Rock Lab
@rocklabtb.bsky.social
Rock Lab @ Rockefeller University. Tuberculosis functional genomics.
Reposted by Rock Lab
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.
www.science.org
November 5, 2025 at 9:57 PM
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Reposted by Rock Lab
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
October 30, 2025 at 3:21 AM
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Reposted by Rock Lab
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Rock Lab
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 9:47 PM
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
Ditto. Thanks for this Sarah. www.statnews.com/2025/10/06/g...
The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all
Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.
www.statnews.com
October 8, 2025 at 9:52 AM
Ditto. Thanks for this Sarah. www.statnews.com/2025/10/06/g...
Reposted by Rock Lab
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 7, 2025 at 4:10 PM
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Reposted by Rock Lab
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 5, 2025 at 12:03 PM
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Reposted by Rock Lab
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Department of Microbiology | The University of Chicago
microbiology.uchicago.edu
October 6, 2025 at 5:32 PM
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Congratulations!
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics reveals gene expression as an axis of variation in host interaction. Underscoring this, variants in a regulator of a key virulence pathway are associated with increased transmission and drug resistance.
dlvr.it
September 30, 2025 at 11:03 PM
Congratulations!
Reposted by Rock Lab
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics reveals gene expression as an axis of variation in host interaction. Underscoring this, variants in a regulator of a key virulence pathway are associated with increased transmission and drug resistance.
dlvr.it
September 30, 2025 at 6:51 PM
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Reposted by Rock Lab
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Reposted by Rock Lab
Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:
National Academy of Medicine to Present Hamburg Award to Carl F. Nathan for Seminal Discoveries That Improve Understanding of Innate Immunity - NAM
WASHINGTON — The National Academy of Medicine (NAM) today announced that Carl F. Nathan is the recipient of the 2025 David and Beatrix Hamburg Award for
nam.edu
September 26, 2025 at 7:23 PM
Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:
Very interesting, excited to see where this goes.
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
September 15, 2025 at 4:56 PM
Very interesting, excited to see where this goes.
Reposted by Rock Lab
We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine
August 20, 2025 at 7:41 PM
We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine
Reposted by Rock Lab
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
Learn more below:
Faculty recruitment - Our Scientists
Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.
www.rockefeller.edu
August 20, 2025 at 3:13 PM
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
Learn more below:
Reposted by Rock Lab
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
www.statnews.com
July 31, 2025 at 9:08 PM
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...
Congrats to all authors! Very cool mechanism. www.nature.com/articles/s41...
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...
www.nature.com
July 31, 2025 at 8:41 PM
Congrats to all authors! Very cool mechanism. www.nature.com/articles/s41...
Reposted by Rock Lab
I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.
July 28, 2025 at 5:37 PM
I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.
Thanks for your leadership on this @asm.org. asm.org/articles/pol...
ASM Leads Letter on Federal Biosecurity & Biosafety Policy | ASM.org
The American Society for Microbiology leads a stakeholder letter expressing concerns on the implementation of EO 14292.
asm.org
July 29, 2025 at 9:56 PM
Thanks for your leadership on this @asm.org. asm.org/articles/pol...
Reposted by Rock Lab
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...
www.biorxiv.org
July 28, 2025 at 9:43 PM
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
"In addition to interrupting lifesaving science, the suspensions will threaten jobs and take money away from universities and their surrounding economies in 10 states representing all regions of the country..."
"In TAG’s view, the suspended TB studies do not pose a substantial risk to the American public in comparison with the clear and present danger of TB, which is the world’s leading cause of death from a single infectious agent."
www.treatmentactiongroup.org/statement/tr...
www.treatmentactiongroup.org/statement/tr...
Treatment Action Group Statement on Suspension of TB Funding Over White House Gain-of-Function Fictions – Treatment Action Group
Treatment Action Group (TAG) opposes in the strongest possible terms the suspension of at least 22 TB research awards by the National Institutes of Health (NIH) following a May 2025 White House execut...
www.treatmentactiongroup.org
July 26, 2025 at 11:14 AM
"In addition to interrupting lifesaving science, the suspensions will threaten jobs and take money away from universities and their surrounding economies in 10 states representing all regions of the country..."
"In TAG’s view, the suspended TB studies do not pose a substantial risk to the American public in comparison with the clear and present danger of TB, which is the world’s leading cause of death from a single infectious agent."
www.treatmentactiongroup.org/statement/tr...
www.treatmentactiongroup.org/statement/tr...
Treatment Action Group Statement on Suspension of TB Funding Over White House Gain-of-Function Fictions – Treatment Action Group
Treatment Action Group (TAG) opposes in the strongest possible terms the suspension of at least 22 TB research awards by the National Institutes of Health (NIH) following a May 2025 White House execut...
www.treatmentactiongroup.org
July 26, 2025 at 11:12 AM
"In TAG’s view, the suspended TB studies do not pose a substantial risk to the American public in comparison with the clear and present danger of TB, which is the world’s leading cause of death from a single infectious agent."
www.treatmentactiongroup.org/statement/tr...
www.treatmentactiongroup.org/statement/tr...
Well done Liam!
An activator of a two-component system controls cell separation and intrinsic drug resistance in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.07.16.665149v1
July 17, 2025 at 10:03 AM
Well done Liam!
Reposted by Rock Lab
The politically appointed NIH deputy director Matt Memoli overrode career staff and the NIAID director to suspend additional projects he deemed risky — mainly about tuberculosis and ones that made the bacterium less dangerous, the WaPo reports.
Trump officials halt ‘dangerous’ research, overriding NIH career scientists
The Trump administration’s actions on NIH gain-of-function research have raised concerns among scientists, who argue the move could block experiments that are safe and potentially lead to new treatmen...
wapo.st
July 16, 2025 at 11:43 PM
The politically appointed NIH deputy director Matt Memoli overrode career staff and the NIAID director to suspend additional projects he deemed risky — mainly about tuberculosis and ones that made the bacterium less dangerous, the WaPo reports.