Jenna ⌬
@chemjenna.bsky.social
Medicinal chemistry, travel, lifting weights, cats, pop punk, SF Bay Area 🌉💙
Reposted by Jenna ⌬
A new analysis of individuals living with HIV reveals key sex differences in innate immune profiles and the complexity of the HIV proviral reservoir.
Read more in #ScienceTranslationalMedicine: https://scim.ag/4mridnp
Read more in #ScienceTranslationalMedicine: https://scim.ag/4mridnp
Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles
Sex-specific differences in immune selection of HIV-1 reservoir cells during long-term antiretroviral therapy are driven by innate immunity.
scim.ag
September 22, 2025 at 6:00 PM
A new analysis of individuals living with HIV reveals key sex differences in innate immune profiles and the complexity of the HIV proviral reservoir.
Read more in #ScienceTranslationalMedicine: https://scim.ag/4mridnp
Read more in #ScienceTranslationalMedicine: https://scim.ag/4mridnp
Reposted by Jenna ⌬
Opportunity for laboratory-based medicinal chemist at Astex Pharmaceuticals (Cambridge UK) ref: MC/0825 | closing: 30-Sep-2025 #MedChem #SynChem #UKChemJobs #ChemJobs #chemsky 🧪
www.cloudonlinerecruitment.co.uk/Astex/Vacanc...
www.cloudonlinerecruitment.co.uk/Astex/Vacanc...
Astex Careers
Astex Careers
Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery (FBDD) platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to three launched oncology drugs (Kisqali® partnered with Novartis, Balversa® partnered with Janssen and Truqap™ partnered with AstraZeneca). We have several opportunities for talented scientists who are committed to developing treatments for patients with Cancer and Neurological Disorders.
www.cloudonlinerecruitment.co.uk
August 19, 2025 at 6:50 AM
Opportunity for laboratory-based medicinal chemist at Astex Pharmaceuticals (Cambridge UK) ref: MC/0825 | closing: 30-Sep-2025 #MedChem #SynChem #UKChemJobs #ChemJobs #chemsky 🧪
www.cloudonlinerecruitment.co.uk/Astex/Vacanc...
www.cloudonlinerecruitment.co.uk/Astex/Vacanc...
Reposted by Jenna ⌬
Rare taxonomic #mycology job in NZ! Conduct fungal biodiversity & taxonomy research, secure funding, publish outputs. Working with the National Collections. PhD + postdoc experience required 🧪. Apply here: careers.sciencenewzealand.org/jobdetails?a...
August 19, 2025 at 11:19 PM
Rare taxonomic #mycology job in NZ! Conduct fungal biodiversity & taxonomy research, secure funding, publish outputs. Working with the National Collections. PhD + postdoc experience required 🧪. Apply here: careers.sciencenewzealand.org/jobdetails?a...
If you’re feeling melancholic lately, I recommend the “Life on our Planet” show on Netflix. There’s something oddly soothing about learning about all the mass extinctions that have already happened, the resilience of life and evolution, and that Earth will survive whatever BS humanity puts it though
August 18, 2025 at 8:56 PM
If you’re feeling melancholic lately, I recommend the “Life on our Planet” show on Netflix. There’s something oddly soothing about learning about all the mass extinctions that have already happened, the resilience of life and evolution, and that Earth will survive whatever BS humanity puts it though
Reposted by Jenna ⌬
Ruh roh
Bloomberg came out with a doomish piece on AI this morning. It had one interesting stat I'll share here ...| www.bloomberg.com/opinion/arti...
August 18, 2025 at 4:06 PM
Ruh roh
Reposted by Jenna ⌬
*internal and external fucking screaming*
RFK has announced that he is developing a vaccine against all viruses. Yes, every single one. The whole, uh, "phylum"
August 8, 2025 at 8:20 PM
*internal and external fucking screaming*
Curious if anyone would be interested in purchasing pre-owned film/digital cameras for any photography buffs out there. I’m tempted to keep the Canon but not sure if I’ll use it. The old Nikon is my grandpa’s from 1955 💙
August 7, 2025 at 2:56 AM
Curious if anyone would be interested in purchasing pre-owned film/digital cameras for any photography buffs out there. I’m tempted to keep the Canon but not sure if I’ll use it. The old Nikon is my grandpa’s from 1955 💙
Reposted by Jenna ⌬
#stihiv2025 🧪
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
July 30, 2025 at 9:19 PM
#stihiv2025 🧪
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
Reposted by Jenna ⌬
Thrilled to share the work of an incredible cross-functional team. 🧪
The article highlights the discovery and engineering of bispecific antibodies that demonstrated efficacy in a recurrent genital herpes in vivo model—the first such evidence for antibodies in this disease model.
The article highlights the discovery and engineering of bispecific antibodies that demonstrated efficacy in a recurrent genital herpes in vivo model—the first such evidence for antibodies in this disease model.
Identification and engineering of potent bispecific antibodies that protect against herpes simplex virus recurrent disease
Lee et al. discovered cell-to-cell spread-blocking anti-HSV antibodies and engineered
them into potent bispecific antibodies that simultaneously target two glycoproteins
essential for viral entry and ...
www.cell.com
July 30, 2025 at 11:18 PM
Thrilled to share the work of an incredible cross-functional team. 🧪
The article highlights the discovery and engineering of bispecific antibodies that demonstrated efficacy in a recurrent genital herpes in vivo model—the first such evidence for antibodies in this disease model.
The article highlights the discovery and engineering of bispecific antibodies that demonstrated efficacy in a recurrent genital herpes in vivo model—the first such evidence for antibodies in this disease model.
Reposted by Jenna ⌬
If my taxes don’t pave my roads or fix my bridges or keep my schools open 5 days a week or pay local teachers a living wage or help keep my hospital open or help my neighbor’s kid eat lunch or fund public television or my healthcare…
Why the f’ck should I pay taxes?
Why the f’ck should I pay taxes?
July 19, 2025 at 12:29 PM
If my taxes don’t pave my roads or fix my bridges or keep my schools open 5 days a week or pay local teachers a living wage or help keep my hospital open or help my neighbor’s kid eat lunch or fund public television or my healthcare…
Why the f’ck should I pay taxes?
Why the f’ck should I pay taxes?
Reposted by Jenna ⌬
The thing about the Epstein disgustingness that strikes me hardest is that hundreds of rich old men raped underage girls and the only person currently in jail for that vile behavior is a woman.
July 16, 2025 at 7:17 PM
The thing about the Epstein disgustingness that strikes me hardest is that hundreds of rich old men raped underage girls and the only person currently in jail for that vile behavior is a woman.
Reposted by Jenna ⌬
You are cordially invited to our Anti-Prime Sale, where every purchase will financially support bookstores, NOT billionaires 🥳
July 8, 2025 at 2:05 PM
You are cordially invited to our Anti-Prime Sale, where every purchase will financially support bookstores, NOT billionaires 🥳
Reposted by Jenna ⌬
They should try doing that to Republicans
After Zohran Mamdani scored a resounding victory in New York City’s Democratic mayoral primary, some in his own party are strategizing about how to defeat him in November.
Zohran Mamdani’s Foes Go to Unusual Lengths to Derail His Mayoral Hopes
After Mr. Mamdani scored a resounding victory in New York City’s Democratic primary, some in his own party are strategizing about how to defeat him in November.
trib.al
July 8, 2025 at 1:17 AM
They should try doing that to Republicans
Reposted by Jenna ⌬
I'm soaking it all up.
All the celebrating.
The victory lapping.
The high-fiving.
The dancing.
All the Republicans crowing that they "won," when all they did was give billionaires a tax break at the expense of poor people's Medicaid and food assistance.
They are applauding pain.
REMEMBER THIS.
All the celebrating.
The victory lapping.
The high-fiving.
The dancing.
All the Republicans crowing that they "won," when all they did was give billionaires a tax break at the expense of poor people's Medicaid and food assistance.
They are applauding pain.
REMEMBER THIS.
July 3, 2025 at 9:35 PM
I'm soaking it all up.
All the celebrating.
The victory lapping.
The high-fiving.
The dancing.
All the Republicans crowing that they "won," when all they did was give billionaires a tax break at the expense of poor people's Medicaid and food assistance.
They are applauding pain.
REMEMBER THIS.
All the celebrating.
The victory lapping.
The high-fiving.
The dancing.
All the Republicans crowing that they "won," when all they did was give billionaires a tax break at the expense of poor people's Medicaid and food assistance.
They are applauding pain.
REMEMBER THIS.
Reposted by Jenna ⌬
No you cannot determine which drugs are safe and effective with machine learning. You cannot. It will not work. People will die.
"At FDA we're accelerating drug approvals so that you don't need to use primates or even animal models. You can do the drug approvals very, very quickly with AI."
July 1, 2025 at 9:15 PM
No you cannot determine which drugs are safe and effective with machine learning. You cannot. It will not work. People will die.
Reposted by Jenna ⌬
dems are still operating on a paradigm where politicians on both sides are assumed to be working to make their states and constituents richer. today's republicans are trying to make everyone poorer because their ideology is to crush the labor market as part of The Plot to Enslave America.
Biden “White House officials & outside analysts touted job creation linked to IRA investments in GOP districts & states as a tangible benefit of the law that would make it politically impossible to overturn.”
Yet here we are, with the GOP on the verge of killing virtually every element of the IRA.
Yet here we are, with the GOP on the verge of killing virtually every element of the IRA.
June 28, 2025 at 8:46 PM
dems are still operating on a paradigm where politicians on both sides are assumed to be working to make their states and constituents richer. today's republicans are trying to make everyone poorer because their ideology is to crush the labor market as part of The Plot to Enslave America.
Reposted by Jenna ⌬
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.
go.nature.com
June 25, 2025 at 4:31 PM
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Reposted by Jenna ⌬
Every day Israel starves 2 million people in Gaza.
Every day it massacres dozens after luring them to its "aid hubs" with the promise of food.
Every day the media treats this as an entirely routine story, barely worth reporting.
Every day it massacres dozens after luring them to its "aid hubs" with the promise of food.
Every day the media treats this as an entirely routine story, barely worth reporting.
June 24, 2025 at 7:40 PM
Every day Israel starves 2 million people in Gaza.
Every day it massacres dozens after luring them to its "aid hubs" with the promise of food.
Every day the media treats this as an entirely routine story, barely worth reporting.
Every day it massacres dozens after luring them to its "aid hubs" with the promise of food.
Every day the media treats this as an entirely routine story, barely worth reporting.
Reposted by Jenna ⌬
An anti-science administration hellbent on uprooting and dismantling 75+ years of American leadership in science.
Why? To what ends? Who benefits when the White House makes it ever harder, if not impossible, to retain talent, advance use-driven research, and train the next generation of innovators?
Why? To what ends? Who benefits when the White House makes it ever harder, if not impossible, to retain talent, advance use-driven research, and train the next generation of innovators?
NEW: NSF will be kicked out of their building. Announcement will be made tomorrow by HUD Sec. and Governor of VA. HUD will take over the NSF building over the next two years.
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
June 25, 2025 at 1:44 AM
An anti-science administration hellbent on uprooting and dismantling 75+ years of American leadership in science.
Why? To what ends? Who benefits when the White House makes it ever harder, if not impossible, to retain talent, advance use-driven research, and train the next generation of innovators?
Why? To what ends? Who benefits when the White House makes it ever harder, if not impossible, to retain talent, advance use-driven research, and train the next generation of innovators?
Reposted by Jenna ⌬
The FDA is literally tasked with overseeing the safety of all food, drugs, medical devices, & cosmetics, as well as “preventing the introduction, transmission, or spread of communicable diseases.” They regulate our safety from cell phones, to sperm donation, to condoms, to domestic animals to lasers
Absolute bloodbath at FDA, very bad
June 24, 2025 at 2:19 AM
The FDA is literally tasked with overseeing the safety of all food, drugs, medical devices, & cosmetics, as well as “preventing the introduction, transmission, or spread of communicable diseases.” They regulate our safety from cell phones, to sperm donation, to condoms, to domestic animals to lasers
Reposted by Jenna ⌬
As a big fan of half-saturated bicycling ring systems, this #OPRDasap from Hong et al @ Genentech is really good work. Some neat chemistry in here detailed in the replies…1/. #Chemsky
Stereocontrolled First Generation Synthesis of RIPK1 Inhibitor GDC-8264
We report an efficient, stereocontrolled, and chromatography-free first-generation manufacturing process for GDC-8264 (1), a RIPK1 inhibitor. Key steps include a diastereoselective reductive amination...
pubs.acs.org
June 23, 2025 at 2:04 PM
Reposted by Jenna ⌬
I am incensed. This is all so heartbreaking and despicable. The Iranian people do not deserve this violence. We do not deserve this governance. The world does not deserve this. These outrages must end.
June 22, 2025 at 2:14 AM
I am incensed. This is all so heartbreaking and despicable. The Iranian people do not deserve this violence. We do not deserve this governance. The world does not deserve this. These outrages must end.
Reposted by Jenna ⌬
Now that's what a true patriotic American sounds like.
THIS x 1,000,000. Honestly I don’t know who this person is (this clip popped up on social media) but I would vote for them tomorrow.
June 22, 2025 at 1:50 AM
Now that's what a true patriotic American sounds like.
Reposted by Jenna ⌬
Phasing out NIH’s HIV clinical guidelines is flat-out immoral and unethical.
These guidelines drive early diagnosis, ART initiation, and viral suppression—82% linked to care within 30 days, 69% virally suppressed by 6 months.
Removing them puts millions of lives at risk.
wapo.st/3FQovhf
These guidelines drive early diagnosis, ART initiation, and viral suppression—82% linked to care within 30 days, 69% virally suppressed by 6 months.
Removing them puts millions of lives at risk.
wapo.st/3FQovhf
Administration to phase out NIH support of HIV clinical guidelines
The National Institutes of Health will phase out its support of the clinical practice guidelines that advise doctors how to diagnose and treat HIV.
wapo.st
June 21, 2025 at 7:45 PM
Phasing out NIH’s HIV clinical guidelines is flat-out immoral and unethical.
These guidelines drive early diagnosis, ART initiation, and viral suppression—82% linked to care within 30 days, 69% virally suppressed by 6 months.
Removing them puts millions of lives at risk.
wapo.st/3FQovhf
These guidelines drive early diagnosis, ART initiation, and viral suppression—82% linked to care within 30 days, 69% virally suppressed by 6 months.
Removing them puts millions of lives at risk.
wapo.st/3FQovhf