Mattia Frontini
@ciavenasc.bsky.social
Functional Genomics, Rare Diseases and Cardiovascular Disease @ Exeter University
ORCID 0000-0001-8074-6299
ORCID 0000-0001-8074-6299
Pinned
Interested in a PhD to study the genetic determinants of protein abundance using paired RNA-seq and proteomic data? Join us with a @gw4biomeddtp.bsky.social funded project available in my group together with Nick Bray (Cardiff) and Kate Burley (Bristol)
Reposted by Mattia Frontini
In ~5 hours…
🔔This Wednesday , in #FragileNucleosome seminar, we are excited to host @ishtiaqueh.bsky.social of Pastor lab and Prof. Sarah Teichmann, @teichlab.bsky.social, to tell us about their exciting studies!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
November 19, 2025 at 12:50 PM
In ~5 hours…
Our latest work dissecting the interplay of endothelial and immune cells in non-communicable diseases genetics. We explained 815 loci (29% to 40%) and revealed the complex relationship between cell types and diseases.
www.biorxiv.org/content/10.1...
@nicolesoranzo.bsky.social @npirastu.bsky.social
www.biorxiv.org/content/10.1...
@nicolesoranzo.bsky.social @npirastu.bsky.social
www.biorxiv.org
November 14, 2025 at 9:40 AM
Our latest work dissecting the interplay of endothelial and immune cells in non-communicable diseases genetics. We explained 815 loci (29% to 40%) and revealed the complex relationship between cell types and diseases.
www.biorxiv.org/content/10.1...
@nicolesoranzo.bsky.social @npirastu.bsky.social
www.biorxiv.org/content/10.1...
@nicolesoranzo.bsky.social @npirastu.bsky.social
Reposted by Mattia Frontini
Congratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Small things matter: Lack of extraislet β cells in type 1 diabetes
Early loss of small extraislet β cells in children with type 1 diabetes could explain age-related differences in disease.
www.science.org
November 13, 2025 at 7:00 AM
Congratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mattia Frontini
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Mattia Frontini
both are right: the best is marine microbiology
November 2, 2025 at 5:47 PM
both are right: the best is marine microbiology
Reposted by Mattia Frontini
Reminder! Deadline to apply is midday today!
How can individuals foster enhanced research culture, and institutions embed it meaningfully?
Exploring this, GW4 Re-Culture is now open for applications!
This creative, skills-based programme explores how we can build a flourishing research culture across GW4 universities: buff.ly/zbS1QJP
Exploring this, GW4 Re-Culture is now open for applications!
This creative, skills-based programme explores how we can build a flourishing research culture across GW4 universities: buff.ly/zbS1QJP
October 22, 2025 at 7:14 AM
Reminder! Deadline to apply is midday today!
Reposted by Mattia Frontini
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Reposted by Mattia Frontini
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by Mattia Frontini
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Mattia Frontini
A quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial.
October 9, 2025 at 7:17 AM
A quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial.
Reposted by Mattia Frontini
🗣️ "You can get test kits sent to you - it's discreet and quick and easy."
Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊
FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit
#ECFC #SemperFidelis
Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊
FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit
#ECFC #SemperFidelis
October 6, 2025 at 8:41 AM
🗣️ "You can get test kits sent to you - it's discreet and quick and easy."
Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊
FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit
#ECFC #SemperFidelis
Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊
FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit
#ECFC #SemperFidelis
Reposted by Mattia Frontini
Very much looking forward to @axelvisel.bsky.social's talk "From Nucleotide to Megabase Scale: Enhancer Function in Development and Disease" in our @enhancedgenomics.bsky.social seminar series "The 3D Regulatory Genome"
📅 02 October 2025 (today!)
⏰ 4 pm GMT
Join:
us02web.zoom.us/webinar/regi...
📅 02 October 2025 (today!)
⏰ 4 pm GMT
Join:
us02web.zoom.us/webinar/regi...
October 2, 2025 at 1:35 PM
Very much looking forward to @axelvisel.bsky.social's talk "From Nucleotide to Megabase Scale: Enhancer Function in Development and Disease" in our @enhancedgenomics.bsky.social seminar series "The 3D Regulatory Genome"
📅 02 October 2025 (today!)
⏰ 4 pm GMT
Join:
us02web.zoom.us/webinar/regi...
📅 02 October 2025 (today!)
⏰ 4 pm GMT
Join:
us02web.zoom.us/webinar/regi...
Reposted by Mattia Frontini
As we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive.
I hope you like it!
www.biorxiv.org/content/10.1...
I hope you like it!
www.biorxiv.org/content/10.1...
Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells
Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...
www.biorxiv.org
September 23, 2025 at 10:49 PM
As we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive.
I hope you like it!
www.biorxiv.org/content/10.1...
I hope you like it!
www.biorxiv.org/content/10.1...
Reposted by Mattia Frontini
Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
September 3, 2025 at 5:40 PM
Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
Reposted by Mattia Frontini
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
August 18, 2025 at 12:23 PM
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
Reposted by Mattia Frontini
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 8:40 AM
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
Reposted by Mattia Frontini
Are you interested in applying for a studentship with us? Come along to our first online Candidate Support Webinar for tips on preparing your application. Thursday 11th September at 4pm (UK time). Click here to register: events.teams.microsoft.com/event/83d5eb...
Microsoft Virtual Events Powered by Teams
Microsoft Virtual Events Powered by Teams
events.teams.microsoft.com
September 9, 2025 at 1:34 PM
Are you interested in applying for a studentship with us? Come along to our first online Candidate Support Webinar for tips on preparing your application. Thursday 11th September at 4pm (UK time). Click here to register: events.teams.microsoft.com/event/83d5eb...
Interested in a PhD to study the genetic determinants of protein abundance using paired RNA-seq and proteomic data? Join us with a @gw4biomeddtp.bsky.social funded project available in my group together with Nick Bray (Cardiff) and Kate Burley (Bristol)
September 8, 2025 at 8:15 AM
Interested in a PhD to study the genetic determinants of protein abundance using paired RNA-seq and proteomic data? Join us with a @gw4biomeddtp.bsky.social funded project available in my group together with Nick Bray (Cardiff) and Kate Burley (Bristol)
Reposted by Mattia Frontini
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted by Mattia Frontini
New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
RNA Pol II-based regulations of chromosome folding
The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. St…
www.sciencedirect.com
August 11, 2025 at 12:32 PM
New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Mattia Frontini
A big blow to All of Science, not just Harvard, not just the Fly community, not just Genetics. All of Science. Turbocharge was just switched off. Flies gave us so many insights.
I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.
August 11, 2025 at 7:07 PM
A big blow to All of Science, not just Harvard, not just the Fly community, not just Genetics. All of Science. Turbocharge was just switched off. Flies gave us so many insights.
Reposted by Mattia Frontini
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
www.biorxiv.org
August 11, 2025 at 2:56 PM
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mattia Frontini
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
August 10, 2025 at 7:50 PM
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
Reposted by Mattia Frontini
Per chi volesse, presenterò il mio libro a Palmi (RC) il prossimo 2 agosto.
July 27, 2025 at 1:31 PM
Per chi volesse, presenterò il mio libro a Palmi (RC) il prossimo 2 agosto.
Reposted by Mattia Frontini
The Perturbation Catalogue is here!
A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place.
The beta version is now live. Find out more and try the platform:
www.ebi.ac.uk/about/news/u...
🧬🖥️
A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place.
The beta version is now live. Find out more and try the platform:
www.ebi.ac.uk/about/news/u...
🧬🖥️
New platform integrates gene perturbation data
The Perturbation Catalogue provides user-friendly access to human gene perturbation, variant analysis, and expression data.
www.ebi.ac.uk
July 23, 2025 at 10:15 AM
The Perturbation Catalogue is here!
A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place.
The beta version is now live. Find out more and try the platform:
www.ebi.ac.uk/about/news/u...
🧬🖥️
A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place.
The beta version is now live. Find out more and try the platform:
www.ebi.ac.uk/about/news/u...
🧬🖥️