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apreston243.bsky.social
@apreston243.bsky.social
64 followers 33 following 82 posts
Editor in Chief of Microbiology, the flagship journal of the Microbiology Society
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New paper alert! Guidance and perspectives on regulatory considerations for approval of phage therapies. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Interpretation guidance for MHRA regulatory considerations for phage therapeutic products
On 4 June 2025, the MHRA published ‘Regulatory considerations for therapeutic use of bacteriophages in the UK’. This was in response to recommendations made by the House of Commons Science, Innovation...
www.microbiologyresearch.org
November 13, 2025 at 6:11 PM
New primer alert! Fantastic insight into how to apply machine learning and AI in microbiology. A must read. @microbiologysociety.org @delafuentelab.bsky.social www.microbiologyresearch.org/content/jour...
Microbial Primer: Artificial intelligence for microbiologists
Artificial intelligence (AI) and machine learning (ML) are reshaping microbiology, enabling rapid antibiotic discovery, resistance prediction and clinical diagnostics. For microbiologists, the goal is...
www.microbiologyresearch.org
November 13, 2025 at 6:07 PM
New paper alert! Mutations in Mtb Esx-3 result in resistance to a broad range of anti-Tb compounds. @microbiologysociety.org @proftanya13.bsky.social www.microbiologyresearch.org/content/jour...
Mutations in the Esx-3 secretion system confer resistance to multiple chemical scaffolds in Mycobacterium tuberculosis
We determined the mechanism of resistance to seven chemical series with potent activity against Mycobacterium tuberculosis. Resistant mutants were isolated against the aminothiazoles, phenylhydrazones...
www.microbiologyresearch.org
November 11, 2025 at 5:03 PM
New paper alert! DNA replication and repair conflicts lead to cell death in gram positive bacteria, possible new targets for novel antimicrobials.
@microbiologysociety.org @winterhalterlab.bsky.social www.microbiologyresearch.org/content/jour...
Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria
Cellular proliferation relies on the successful coordination and completion of genome replication and segregation. To help achieve this, many bacteria utilize regulatory pathways that ensure DNA repli...
www.microbiologyresearch.org
November 11, 2025 at 4:59 PM
New profile alert! Microbial profile: Streptomyces formicae KY5, all you need to know about this formicamycin producing machine. @microbiologysociety.org @matthutchings.bsky.social www.microbiologyresearch.org/content/jour...
Microbe Profile: Streptomyces formicae KY5: an ANT-ibiotic factory
Streptomyces formicae KY5 was isolated from a Tetraponera penzigi plant-ant nest. It is primarily known for its production of the formicamycins, antibiotics with potent activity against Gram-positive ...
www.microbiologyresearch.org
October 25, 2025 at 8:49 AM
New paper alert! Seaweeds affect plasmid conjugation rates. Insight into the effect of biotic factors on HGT. @microbiologysociety.org
@davvi36.bsky.social www.microbiologyresearch.org/content/jour...
Seaweed exposure modulates Escherichia coli plasmid conjugation rate
Seaweeds are a common and diverse component of coastal ecosystems and are known to be associated with Escherichia coli due to faecal pollution. As a biotic substrate, beach-cast seaweed may affect bac...
www.microbiologyresearch.org
October 15, 2025 at 8:27 AM
New paper alert! Commentary on the Micro Soc annual conference 'Beyond the lab' symposium. The role of policy and regulation on translational research. @microbiologysociety.org @nicholden.bsky.social @drgvank.bsky.social www.microbiologyresearch.org/content/jour...
A commentary on the 2025 Annual Conference (Liverpool) Session ‘Beyond the lab – Turning your research into reality’
A session at the annual conference of the Microbiology Society 2025 (Liverpool) was held on gaining impact from basic and applied research, ‘Beyond the lab – Turning your research into reality’. This ...
www.microbiologyresearch.org
October 15, 2025 at 8:21 AM
New paper alert! Exploring the anti-cryptospiroidal activities of peptoids, urgently needed new drug discovery.
@microbiologysociety.org www.microbiologyresearch.org/content/jour...
Antiparasitic effect of peptoids against Cryptosporidium parvum
Cryptosporidiosis, caused by Cryptosporidium parvum, poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable...
www.microbiologyresearch.org
October 15, 2025 at 8:15 AM
New paper alert! Enterococcus faecalis FabG1 is the only β-ketoacyl-acyl carrier protein (ACP) reductase, even though it encodes two other homologues. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Two putative Enterococcus faecalis fabG genes do not encode β-ketoacyl-acyl carrier protein reductases
Enterococcus faecalis encodes three putative Escherichia coli β-ketoacyl-acyl carrier protein (ACP) reductases (FabG). The fabG1 gene is located within the operon that encodes most of the fatty acid s...
www.microbiologyresearch.org
September 24, 2025 at 4:19 PM
New paper alert. Vanadate sequestration by Phycomyces blakesleeanus is accompanied by an increase in cellular lipid content. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Increase in lipid portion of Phycomyces blakesleeanus biomass induced by vanadate uptake and accumulation
Fungi are ubiquitous micro-organisms involved in various environmental processes, with a particularly important role in the transformation of metals and minerals, bioremediation and biomining. Filamen...
www.microbiologyresearch.org
September 24, 2025 at 4:12 PM
Reposted by apreston243.bsky.social
bacpop.org
The EMBL PhD programme is open until 13th October (entry ~Sep 2026):
www.embl.org/about/info/e...

We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
EMBL International PhD Programme – Unique in the world and waiting for you!
www.embl.org
September 17, 2025 at 3:49 PM
New paper alert! Changes to gut microbiome profiles associate with inflammatory markers in children with cholestatic liver disease. Is dysbiosis driving the pathology? @microbiologysociety.org www.microbiologyresearch.org/content/jour...
The interaction between IL-17 and gut microbiota contributes to cholestatic liver disease in children
The pathogenesis of cholestatic liver disease (CLD) is unknown, but the influence of gut microbiota and inflammation cannot be ignored. In this study, we attempted to provide theoretical insights for ...
www.microbiologyresearch.org
September 16, 2025 at 4:23 PM
New paper alert! Another good read from @webberma.bsky.social. Different food preservatives induce similar responses in Salmonella typhimurium, including oxidative stress responses. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Common food preservatives induce an oxidative stress response in Salmonella enterica serovar Typhimurium
Despite their frequent use, the mechanisms of action of common food preservatives are poorly understood. As there is a drive to develop alternative preservatives, understanding the mechanisms of actio...
www.microbiologyresearch.org
September 15, 2025 at 7:18 PM
New paper alert! Serial selection for hyper-biofilm production identifies c-di-GMP as central to genetic control and phenotypic dynamics. @microbiologysociety.org @webberma.bsky.social www.microbiologyresearch.org/content/jour...
Cyclic-di-GMP signalling mutants drive ecological succession and self-generated diversity in experimentally evolved biofilms of Pseudomonas aeruginosa
Biofilms represent a discrete form of microbial life which are physiologically distinct from free-living planktonic cells. The altered phenotypic manifestations of the biofilm may also elicit lifestyl...
www.microbiologyresearch.org
September 15, 2025 at 7:13 PM
Reposted by apreston243.bsky.social
lucyweinert.bsky.social
www.findaphd.com/phds/project...
Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge on FindAPhD.com
PhD Project - Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge, listed on FindAPhD.com
www.findaphd.com
September 15, 2025 at 6:43 PM
New Primer alert! And now with the correct link, apologies @dezieleric.bsky.social! Microbial Primer on the essentials of biosurfactants. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Microbial Primer: Biosurfactants – the ABCs of microbial surface-active metabolites
Microbial surfactants (biosurfactants) are low-molecular-weight amphiphilic secondary metabolites synthesized by a wide range of micro-organisms, including bacteria, yeasts and fungi. These compounds ...
www.microbiologyresearch.org
September 5, 2025 at 4:14 PM
New paper alert! Complex interactions between Pseudomona aeruginosa and Staph aureus involved in tolerance to silver of Staph. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Role of AprA and pyocyanin from Pseudomonas aeruginosa on Staphylococcus aureus tolerance to silver
The opportunistic pathogens Staphylococcus aureus and Pseudomonas aeruginosa are often found together causing persistent infections where they exhibit complex interactions that affect their virulence ...
www.microbiologyresearch.org
September 3, 2025 at 5:15 PM
Reposted by apreston243.bsky.social
alanmcn1.bsky.social
We have a position for an Assist Prof in Microbial Genomics in our School of III.

Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it

www.jobs.ac.uk/job/DOO184/a...
Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham
Apply now for the Assistant Professor (Research and Education) in Bacterial Genomics role on jobs.ac.uk - the leading job board for higher education jobs. View details.
www.jobs.ac.uk
September 3, 2025 at 4:02 PM
New paper alert! Nice insight into the basis for the toxicity of environmental saturated fatty acids towards Enterococcus faecalis. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Enterococcus faecalis requires unsaturated fatty acids to overcome toxicity of environmental saturated fatty acids
Enterococcus faecalis synthesizes phospholipids from either de novo synthesized or exogenous fatty acids. However, environmental saturated fatty acids are toxic to E. faecalis. The mechanism of toxici...
www.microbiologyresearch.org
September 3, 2025 at 5:08 PM
New paper alert! Novel insight into regulation of Staph aureus toxicity by phosphate via PhoPR, including a role for the unphosphorylated response regulator. @microbiologysociety.org @masseylab.bsky.social www.microbiologyresearch.org/content/jour...
Phosphate sensing by PhoPR regulates the cytotoxicity of Staphylococcus aureus
Staphylococcus aureus has evolved a complex regulatory network to coordinate expression of virulence factors, including cytolytic toxins, with host environmental signals. Central to this network are t...
www.microbiologyresearch.org
September 2, 2025 at 4:32 PM
Fantastic PhD project available (I'm biased obviously) with me and the wonderful Stefano Pagliara at Exeter and @jodymmason.bsky.social at Bath. Bioinformatics, metabolic modelling, single cell imaging and new antibiotics. Who could want more? Apply now! gw4biomed.ac.uk/bacterial-hu...
Bacterial Hunger Games: Targeting Nutrient Transport for Novel Antibiotic Development - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ba Preston Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Most current antibiotics are derivatives ...
gw4biomed.ac.uk
September 1, 2025 at 4:01 PM
New paper alert! Selective TLO gene families are required for expression of Tac-1 mediated fluconazole resistance in Candida albicans. Towards understanding drug resistance in this important pathogen. @microbiologysociety.org @gazmoran.bsky.social www.microbiologyresearch.org/content/jour...
Fluconazole resistance and CDR1 expression in Candida albicans mediated by the hyperactive Tac1-5 transcriptional activator requires Tlo proteins
Candida albicans is an opportunistic fungal pathogen associated with superficial and systemic infections in humans. Azole antifungal resistance in C. albicans is of clinical concern, and both oral and...
www.microbiologyresearch.org
September 1, 2025 at 3:57 PM
Fantastic PhD project available (I'm biased obviously) with me and the wonderful @PagliaraExeter and @JodyMMason. Bioinformatics, metabolic modelling, single cell imaging and new antibiotics. Who could want more? Apply now! gw4biomed.ac.uk/bacterial-hu...
Bacterial Hunger Games: Targeting Nutrient Transport for Novel Antibiotic Development - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ba Preston Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Most current antibiotics are derivatives ...
gw4biomed.ac.uk
September 1, 2025 at 9:37 AM
New paper alert. Insight into metabolic shifts in response to temperature in marine strains of Rhodococcus. Implications for mining the biochemistry of rare Actinomycetes. @microbiologysociety.org @kateduncan.bsky.social www.microbiologyresearch.org/content/jour...
Assessing the effect of temperature on Rhodococcus metabolite production
Rare actinomycetes are increasingly recognised as a valuable yet underexplored source of bioactive compounds with significant biomedical potential. While it is well established that bacteria have evol...
www.microbiologyresearch.org
August 26, 2025 at 4:22 PM
New paper alert! Toxins can skew the results of competition assays, fascinating short communication from @prokaryota.bsky.social and @willpjsmith.bsky.social. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency
Competition assays are a mainstay of modern microbiology, offering a simple and cost-effective means to quantify microbe–microbe interactions in vitro. Here, we demonstrate a key weakness of this meth...
www.microbiologyresearch.org
August 26, 2025 at 4:16 PM