David A. Delgadillo
@daverdude.bsky.social
Organic-Natural Products-Medicinal-Analytical- Chemist. Postdoc in the Nelson Group @Caltech leveraging electron diffraction to discover natural products.
Trying to do more with less.
https://orcid.org/0000-0002-0897-4470
Trying to do more with less.
https://orcid.org/0000-0002-0897-4470
Pinned
Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites
Nature remains a vast repository of complex and functional metabolites whose structural characterization continues to drive innovations in pharmaceuticals, agrochemicals, and materials science. The cr...
pubs.acs.org
There's been a rich connection between electron diffraction and the nature of the chemical bond over the years. Here, we've shown how you can leverage electron diffraction to discover and characterize novel natural products.
@caltechcce.bsky.social @uclacb.bsky.social
pubs.acs.org/doi/10.1021/...
@caltechcce.bsky.social @uclacb.bsky.social
pubs.acs.org/doi/10.1021/...
@dmeremin.bsky.social Absolutely crushed it with this automated workflow! It ain’t about the size of your crystals, nor the way that they look, that matters…it’s all about how they diffract! Cheers to the whole team!
🚨Hot off the press @jacs.acspublications.org!
Your TEM can now solve crystal structures on its own.
Small molecules, materials, proteins—all with one platform: REyes, the first end-to-end autonomous electron diffraction suite
doi.org/10.1021/jacs...
@caltechcce.bsky.social @uclacb.bsky.social
Your TEM can now solve crystal structures on its own.
Small molecules, materials, proteins—all with one platform: REyes, the first end-to-end autonomous electron diffraction suite
doi.org/10.1021/jacs...
@caltechcce.bsky.social @uclacb.bsky.social
November 12, 2025 at 5:08 PM
@dmeremin.bsky.social Absolutely crushed it with this automated workflow! It ain’t about the size of your crystals, nor the way that they look, that matters…it’s all about how they diffract! Cheers to the whole team!
Reposted by David A. Delgadillo
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
November 5, 2025 at 4:23 PM
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
Reposted by David A. Delgadillo
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
October 18, 2025 at 6:59 PM
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Reposted by David A. Delgadillo
‘Economics Nobel prize won by researchers who showed how science boosts growth’ by @philipcball.bsky.social in @nature.com www.nature.com/articles/d41...
October 13, 2025 at 8:34 PM
‘Economics Nobel prize won by researchers who showed how science boosts growth’ by @philipcball.bsky.social in @nature.com www.nature.com/articles/d41...
Reposted by David A. Delgadillo
Metabolic controls on the carbon isotope fractionations of bacterial fermentation www.pnas.org/doi/abs/10.1... #jcampubs
Metabolic controls on the carbon isotope fractionations of bacterial fermentation | PNAS
Microbial fermentation facilitates the initial breakdown of organic matter into small
molecules and is thought to be the rate-limiting step of anox...
www.pnas.org
October 10, 2025 at 9:19 PM
Metabolic controls on the carbon isotope fractionations of bacterial fermentation www.pnas.org/doi/abs/10.1... #jcampubs
Reposted by David A. Delgadillo
Reposted by David A. Delgadillo
The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...
#ChemNobel #Chem #Chemistry #chemsky 🧪
#ChemNobel #Chem #Chemistry #chemsky 🧪
The 2025 chemistry Nobel goes to MOFs
Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks
cen.acs.org
October 8, 2025 at 10:12 AM
The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...
#ChemNobel #Chem #Chemistry #chemsky 🧪
#ChemNobel #Chem #Chemistry #chemsky 🧪
Reposted by David A. Delgadillo
A new electron diffraction technique could make it easier to study molecules that need to remain solvated at all times.
New electron diffraction strategy could make it easier to study solvated organic microcrystals
The approach combines carbon liquid cells and rapid data acquisition to study solvated molecules at room temperature
www.chemistryworld.com
September 21, 2025 at 8:00 AM
A new electron diffraction technique could make it easier to study molecules that need to remain solvated at all times.
Reposted by David A. Delgadillo
❄️ NEW PRE-PRINT ❄️ Happy to see our latest work online. Here we present a super simple solution to the preferred orientation problem in single particle cryo-EM: the use of ultrasonic excitation during vitrification! Details in the 🧵 below... #cryoEM #structuralbiology
Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification https://www.biorxiv.org/content/10.1101/2025.09.14.676144v1
September 18, 2025 at 8:04 AM
❄️ NEW PRE-PRINT ❄️ Happy to see our latest work online. Here we present a super simple solution to the preferred orientation problem in single particle cryo-EM: the use of ultrasonic excitation during vitrification! Details in the 🧵 below... #cryoEM #structuralbiology
Reposted by David A. Delgadillo
is the dimer core of the H-cluster of FeFe hydrogenase formed by rSAM chemistry in HydE?
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
The Radical S-Adenosyl-l-methionine Enzyme HydE Forms an Fe(I)Fe(I) Dimer En Route to the [FeFe] Hydrogenase H-Cluster
[FeFe] hydrogenases are highly efficient metalloenzymes that catalyze hydrogen conversion via a sophisticated active site cofactor known as the H-cluster. Biosynthesis of its [2Fe]H subcluster, which ...
pubs.acs.org
August 30, 2025 at 5:28 PM
is the dimer core of the H-cluster of FeFe hydrogenase formed by rSAM chemistry in HydE?
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Trying to do more with less 🙂↕️
August 28, 2025 at 5:01 PM
Trying to do more with less 🙂↕️
Reposted by David A. Delgadillo
ACS Council approves the petition to establish the Committee on the Advancement of LGBTQ+ Chemists, 86% to 14%.
#chemsky 🧪⚗️ #acsfall2025
#chemsky 🧪⚗️ #acsfall2025
August 20, 2025 at 1:34 PM
ACS Council approves the petition to establish the Committee on the Advancement of LGBTQ+ Chemists, 86% to 14%.
#chemsky 🧪⚗️ #acsfall2025
#chemsky 🧪⚗️ #acsfall2025
Reposted by David A. Delgadillo
Scientists’ role in defending democracy www.science.org/doi/10.1126/...
Let's all support this vital need: the ability to tell the truth. 💪
"Those in the science community who are willing & able to be more visible can step up. Acting together will be more impactful than going it alone."
Let's all support this vital need: the ability to tell the truth. 💪
"Those in the science community who are willing & able to be more visible can step up. Acting together will be more impactful than going it alone."
Scientists’ role in defending democracy
The United States’ democratic leadership, commitment to freedom of expression, and investment in the pursuit of knowledge have long enabled its preeminence in science and technology. Yet today we are ...
www.science.org
August 14, 2025 at 9:08 PM
Scientists’ role in defending democracy www.science.org/doi/10.1126/...
Let's all support this vital need: the ability to tell the truth. 💪
"Those in the science community who are willing & able to be more visible can step up. Acting together will be more impactful than going it alone."
Let's all support this vital need: the ability to tell the truth. 💪
"Those in the science community who are willing & able to be more visible can step up. Acting together will be more impactful than going it alone."
Reposted by David A. Delgadillo
August 14, 2025 at 6:05 PM
Reposted by David A. Delgadillo
#ChemSky #ACSFall2025 Huge thank you to Prof. Isaiah Speight, Prof. Kensha Clark, and Prof. Davita Watkins for organizing this amazing lineup of impressive speakers. Hosted by organicdivision.org POLY and INOR. Thank you to ACS President Dr. Phillips for elevating this to a Presidential Symposium
August 8, 2025 at 11:49 PM
#ChemSky #ACSFall2025 Huge thank you to Prof. Isaiah Speight, Prof. Kensha Clark, and Prof. Davita Watkins for organizing this amazing lineup of impressive speakers. Hosted by organicdivision.org POLY and INOR. Thank you to ACS President Dr. Phillips for elevating this to a Presidential Symposium
Reposted by David A. Delgadillo
@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪
Jennifer Doudna is named 2026 Priestley Medalist
The award recognizes the biochemist for discoveries on ribozyme function and CRISPR gene editing, and international science leadership
cen.acs.org
August 2, 2025 at 4:08 PM
@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪
Reposted by David A. Delgadillo
Natural products (NPs) play a crucial role in medicine, inspiring over 50% of the drugs on the market.
🔎In this work, the team used an 'arrayED' workflow, that enabled high-throughput screening for crystalline NPs amenable to microcrystal electron diffraction (microED).
🔗 ccdc-info.com/3GP4yb2
🔎In this work, the team used an 'arrayED' workflow, that enabled high-throughput screening for crystalline NPs amenable to microcrystal electron diffraction (microED).
🔗 ccdc-info.com/3GP4yb2
July 22, 2025 at 11:25 AM
Natural products (NPs) play a crucial role in medicine, inspiring over 50% of the drugs on the market.
🔎In this work, the team used an 'arrayED' workflow, that enabled high-throughput screening for crystalline NPs amenable to microcrystal electron diffraction (microED).
🔗 ccdc-info.com/3GP4yb2
🔎In this work, the team used an 'arrayED' workflow, that enabled high-throughput screening for crystalline NPs amenable to microcrystal electron diffraction (microED).
🔗 ccdc-info.com/3GP4yb2
Reposted by David A. Delgadillo
Check out the stunning cover featuring recent paper from @hoseanelson.bsky.social Lab, led by our one and only @daverdude.bsky.social! He discovered an entire class of natural products using microED powered by arrayED
@caltech.edu @caltechcce.bsky.social @uclacb.bsky.social
@caltech.edu @caltechcce.bsky.social @uclacb.bsky.social
On the front cover of this week's issue: "Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites"
Read it here 🔗: buff.ly/F6E8Ygs
#ChemSky #JACS
Read it here 🔗: buff.ly/F6E8Ygs
#ChemSky #JACS
July 30, 2025 at 4:31 PM
Check out the stunning cover featuring recent paper from @hoseanelson.bsky.social Lab, led by our one and only @daverdude.bsky.social! He discovered an entire class of natural products using microED powered by arrayED
@caltech.edu @caltechcce.bsky.social @uclacb.bsky.social
@caltech.edu @caltechcce.bsky.social @uclacb.bsky.social
Reposted by David A. Delgadillo
On the front cover of this week's issue: "Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites"
Read it here 🔗: buff.ly/F6E8Ygs
#ChemSky #JACS
Read it here 🔗: buff.ly/F6E8Ygs
#ChemSky #JACS
July 30, 2025 at 12:00 PM
On the front cover of this week's issue: "Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites"
Read it here 🔗: buff.ly/F6E8Ygs
#ChemSky #JACS
Read it here 🔗: buff.ly/F6E8Ygs
#ChemSky #JACS
Reposted by David A. Delgadillo
Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes pubmed.ncbi.nlm.nih.gov/40720654/ #cryoem
July 29, 2025 at 11:36 PM
Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes pubmed.ncbi.nlm.nih.gov/40720654/ #cryoem
Reposted by David A. Delgadillo
Today in @science.org, @mikusp.bsky.social reports a method to replace the C2 of pyridines with N, affording pyridazines.
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...
July 17, 2025 at 11:13 PM
Today in @science.org, @mikusp.bsky.social reports a method to replace the C2 of pyridines with N, affording pyridazines.
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...
Reposted by David A. Delgadillo
Next one out from @oconnorlab.bsky.social department in @natchembio.nature.com. Work led by my office mate Allwin McDonald on the epimerisation of monoterpenoid indole alkaloids in Kratom!
#PlantSci
#NatProd
rdcu.be/ewvtP
#PlantSci
#NatProd
rdcu.be/ewvtP
Enzymatic epimerization of monoterpene indole alkaloids in kratom
Nature Chemical Biology - Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization...
rdcu.be
July 16, 2025 at 2:33 PM
Next one out from @oconnorlab.bsky.social department in @natchembio.nature.com. Work led by my office mate Allwin McDonald on the epimerisation of monoterpenoid indole alkaloids in Kratom!
#PlantSci
#NatProd
rdcu.be/ewvtP
#PlantSci
#NatProd
rdcu.be/ewvtP
Reposted by David A. Delgadillo
Check out this amazing new work from @sattelylab.bsky.social along with collaborator and @stanford-chemh.bsky.social Institute Scholar @pollyfordyce.bsky.social !
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature
An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
www.nature.com
July 11, 2025 at 5:29 AM
Check out this amazing new work from @sattelylab.bsky.social along with collaborator and @stanford-chemh.bsky.social Institute Scholar @pollyfordyce.bsky.social !
www.nature.com/articles/s41...
www.nature.com/articles/s41...