Robert Screaton
@roblab.bsky.social
scientist. regeneration. mitochondria. diabetes. cancer. views my own.
The 6th Annual 🇨🇦 National Graduate Course in #Islet Biology and #Diabetes hosted at @utoronto.ca kicks off today with 21 students and 30 outstanding lecturers from around the world. Today Drs. Wicklow and Gerstein will talk about #T2D and GDM in indigenous populations and the latest on #remission.
a man in front of a microphone with the words we 're back on his face
Alt: Neil deGrasse Tyson in front of a microphone mouthing the words "We're Back"
media.tenor.com
January 7, 2026 at 5:32 PM
The 6th Annual 🇨🇦 National Graduate Course in #Islet Biology and #Diabetes hosted at @utoronto.ca kicks off today with 21 students and 30 outstanding lecturers from around the world. Today Drs. Wicklow and Gerstein will talk about #T2D and GDM in indigenous populations and the latest on #remission.
Reposted by Robert Screaton
Study shows that neonatal #betacells sense gut microbiota-derived #bileacids via #FXR, limiting their development. Declining postnatal beta cell FXR expression allows normal neonatal beta cell growth and reduces #diabetes risk link.springer.com/article/10.1...
link.springer.com
December 22, 2025 at 4:40 PM
Study shows that neonatal #betacells sense gut microbiota-derived #bileacids via #FXR, limiting their development. Declining postnatal beta cell FXR expression allows normal neonatal beta cell growth and reduces #diabetes risk link.springer.com/article/10.1...
Reposted by Robert Screaton
(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO).
Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply
sites.wustl.edu/millmanlab/
Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply
sites.wustl.edu/millmanlab/
December 19, 2025 at 8:25 PM
(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO).
Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply
sites.wustl.edu/millmanlab/
Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply
sites.wustl.edu/millmanlab/
Reposted by Robert Screaton
Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪
#PancSky
www.nature.com/articles/s41...
#PancSky
www.nature.com/articles/s41...
Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells - Nature Communications
Here they show that PPARα-dependent mitochondrial programming promotes the differentiation of pluripotent stem cell-derived β cells. Targeting mitochondria has the potential to improve β cell replacem...
www.nature.com
December 12, 2025 at 9:52 AM
Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪
#PancSky
www.nature.com/articles/s41...
#PancSky
www.nature.com/articles/s41...
Reposted by Robert Screaton
Download our large database of postdoc fellowships in all fields of research.
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
December 13, 2025 at 1:38 PM
Download our large database of postdoc fellowships in all fields of research.
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Reposted by Robert Screaton
Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...
Spatial and morphological organization of mitochondria in neurons across a connectome
Neuronal function depends on mitochondria, but little is known about their organization across neurons. Using an electron microscopy Drosophila connectome, we uncovered quantitative rules governing th...
www.science.org
December 11, 2025 at 7:26 PM
Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...
Reposted by Robert Screaton
Our Novo Nordisk Research Chair in Equitable Care of Diabetes and Related Conditions, Dr. Baiju Shah, was interviewed about the importance of including diverse populations in research. Check out this video podcast from the T2D Network and @kristalamb.bsky.social!
www.youtube.com/watch?v=SGIG...
www.youtube.com/watch?v=SGIG...
December 1, 2025 at 8:26 PM
Our Novo Nordisk Research Chair in Equitable Care of Diabetes and Related Conditions, Dr. Baiju Shah, was interviewed about the importance of including diverse populations in research. Check out this video podcast from the T2D Network and @kristalamb.bsky.social!
www.youtube.com/watch?v=SGIG...
www.youtube.com/watch?v=SGIG...
Reposted by Robert Screaton
How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia
Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...
link.springer.com
November 26, 2025 at 12:34 PM
How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓
Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social
November 26, 2025 at 3:45 AM
Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social
Reposted by Robert Screaton
Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
November 25, 2025 at 1:40 AM
Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
Reposted by Robert Screaton
Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia
Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...
link.springer.com
November 21, 2025 at 12:51 PM
Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Reposted by Robert Screaton
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
A future star in 🇨🇦 diabetes research
Today is World Diabetes Day! Each year, we mark the day by highlighting BBDC trainees, who represent the future of diabetes research. This year, we asked why diabetes research matters to them. Mithusha Peragerasingam from the lab of Dr. @roblab.bsky.social shares her reflections below.
November 14, 2025 at 5:27 PM
A future star in 🇨🇦 diabetes research
Reposted by Robert Screaton
Diabetologia supports this year’s #WorldDiabetesDay focus on diabetes and well-being. Well-being is key to people’s lived experiences of diabetes around the world, and we were honoured to explore this through the voices of PLWD in our recent special issue link.springer.com/article/10.1...
Diabetes in four dialects: a global call for equity across lived, loved, learned and laboured experiences - Diabetologia
Diabetologia -
link.springer.com
November 14, 2025 at 9:08 AM
Diabetologia supports this year’s #WorldDiabetesDay focus on diabetes and well-being. Well-being is key to people’s lived experiences of diabetes around the world, and we were honoured to explore this through the voices of PLWD in our recent special issue link.springer.com/article/10.1...
Reposted by Robert Screaton
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
https://link.springer.com/article/10.100…
November 14, 2025 at 3:33 AM
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Reposted by Robert Screaton
During the workday, people living with #diabetes may need time for blood sugar checks, insulin and breaks.
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
November 14, 2025 at 10:20 AM
During the workday, people living with #diabetes may need time for blood sugar checks, insulin and breaks.
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
Reposted by Robert Screaton
Happening TODAY! Join us in 500 JBRC for the 7th Annual DREAM Trainee Lectureship, where Dr. Hertzel Gerstein (@mcmasteruniversity.bsky.social) will present on "Type 2 Diabetes Remission: The Quest" from 12 - 1 p.m. Don't miss this! @chrimanitoba.bsky.social @um-radyfhs.bsky.social
November 14, 2025 at 3:14 PM
Happening TODAY! Join us in 500 JBRC for the 7th Annual DREAM Trainee Lectureship, where Dr. Hertzel Gerstein (@mcmasteruniversity.bsky.social) will present on "Type 2 Diabetes Remission: The Quest" from 12 - 1 p.m. Don't miss this! @chrimanitoba.bsky.social @um-radyfhs.bsky.social
Reposted by Robert Screaton
Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference!
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
October 31, 2025 at 5:37 PM
Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference!
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
Reposted by Robert Screaton
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
Reposted by Robert Screaton
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
September 2, 2025 at 6:46 PM
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca
this is why we put a runner on second
October 28, 2025 at 6:01 AM
this is why we put a runner on second
but the dodgers are better 😛
October 25, 2025 at 5:27 AM
but the dodgers are better 😛
Reposted by Robert Screaton
The Dome is going to collapse.
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
October 25, 2025 at 2:37 AM
The Dome is going to collapse.
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
Reposted by Robert Screaton
Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch
Untargeted metabolomics profiling of fasting blood in DPPOS reveals that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a diabetes diagnosis link.springer.com/article/10.1... 🔓
Shared and distinct metabolomics profiles associated with microvascular complications in the Diabetes Prevention Program Outcomes Study - Diabetologia
Aims/hypothesis The aim of this study was to identify shared and distinct metabolite profiles prospectively associated with nephropathy, retinopathy and neuropathy at 15 years’ follow-up among 1947 pa...
link.springer.com
October 20, 2025 at 11:19 AM
Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch