Nils Blüthgen
@molsysbio.bsky.social
Charité and Humboldt University Berlin, Computational Modelling, Cancer, Signaling
Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine.
www.tagesspiegel.de/berlin/senat...
www.tagesspiegel.de/berlin/senat...
Senat will 12,5 Millionen Euro investieren: NFL kommt 2025 für ein Spiel nach Berlin
Die nordamerikanische Football-Liga NFL wird 2025 ein Spiel in Berlin austragen. Bis 2029 könnten zwei weitere Folgen. Die Kosten dafür sind hoch. Das Land muss trotz Haushaltskrise Millionen investie...
www.tagesspiegel.de
November 6, 2025 at 7:50 PM
Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine.
www.tagesspiegel.de/berlin/senat...
www.tagesspiegel.de/berlin/senat...
“Stands out … for its contribution to the society in the field to finance”???? Maybe the most bizarre spam email I ever received…
November 6, 2025 at 12:28 PM
“Stands out … for its contribution to the society in the field to finance”???? Maybe the most bizarre spam email I ever received…
Reposted by Nils Blüthgen
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reposted by Nils Blüthgen
When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety
Who knows what will happen now
Just in case, remember Euruope-PMC
(europepmc.org )
Who knows what will happen now
Just in case, remember Euruope-PMC
(europepmc.org )
a cartoon of donald trump with the words be prepared above him
ALT: a cartoon of donald trump with the words be prepared above him
media.tenor.com
September 29, 2025 at 1:35 PM
When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety
Who knows what will happen now
Just in case, remember Euruope-PMC
(europepmc.org )
Who knows what will happen now
Just in case, remember Euruope-PMC
(europepmc.org )
The Ärzteblatt asked me about the instability of Pubmed (Why my? Don't know...). Not sure if I agree with the colleagues that we should build up national resources, I rather think we should strengthen existing European ones (e.g. EuropePMC, ENA, EGA...)... www.aerzteblatt.de/archiv/wisse...
Wissenschaftliche Resilienz: Auf dem Weg aus der PubMed-Abhängigkeit – Deutsches Ärzteblatt
www.aerzteblatt.de
October 4, 2025 at 11:27 AM
The Ärzteblatt asked me about the instability of Pubmed (Why my? Don't know...). Not sure if I agree with the colleagues that we should build up national resources, I rather think we should strengthen existing European ones (e.g. EuropePMC, ENA, EGA...)... www.aerzteblatt.de/archiv/wisse...
Reposted by Nils Blüthgen
Nicky McGranahan kicking off the last day showing the evolutionary history of metastasis. Amazing data and analysis.
September 26, 2025 at 9:55 AM
Nicky McGranahan kicking off the last day showing the evolutionary history of metastasis. Amazing data and analysis.
Reposted by Nils Blüthgen
Very dynamic poster sessions at the late summer school on tumor heterogeneity and treatment followed by a rooftop party. Thank you @mdc-bimsb.bsky.social for hosting us!
September 26, 2025 at 7:32 AM
Very dynamic poster sessions at the late summer school on tumor heterogeneity and treatment followed by a rooftop party. Thank you @mdc-bimsb.bsky.social for hosting us!
Reposted by Nils Blüthgen
Great talks from PhD students Tancredi Massimo Pentimalli, Adila Apsara: and Siddharth Annaldasula!
September 25, 2025 at 9:27 AM
Great talks from PhD students Tancredi Massimo Pentimalli, Adila Apsara: and Siddharth Annaldasula!
Reposted by Nils Blüthgen
Efrat Shema kicking off today’s program with a lecture on epigenetics and single cell methods.
September 25, 2025 at 9:23 AM
Efrat Shema kicking off today’s program with a lecture on epigenetics and single cell methods.
Reposted by Nils Blüthgen
Final session for today: Sven Nelander discusses how patient specific models combined with advanced molecular biology and large scale computation allow for a better understanding of CNS cancers.
September 24, 2025 at 2:01 PM
Final session for today: Sven Nelander discusses how patient specific models combined with advanced molecular biology and large scale computation allow for a better understanding of CNS cancers.
Reposted by Nils Blüthgen
We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!
September 24, 2025 at 1:48 PM
We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!
Reposted by Nils Blüthgen
First session: Uli Keilholz of the comprehensive cancer center on how complex data and models are now used in the clinics, and Heiko Enderling on modeling approaches. Both show excellent examples on how computation already now is impotent for clinical decisions, and how it will be in future.
September 24, 2025 at 8:56 AM
First session: Uli Keilholz of the comprehensive cancer center on how complex data and models are now used in the clinics, and Heiko Enderling on modeling approaches. Both show excellent examples on how computation already now is impotent for clinical decisions, and how it will be in future.
Reposted by Nils Blüthgen
Kicking off today’s Late Summer School on tumor heterogeneity and treatment resistance with an amazing program. Great to see a huge turnout!
September 24, 2025 at 8:51 AM
Kicking off today’s Late Summer School on tumor heterogeneity and treatment resistance with an amazing program. Great to see a huge turnout!
Reposted by Nils Blüthgen
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target
transcripts within hours. Boehm et al. use conditional protein degradation and advanced
transcriptomics to map t...
www.cell.com
September 12, 2025 at 7:26 AM
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU
September 8, 2025 at 7:12 PM
Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU
Reposted by Nils Blüthgen
Spatenstich für den Forschungsneubau Optobiologie an der #HumboldtUni. Gemeinsam mit der Charité und der @berlinualliance.bsky.social entsteht ein Zentrum für interdisziplinäre Spitzenforschung. Auf rund 3.800 m² entstehen Laborflächen für 110 Wissenschaftler*innen 👉 www.hu-berlin.de/de/pr/nachri...
August 26, 2025 at 1:15 PM
Spatenstich für den Forschungsneubau Optobiologie an der #HumboldtUni. Gemeinsam mit der Charité und der @berlinualliance.bsky.social entsteht ein Zentrum für interdisziplinäre Spitzenforschung. Auf rund 3.800 m² entstehen Laborflächen für 110 Wissenschaftler*innen 👉 www.hu-berlin.de/de/pr/nachri...
Why do kids respond differently to a new virus than adults? Lev has the answer… it is differences in Stat signaling. Happy that we (mainly @astaburuaga-garcia.bsky.social ) could contribute a bit. Congratulations @sawitzkilab.bsky.social and @woodenrobo.bsky.social to this great paper!
Excited to see my magnum opus published! Here, we explore how age correlates with changes in STAT signaling and modulates the immune response towards inflammation. See for youself!
Also, it's been a long time since pre-print, so here's the reworked explainer thread!
www.cell.com/cell-reports...
Also, it's been a long time since pre-print, so here's the reworked explainer thread!
www.cell.com/cell-reports...
Rewired type I IFN signaling is linked to age-dependent differences in COVID-19
Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2
infection, with older individuals favoring a STAT3-driven inflammatory response. This
mechanistic insight helps ...
www.cell.com
August 19, 2025 at 7:51 PM
Why do kids respond differently to a new virus than adults? Lev has the answer… it is differences in Stat signaling. Happy that we (mainly @astaburuaga-garcia.bsky.social ) could contribute a bit. Congratulations @sawitzkilab.bsky.social and @woodenrobo.bsky.social to this great paper!
Very moving obituary by Stas Svartsman for Benny Shilo. I met Benny a few years ago at the WiKo in Berlin and enjoyed our very inspiring conversations about signaling dynamics and patterning. Glad that I met him.
www.cell.com/developmenta...
www.cell.com/developmenta...
Ben-Zion Shilo (1951–2025)
Ben-Zion Shilo, a distinguished Israeli geneticist (Figure 1), passed away this April
at the age of 73 at his home in Rehovot. Benny, as he was known to his friends and
colleagues around the world, ma...
www.cell.com
August 19, 2025 at 7:46 PM
Very moving obituary by Stas Svartsman for Benny Shilo. I met Benny a few years ago at the WiKo in Berlin and enjoyed our very inspiring conversations about signaling dynamics and patterning. Glad that I met him.
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Nils Blüthgen
Excited to see my magnum opus published! Here, we explore how age correlates with changes in STAT signaling and modulates the immune response towards inflammation. See for youself!
Also, it's been a long time since pre-print, so here's the reworked explainer thread!
www.cell.com/cell-reports...
Also, it's been a long time since pre-print, so here's the reworked explainer thread!
www.cell.com/cell-reports...
Rewired type I IFN signaling is linked to age-dependent differences in COVID-19
Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2
infection, with older individuals favoring a STAT3-driven inflammatory response. This
mechanistic insight helps ...
www.cell.com
August 19, 2025 at 4:56 PM
Reposted by Nils Blüthgen
Excited to share our new study on how age-related changes in STAT signaling impact antiviral responses and hyperinflammation in COVID-19!
🧵 Explainer thread by the first author Lev Petrov linked below ⬇️
🧵 Explainer thread by the first author Lev Petrov linked below ⬇️
Rewired type I IFN signaling is linked to age-dependent differences in COVID-19
Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2
infection, with older individuals favoring a STAT3-driven inflammatory response. This
mechanistic insight helps ...
www.cell.com
August 19, 2025 at 4:56 PM
Excited to share our new study on how age-related changes in STAT signaling impact antiviral responses and hyperinflammation in COVID-19!
🧵 Explainer thread by the first author Lev Petrov linked below ⬇️
🧵 Explainer thread by the first author Lev Petrov linked below ⬇️
Reposted by Nils Blüthgen
Wollen Sie mit einer komplizierten Infektion von Infektionsspezialisten behandelt werden oder soll das einfach irgendwer nebenbei "mitmachen"? Die Politik meint: Letzteres muss reichen in Deutschland. Anders ist die Abschaffung der LG Infektiologie nicht zu verstehen. #KHAG @spdfraktion.de #CDUCSU
Der aktuelle Entwurf der Bundesregierung zum Krankenhausanpassungsgesetz (KHAG) enthält gravierende Rückschritte, allen voran die Streichung der Leistungsgruppe Infektiologie. Mit dieser Fehlentscheidung schwächt das BMG die Effizienz + Qualität der Versorgung & konterkariert die Ziele der Reform. 🧵
August 7, 2025 at 4:19 PM
Wollen Sie mit einer komplizierten Infektion von Infektionsspezialisten behandelt werden oder soll das einfach irgendwer nebenbei "mitmachen"? Die Politik meint: Letzteres muss reichen in Deutschland. Anders ist die Abschaffung der LG Infektiologie nicht zu verstehen. #KHAG @spdfraktion.de #CDUCSU
Reposted by Nils Blüthgen
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
August 1, 2025 at 9:38 AM
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
August 1, 2025 at 9:38 AM
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?
July 25, 2025 at 5:32 PM
Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?
Reposted by Nils Blüthgen
Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer
A cell-sorting approach reveals distinct modes of cancer resistance to active-state RAS inhibitors.
www.science.org
July 22, 2025 at 7:55 PM
Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...