Nils Blüthgen
@molsysbio.bsky.social
Charité and Humboldt University Berlin, Computational Modelling, Cancer, Signaling
“Stands out … for its contribution to the society in the field to finance”???? Maybe the most bizarre spam email I ever received…
November 6, 2025 at 12:28 PM
“Stands out … for its contribution to the society in the field to finance”???? Maybe the most bizarre spam email I ever received…
Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU
September 8, 2025 at 7:12 PM
Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
August 1, 2025 at 9:38 AM
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?
July 25, 2025 at 5:32 PM
Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?
Dear Professor [Last Name]...
![Foto of an email: Dear Professor [Last Name], I hope you are well...](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:sygptg3ye5eh7rxh3vr3mvnc/bafkreiciiwxovkhcl5fysmnn36qrjbmnpktvjxy4tlnib7euq24rmnze6q@jpeg)
July 10, 2025 at 6:02 AM
Dear Professor [Last Name]...
Definitely the most professional equipment for photographing the eclipse. And clearly the best photo…
March 29, 2025 at 11:43 AM
Definitely the most professional equipment for photographing the eclipse. And clearly the best photo…
Opening of a new exhibition in Charite’s medical history museum: Erfindungswahn, telling the story of patient in the psychiatry in 1908 from his medical records with all its facets and from many different angles. Extremely well done, worth visiting! bmm-charite.de/ausstellunge...
March 6, 2025 at 8:49 PM
Opening of a new exhibition in Charite’s medical history museum: Erfindungswahn, telling the story of patient in the psychiatry in 1908 from his medical records with all its facets and from many different angles. Extremely well done, worth visiting! bmm-charite.de/ausstellunge...
See you in Dublin in October for the ICSB2024! Early registration is open at: ICSB2025.com. I will chair an exciting session on "Cell Engineering & Pathway Engineering".
February 24, 2025 at 10:12 AM
See you in Dublin in October for the ICSB2024! Early registration is open at: ICSB2025.com. I will chair an exciting session on "Cell Engineering & Pathway Engineering".
Yesterdays cuts in more detail:
- Support for students (Studierendenwerk): -32%
- Einsteinstiftung: -18%
- Budget for building costs: -80%
- Invest for Universities: -20%
- Support to update technical infrastructure at Charite: -48%
- Invests in Buildings -40%
This is how you ruin the future.
- Support for students (Studierendenwerk): -32%
- Einsteinstiftung: -18%
- Budget for building costs: -80%
- Invest for Universities: -20%
- Support to update technical infrastructure at Charite: -48%
- Invests in Buildings -40%
This is how you ruin the future.
December 20, 2024 at 5:57 PM
Yesterdays cuts in more detail:
- Support for students (Studierendenwerk): -32%
- Einsteinstiftung: -18%
- Budget for building costs: -80%
- Invest for Universities: -20%
- Support to update technical infrastructure at Charite: -48%
- Invests in Buildings -40%
This is how you ruin the future.
- Support for students (Studierendenwerk): -32%
- Einsteinstiftung: -18%
- Budget for building costs: -80%
- Invest for Universities: -20%
- Support to update technical infrastructure at Charite: -48%
- Invests in Buildings -40%
This is how you ruin the future.
Good to see thousands on the street to protest against terrible cuts into Berlin‘s university. The planned 10% cuts in the budget will definitely cause major and sustaining damage to research and education!
December 19, 2024 at 8:54 AM
Good to see thousands on the street to protest against terrible cuts into Berlin‘s university. The planned 10% cuts in the budget will definitely cause major and sustaining damage to research and education!
Maybe interesting, @zidlab.bsky.social: If we split the mito. transcripts into cytosole enriched and the others (membrane enriched, n=74 and undefined, n=28), those 102 look like they are co-translationally targeted. For the other 661 it looks rather post-translationally targeted.
November 24, 2024 at 3:07 PM
Maybe interesting, @zidlab.bsky.social: If we split the mito. transcripts into cytosole enriched and the others (membrane enriched, n=74 and undefined, n=28), those 102 look like they are co-translationally targeted. For the other 661 it looks rather post-translationally targeted.
We noticed that CyTOF data is highly correlated between all markers (lower triange). This is (at least partially) due to different cell sizes. We describe an approach that reduces such unwanted covariance using regression on a set of surrogates of sources unwanted covariance (upper triange).
November 24, 2024 at 2:26 PM
We noticed that CyTOF data is highly correlated between all markers (lower triange). This is (at least partially) due to different cell sizes. We describe an approach that reduces such unwanted covariance using regression on a set of surrogates of sources unwanted covariance (upper triange).
🎉 New paper alert! Our new method "RUCova" to normalise CyTOF data is finally out in Bioinformatics! dx.doi.org/10.1093/bioi...
November 24, 2024 at 2:26 PM
🎉 New paper alert! Our new method "RUCova" to normalise CyTOF data is finally out in Bioinformatics! dx.doi.org/10.1093/bioi...
The model consists of two parts. One is the dynamic flow through the cell, the other is modelling the transcription elongation rate that leads to delays in the labeling of more 5' sequences.
November 21, 2024 at 2:56 PM
The model consists of two parts. One is the dynamic flow through the cell, the other is modelling the transcription elongation rate that leads to delays in the labeling of more 5' sequences.
Functionally related transcripts have similar profiles, for instance mRNAs encoding transcription factors having short nuclear and cytosolic half-lives, while those encoding mitochondrial and ribosomal proteins have long nuclear retention and overall high stability.
November 21, 2024 at 2:56 PM
Functionally related transcripts have similar profiles, for instance mRNAs encoding transcription factors having short nuclear and cytosolic half-lives, while those encoding mitochondrial and ribosomal proteins have long nuclear retention and overall high stability.
We discriminate between transcripts that are enriched in the cytoplasm and those in membranes. Cytosolic transcripts have a median cytosolic half-life of 13 min. Those that are enriched in the membranes leave the cytosole in 1 min and remain in the membrane for 20 min.
November 21, 2024 at 2:56 PM
We discriminate between transcripts that are enriched in the cytoplasm and those in membranes. Cytosolic transcripts have a median cytosolic half-life of 13 min. Those that are enriched in the membranes leave the cytosole in 1 min and remain in the membrane for 20 min.
Surprisingly, we find that (in mESCs), the average residence time for mRNAs in the nucleus is 78 min, being the rate limiting step for turnover for most mRNAs.
November 21, 2024 at 2:56 PM
Surprisingly, we find that (in mESCs), the average residence time for mRNAs in the nucleus is 78 min, being the rate limiting step for turnover for most mRNAs.
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
November 21, 2024 at 2:56 PM
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
How does the immune response at first virus contact differ between kids and older people? Data from larger Covid cohorts help to disentangle this.
October 26, 2024 at 8:41 AM
How does the immune response at first virus contact differ between kids and older people? Data from larger Covid cohorts help to disentangle this.
Immerhin kein Apostroph!
August 20, 2024 at 2:36 PM
Immerhin kein Apostroph!
Interestingly, we find really high quantitative agreement between laborious bulk experiments and the perturb seq data.
January 16, 2024 at 4:11 PM
Interestingly, we find really high quantitative agreement between laborious bulk experiments and the perturb seq data.
An aspect that we might still be missing is feedback regulation to signalling - We know that many transcripts (such as the DUSPs) are encoding negative regulators (see also: www.embopress.org/doi/full/10.... )
January 16, 2024 at 4:11 PM
An aspect that we might still be missing is feedback regulation to signalling - We know that many transcripts (such as the DUSPs) are encoding negative regulators (see also: www.embopress.org/doi/full/10.... )
To really get single-gene resolution, we used a modified targeted scRNA-seq approach (from the Schraivogel TAP seq) which was crucial to get enough coverage (www.nature.com/articles/s41... )
January 16, 2024 at 4:10 PM
To really get single-gene resolution, we used a modified targeted scRNA-seq approach (from the Schraivogel TAP seq) which was crucial to get enough coverage (www.nature.com/articles/s41... )
We find that EGR1 and FOS are really the major TFs controlling later waves of gene expression, and other TFs (often downstream of EGR1 and FOS) control rather small, defined sets of genes.
January 16, 2024 at 4:09 PM
We find that EGR1 and FOS are really the major TFs controlling later waves of gene expression, and other TFs (often downstream of EGR1 and FOS) control rather small, defined sets of genes.