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candicefung.bsky.social
Candice Fung
@candicefung.bsky.social
83 followers 170 following 4 posts
Enteric Nervous System and Gut Physiology 🔬
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candicefung.bsky.social
Candice Fung @candicefung.bsky.social · Jul 9
Ecstatic to share our paper on nutrient signaling in the #EntericNervousSystem published in Nature! 🧪

We explored how neurons in the gut respond to basic nutrients that we typically ingest and tested whether they can distinguish between different nutrients 🔬

Check it out 👉 tinyurl.com/3vc756dv
Reposted by Candice Fung
benchsidestory.bsky.social
STEM CELL THERAPIES FOR ENTERIC NEUROPATHIES, with Dr Lincon Stamp, Senior Research Fellow & Group Leader, Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne @unimelb.bsky.social , Victoria, Australia @stamphaolab.bsky.social youtu.be/4EdI2jJL1l8
October 11, 2025 at 8:07 AM
Reposted by Candice Fung
dgnm.bsky.social
👉 We generated a starter pack for #neurogastroenterology and enteric #neuroscience!

Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐

go.bsky.app/3Z82PbH
November 1, 2025 at 6:37 PM
Reposted by Candice Fung
mlacyphd.bsky.social
💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback."
Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)
When is a Monomer not a Monomer? The Top Three Ways Your Favorite Fluorescent Protein Oligomerizes in Cells
Many commonly used fluorescent proteins form dimers producing artifacts in a variety of experimental settings. Learn how to avoid these artifacts.
blog.addgene.org
July 29, 2025 at 4:04 PM
Reposted by Candice Fung
natrevgastrohep.nature.com
New online! Nutrient sensing and small intestinal enteric neurons
Nutrient sensing and small intestinal enteric neurons
Nature Reviews Gastroenterology & Hepatology, Published online: 24 July 2025; doi:10.1038/s41575-025-01105-4Nutrient sensing and small intestinal enteric neurons
www.nature.com
July 24, 2025 at 2:57 PM
Reposted by Candice Fung
nature.com
Nature research paper: Nutrients activate distinct patterns of small-intestinal enteric neurons

go.nature.com/4lr616y
Nutrients activate distinct patterns of small-intestinal enteric neurons - Nature
Calcium imaging of the mouse jejunum shows that specific nutrients in the intestinal lumen are detected by epithelial cells, which activate specific sets of enteric neurons through a serotonin-mediated signalling process.
go.nature.com
July 10, 2025 at 7:13 PM
candicefung.bsky.social
Ecstatic to share our paper on nutrient signaling in the #EntericNervousSystem published in Nature! 🧪

We explored how neurons in the gut respond to basic nutrients that we typically ingest and tested whether they can distinguish between different nutrients 🔬

Check it out 👉 tinyurl.com/3vc756dv
July 9, 2025 at 7:01 PM
Reposted by Candice Fung
wboesmans.bsky.social
The website for next year's symposium on 'ENS development, function and repair' is online!

Please visit ens-leuven2026.eu and mark your 📆 Updates and more information will follow soon.

We hope to see you next April in Leuven 🇧🇪 with your most exciting #ENS science!

@pietervandenberghe.bsky.social
ens-leuven2026.eu
ens-leuven2026.eu
July 9, 2025 at 6:36 AM
Reposted by Candice Fung
ulrikakmarklund.bsky.social
Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz
The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine
Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...
rdcu.be
May 29, 2025 at 11:28 AM
Reposted by Candice Fung
conormccann-ens.bsky.social
New preprint from our group on bioRxiv, a little step towards a better understanding of how coordinated contractions develop in the human intestine. Please check it out and let us know your thoughts.
biorxivpreprint.bsky.social bioRxivpreprint @biorxivpreprint.bsky.social · Apr 20
Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development https://www.biorxiv.org/content/10.1101/2025.04.17.649306v1
April 20, 2025 at 11:27 AM
Reposted by Candice Fung
cp-trendsneuro.bsky.social
April 2025 issue of Trends in Neurosciences:
www.cell.com/issue/S0166-...

Free featured articles & more:
cell.com/trends/neuro...

Cover article: ‘MicroRNA regulation of enteric nervous system development and disease’ by Holland et al., @wboesmans.bsky.social group
www.cell.com/trends/neuro...
April 8, 2025 at 7:17 PM
Reposted by Candice Fung
margolislabnyu.bsky.social
New study: Boosting serotonin in the gut (not the brain) eases anxiety + depression—without the side effects. A safer path for treatment, especially during pregnancy. #GutBrainAxis #MentalHealth #SSRI
@karapedsgastrodoc.bsky.social
@nyupainresearch.bsky.social

www.nyu.edu/about/news-p...
Scientists Find Promising New Target for Antidepressants—In the Gut
Increasing serotonin in the lining of the gut improves anxiety and depression in animal studies and may offer new therapeutic approach during pregnancy to avoid newfound risk of digestive issues in ch...
www.nyu.edu
April 7, 2025 at 3:52 PM
Reposted by Candice Fung
labsoap.bsky.social
Check this #JS2025 #colloque #GLICO Glial communication 🧠
🎤 @wboesmans.bsky.social @candicechaps.bsky.social #IBrunet #QRoux @laisbfugio.bsky.social #VMoulle #CLeBerre
💻 #MDerkindren #TDurand @labsoap.bsky.social
🗓️ 27-05 Nantes
🚧 Free Registration limited seats
js.univ-nantes.fr/jassiste-aux...
April 2, 2025 at 7:17 AM
Reposted by Candice Fung
cp-cellreports.bsky.social
Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections
Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections
Intrinsic enteric neurons (iENs) emerge as crucial regulators of immune responses in the intestine, but the underlying molecular mechanisms remain unclear. Sun et al. show that AHR differentially regulates iEN activation in different intestinal segments and that AHR expression in neurons constrains ILC3 responses and antibacterial immunity in the ileum.
dlvr.it
April 2, 2025 at 2:39 PM
Reposted by Candice Fung
cp-cell.bsky.social
Now online! Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.
dlvr.it
March 24, 2025 at 10:38 PM
Reposted by Candice Fung
irenemiguel-aliaga.bsky.social
Epic effort led by Tomo Ameku in the lab, with contributions from the labs of Nick Bellono, Vassilis Pachnis, @francoisleulier.bsky.social, @schwarzergnoto.bsky.social, @priscaliberali.bsky.social, ‪@coxlabkcl.bsky.social,‬ @priscaliberali.bsky.social and Maria Rodriguez-Colman
irenemiguel-aliaga.bsky.social Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · Mar 19
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...
March 19, 2025 at 5:32 PM
Reposted by Candice Fung
jphysiol.bsky.social
📖 LATEST ISSUE NOW LIVE 📖

This issue commemorates the late Dr. Gary M. Mawe who was a highly respected and much-loved Reviewing Editor for The Journal of Physiology. His snowflake photography features as the issue cover art❄️📷

🔗https://buff.ly/8BaJ270
March 15, 2025 at 12:00 PM
Reposted by Candice Fung
cp-neuron.bsky.social
Enteric glutamatergic interneurons regulate intestinal motility
Hamnett, Bendrick, et al. identify two populations of glutamatergic enteric neurons—longitudinal descending interneurons and a previously unreported population of circumferential neurons. They observe that these VGLUT2+ neurons form synaptic contact with…
dlvr.it
February 20, 2025 at 4:24 PM
Reposted by Candice Fung
carolynbertozzi.bskyverified.social
Excited to share this collaborative work led by Guosong Hong’s group @stanfordneuro.bsky.social. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum 🌈

www.biorxiv.org/content/10.1...
Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice
Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely...
www.biorxiv.org
February 28, 2025 at 6:39 AM
Reposted by Candice Fung
nature.com
Nature research paper: Topological segregation of stress sensors along the gut crypt–villus axis

https://go.nature.com/4b4jcpC
Topological segregation of stress sensors along the gut crypt–villus axis - Nature
Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of the gut.
go.nature.com
February 12, 2025 at 8:05 PM
Reposted by Candice Fung
nature.com
There is a disconnect between the current molecular, morphological and functional descriptions of cells in most nervous systems

https://go.nature.com/4jUeXRq
Does a cell’s gene expression always reflect its function?
Transcriptionally similar neurons can be functionally diverse.
go.nature.com
February 12, 2025 at 6:36 PM
Reposted by Candice Fung
crick.ac.uk
Does what's happening in your gut affect what's happening in your brain?

Researchers at the Crick are continuously learning new things about this complex relationship.

Read more about their work and the gut-brain connection. 👇
www.crick.ac.uk/news/2025-01...
Understanding our complex gut brain
Researchers are uncovering the complex connection between your gut and brain.
www.crick.ac.uk
February 6, 2025 at 10:30 AM
Reposted by Candice Fung
liam-rooney.bsky.social
🚨 New pre-print out! 🚨

The world’s first fully 3D printed microscope!

Is Santa bringing you a 3D printer for Christmas, or maybe you need a gift for your favourite microscopist - print the lenses, print the frame, and start imaging! ✨🔬

Check it out below and please repost!👇🏻🙏🏻

(1/N)
biorxiv-biophys.bsky.social bioRxiv Biophysics @biorxiv-biophys.bsky.social · Dec 20
A fully 3D-printed optical microscope for low-cost histological imaging https://www.biorxiv.org/content/10.1101/2024.12.16.628684v1
December 21, 2024 at 4:01 PM
Reposted by Candice Fung
meghanazad.bsky.social
The gut 'remodels' itself during pregnancy and #breastfeeding - nearly doubling its surface area! 🧪

www.livescience.com/health/ferti...
The gut 'remodels' itself during pregnancy, study finds
The inner lining of the small intestine nearly doubles in size during pregnancy and breastfeeding, according to new research in mice and human tissue.
www.livescience.com
December 28, 2024 at 8:06 PM
Reposted by Candice Fung
massecklab.bsky.social
🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
December 18, 2024 at 10:01 AM
Reposted by Candice Fung
cedricboeckx.bsky.social
Such a nice, comprehensive review by @marcvoo.bsky.social and @erin-schuman.bsky.social on the molecular diversity of synapses (h/t @djabaudon.bsky.social):
www.nature.com/articles/s41...
Understanding the molecular diversity of synapses - Nature Reviews Neuroscience
The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...
www.nature.com
December 8, 2024 at 9:48 AM