Irfan Lodhi
@lodhilab.bsky.social
Professor of Medicine at Washington University| Studying lipid metabolism| Adipocyte Biology, BAT, Diabetes, NAFLD, Obesity, Peroxisomes| PhD UMICH
Pinned
Irfan Lodhi
@lodhilab.bsky.social
· Sep 17
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Irfan Lodhi
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 17, 2025 at 7:24 PM
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 17, 2025 at 3:45 PM
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Irfan Lodhi
Channel 2, 4, 5, and 13 as well as a few local newspapers reached out to me today regarding our study on semaglutide we published in Cell Metabolism last week.
This interview is from NBC/KSL.
This interview is from NBC/KSL.
Weight loss drugs: Utah study in mice finds 'unexpected' effects
Weight loss drugs and muscle mass are at the center of a new Utah study.
ksltv.com
August 12, 2025 at 4:13 AM
Channel 2, 4, 5, and 13 as well as a few local newspapers reached out to me today regarding our study on semaglutide we published in Cell Metabolism last week.
This interview is from NBC/KSL.
This interview is from NBC/KSL.
Congratulations, Katsu! Look forward to reading this.
Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/
Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice
Loss of lean mass is a potential concern for semaglutide-induced weight loss. This
study indicates that semaglutide has unexpected effects on skeletal muscle mass and
strength in mice, demonstrating a...
www.cell.com
August 8, 2025 at 1:38 AM
Congratulations, Katsu! Look forward to reading this.
Reposted by Irfan Lodhi
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 21, 2025 at 6:21 PM
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Reposted by Irfan Lodhi
Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340
jci.org/articles/view/185340
March 19, 2025 at 1:41 PM
Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340
jci.org/articles/view/185340
Reposted by Irfan Lodhi
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Irfan Lodhi
This is as good an introduction as any - the reason why I am here. #StandUpForScience. Nice to see you all.
March 8, 2025 at 5:23 AM
This is as good an introduction as any - the reason why I am here. #StandUpForScience. Nice to see you all.