Elizabeth Rideout
@ejrideout.bsky.social
My lab studies sex differences in metabolism and metabolic disease in flies and mice. #sexdifferences #Drosophila #lipid #insulin #betacell
Not going to lie…I have gotten very distracted by this feature before 😂
September 24, 2025 at 2:35 PM
Not going to lie…I have gotten very distracted by this feature before 😂
Feeling fortunate to have contributed data to this effort led by Dr Soumitra Pal, Dr Teresa Przytycka, Dr Brian Oliver, along with Dr George Vogler and Dr Frank Schnorrer. Puja in the lab also produced data on fat body cell counts.
September 20, 2025 at 2:24 PM
Feeling fortunate to have contributed data to this effort led by Dr Soumitra Pal, Dr Teresa Przytycka, Dr Brian Oliver, along with Dr George Vogler and Dr Frank Schnorrer. Puja in the lab also produced data on fat body cell counts.
Supporting and extending these data, Dr Kim Rewitz’s lab has posted a beautiful paper on this topic www.biorxiv.org/content/10.1... We were fortunate to have lots of great discussions about these data!
Gut hormone signaling drives sex differences in metabolism and behavior
Males and females have different physiological and reproductive demands, and consequently exhibit widespread differences in metabolism and behavior. One of the most consistent differences across anima...
www.biorxiv.org
September 20, 2025 at 2:07 PM
Supporting and extending these data, Dr Kim Rewitz’s lab has posted a beautiful paper on this topic www.biorxiv.org/content/10.1... We were fortunate to have lots of great discussions about these data!
There are lots of interesting questions left from this work, but we were excited to report such a strong sex difference in these cells.
September 20, 2025 at 2:07 PM
There are lots of interesting questions left from this work, but we were excited to report such a strong sex difference in these cells.
Puja’s data suggests that Tachykinin and Allatostatin C act on neurons to mediate this effect on fat storage. However, the subset of neurons upon which they act is unclear (but was not the insulin- or Akh-producing cells).
September 20, 2025 at 2:07 PM
Puja’s data suggests that Tachykinin and Allatostatin C act on neurons to mediate this effect on fat storage. However, the subset of neurons upon which they act is unclear (but was not the insulin- or Akh-producing cells).
Because these hormones affect behavior and physiology, Puja tested whether this female biss in hormone production affected fat storage. She found Tachykinin and Allatostatin C contribute to greater fat storage in female flies with no effect in males.
September 20, 2025 at 2:07 PM
Because these hormones affect behavior and physiology, Puja tested whether this female biss in hormone production affected fat storage. She found Tachykinin and Allatostatin C contribute to greater fat storage in female flies with no effect in males.
Briefly, Puja saw a strong female bias in mRNA levels of hormones produced by gut enteroendocrine cells. This sex bias was not caused by sex determination gene transformer.
September 20, 2025 at 2:07 PM
Briefly, Puja saw a strong female bias in mRNA levels of hormones produced by gut enteroendocrine cells. This sex bias was not caused by sex determination gene transformer.