila - Nature Communications
Disruption of the calcium network is associated with cellular ageing. In this study, Zhang et al. show that the breakdown of mitochondria-ER contacts causes disruption of ER-mitochondrial calcium flux...
www.nature.com
December 19, 2025 at 5:39 PM
Zhang, Y., Ma, P., Wang, S., Chen, S., Deng, H. (2025). Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila. Nat Commun, 16(1):4909 www.nature.com/articles/s41...
Dewan, N., Kennington, W. J., Tomkins, J. L., Dugand, R. J. (2025). Heroic heirs: evidence for sexy and competitive sons. Evolution, academic.oup.com/evolut/artic...
Heroic heirs: evidence for sexy and competitive sons
Abstract. Leks are the quintessential example of female mate choice, yet male–male interactions at leks may predominate. How, and how much, female mate cho
academic.oup.com
December 17, 2025 at 8:40 PM
Dewan, N., Kennington, W. J., Tomkins, J. L., Dugand, R. J. (2025). Heroic heirs: evidence for sexy and competitive sons. Evolution, academic.oup.com/evolut/artic...