Lamming Lab
@lamminglab.bsky.social
The Molecular Physiology of Aging in Madison, WI.
All views that of Dr. Lamming and do not necessarily reflect that of my employers, funders, or societies. Retweet≠Endorse.
http://www.lamminglab.org/
All views that of Dr. Lamming and do not necessarily reflect that of my employers, funders, or societies. Retweet≠Endorse.
http://www.lamminglab.org/
Perhaps the most important paper of the decade with respect to how cells sense amino acid insufficiency, finally laying to rest the idea that GCN2 is activated by uncharged tRNAs!
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 3, 2025 at 12:07 PM
Perhaps the most important paper of the decade with respect to how cells sense amino acid insufficiency, finally laying to rest the idea that GCN2 is activated by uncharged tRNAs!
We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...
September 12, 2025 at 2:23 PM
We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...
Our most recent work by graduate student @mariahcalubag
- demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!
- demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!
September 5, 2025 at 2:22 PM
Our most recent work by graduate student @mariahcalubag
- demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!
- demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...
Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications
Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...
www.nature.com
August 4, 2025 at 7:27 PM
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...
I am pleased to report our new manuscript from graduate student Mariah Calubag and collaborators and colleagues, "Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids" is now available! onlinelibrary.wiley.com/doi/10.1111/...
July 29, 2025 at 1:28 PM
I am pleased to report our new manuscript from graduate student Mariah Calubag and collaborators and colleagues, "Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids" is now available! onlinelibrary.wiley.com/doi/10.1111/...
Pleased to announce the last major project from former graduate student Dr. Babygirija is now available on biorxiv - "Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice" www.biorxiv.org/content/10.1...
Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimers disease in 3xTg mice
Dietary protein is a critical regulator of metabolic health and aging in diverse species. Recent discoveries have determined that many benefits of a low protein diet are the result of reduced consumpt...
www.biorxiv.org
July 27, 2025 at 3:17 PM
Pleased to announce the last major project from former graduate student Dr. Babygirija is now available on biorxiv - "Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice" www.biorxiv.org/content/10.1...
Another win for rapamycin: www.nature.com/articles/s41...
Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery - Scientific Reports
Scientific Reports - Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery
www.nature.com
June 9, 2025 at 11:54 AM
Another win for rapamycin: www.nature.com/articles/s41...
Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...
www.legacy.com/us/obituarie...
THOMAS BLACKWELL Obituary (1957 - 2025-05-09) - Boston, MA - Boston Globe
View THOMAS KEITH BLACKWELL's obituary, send flowers and sign the guestbook.
www.legacy.com
May 30, 2025 at 1:09 PM
Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...
www.legacy.com/us/obituarie...
Reposted by Lamming Lab
Excited to collaborate with Caroline Alexander’s group and @lamminglab.bsky.social demonstrating the contribution of dietary lipids to skin lipids and their insulating properties. Proud of Raghav for leading this collaboration in my lab!
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Dietary lipids are largely deposited in skin and rapidly affect insulating properties - Nature Communications
The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target...
www.nature.com
May 16, 2025 at 9:32 PM
Excited to collaborate with Caroline Alexander’s group and @lamminglab.bsky.social demonstrating the contribution of dietary lipids to skin lipids and their insulating properties. Proud of Raghav for leading this collaboration in my lab!
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Reposted by Lamming Lab
Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social
Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15) breaks down bis(monoacylglycerol)phosphate (BMP) lipids to shift lysosomal function and metabolism in response to direct transcription factor EB regulation.
dlvr.it
May 15, 2025 at 12:06 PM
Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social
Reposted by Lamming Lab
Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15) breaks down bis(monoacylglycerol)phosphate (BMP) lipids to shift lysosomal function and metabolism in response to direct transcription factor EB regulation.
dlvr.it
May 14, 2025 at 3:42 PM
Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...
May 16, 2025 at 8:15 PM
Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...
Reposted by Lamming Lab
New in GeroScience, "A machine learning approach for quantifying age-related histological changes in the mouse kidney" with Susan Sheehan, Seamus Mawe, Mandy Chen,
Ron Korstanje & J Matthew Mahoney 🧪🤝🖥️ 🧬 #machinelearning #ArtificialIntelligence:
link.springer.com/article/10.1...
Ron Korstanje & J Matthew Mahoney 🧪🤝🖥️ 🧬 #machinelearning #ArtificialIntelligence:
link.springer.com/article/10.1...
A machine learning approach for quantifying age-related histological changes in the mouse kidney - G...
The ability to quantify aging-related changes in histological samples is important, as it allows for evaluation of interventions intended to effect health span. We used a machine learning architecture...
link.springer.com
January 11, 2024 at 7:48 PM
New in GeroScience, "A machine learning approach for quantifying age-related histological changes in the mouse kidney" with Susan Sheehan, Seamus Mawe, Mandy Chen,
Ron Korstanje & J Matthew Mahoney 🧪🤝🖥️ 🧬 #machinelearning #ArtificialIntelligence:
link.springer.com/article/10.1...
Ron Korstanje & J Matthew Mahoney 🧪🤝🖥️ 🧬 #machinelearning #ArtificialIntelligence:
link.springer.com/article/10.1...
Heading to the @americanaging.bsky.social meeting with @mattyousefzadeh.bsky.social and Holly Brown-Borg!
May 10, 2025 at 10:51 PM
Heading to the @americanaging.bsky.social meeting with @mattyousefzadeh.bsky.social and Holly Brown-Borg!
It was an honor yesterday to hood graduate student Reji Babygirija and escort her at commencement. Big thanks to the keynote speaker for our hooding ceremony Dr. Christine Whelan who gave a highly inspiring and impactful address!
May 10, 2025 at 2:26 PM
It was an honor yesterday to hood graduate student Reji Babygirija and escort her at commencement. Big thanks to the keynote speaker for our hooding ceremony Dr. Christine Whelan who gave a highly inspiring and impactful address!
Catching up on the week - awesome @AgingMidwest
meeting in Rochester, MN! Congrats to @baileyknopf
for a terrific talk and winning a travel award, and @iCCup_Spec
for winning a poster award!
meeting in Rochester, MN! Congrats to @baileyknopf
for a terrific talk and winning a travel award, and @iCCup_Spec
for winning a poster award!
April 25, 2025 at 8:58 PM
Catching up on the week - awesome @AgingMidwest
meeting in Rochester, MN! Congrats to @baileyknopf
for a terrific talk and winning a travel award, and @iCCup_Spec
for winning a poster award!
meeting in Rochester, MN! Congrats to @baileyknopf
for a terrific talk and winning a travel award, and @iCCup_Spec
for winning a poster award!
Reposted by Lamming Lab
I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology
Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...
www.nature.com
March 26, 2025 at 2:02 PM
I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lamming Lab
It looks like the bill posted this morning (Saturday)-to be voted on next week-will cut the BRAIN Iniitiative and All Of Us by proposing a 69% reduction in funding for the NIH Innovation Account (CURES Act) by reducing its allocation from $407 million to $127 million.
rules.house.gov/sites/evo-su...
rules.house.gov/sites/evo-su...
March 8, 2025 at 6:49 PM
It looks like the bill posted this morning (Saturday)-to be voted on next week-will cut the BRAIN Iniitiative and All Of Us by proposing a 69% reduction in funding for the NIH Innovation Account (CURES Act) by reducing its allocation from $407 million to $127 million.
rules.house.gov/sites/evo-su...
rules.house.gov/sites/evo-su...
Reposted by Lamming Lab
Happy to have made a contribution to these important studies detailing the effects of dietary protein restriction on food intake, metabolism and adipose tissue in young men
March 7, 2025 at 2:17 AM
Happy to have made a contribution to these important studies detailing the effects of dietary protein restriction on food intake, metabolism and adipose tissue in young men
Reposted by Lamming Lab
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Pleased to announce our lab's latest pre-print by graduate student Mariah Calubag "Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids" www.biorxiv.org/content/10.1...
Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids
Dietary protein is a key regulator of healthy aging in both mice and humans. In mice, reducing dietary levels of the branched-chain amino acids (BCAAs) recapitulates many of the benefits of a low prot...
www.biorxiv.org
January 17, 2025 at 4:17 PM
Pleased to announce our lab's latest pre-print by graduate student Mariah Calubag "Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids" www.biorxiv.org/content/10.1...
With the end of the year upon us, it's time for the 2024 @LammingLab year in review! Some of our accomplishments and successes are described in the thread below.
December 31, 2024 at 1:31 PM
With the end of the year upon us, it's time for the 2024 @LammingLab year in review! Some of our accomplishments and successes are described in the thread below.
Reposted by Lamming Lab
New paper! Maternal age and offspring diet interact to change reproductive timing, with consequences for fitness.
#aging #gerosky #evosky
besjournals.onlinelibrary.wiley.com/doi/full/10....
#aging #gerosky #evosky
besjournals.onlinelibrary.wiley.com/doi/full/10....
Maternal effect senescence and caloric restriction interact to affect fitness through changes in life history timing
With matrix models and individual life histories, this study shows that maternal effect senescence - reduced offspring quality for older mothers - and caloric restriction interact to to affect fitnes...
besjournals.onlinelibrary.wiley.com
December 4, 2024 at 1:51 AM
New paper! Maternal age and offspring diet interact to change reproductive timing, with consequences for fitness.
#aging #gerosky #evosky
besjournals.onlinelibrary.wiley.com/doi/full/10....
#aging #gerosky #evosky
besjournals.onlinelibrary.wiley.com/doi/full/10....
Reposted by Lamming Lab
Trainees: Show your PIs the raw data, not just the summary result.
PIs: Look at the raw data. 🤓
🧪
PIs: Look at the raw data. 🤓
🧪
December 3, 2024 at 8:50 PM
Trainees: Show your PIs the raw data, not just the summary result.
PIs: Look at the raw data. 🤓
🧪
PIs: Look at the raw data. 🤓
🧪
Reposted by Lamming Lab
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging 🧪
great work from @lamminglab.bsky.social
www.nature.com/articles/s43...
great work from @lamminglab.bsky.social
www.nature.com/articles/s43...
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging
Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorp...
www.nature.com
December 1, 2024 at 6:30 AM
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging 🧪
great work from @lamminglab.bsky.social
www.nature.com/articles/s43...
great work from @lamminglab.bsky.social
www.nature.com/articles/s43...