Adam J Rose
@drajrose.bsky.social
Scientist studying signalling pathways & processes in metabolism and vice versa. Thoughts are my own.
Reposted by Adam J Rose
Online now: New approach methodologies: Don’t throw the baby out with the bathwater
New approach methodologies: Don’t throw the baby out with the bathwater
The NIH has recently called for expanding use of new approach methodologies (NAMs) to reduce use of animals in research. Arany discusses the need not to forget the irreplaceable aspects of animal research and their fundamental importance to biomedical advancement.
dlvr.it
February 11, 2026 at 7:50 PM
Online now: New approach methodologies: Don’t throw the baby out with the bathwater
Reposted by Adam J Rose
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
January 16, 2026 at 4:27 PM
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
Reposted by Adam J Rose
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
January 13, 2026 at 4:12 PM
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
Reposted by Adam J Rose
Excited to share our latest research, out today in Cell (@cellpress.bsky.social)
Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling.
Read the paper here: doi.org/10.1016/j.ce...
Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling.
Read the paper here: doi.org/10.1016/j.ce...
January 9, 2026 at 7:11 AM
Excited to share our latest research, out today in Cell (@cellpress.bsky.social)
Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling.
Read the paper here: doi.org/10.1016/j.ce...
Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling.
Read the paper here: doi.org/10.1016/j.ce...
Reposted by Adam J Rose
"I'm very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that's something to prioritize. It does go against decades and decades of evidence and research," says Christopher Gardner, a nutrition expert at Stanford University.”
RFK Jr.'s new food pyramid puts meat, cheese and vegetables at the top
Health Secretary Robert F. Kennedy Jr. has announced new dietary guidelines for Americans focused on promoting whole foods, healthy proteins and fats. And he has "declare[d] war" on added sugar.
www.npr.org
January 7, 2026 at 10:15 PM
"I'm very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that's something to prioritize. It does go against decades and decades of evidence and research," says Christopher Gardner, a nutrition expert at Stanford University.”
Reposted by Adam J Rose
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism
Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...
www.nature.com
December 10, 2025 at 11:13 AM
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Reposted by Adam J Rose
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Evolution of taste processing shifts dietary preference - Nature
Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...
www.nature.com
November 26, 2025 at 4:33 PM
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Reposted by Adam J Rose
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
October 29, 2025 at 12:11 PM
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
Reposted by Adam J Rose
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics
Single-cell metabolomics (SCM) can probe metabolic heterogeneity but is hindered by
low sensitivity for small molecules, limited scalability, and the lack of standardized
frameworks for data analysis....
www.cell.com
October 16, 2025 at 4:28 PM
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...
Reposted by Adam J Rose
A famous graphic, now updated, compares locomotion in the animal kingdom
The Most Efficient Traveler Isn’t a Bird or a Fish—It’s You on a Bike
A famous graphic, now updated, compares locomotion in the animal kingdom
www.scientificamerican.com
October 14, 2025 at 1:52 PM
A famous graphic, now updated, compares locomotion in the animal kingdom
Reposted by Adam J Rose
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 3, 2025 at 11:02 AM
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
Reposted by Adam J Rose
Reposted by Adam J Rose
Nominations are now open for the AuPS Publication Prizes — and they close on 15 October 2025.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
a gold trophy with a laurel wreath around it and the words well done on a gold ribbon
ALT: a gold trophy with a laurel wreath around it and the words well done on a gold ribbon
media.tenor.com
September 23, 2025 at 6:46 AM
Nominations are now open for the AuPS Publication Prizes — and they close on 15 October 2025.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
Reposted by Adam J Rose
RACMEM 2025
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Home | RACMEM
Recent Advances and Controversies in the Measurement of Energy Metabolism
www.racmem.com
September 23, 2025 at 8:20 AM
RACMEM 2025
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Reposted by Adam J Rose
Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/
Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice
Loss of lean mass is a potential concern for semaglutide-induced weight loss. This
study indicates that semaglutide has unexpected effects on skeletal muscle mass and
strength in mice, demonstrating a...
www.cell.com
August 6, 2025 at 5:29 AM
Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/
Reposted by Adam J Rose
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 17, 2025 at 3:45 PM
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adam J Rose
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 17, 2025 at 7:24 PM
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adam J Rose
Based on studies of mice with increased energy expenditure the authors propose myeloid CAMKK2 as a key regulator of macrophage function and a potential therapeutic target for treating #obesity and related metabolic disorders www.sciencedirect.com/science/arti...
September 13, 2025 at 10:48 PM
Based on studies of mice with increased energy expenditure the authors propose myeloid CAMKK2 as a key regulator of macrophage function and a potential therapeutic target for treating #obesity and related metabolic disorders www.sciencedirect.com/science/arti...
Reposted by Adam J Rose
This is a friendly reminder that early-bird registration and abstract submission for the 2025 AuPS annual meeting hosted by the University of Western Sydney in Paramatta is open until Friday 12/09/2025. Nominations for our prizes, grants and awards are also due tomorrow- exception Publication prize
September 11, 2025 at 4:53 AM
This is a friendly reminder that early-bird registration and abstract submission for the 2025 AuPS annual meeting hosted by the University of Western Sydney in Paramatta is open until Friday 12/09/2025. Nominations for our prizes, grants and awards are also due tomorrow- exception Publication prize
Reposted by Adam J Rose
An excellent write-up on our collective obsession with PROTEIN! by @erictopol.bsky.social.
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
Our Preoccupation With Protein Intake
The data on high protein diets, bars, supplements, and powders will surprise you
open.substack.com
September 5, 2025 at 5:42 PM
An excellent write-up on our collective obsession with PROTEIN! by @erictopol.bsky.social.
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
Reposted by Adam J Rose
An amygdala–liver axis that regulates rapid glycaemic adaptations to stress and links recurrent stress to metabolic dysfunction www.nature.com/articles/s41...
Amygdala–liver signalling orchestrates glycaemic responses to stress - Nature
Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independen...
www.nature.com
September 3, 2025 at 3:18 PM
An amygdala–liver axis that regulates rapid glycaemic adaptations to stress and links recurrent stress to metabolic dysfunction www.nature.com/articles/s41...
Reposted by Adam J Rose
Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids
go.nature.com/3V8r3Lw
go.nature.com/3V8r3Lw
Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature
Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth.
go.nature.com
August 24, 2025 at 3:00 PM
Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids
go.nature.com/3V8r3Lw
go.nature.com/3V8r3Lw
Reposted by Adam J Rose
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...
Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications
Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...
www.nature.com
August 4, 2025 at 7:27 PM
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...
Reposted by Adam J Rose
The 2025 AuPS Annual Meeting is open for registration and abstract submissions!
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au
July 30, 2025 at 1:02 AM
The 2025 AuPS Annual Meeting is open for registration and abstract submissions!
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au