Chris Caffalette
@caffalette.bsky.social
Postdoc at The Rockefeller University
Reposted by Chris Caffalette
CUNY and SUNY colleagues: ICYMI Please sign and share this letter to the NY Congressional Delegation asking them to protect NIH and NSF funding!
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...
June 11, 2025 at 12:47 PM
CUNY and SUNY colleagues: ICYMI Please sign and share this letter to the NY Congressional Delegation asking them to protect NIH and NSF funding!
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...
Reposted by Chris Caffalette
MIT News reports on focused research organizations (FROs), non-profit startups, developed by some of our group members and alumni. FROs can work on problems that are a poor fit for academia or the for-profit startup world. news.mit.edu/2025/former-...
Former MIT researchers advance a new model for innovation
Developed by former MIT researchers, focused research organizations (FROs) undertake large research efforts and have begun to contribute to scientific advances.
news.mit.edu
June 7, 2025 at 9:59 PM
MIT News reports on focused research organizations (FROs), non-profit startups, developed by some of our group members and alumni. FROs can work on problems that are a poor fit for academia or the for-profit startup world. news.mit.edu/2025/former-...
Reposted by Chris Caffalette
The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
The vault protein is expressed in most eukaryotic cells, where it is assembled on polyribosomes into large hollow barrel-shaped complexes. Despite its widespread and abundant presence in cells, the bi...
www.biorxiv.org
May 28, 2025 at 7:33 AM
The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Chris Caffalette
This isn’t just numbers on a table–it’s my lab and the labs of my colleagues. Terminated grants mean shuttered projects, lost talent, and stalled progress against deadly pathogens. The damage to science–and to public health–is real and immediate. Thanks @peterhotezmdphd.bsky.social for speaking out.
Devastating NIH cuts to infectious disease research, eviscerating our nation’s capacity to fight emerging infections and pandemic threats. From @sanders.senate.gov report out yesterday www.sanders.senate.gov/wp-content/u...
May 23, 2025 at 10:25 AM
This isn’t just numbers on a table–it’s my lab and the labs of my colleagues. Terminated grants mean shuttered projects, lost talent, and stalled progress against deadly pathogens. The damage to science–and to public health–is real and immediate. Thanks @peterhotezmdphd.bsky.social for speaking out.
Reposted by Chris Caffalette
Back to @mblscience.bsky.social Woods Hole - teaching on the Pair Up Microscopy Course. Great experience and awesome participants.
Wild - last time here I was a student (Physical Biology of the Cell Course in 2018). Now introducing my lab.
Thanks Abhishek Kumar for organising and the invitation.
Wild - last time here I was a student (Physical Biology of the Cell Course in 2018). Now introducing my lab.
Thanks Abhishek Kumar for organising and the invitation.
May 18, 2025 at 10:36 PM
Back to @mblscience.bsky.social Woods Hole - teaching on the Pair Up Microscopy Course. Great experience and awesome participants.
Wild - last time here I was a student (Physical Biology of the Cell Course in 2018). Now introducing my lab.
Thanks Abhishek Kumar for organising and the invitation.
Wild - last time here I was a student (Physical Biology of the Cell Course in 2018). Now introducing my lab.
Thanks Abhishek Kumar for organising and the invitation.
Reposted by Chris Caffalette
If people of means are interested in establishing a 2025 “Institute for Advanced Study” for displaced/defunded biomedical scientists, I know many people who will help, including myself.
@mcuban.bsky.social
@arcadiascience.com
@arcinstitute.org
@mcuban.bsky.social
@arcadiascience.com
@arcinstitute.org
Let's talk about these two department store owners: brother and sister Louis Bamberger and Caroline Bamberger Fuld. From Newark, New Jersey.
They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵
They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵
May 19, 2025 at 12:07 AM
If people of means are interested in establishing a 2025 “Institute for Advanced Study” for displaced/defunded biomedical scientists, I know many people who will help, including myself.
@mcuban.bsky.social
@arcadiascience.com
@arcinstitute.org
@mcuban.bsky.social
@arcadiascience.com
@arcinstitute.org
Reposted by Chris Caffalette
Just found out my two related NSF grants (on discovery of phages that target antibiotic resistance vectors and building synthetic systems to understand the biology of those vectors) were also caught in Harvard’s mass grant termination
May 15, 2025 at 11:18 AM
Just found out my two related NSF grants (on discovery of phages that target antibiotic resistance vectors and building synthetic systems to understand the biology of those vectors) were also caught in Harvard’s mass grant termination
Reposted by Chris Caffalette
Here’s another spectacle of New York spring entomology: Eastern tent caterpillars (Malacosoma americanum) are among the most social lepidopterans. In May, you can find their silken tents, in which they aggregate (and defecate).
May 6, 2025 at 1:42 AM
Here’s another spectacle of New York spring entomology: Eastern tent caterpillars (Malacosoma americanum) are among the most social lepidopterans. In May, you can find their silken tents, in which they aggregate (and defecate).
Reposted by Chris Caffalette
They have three daily feeding bouts, during which they exit the nest and move together to distant feeding sites. They mark their route with silk and trail pheromone. Successful “scouts” can even recruit the colony to new food sources. They’re kind of the ants among the butterflies.
Woodstock, NY.
Woodstock, NY.
May 6, 2025 at 1:42 AM
They have three daily feeding bouts, during which they exit the nest and move together to distant feeding sites. They mark their route with silk and trail pheromone. Successful “scouts” can even recruit the colony to new food sources. They’re kind of the ants among the butterflies.
Woodstock, NY.
Woodstock, NY.
Reposted by Chris Caffalette
My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
April 30, 2025 at 5:01 PM
My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681
Reposted by Chris Caffalette
Tomorrow at the Systems Virology Journal Club, @tamanash.bsky.social will present his beautiful work with @harmitmalik.bsky.social on optimizing temperature-dependent trade-off between protein production and processing in alphaviruses through stop codon selectivity pubmed.ncbi.nlm.nih.gov/40249804/
@wmschneider.bsky.social and I are thrilled to invite you to the 7th series of the International *Systems Virology Journal Club*! 🎉 🥂🌟
We are hosting a stellar line-up of speakers working at the intersection of virology and systems biology.
Registration (free): forms.gle/edTyLwR8jWkh...
We are hosting a stellar line-up of speakers working at the intersection of virology and systems biology.
Registration (free): forms.gle/edTyLwR8jWkh...
April 30, 2025 at 10:38 PM
Tomorrow at the Systems Virology Journal Club, @tamanash.bsky.social will present his beautiful work with @harmitmalik.bsky.social on optimizing temperature-dependent trade-off between protein production and processing in alphaviruses through stop codon selectivity pubmed.ncbi.nlm.nih.gov/40249804/
Reposted by Chris Caffalette
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers
can have drastically different phospholipid abundances between their two leaflets.
This lipid abundance asymmetry...
www.cell.com
April 3, 2025 at 3:07 PM
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Reposted by Chris Caffalette
Rachael, thank you for this. We can all benefit from the example of your courage and wisdom in speaking out.
Hey Bluesky, I was interviewed about the attacks on science for NPR’s All Things Considered. Listen, below! www.wbur.org/news/2025/03...
UMass biomedical scientist freezes pediatric brain cancer research due to federal funding problems
UMass Chan Medical School biomedical engineer and professor Rachael Sirianni leads a lab that researches new technologies to help treat brain tumors in children. Delays in federal grants have led her ...
www.wbur.org
March 28, 2025 at 11:40 AM
Rachael, thank you for this. We can all benefit from the example of your courage and wisdom in speaking out.
Reposted by Chris Caffalette
Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase. New study from Lauren Vostal, Tarun Kapoor and colleagues @rockefelleruniv.bsky.social: rupress.org/jcb/article/...
#StructuralBiology #Biochemistry #ProteinHomeostasis #CryoEM
#StructuralBiology #Biochemistry #ProteinHomeostasis #CryoEM
March 21, 2025 at 2:27 PM
Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase. New study from Lauren Vostal, Tarun Kapoor and colleagues @rockefelleruniv.bsky.social: rupress.org/jcb/article/...
#StructuralBiology #Biochemistry #ProteinHomeostasis #CryoEM
#StructuralBiology #Biochemistry #ProteinHomeostasis #CryoEM
Reposted by Chris Caffalette
WE GOT THE COVER!!!
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 7:16 PM
WE GOT THE COVER!!!
Reposted by Chris Caffalette
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 6:20 PM
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
Reposted by Chris Caffalette
Congratulations to first authors @rufeili.bsky.social and @tshindmarsh.bsky.social !!!!
March 20, 2025 at 2:45 PM
Congratulations to first authors @rufeili.bsky.social and @tshindmarsh.bsky.social !!!!
Reposted by Chris Caffalette
Here is the paper, worth a read for those interested in behavior, neuroscience, and mating competition: www.cell.com/cell/fulltex...
www.cell.com
March 20, 2025 at 2:44 PM
Here is the paper, worth a read for those interested in behavior, neuroscience, and mating competition: www.cell.com/cell/fulltex...
Reposted by Chris Caffalette
Proud that one of my photographs has made the cover of Cell. (first 'official' photograph publication) Very happy to contribute the pic and highlight the latest publication of the Ruta lab.
March 20, 2025 at 2:43 PM
Proud that one of my photographs has made the cover of Cell. (first 'official' photograph publication) Very happy to contribute the pic and highlight the latest publication of the Ruta lab.
Reposted by Chris Caffalette
In preparation for the lecture tomorrow, I opened "The Cell in Development and Heredity" by E.B. Wilson (Columbia Univ), and realized that this 3rd edition was published in 100 years ago.
So many things happened since then, including the fact that I, a Japanese Prof in NY, own and read the book.
So many things happened since then, including the fact that I, a Japanese Prof in NY, own and read the book.
March 12, 2025 at 11:48 PM
In preparation for the lecture tomorrow, I opened "The Cell in Development and Heredity" by E.B. Wilson (Columbia Univ), and realized that this 3rd edition was published in 100 years ago.
So many things happened since then, including the fact that I, a Japanese Prof in NY, own and read the book.
So many things happened since then, including the fact that I, a Japanese Prof in NY, own and read the book.
Reposted by Chris Caffalette
Fantastic #TeamTomo story on retrotransposon particles by @svenklumpe.bsky.social and friends. Take a look! 🧪🧶🧬
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
March 6, 2025 at 1:23 AM
Fantastic #TeamTomo story on retrotransposon particles by @svenklumpe.bsky.social and friends. Take a look! 🧪🧶🧬
Reposted by Chris Caffalette
Retrotransposon-derived capsids in the Dros. ovary revealed by CryoET! Amazing PhD work by @svenklumpe.bsky.social (still MPI Biochemistry) in collab with @juliusbrennecke.bsky.social lab - congrats to all authors! Really looking forward to exciting times with Sven @viennabiocenter.bsky.social!
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
March 5, 2025 at 9:39 PM
Retrotransposon-derived capsids in the Dros. ovary revealed by CryoET! Amazing PhD work by @svenklumpe.bsky.social (still MPI Biochemistry) in collab with @juliusbrennecke.bsky.social lab - congrats to all authors! Really looking forward to exciting times with Sven @viennabiocenter.bsky.social!
Reposted by Chris Caffalette
This has to be one of the coolest papers of the year: retrotransposon VLPs, visualized inside cells!
#TeamTomo #CryoET
#TeamTomo #CryoET
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
March 5, 2025 at 5:11 PM
Reposted by Chris Caffalette
Congrats to our postdoc Jan-Hannes Schaefer @jhschaef.bsky.social on being awarded a fellowship from the Walter Benjamin Program! Jan is collaborating with the Kelly lab here at Scripps Research @scripps.edu to understand how transthyretin forms amyloids that lead to heart disease.
March 3, 2025 at 11:33 PM
Congrats to our postdoc Jan-Hannes Schaefer @jhschaef.bsky.social on being awarded a fellowship from the Walter Benjamin Program! Jan is collaborating with the Kelly lab here at Scripps Research @scripps.edu to understand how transthyretin forms amyloids that lead to heart disease.