David Sünderhauf
@davvi36.bsky.social
Microbiologist at the University of Exeter: AMR🧫 | Loves plasmids & MGEs | Green Councillor on Truro City Council 🌿 | Would love to do more sci-comm in Cornwall 〓〓 | he/him
Promoted by David Sünderhauf (Green Party), at 17 Great George St, Bristol BS1 5
Promoted by David Sünderhauf (Green Party), at 17 Great George St, Bristol BS1 5
Pinned
David Sünderhauf
@davvi36.bsky.social
· May 12
I *finally* get to share our work on plasmid competition– super proud to now have this on bioRxiv:
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
I thoroughly enjoyed visiting the @biology.ox.ac.uk department - thanks so much for hosting me @annadewar.bsky.social !
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
November 7, 2025 at 5:40 PM
I thoroughly enjoyed visiting the @biology.ox.ac.uk department - thanks so much for hosting me @annadewar.bsky.social !
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
Reposted by David Sünderhauf
Great to have Dr David Sünderhauf visit Oxford over the past couple of days!
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
November 7, 2025 at 4:22 PM
Great to have Dr David Sünderhauf visit Oxford over the past couple of days!
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
Reposted by David Sünderhauf
New publication in @microbiologysociety.org "Seaweed exposure modulates Escherichia coli plasmid conjugation rate."
www.microbiologyresearch.org/content/jour...
#AMR #AntiMicrobialResistance #seaweed
Authors: David Sünderhauf, Macaulay Winter, Jasmine Ramshaw, Emily Stevenson and Michiel Vos.
www.microbiologyresearch.org/content/jour...
#AMR #AntiMicrobialResistance #seaweed
Authors: David Sünderhauf, Macaulay Winter, Jasmine Ramshaw, Emily Stevenson and Michiel Vos.
October 30, 2025 at 2:54 PM
New publication in @microbiologysociety.org "Seaweed exposure modulates Escherichia coli plasmid conjugation rate."
www.microbiologyresearch.org/content/jour...
#AMR #AntiMicrobialResistance #seaweed
Authors: David Sünderhauf, Macaulay Winter, Jasmine Ramshaw, Emily Stevenson and Michiel Vos.
www.microbiologyresearch.org/content/jour...
#AMR #AntiMicrobialResistance #seaweed
Authors: David Sünderhauf, Macaulay Winter, Jasmine Ramshaw, Emily Stevenson and Michiel Vos.
Reposted by David Sünderhauf
We tried to place this story - very expensive polling, the first of its kind, strong quantitative data about what trans people feel about Britain: bluntly there is no better way to tell the story - with the BBC but it said it was "too weak".
But it will pick up any old piece of transhating garbage.
But it will pick up any old piece of transhating garbage.
In @yougov.co.uk polling of the trans community, to the best of our knowledge the first of its kind ever conducted, an astonishing 84% said Britain is “fairly unsafe” or “very unsafe” for trans people.
goodlaw.social/ncfw
goodlaw.social/ncfw
‘Abject terror’: survey shows 84% of trans people feel Britain is unsafe
YouGov poll reveals safety crisis for trans people in the UK
goodlaw.social
October 28, 2025 at 8:00 AM
We tried to place this story - very expensive polling, the first of its kind, strong quantitative data about what trans people feel about Britain: bluntly there is no better way to tell the story - with the BBC but it said it was "too weak".
But it will pick up any old piece of transhating garbage.
But it will pick up any old piece of transhating garbage.
Reposted by David Sünderhauf
Reposted by David Sünderhauf
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
October 15, 2025 at 1:07 PM
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
Reposted by David Sünderhauf
Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab!
For more information and how to apply, see below 👇
Please RT!
For more information and how to apply, see below 👇
Please RT!
📢 The #HIRI is looking for a #postdoc & a #PhD student to join the research group of @jenshoer.bsky.social. His lab focuses on understanding the molecular mechanisms of #phages with #RNA genomes during infection, host takeover & anti-phage defense. 🧫🦠 More info: www.helmholtz-hiri.de/en/jobs-tale...
Working at HIRI
At the HIRI, we do not just value excellent research. Short distances, an open door policy, and a good working atmosphere—this is what distinguishes us from others. Have a look at our current job…
www.helmholtz-hiri.de
October 17, 2025 at 12:52 PM
Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab!
For more information and how to apply, see below 👇
Please RT!
For more information and how to apply, see below 👇
Please RT!
Reposted by David Sünderhauf
New paper alert! Seaweeds affect plasmid conjugation rates. Insight into the effect of biotic factors on HGT. @microbiologysociety.org
@davvi36.bsky.social www.microbiologyresearch.org/content/jour...
@davvi36.bsky.social www.microbiologyresearch.org/content/jour...
Seaweed exposure modulates Escherichia coli plasmid conjugation rate
Seaweeds are a common and diverse component of coastal ecosystems and are known to be associated with Escherichia coli due to faecal pollution. As a biotic substrate, beach-cast seaweed may affect bac...
www.microbiologyresearch.org
October 15, 2025 at 8:27 AM
New paper alert! Seaweeds affect plasmid conjugation rates. Insight into the effect of biotic factors on HGT. @microbiologysociety.org
@davvi36.bsky.social www.microbiologyresearch.org/content/jour...
@davvi36.bsky.social www.microbiologyresearch.org/content/jour...
Reposted by David Sünderhauf
New pre-print: Eco-evolutionary responses of phage to different thermal regimes.
Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
1/2
www.biorxiv.org/content/10.1...
Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
1/2
www.biorxiv.org/content/10.1...
Evolutionary rescue accelerates competitive exclusion in a parasite community
Environmental stress drives biodiversity loss by altering competitive hierarchies and pushing taxa towards extinction. Parasites and their communities are particularly vulnerable to stress due to envi...
www.biorxiv.org
September 29, 2025 at 1:54 PM
New pre-print: Eco-evolutionary responses of phage to different thermal regimes.
Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
1/2
www.biorxiv.org/content/10.1...
Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
1/2
www.biorxiv.org/content/10.1...
I'm just trying to find a plasmid term and now Google's AI thinks I'm having a meltdown over grammar 😭
September 8, 2025 at 3:36 PM
I'm just trying to find a plasmid term and now Google's AI thinks I'm having a meltdown over grammar 😭
Reposted by David Sünderhauf
Searching for a PhD in Microbiology? 🦠
Prof Stineke van Houte& @davvi36.bsky.social are looking for a prospective PhD student to start in October 2026 who is excited about bacteria, how they interact, and how they exchange DNA with each other.
Deadline 20.10.25.
gw4biomed.ac.uk/developing-c...
Prof Stineke van Houte& @davvi36.bsky.social are looking for a prospective PhD student to start in October 2026 who is excited about bacteria, how they interact, and how they exchange DNA with each other.
Deadline 20.10.25.
gw4biomed.ac.uk/developing-c...
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a ...
gw4biomed.ac.uk
September 2, 2025 at 12:23 PM
Searching for a PhD in Microbiology? 🦠
Prof Stineke van Houte& @davvi36.bsky.social are looking for a prospective PhD student to start in October 2026 who is excited about bacteria, how they interact, and how they exchange DNA with each other.
Deadline 20.10.25.
gw4biomed.ac.uk/developing-c...
Prof Stineke van Houte& @davvi36.bsky.social are looking for a prospective PhD student to start in October 2026 who is excited about bacteria, how they interact, and how they exchange DNA with each other.
Deadline 20.10.25.
gw4biomed.ac.uk/developing-c...
Reposted by David Sünderhauf
Preprint: De-novo design of proteins that inhibit bacterial defenses
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection
Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...
www.biorxiv.org
September 2, 2025 at 10:48 AM
Preprint: De-novo design of proteins that inhibit bacterial defenses
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
PhD opportunity, please share:
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a ...
gw4biomed.ac.uk
September 2, 2025 at 9:48 AM
PhD opportunity, please share:
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
Reposted by David Sünderhauf
Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨
👉 www.nature.com/articles/s41...
@cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social
👉 www.nature.com/articles/s41...
@cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social
Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli - Nature Communications
pOXA-48 plasmids have emerged as key vectors of carbapenem resistance within Enterobacteriaceae. In this study, the authors use a transposon sequencing (Tn-seq) approach to identify genetic determinan...
www.nature.com
August 20, 2025 at 3:19 PM
Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨
👉 www.nature.com/articles/s41...
@cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social
👉 www.nature.com/articles/s41...
@cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social
Reposted by David Sünderhauf
#phagesky
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
August 19, 2025 at 8:11 AM
#phagesky
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
Reposted by David Sünderhauf
New paper out! 🔈🔈📣📣
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation
Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...
www.biorxiv.org
August 13, 2025 at 6:26 AM
New paper out! 🔈🔈📣📣
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Reposted by David Sünderhauf
🧬💊Our new paper in @ismepublications.bsky.social🧬💊
"Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance"
In collaboration with @umweltbundesamt.bsky.social
Read the thread below:
academic.oup.com/ismej/advanc...
#AMR
1/9
"Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance"
In collaboration with @umweltbundesamt.bsky.social
Read the thread below:
academic.oup.com/ismej/advanc...
#AMR
1/9
Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance
Abstract. Selection for antibiotic resistance has been demonstrated at low, environmentally relevant antibiotic concentrations. The concept of minimum sele
academic.oup.com
August 11, 2025 at 11:57 AM
🧬💊Our new paper in @ismepublications.bsky.social🧬💊
"Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance"
In collaboration with @umweltbundesamt.bsky.social
Read the thread below:
academic.oup.com/ismej/advanc...
#AMR
1/9
"Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance"
In collaboration with @umweltbundesamt.bsky.social
Read the thread below:
academic.oup.com/ismej/advanc...
#AMR
1/9
Phage resistance research position with a fantastic supervisor 👇
Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...
www.jobbnorge.no/en/available...
Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway
Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025
www.jobbnorge.no
August 8, 2025 at 8:13 AM
Phage resistance research position with a fantastic supervisor 👇
Reposted by David Sünderhauf
Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...
www.jobbnorge.no/en/available...
Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway
Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025
www.jobbnorge.no
August 8, 2025 at 7:52 AM
Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...
www.jobbnorge.no/en/available...
Brilliant idea!
Want to name a real virus? I have recently discovered 9 new phages which now need names! To enter, you simply need to donate to the Cystic Fibrosis Trust on my JustGiving page (£2 = 1 entry) and share your email with me on donation (see link info). Please share 💚 www.justgiving.com/page/meaghan-c-1
August 5, 2025 at 4:07 PM
Brilliant idea!
Reposted by David Sünderhauf
Want to name a real virus? I have recently discovered 9 new phages which now need names! To enter, you simply need to donate to the Cystic Fibrosis Trust on my JustGiving page (£2 = 1 entry) and share your email with me on donation (see link info). Please share 💚 www.justgiving.com/page/meaghan-c-1
August 5, 2025 at 12:45 PM
Want to name a real virus? I have recently discovered 9 new phages which now need names! To enter, you simply need to donate to the Cystic Fibrosis Trust on my JustGiving page (£2 = 1 entry) and share your email with me on donation (see link info). Please share 💚 www.justgiving.com/page/meaghan-c-1
Plasmid leading regions & their contribution to plasmid establishment are all the rage in the plasmid world right now. This review summarizes why 👉 www.sciencedirect.com/science/arti...
Strategies for zygotic gene expression during plasmid establishment
Conjugative plasmids are key drivers of horizontal gene transfer and the spread of antimicrobial resistance. Their successful establishment in new hos…
www.sciencedirect.com
July 24, 2025 at 10:47 AM
Plasmid leading regions & their contribution to plasmid establishment are all the rage in the plasmid world right now. This review summarizes why 👉 www.sciencedirect.com/science/arti...
Please share! 🦠
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
July 22, 2025 at 7:03 PM
Please share! 🦠
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Reposted by David Sünderhauf
New manuscript from the group
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium , but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of t...
www.biorxiv.org
July 17, 2025 at 8:39 AM
New manuscript from the group
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
Reposted by David Sünderhauf
New paper with @rwheatley8.bsky.social and Cedric Lood
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Chromosomal capture of beneficial genes drives plasmids toward ecological redundancy
Abstract. Plasmids are a ubiquitous feature of bacterial genomes, but the forces driving genes and phenotypes to become associated with plasmids are poorly
academic.oup.com
July 16, 2025 at 9:17 AM
New paper with @rwheatley8.bsky.social and Cedric Lood
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...