Yay for actinos and #natprod! See you in Belfast?!
🧫🧪🧬🦠
🧫🧪🧬🦠
Work with actinomycetes or mycobacteria? Dedicated symposia shine the spotlight on these remarkable bacteria at #Microbio26 in Belfast. Explore the full variety of sessions and submit your work today.
Abstract submissions close on 11 November: microb.io/AC26Abstracts
Abstract submissions close on 11 November: microb.io/AC26Abstracts
November 2, 2025 at 9:06 PM
Yay for actinos and #natprod! See you in Belfast?!
🧫🧪🧬🦠
🧫🧪🧬🦠
Working on tailoring enzymes and want to learn more about the MITE database? We are organizing a hands-on training session on how use the DB and create new entries: October 30th and November 4th 10-11 am Amsterdam time. Sign up here: forms.gle/KHPqe9XV1RRg... See you there! #secmet #natprod
MITE training session registration form
Registration form for mailing list
forms.gle
October 24, 2025 at 1:37 PM
Working on tailoring enzymes and want to learn more about the MITE database? We are organizing a hands-on training session on how use the DB and create new entries: October 30th and November 4th 10-11 am Amsterdam time. Sign up here: forms.gle/KHPqe9XV1RRg... See you there! #secmet #natprod
Hey #streptomyces #natprod fans:
1. What is your favourite agar for growing really thick and dense aerial mycelial lawns?
2. How many spores would you inoculate on one 🧫 for thick and dense lawns?
#microsky 🧪🧬🔬
1. What is your favourite agar for growing really thick and dense aerial mycelial lawns?
2. How many spores would you inoculate on one 🧫 for thick and dense lawns?
#microsky 🧪🧬🔬
October 14, 2025 at 4:30 PM
Hey #streptomyces #natprod fans:
1. What is your favourite agar for growing really thick and dense aerial mycelial lawns?
2. How many spores would you inoculate on one 🧫 for thick and dense lawns?
#microsky 🧪🧬🔬
1. What is your favourite agar for growing really thick and dense aerial mycelial lawns?
2. How many spores would you inoculate on one 🧫 for thick and dense lawns?
#microsky 🧪🧬🔬
Very exciting to finally see our iridoid cyclase ICYC online @natplants.nature.com!
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
Discovery of iridoid cyclase completes the iridoid pathway in asterids - Nature Plants
Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.
www.nature.com
October 3, 2025 at 9:39 AM
Very exciting to finally see our iridoid cyclase ICYC online @natplants.nature.com!
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
I’m excited to share the first paper from my lab that was led largely by undergraduate students at University of Wisconsin and Washington College! #secmet #natprod
www.frontiersin.org/journals/mic...
www.frontiersin.org/journals/mic...
September 30, 2025 at 8:54 PM
I’m excited to share the first paper from my lab that was led largely by undergraduate students at University of Wisconsin and Washington College! #secmet #natprod
www.frontiersin.org/journals/mic...
www.frontiersin.org/journals/mic...
Be sure to read this review, part of our Industrial Perspective themed collection, by Stefano Donadio & co. from NAICONS Srl discussing the trends in metabolite discovery from Actinomycetes #secmet #natprod
Find it in full below👇
Find it in full below👇
Trends in metabolite discovery from Actinomycetes
Covering: 2013 to 2023 In this review, we analyzed the scientific literature of the period 2013–2023 that reported novel specialized metabolites from the Actinomycetes, one of the most prolific…
pubs.rsc.org
September 26, 2025 at 11:56 AM
The latest Marine Natural Products review in Natural Product Reports has just been published - open access! Read it here for free.
#ChemSky #NatProd
#ChemSky #NatProd
Marine natural products
Covering: January to the end of December 2023This review covers the literature published in 2023 for marine natural products (MNPs), with 582 citations (541 for the period January to December 2023) re...
doi.org
February 7, 2025 at 3:45 PM
🔓Our annual Marine Natural Products review is in our latest issue and it's #OpenAccess! #ChemSky #NatProd
A big thank you to the authors:
Tony Carroll, Brent Copp, Tanja Grkovic, Robert Keyzers & Michèle Prinsep
Read their coverage of the 2023 MNP literature here🔽
pubs.rsc.org/en/content/a...
A big thank you to the authors:
Tony Carroll, Brent Copp, Tanja Grkovic, Robert Keyzers & Michèle Prinsep
Read their coverage of the 2023 MNP literature here🔽
pubs.rsc.org/en/content/a...
Marine natural products
Covering: January to the end of December 2023
This review covers the literature published in 2023 for marine natural products (MNPs), with 582 citations (541 for the period January to December 2...
pubs.rsc.org
March 5, 2025 at 11:15 AM
🔓Our annual Marine Natural Products review is in our latest issue and it's #OpenAccess! #ChemSky #NatProd
A big thank you to the authors:
Tony Carroll, Brent Copp, Tanja Grkovic, Robert Keyzers & Michèle Prinsep
Read their coverage of the 2023 MNP literature here🔽
pubs.rsc.org/en/content/a...
A big thank you to the authors:
Tony Carroll, Brent Copp, Tanja Grkovic, Robert Keyzers & Michèle Prinsep
Read their coverage of the 2023 MNP literature here🔽
pubs.rsc.org/en/content/a...
#natprod 🧫🧪
Biotechnological & pharmaceutical potential of 28 novel type strains of Actinomycetes (incl. 23 Streptomyces species) from different environments worldwide.
Proposed species names in honour of female scientists 👏 incl Lone Gram & Liz Wellington doi.org/10.1016/j.cr...
Proposed species names in honour of female scientists 👏 incl Lone Gram & Liz Wellington doi.org/10.1016/j.cr...
October 27, 2024 at 8:01 PM
#natprod 🧫🧪
Been away from social media for a bit. We (Joe Egan and I) are in the early stages of setting up a blog on computation for pharmacognosy. We're starting with the basics of using code to analyze Mass Spec and NMR data and then will move on from there
code4np.github.io
#natprod #chemsky
code4np.github.io
#natprod #chemsky
March 29, 2024 at 5:26 PM
Been away from social media for a bit. We (Joe Egan and I) are in the early stages of setting up a blog on computation for pharmacognosy. We're starting with the basics of using code to analyze Mass Spec and NMR data and then will move on from there
code4np.github.io
#natprod #chemsky
code4np.github.io
#natprod #chemsky
Next one out from @oconnorlab.bsky.social department in @natchembio.nature.com. Work led by my office mate Allwin McDonald on the epimerisation of monoterpenoid indole alkaloids in Kratom!
#PlantSci
#NatProd
rdcu.be/ewvtP
#PlantSci
#NatProd
rdcu.be/ewvtP
Enzymatic epimerization of monoterpene indole alkaloids in kratom
Nature Chemical Biology - Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization...
rdcu.be
July 16, 2025 at 2:33 PM
Next one out from @oconnorlab.bsky.social department in @natchembio.nature.com. Work led by my office mate Allwin McDonald on the epimerisation of monoterpenoid indole alkaloids in Kratom!
#PlantSci
#NatProd
rdcu.be/ewvtP
#PlantSci
#NatProd
rdcu.be/ewvtP
Whenever someone types out Secondary Metabolism, Secondary Metabolites, Specilialized Metabolism/ites, Natural Products or secmet or natprod, the post will be in that feed.
This spreadsheet has lots of other great science feeds:
docs.google.com/spreadsheets...
This spreadsheet has lots of other great science feeds:
docs.google.com/spreadsheets...
October 12, 2023 at 10:33 PM
Whenever someone types out Secondary Metabolism, Secondary Metabolites, Specilialized Metabolism/ites, Natural Products or secmet or natprod, the post will be in that feed.
This spreadsheet has lots of other great science feeds:
docs.google.com/spreadsheets...
This spreadsheet has lots of other great science feeds:
docs.google.com/spreadsheets...
Finally pathway discovery and pharmacological activity combined in one study, nice work!
#natprod
#PlantScience
#natprod
#PlantScience
Really happy to have the chance to contribute to this paper by @dashagolubova.bsky.social, Melissa salmon and @honghaosu.bsky.social. We couldn’t have got it done without @nicolabiologist.bsky.social and Maria O’Connell guiding us. It’s been a super fun collaboration!
Biosynthesis and Bioactivity of Anti-Inflammatory Triterpenoids in Calendula officinalis (pot marigold) https://www.biorxiv.org/content/10.1101/2025.01.11.632544v1
January 16, 2025 at 7:31 AM
Finally pathway discovery and pharmacological activity combined in one study, nice work!
#natprod
#PlantScience
#natprod
#PlantScience
Check out this review from Hang Li, Wencong Yang & co. at Sun Yat-sen University in our latest issue providing an overview on the discovery, bioactivity, total synthesis and biosynthesis of harziane diterpenoids #natprod #secmet
Read the full article on our website🔽
Read the full article on our website🔽
Overview of harziane diterpenoids: discovery, bioactivity, total synthesis and biosynthesis
Harziane diterpenoids constitute a unique class of diterpenoids distinguished by their intricate 6/5/7/4 carbocyclic scaffold, presenting notable structural complexity. Since the first harziane…
pubs.rsc.org
October 19, 2025 at 8:48 AM
Eight new genes in the Taxol biosynthetic pathway, a method to find them, and de novo biosynthesis. #natprod #secmet 🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...
www.biorxiv.org
November 11, 2024 at 7:09 PM
Eight new genes in the Taxol biosynthetic pathway, a method to find them, and de novo biosynthesis. #natprod #secmet 🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Next preprint out from my work @oconnorlab.bsky.social @mpi-ce.bsky.social : the discovery or iridoid cyclase in asterids!
Thread below.
#PlantScience
#natprod
www.biorxiv.org/content/10.1...
Thread below.
#PlantScience
#natprod
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 18, 2025 at 1:28 PM
Next preprint out from my work @oconnorlab.bsky.social @mpi-ce.bsky.social : the discovery or iridoid cyclase in asterids!
Thread below.
#PlantScience
#natprod
www.biorxiv.org/content/10.1...
Thread below.
#PlantScience
#natprod
www.biorxiv.org/content/10.1...
I'm not sure the emoji version is clear enough for people to discover it. #natprod would side-step the secondary vs. specialised debate :)
October 12, 2023 at 6:51 AM
I'm not sure the emoji version is clear enough for people to discover it. #natprod would side-step the secondary vs. specialised debate :)
🔓Take a look at this #OpenAccess article in our latest issue, part of our Emerging Investigators collection, from Mamoalosi A. Selepe & co. covering the total synthesis of isoflavonoids #natprod #orgchem
📍University of Pretoria, Sol Plaatje University
📍University of Pretoria, Sol Plaatje University
Total synthesis of isoflavonoids
Covering: 2012 to 2024 Isoflavonoids are phenolic compounds with wide structural diversity and a plethora of biological activities. Owing to their structural variation and potential health-promoting…
pubs.rsc.org
April 1, 2025 at 12:14 PM
🔓Take a look at this #OpenAccess article in our latest issue, part of our Emerging Investigators collection, from Mamoalosi A. Selepe & co. covering the total synthesis of isoflavonoids #natprod #orgchem
📍University of Pretoria, Sol Plaatje University
📍University of Pretoria, Sol Plaatje University
Read this Highlight article in our latest issue from Shotaro Hoshino, Hiroyasu Onaka & Ikuro Abe @utokyoofficial.bsky.social covering recent advances in the biosynthetic studies of bacterial organoarsenic natural products #natprod
Find it in full on our website👇
pubs.rsc.org/en/content/a...
Find it in full on our website👇
pubs.rsc.org/en/content/a...
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products
Covering: 1977 to present Arsenic is widely distributed throughout terrestrial and aquatic environments, mainly in highly toxic inorganic forms. To adapt to environmental inorganic arsenic, bacteria…
pubs.rsc.org
May 1, 2025 at 8:01 AM
Read this Highlight article in our latest issue from Shotaro Hoshino, Hiroyasu Onaka & Ikuro Abe @utokyoofficial.bsky.social covering recent advances in the biosynthetic studies of bacterial organoarsenic natural products #natprod
Find it in full on our website👇
pubs.rsc.org/en/content/a...
Find it in full on our website👇
pubs.rsc.org/en/content/a...