Dani León-Periñán 🇵🇸
@danilexn.bsky.social
Cells talk; I build tools to listen to them
Computational biologist • Occasional composer and pianist • he/him
Opinions are my own.
Computational biologist • Occasional composer and pianist • he/him
Opinions are my own.
Reposted by Dani León-Periñán 🇵🇸
SpatialZ generates virtual single-cell transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 14, 2026 at 4:26 PM
SpatialZ generates virtual single-cell transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dani León-Periñán 🇵🇸
‘A bombshell’: doubt cast on discoveries of #microplastics throughout human body, from brain to blood, arteries to testes
Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’
Story by me
www.theguardian.com/environment/...
Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’
Story by me
www.theguardian.com/environment/...
‘A bombshell’: doubt cast on discovery of microplastics throughout human body
Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’
www.theguardian.com
January 13, 2026 at 2:33 PM
‘A bombshell’: doubt cast on discoveries of #microplastics throughout human body, from brain to blood, arteries to testes
Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’
Story by me
www.theguardian.com/environment/...
Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’
Story by me
www.theguardian.com/environment/...
Reposted by Dani León-Periñán 🇵🇸
MAGA: The USA economy is 40% larger than all of Europe.
Close your borders.
EU: Buddy, inflated economy does not count. GDP does not count when people cant even pay their healthcare.
Close your borders.
EU: Buddy, inflated economy does not count. GDP does not count when people cant even pay their healthcare.
January 7, 2026 at 3:38 PM
MAGA: The USA economy is 40% larger than all of Europe.
Close your borders.
EU: Buddy, inflated economy does not count. GDP does not count when people cant even pay their healthcare.
Close your borders.
EU: Buddy, inflated economy does not count. GDP does not count when people cant even pay their healthcare.
Reposted by Dani León-Periñán 🇵🇸
Members of Congress: stop posting online and APPEAR, PHYSICALLY on the steps of the Capitol to decry this unconstitutional violation of domestic & international law. SHOW THE PEOPLE the level of danger we are facing as a country.
@housedemocrats.bsky.social
@senatedemocrats.bsky.social
@housedemocrats.bsky.social
@senatedemocrats.bsky.social
January 3, 2026 at 5:17 PM
Members of Congress: stop posting online and APPEAR, PHYSICALLY on the steps of the Capitol to decry this unconstitutional violation of domestic & international law. SHOW THE PEOPLE the level of danger we are facing as a country.
@housedemocrats.bsky.social
@senatedemocrats.bsky.social
@housedemocrats.bsky.social
@senatedemocrats.bsky.social
Reposted by Dani León-Periñán 🇵🇸
Reposted by Dani León-Periñán 🇵🇸
not safe for non-america countries to have a president these days. trump would've done this to greenland already if anybody in the administration could figure out who the main guys are in a parliamentary government
January 3, 2026 at 1:04 PM
not safe for non-america countries to have a president these days. trump would've done this to greenland already if anybody in the administration could figure out who the main guys are in a parliamentary government
Reposted by Dani León-Periñán 🇵🇸
Greenland’s next.
January 3, 2026 at 2:12 PM
Greenland’s next.
Reposted by Dani León-Periñán 🇵🇸
Venezuela hoy da la imagen del mundo que traen las fuerzas reaccionarias: agresiones militares ilegales, la razón de la fuerza bruta, el capricho imperial como norma.
Un mundo de siervos en el que nadie esté a salvo.
Un mundo de siervos en el que nadie esté a salvo.
January 3, 2026 at 10:59 AM
Venezuela hoy da la imagen del mundo que traen las fuerzas reaccionarias: agresiones militares ilegales, la razón de la fuerza bruta, el capricho imperial como norma.
Un mundo de siervos en el que nadie esté a salvo.
Un mundo de siervos en el que nadie esté a salvo.
Who would’ve thought that the pedophile that encouraged an assault to the Capitol could kidnap the president of another sovereign nation?
Wow mind blowing stuff.
Wow mind blowing stuff.
January 3, 2026 at 1:55 PM
Who would’ve thought that the pedophile that encouraged an assault to the Capitol could kidnap the president of another sovereign nation?
Wow mind blowing stuff.
Wow mind blowing stuff.
The problem is thinking that US is the world’s number one superpower.
The world’s number one superpowers are Europe and China. They’ve been for thousands of years and they’ll still be for another thousand.
US is just a third-world country with Gucci outfits.
The world’s number one superpowers are Europe and China. They’ve been for thousands of years and they’ll still be for another thousand.
US is just a third-world country with Gucci outfits.
Kidnapping the leader of a foreign state without any declaration of war and announcing it via social media is full-on rogue state stuff. From the world’s number one superpower.
January 3, 2026 at 1:48 PM
The problem is thinking that US is the world’s number one superpower.
The world’s number one superpowers are Europe and China. They’ve been for thousands of years and they’ll still be for another thousand.
US is just a third-world country with Gucci outfits.
The world’s number one superpowers are Europe and China. They’ve been for thousands of years and they’ll still be for another thousand.
US is just a third-world country with Gucci outfits.
Reposted by Dani León-Periñán 🇵🇸
Lourd est le parpaing des Trump, Poutine, Netanyahou et consorts sur la tartelette aux fraises du droit international.
January 3, 2026 at 8:37 AM
Lourd est le parpaing des Trump, Poutine, Netanyahou et consorts sur la tartelette aux fraises du droit international.
Reposted by Dani León-Periñán 🇵🇸
Repeat after me: GENE 👏 EXPRESSION 👏 PROFILING 👏 DOES 👏 NOT 👏 A 👏 VIRTUAL 👏 CELL 👏 MAKE 👏
December 26, 2025 at 12:11 PM
Repeat after me: GENE 👏 EXPRESSION 👏 PROFILING 👏 DOES 👏 NOT 👏 A 👏 VIRTUAL 👏 CELL 👏 MAKE 👏
Reposted by Dani León-Periñán 🇵🇸
Today is a big day.
After many years of work, I’m excited to finally share a paper describing a novel approach to identifying potential breakthroughs in biomedical research, up to twelve years before the breakthrough itself occurs. 1/15
After many years of work, I’m excited to finally share a paper describing a novel approach to identifying potential breakthroughs in biomedical research, up to twelve years before the breakthrough itself occurs. 1/15
December 18, 2025 at 8:38 PM
Today is a big day.
After many years of work, I’m excited to finally share a paper describing a novel approach to identifying potential breakthroughs in biomedical research, up to twelve years before the breakthrough itself occurs. 1/15
After many years of work, I’m excited to finally share a paper describing a novel approach to identifying potential breakthroughs in biomedical research, up to twelve years before the breakthrough itself occurs. 1/15
Reposted by Dani León-Periñán 🇵🇸
🧮 Just out in Bioinformatics Advances: “FroM Superstring to Indexing: A space-efficient index for unconstrained k-mer sets using the Masked Burrows-Wheeler Transform (MBWT)”
Full article available: https://doi.org/10.1093/bioadv/vbaf290
Authors include: @pavelvesely.bsky.social, @brinda.eu
Full article available: https://doi.org/10.1093/bioadv/vbaf290
Authors include: @pavelvesely.bsky.social, @brinda.eu
December 5, 2025 at 10:01 AM
🧮 Just out in Bioinformatics Advances: “FroM Superstring to Indexing: A space-efficient index for unconstrained k-mer sets using the Masked Burrows-Wheeler Transform (MBWT)”
Full article available: https://doi.org/10.1093/bioadv/vbaf290
Authors include: @pavelvesely.bsky.social, @brinda.eu
Full article available: https://doi.org/10.1093/bioadv/vbaf290
Authors include: @pavelvesely.bsky.social, @brinda.eu
History will remember Claudia Sheinbaum as the idiot who demanded a government to say sorry for stuff that happened 500 years ago, while taking selfies with a nazi-pedophile.
elpais.com/deportes/mun...
elpais.com/deportes/mun...
El sorteo del Mundial de Fútbol 2026, en directo | Uruguay, Arabia Saudí y Cabo Verde se enfrentarán a España en la fase de grupos del Mundial
La selección de Luis de la Fuente cae en el grupo H, que disputará sus partidos en Miami, Atlanta, Houston y Guadalajara | El partido inaugural será entre México y Sudáfrica el próximo 11 de junio | L...
elpais.com
December 5, 2025 at 8:10 PM
History will remember Claudia Sheinbaum as the idiot who demanded a government to say sorry for stuff that happened 500 years ago, while taking selfies with a nazi-pedophile.
elpais.com/deportes/mun...
elpais.com/deportes/mun...
Reposted by Dani León-Periñán 🇵🇸
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
October 28, 2025 at 6:50 PM
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Reposted by Dani León-Periñán 🇵🇸
Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine.
www.tagesspiegel.de/berlin/senat...
www.tagesspiegel.de/berlin/senat...
Senat will 12,5 Millionen Euro investieren: NFL kommt 2025 für ein Spiel nach Berlin
Die nordamerikanische Football-Liga NFL wird 2025 ein Spiel in Berlin austragen. Bis 2029 könnten zwei weitere Folgen. Die Kosten dafür sind hoch. Das Land muss trotz Haushaltskrise Millionen investie...
www.tagesspiegel.de
November 6, 2025 at 7:50 PM
Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine.
www.tagesspiegel.de/berlin/senat...
www.tagesspiegel.de/berlin/senat...
This is pure bullshit. You don’t need to run 200 LLM agents for >8 hours to do DE, GSEA and generate a couple of heatmaps.
And if you do, just spend 2 weeks learning bioinformatics and you won’t need to give money to a company selling snake oil.
arxiv.org/pdf/2511.02824
And if you do, just spend 2 weeks learning bioinformatics and you won’t need to give money to a company selling snake oil.
arxiv.org/pdf/2511.02824
arxiv.org
November 6, 2025 at 1:09 PM
This is pure bullshit. You don’t need to run 200 LLM agents for >8 hours to do DE, GSEA and generate a couple of heatmaps.
And if you do, just spend 2 weeks learning bioinformatics and you won’t need to give money to a company selling snake oil.
arxiv.org/pdf/2511.02824
And if you do, just spend 2 weeks learning bioinformatics and you won’t need to give money to a company selling snake oil.
arxiv.org/pdf/2511.02824
Reposted by Dani León-Periñán 🇵🇸
🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
October 30, 2025 at 5:50 PM
🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
My humble advice to 10X:
Why don’t you invest a bit more on R&D and a little bit less on legal?
www.genomeweb.com/business-new...
Why don’t you invest a bit more on R&D and a little bit less on legal?
www.genomeweb.com/business-new...
10x Genomics to Sue Illumina Alleging Infringement of Single-Cell, Spatial Patents
The lawsuits are the latest IP battle for 10x, which has sued just about every competitor it has faced in both the single-cell and spatial transcriptomics markets.
www.genomeweb.com
October 21, 2025 at 8:37 PM
My humble advice to 10X:
Why don’t you invest a bit more on R&D and a little bit less on legal?
www.genomeweb.com/business-new...
Why don’t you invest a bit more on R&D and a little bit less on legal?
www.genomeweb.com/business-new...
Reposted by Dani León-Periñán 🇵🇸
When I was an undergrad, I saw a talk by Oliver Sacks about music. During the Q&A, someone asked Sacks if he thought science would reveal the deepest mysteries of art. Sacks (a rare humanist among scientists) said that he doubted it, at which Eric Kandel (the host) leaped up and grabbed the mic.
October 15, 2025 at 9:27 AM
When I was an undergrad, I saw a talk by Oliver Sacks about music. During the Q&A, someone asked Sacks if he thought science would reveal the deepest mysteries of art. Sacks (a rare humanist among scientists) said that he doubted it, at which Eric Kandel (the host) leaped up and grabbed the mic.
Reposted by Dani León-Periñán 🇵🇸
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data
YouTube video by Prof. Jean Fan
youtu.be
October 13, 2025 at 7:09 PM
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
Reposted by Dani León-Periñán 🇵🇸
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
October 9, 2025 at 5:05 PM
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
Reposted by Dani León-Periñán 🇵🇸
Ca n'est pas si souvent, un article publié dans Nature met ma communauté à l'honneur (la bioinformatique des séquences). Je vous raconte ?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘Google for DNA’ brings order to biology’s big data
MetaGraph compresses vast data archives into a search engine for scientists, opening up new frontiers of biological discovery.
www.nature.com
October 9, 2025 at 3:00 PM
Ca n'est pas si souvent, un article publié dans Nature met ma communauté à l'honneur (la bioinformatique des séquences). Je vous raconte ?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Dani León-Periñán 🇵🇸
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Molecular determinants underlying functional divergence of TBP homologs
The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...
www.biorxiv.org
October 7, 2025 at 7:43 PM
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription