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margolislabnyu.bsky.social
MargolisLab
@margolislabnyu.bsky.social
450 followers 450 following 93 posts
Margolis Lab | NYU Pain Research Center 🧠💩 Discovering how gut signaling impacts brain & GI disorders. Exploring the role of serotonin in gut-brain interaction, DGBI, neurodevelopmental disorders, and visceral pain.
PI: @karapedsgastrodoc.bsky.social
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margolislabnyu.bsky.social
📢New paper in Nature Mental Health!
Dr. @karapedsgastrodoc.bsky.social is co-author on a review exploring how the gut microbiota shapes mental health through the gut–brain axis.🧠

🔗 doi.org/10.1038/s442...
Distinguishing the causative, correlative and bidirectional roles of the gut microbiota in mental health - Nature Mental Health
This Review provides a critical assessment of current mechanistic and clinical evidence on the interaction between the gut microbiota and mental health to differentiate causative, correlative and bidi...
doi.org
September 19, 2025 at 8:14 PM
margolislabnyu.bsky.social
Big congratulations to postdoc @sarahanajjar.bsky.social on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏
@karapedsgastrodoc.bsky.social
September 18, 2025 at 5:26 PM
margolislabnyu.bsky.social
Cool new study showing a comprehensive map of neuroimmune interactions throughout the gut!
www.pnas.org/doi/full/10....
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 2, 2025 at 7:50 PM
margolislabnyu.bsky.social
New research highlights a stomach–brain connection in mental health.
👉 Stronger frontoparietal coupling to gastric rhythms = a marker of poorer mental health (anxiety, depression, stress, well-being).
Visceral rhythms aren’t just gut feelings, they shape our emotions
www.nature.com/articles/s44...
Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health
Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...
www.nature.com
September 2, 2025 at 7:48 PM
margolislabnyu.bsky.social
Happy Birthday to the best mentor ever, Prof. Margolis! 🥳 Thank you for always guiding and supporting us, we’re so lucky to learn from you!
@karapedsgastrodoc.bsky.social
August 29, 2025 at 4:40 PM
margolislabnyu.bsky.social
Amazing week at ANMS 2025! 🌟
Sarah, Chalystha, Lin and Kara gave fantastic talks with Chalystha winning the Frank Hamilton Travel Award and Sarah named a Young Investigator Forum Fellow. Kara’s plenary lecture was a highlight, along with meeting Nobel laureate David Julius.
August 15, 2025 at 8:06 PM
margolislabnyu.bsky.social
New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues.
@karapedsgastrodoc.bsky.social

🔗 www.nature.com/articles/s41...
A gut sense for a microbial pattern regulates feeding - Nature
A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.
www.nature.com
July 24, 2025 at 8:51 PM
Reposted by MargolisLab
chalysthalee.bsky.social
Just back from a great week in Vienna for #ISSR2025. I am grateful for the travel award and the opportunity to share my work. Big thanks to @karapedsgastrodoc.bsky.social and Mike Gershon for their steady support in the lab and my career. Loved connecting with 5-HT researchers from around the world!
July 15, 2025 at 3:34 PM
Reposted by MargolisLab
chalysthalee.bsky.social
@karapedsgastrodoc.bsky.social gave a fantastic talk on the lab's important work on SSRI use in the gastrointestinal tract
@margolislabnyu.bsky.social highlighting @linyhung.bsky.social and @sarahanajjar.bsky.social 's work!
@nyupainresearch.bsky.social
July 8, 2025 at 9:07 AM
margolislabnyu.bsky.social
Our amazing mentor and team lead @karapedsgastrodoc.bsky.social is now officially Professor Margolis! 👏👩‍🏫
She’s the definition of supportive, visionary, and unstoppable! no one deserves it more!
Feeling so lucky to be part of her team 💜
#ProfessorKara #WomenInScience #ProudTeam 💫🌟
June 27, 2025 at 8:19 PM
margolislabnyu.bsky.social
The Fattahi Lab successfully transplanted hPSC‑derived nitrergic enteric neurons into NO‑neuron–deficient mice, restoring gut motility, and created scalable 2D/3D human ENS models to support drug discovery and cell‑therapy approaches for enteric neuropathies.

www.nature.com/articles/s41...
Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice - Nature
A study presents a strategy based on human pluripotent stem cells for treating neurodegenerative disorders of the gastrointestinal tract.
www.nature.com
June 26, 2025 at 3:18 PM
margolislabnyu.bsky.social
A new study shows that food structure plays a key role in determining which gut hormones are released.
@karapedsgastrodoc.bsky.social

#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege

📖 Nature Metabolism
www.nature.com/articles/s42...
Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism
In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...
www.nature.com
June 24, 2025 at 8:32 PM
margolislabnyu.bsky.social
🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌
Game-changer for gut health.
sciencedirect.com/science/arti...

#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social
Blood-based T Cell Diagnosis of Celiac Disease
Current diagnosis of celiac disease (CeD) is inaccurate in patients following a gluten-free diet (GFD). Blood-based diagnostics targeting gluten-speci…
sciencedirect.com
June 20, 2025 at 3:46 PM
margolislabnyu.bsky.social
Big congrats to @linyhung.bsky.social on her Nature Reviews Journal Club piece spotlighting gut serotonin as a target for mood disorder treatment!
@karapedsgastrodoc.bsky.social

file:///C:/Users/Eb4415/Downloads/Hung-2025-Nature_Reviews_Gastroenterology_&_Hepatology.pdf
June 2, 2025 at 7:59 PM
margolislabnyu.bsky.social
🎉 Big wins for the Margolis Lab at AMPIRS 2025!

👏 Chalystha and Lin rocked their talks, Taeseon and Daniel nailed their posters, and Sarah delivered an epic flash talk!

🏆 Huge congrats to Lin and Sarah for taking 1st place! So proud of this amazing team! 💜🧠
@karapedsgastrodoc.bsky.social
June 2, 2025 at 2:34 PM
Reposted by MargolisLab
nyupainresearch.bsky.social
Titles:
Maria Fernanda: Neuropilin-1 Modules nerve growth factor signaling to sustain periorbital pain
Zhiting Gong: Mice lacking LRP1 in Schwann cells exhibit orofacial pain
Chalystha Yie Qin Lee: Epithelial 5HT4 receptor in mood, gastrointestinal motility, and visceral pain
May 30, 2025 at 2:09 PM
Reposted by MargolisLab
nyupainresearch.bsky.social
Happening Now! The 5th Annual Molecular Pathobiology Innovative Research Symposium is in full swing! Dazzling presentations 🎬 by the brilliant minds of Maria Fernanda, Zhiting Gong, and Chalystha Yie Qin Lee. Shoutout to Jean-Pierre N. Saint-Jeannet, PhD, for inspiring opening remarks. Stay tuned!
May 30, 2025 at 2:05 PM
Reposted by MargolisLab
nyupainresearch.bsky.social
🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter
May 30, 2025 at 4:39 PM
Reposted by MargolisLab
nyupainresearch.bsky.social
Shoutout to our PRC pros who rocked the Flash Talk! Titles listed below🎤mic drops all around!
Sarah Najjar: Sex differences in gut serotonergic signaling of visceral pain
Badr Sokrat: Compartmentalized intracellular signaling of the prostaglandin EP4 receptor contributes to pain
May 30, 2025 at 11:52 PM
Reposted by MargolisLab
nyupainresearch.bsky.social
🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity
May 30, 2025 at 10:23 PM
Reposted by MargolisLab
nyupainresearch.bsky.social
Lin Hung- Early Life Stress leads to dysregulated serotonin development in the gut and predisposes to intestinal pain/dysmotility later life
Andres Cabezas- Structural studies of a mechanosensing ion channel in a native-like environment
Emmanuel Flores- Vasopressin V2 receptor activity at lysosomes
May 31, 2025 at 1:40 AM
Reposted by MargolisLab
nyupainresearch.bsky.social
And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride
May 31, 2025 at 1:25 AM
margolislabnyu.bsky.social
IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells
@karapedsgastrodoc.bsky.social
www.pnas.org/doi/10.1073/...
The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury | PNAS
Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response in underlying IL18R1+ lamina propria cells. Notably, Il18r1 ...
www.pnas.org
May 29, 2025 at 8:49 PM
Reposted by MargolisLab
kuchroolab.bsky.social
🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...
www.science.org
May 23, 2025 at 1:26 AM
margolislabnyu.bsky.social
New study! Aging and nerve injury cause senescent neurons in the peripheral nervous system, driving increased pain; targeting these cells could offer a new pain treatment especially in older adults.
@vivtawfik-mdphd.bsky.social
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...
Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience
The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
www.nature.com
May 29, 2025 at 1:44 PM