David Sünderhauf
@davvi36.bsky.social
Microbiologist at the University of Exeter: AMR🧫 | Loves plasmids & MGEs | Green Councillor on Truro City Council 🌿 | Would love to do more sci-comm in Cornwall 〓〓 | he/him
Promoted by David Sünderhauf (Green Party), at 17 Great George St, Bristol BS1 5
Promoted by David Sünderhauf (Green Party), at 17 Great George St, Bristol BS1 5
I thoroughly enjoyed visiting the @biology.ox.ac.uk department - thanks so much for hosting me @annadewar.bsky.social !
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
November 7, 2025 at 5:40 PM
I thoroughly enjoyed visiting the @biology.ox.ac.uk department - thanks so much for hosting me @annadewar.bsky.social !
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
And thanks to everyone who chatted to me about plasmids, genomes, and more.
I even manage to find a phage in the natural history museum before leaving :)
I'm just trying to find a plasmid term and now Google's AI thinks I'm having a meltdown over grammar 😭
September 8, 2025 at 3:36 PM
I'm just trying to find a plasmid term and now Google's AI thinks I'm having a meltdown over grammar 😭
Please share! 🦠
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
July 22, 2025 at 7:03 PM
Please share! 🦠
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
. @emgoodall.bsky.social presenting her cool new transposon-based method on discovery of novel small proteins #EESMicrobiology
June 24, 2025 at 1:31 PM
. @emgoodall.bsky.social presenting her cool new transposon-based method on discovery of novel small proteins #EESMicrobiology
Made it to Heidelberg for #EESMicrobiology @events.embl.org!
Find me at poster 240 and make to check out @annaolina.bsky.social & @alekseiagapov.bsky.social 's posters and @emgoodall.bsky.social 's talk to see everyone from the lab 😁
Find me at poster 240 and make to check out @annaolina.bsky.social & @alekseiagapov.bsky.social 's posters and @emgoodall.bsky.social 's talk to see everyone from the lab 😁
June 24, 2025 at 11:25 AM
Made it to Heidelberg for #EESMicrobiology @events.embl.org!
Find me at poster 240 and make to check out @annaolina.bsky.social & @alekseiagapov.bsky.social 's posters and @emgoodall.bsky.social 's talk to see everyone from the lab 😁
Find me at poster 240 and make to check out @annaolina.bsky.social & @alekseiagapov.bsky.social 's posters and @emgoodall.bsky.social 's talk to see everyone from the lab 😁
That sounds rough as hell, sorry you're both going through that.
Ask and LGH shall deliver 😌
Ask and LGH shall deliver 😌
May 13, 2025 at 7:42 AM
That sounds rough as hell, sorry you're both going through that.
Ask and LGH shall deliver 😌
Ask and LGH shall deliver 😌
CRISPRs on plasmids are great in defence, but in offence limited by TA – this helps explain how bacterial immune systems act & informs use of CRISPR technology.
Big thanks also to co-authors Jahn Ringger, Rafa Pinilla-Redondo, @willhgaze.bsky.social, and of course Stineke van Houte
6/6
Big thanks also to co-authors Jahn Ringger, Rafa Pinilla-Redondo, @willhgaze.bsky.social, and of course Stineke van Houte
6/6
May 12, 2025 at 5:18 AM
CRISPRs on plasmids are great in defence, but in offence limited by TA – this helps explain how bacterial immune systems act & informs use of CRISPR technology.
Big thanks also to co-authors Jahn Ringger, Rafa Pinilla-Redondo, @willhgaze.bsky.social, and of course Stineke van Houte
6/6
Big thanks also to co-authors Jahn Ringger, Rafa Pinilla-Redondo, @willhgaze.bsky.social, and of course Stineke van Houte
6/6
Great, but what about the real world? @leightonpayne.bsky.social bioinformatically analysed plasmid-borne CRISPR-Cas systems and the plasmids they target. When we look at (nucleolytic, non-Type IV) plasmid-borne CRISPR-Cas we find that they try to avoid targeting plasmids with TA!
5/6
5/6
May 12, 2025 at 5:16 AM
Great, but what about the real world? @leightonpayne.bsky.social bioinformatically analysed plasmid-borne CRISPR-Cas systems and the plasmids they target. When we look at (nucleolytic, non-Type IV) plasmid-borne CRISPR-Cas we find that they try to avoid targeting plasmids with TA!
5/6
5/6
And this is also what we see experimentally! Defensive or co-invading CRISPR-Cas are always beneficial, but offensive CRISPR is severely limited by and even detrimental when there is TA.
4/6
4/6
May 12, 2025 at 5:15 AM
And this is also what we see experimentally! Defensive or co-invading CRISPR-Cas are always beneficial, but offensive CRISPR is severely limited by and even detrimental when there is TA.
4/6
4/6
First, we conceptualise: modelling by @brownlab.bsky.social predicts that resident CRISPR-Cas usually benefits its plasmid (higher competitive outcome), but that CRISPR can actually be a liability when it is offensive & the competitor plasmid has TA! (lower competitive outcome)
3/6
3/6
May 12, 2025 at 5:15 AM
First, we conceptualise: modelling by @brownlab.bsky.social predicts that resident CRISPR-Cas usually benefits its plasmid (higher competitive outcome), but that CRISPR can actually be a liability when it is offensive & the competitor plasmid has TA! (lower competitive outcome)
3/6
3/6
Immune systems on MGEs are so cool!
We know that plasmid-borne CRISPR-Cas are active in plasmid competition, we know that toxin-antitoxin systems are prevalent on plasmids, and we know that they interfere with each other – so why have CRISPR on a plasmid?
2/6
We know that plasmid-borne CRISPR-Cas are active in plasmid competition, we know that toxin-antitoxin systems are prevalent on plasmids, and we know that they interfere with each other – so why have CRISPR on a plasmid?
2/6
May 12, 2025 at 5:13 AM
Immune systems on MGEs are so cool!
We know that plasmid-borne CRISPR-Cas are active in plasmid competition, we know that toxin-antitoxin systems are prevalent on plasmids, and we know that they interfere with each other – so why have CRISPR on a plasmid?
2/6
We know that plasmid-borne CRISPR-Cas are active in plasmid competition, we know that toxin-antitoxin systems are prevalent on plasmids, and we know that they interfere with each other – so why have CRISPR on a plasmid?
2/6
I *finally* get to share our work on plasmid competition– super proud to now have this on bioRxiv:
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
May 12, 2025 at 5:11 AM
I *finally* get to share our work on plasmid competition– super proud to now have this on bioRxiv:
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
Very happy to say I've been re-elected to Truro City Council! 🥳
May 3, 2025 at 8:10 AM
Very happy to say I've been re-elected to Truro City Council! 🥳
here's the same data on a bar chart that's actually drawn to scale
May 1, 2025 at 1:22 PM
here's the same data on a bar chart that's actually drawn to scale
"Bar chart not drawn to scale" is a crime against data science
May 1, 2025 at 8:58 AM
"Bar chart not drawn to scale" is a crime against data science
I've really enjoyed #Microbio25 @microbiologysociety.org so far, and this afternoon things are heating up with the bacterial warfare session 🦠⚔️
I'll be giving my own talk at 3.30, looking forward to sharing all this! 😁
I'll be giving my own talk at 3.30, looking forward to sharing all this! 😁
April 2, 2025 at 7:46 AM
I've really enjoyed #Microbio25 @microbiologysociety.org so far, and this afternoon things are heating up with the bacterial warfare session 🦠⚔️
I'll be giving my own talk at 3.30, looking forward to sharing all this! 😁
I'll be giving my own talk at 3.30, looking forward to sharing all this! 😁
Cheeky bit of greenwashing - @microbiologysociety.org #Microbio25 cardboard badges contain a hidden layer of plastic. Maybe a different supplier next time?
March 31, 2025 at 4:03 PM
Cheeky bit of greenwashing - @microbiologysociety.org #Microbio25 cardboard badges contain a hidden layer of plastic. Maybe a different supplier next time?
Spotted a @pinkpetri.bsky.social sticker in-talk #Microbio25
March 31, 2025 at 3:06 PM
Spotted a @pinkpetri.bsky.social sticker in-talk #Microbio25
Name a more iconic duo... I'll wait.
March 3, 2025 at 1:39 PM
Name a more iconic duo... I'll wait.
I thoroughly enjoyed talking at #Klebs2024 in November, and I'm proud to say I even won a prize for this flash talk 😁 Have a look for a one-minute overview of using #CRISPR vs #AMR 👇
January 6, 2025 at 10:15 AM
I thoroughly enjoyed talking at #Klebs2024 in November, and I'm proud to say I even won a prize for this flash talk 😁 Have a look for a one-minute overview of using #CRISPR vs #AMR 👇
Register now to join me at The Festival of Genomics & Biodata next month. I'm excited to talk about my work to a non-microbiology audience.
Curious? Let me know what you’d love me to cover in my session!
Registration is free for most: hubs.la/Q02TptWZ0
#FOG2025
Curious? Let me know what you’d love me to cover in my session!
Registration is free for most: hubs.la/Q02TptWZ0
#FOG2025
December 5, 2024 at 9:06 AM
Register now to join me at The Festival of Genomics & Biodata next month. I'm excited to talk about my work to a non-microbiology audience.
Curious? Let me know what you’d love me to cover in my session!
Registration is free for most: hubs.la/Q02TptWZ0
#FOG2025
Curious? Let me know what you’d love me to cover in my session!
Registration is free for most: hubs.la/Q02TptWZ0
#FOG2025
POV you want some primers but you live in Cornwall
December 3, 2024 at 1:06 PM
POV you want some primers but you live in Cornwall