Robert Screaton
@roblab.bsky.social
scientist. regeneration. mitochondria. diabetes. cancer. views my own.
Reposted by Robert Screaton
Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference!
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
October 31, 2025 at 5:37 PM
Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference!
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
Reposted by Robert Screaton
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
Reposted by Robert Screaton
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
September 2, 2025 at 6:46 PM
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
this is why we put a runner on second
October 28, 2025 at 6:01 AM
this is why we put a runner on second
but the dodgers are better 😛
October 25, 2025 at 5:27 AM
but the dodgers are better 😛
Reposted by Robert Screaton
The Dome is going to collapse.
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
October 25, 2025 at 2:37 AM
The Dome is going to collapse.
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
Reposted by Robert Screaton
Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch
Untargeted metabolomics profiling of fasting blood in DPPOS reveals that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a diabetes diagnosis link.springer.com/article/10.1... 🔓
Shared and distinct metabolomics profiles associated with microvascular complications in the Diabetes Prevention Program Outcomes Study - Diabetologia
Aims/hypothesis The aim of this study was to identify shared and distinct metabolite profiles prospectively associated with nephropathy, retinopathy and neuropathy at 15 years’ follow-up among 1947 pa...
link.springer.com
October 20, 2025 at 11:19 AM
Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch
Reposted by Robert Screaton
“People with advanced lung or skin cancer who received a COVID-19 mRNA vaccine within 100 days of beginning immunotherapy lived considerably longer than those who did not… .”
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Cancer patients who got a COVID vaccine lived much longer
A groundbreaking study reveals that cancer patients who received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy lived dramatically longer than those who didn’t. Researchers from the...
www.sciencedaily.com
October 19, 2025 at 11:26 PM
“People with advanced lung or skin cancer who received a COVID-19 mRNA vaccine within 100 days of beginning immunotherapy lived considerably longer than those who did not… .”
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Reposted by Robert Screaton
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Reposted by Robert Screaton
Reposted by Robert Screaton
Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 9, 2025 at 9:43 PM
Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Reposted by Robert Screaton
🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.
www.science.org
October 8, 2025 at 8:28 PM
🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
front 3 rows half empty for an elimination game, guess they know who's going to win 📝
October 7, 2025 at 11:51 PM
front 3 rows half empty for an elimination game, guess they know who's going to win 📝
Reposted by Robert Screaton
A genetic map of human metabolism across the allele frequency spectrum
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A genetic map of human metabolism across the allele frequency spectrum - Nature Genetics
Genome-wide association analyses of 249 circulating small molecules and lipoprotein characteristics across the allele frequency spectrum in UK Biobank advance understanding of genes and pathways regulating human metabolism.
www.nature.com
October 5, 2025 at 6:39 AM
A genetic map of human metabolism across the allele frequency spectrum
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Robert Screaton
In this week's mitophagy news 🪫🗑️
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
October 5, 2025 at 12:09 PM
In this week's mitophagy news 🪫🗑️
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
Reposted by Robert Screaton
🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!
October 1, 2025 at 8:50 PM
🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!
Reposted by Robert Screaton
On Truth and Reconciliation Day, we wear orange to honour survivors of residential schools and remember those who we lost. Reconciliation is ongoing work, and we remain committed to listening, learning, and walking together with respect.
#EveryChildMatters #OrangeShirtDay #TruthAndReconciliation
#EveryChildMatters #OrangeShirtDay #TruthAndReconciliation
September 30, 2025 at 3:50 PM
On Truth and Reconciliation Day, we wear orange to honour survivors of residential schools and remember those who we lost. Reconciliation is ongoing work, and we remain committed to listening, learning, and walking together with respect.
#EveryChildMatters #OrangeShirtDay #TruthAndReconciliation
#EveryChildMatters #OrangeShirtDay #TruthAndReconciliation
Reposted by Robert Screaton
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
September 30, 2025 at 4:45 PM
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
Reposted by Robert Screaton
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 5:50 AM
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Robert Screaton
Reposted by Robert Screaton
HHMI adopts Plan U journals.plos.org/plosbiology/...
September 24, 2025 at 6:08 PM
HHMI adopts Plan U journals.plos.org/plosbiology/...
Reposted by Robert Screaton
I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.
September 20, 2025 at 1:39 PM
I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.