BACKGROUND Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. However, there is currently no clinical evidence demonstrating the .....

Although the gut microbiota can influence brain function, evidence for brain activity-driven changes in microbial communities is limited. Here, the authors provide direct support for bidirectional com...

Nature Metabolism, Published online: 15 April 2025; doi:10.1038/s42255-025-01277-yA Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.

Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men, which outlasted the time-frame of overeating.

In a new study published in Cell Reports, Finnish researchers show that pituitary macrophages, the immune cells located in the pituitary gland, help regulate hormonal balance.

Scientists identify nine genetic variants that could have helped a man avoid dementia at least two decades longer than expected.

The brain of humans and other animals is known to contribute to the protection of the body from infections. Past studies have unveiled the existence of the so-called conditioned immune response (CIR), which is a form of Pavlovian conditioning that entails the formation of mental associations between specific sensory stimuli (e.g., a specific odor, taste, etc.) and immunomodulatory agents (i.e., a substance that influences the immune system).

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) in Elche, have identified a strategy to slow their progression, which could improve the response to current treatments.

The anti-ageing effect was even greater when combined with vitamin D and exercise.

The authors show that a bidirectional circuit connecting the anterior and posterior (aIC–pIC) insula mediates the conditioned immune response in male mice, illustrating a mechanism by which sensory ex...

This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. Our findings highlight clinically relevant im...

Nature - Publishing highly cited papers helps postdoctoral researchers to land a faculty job.

This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...

Publishing highly cited papers helps postdoctoral researchers to land a faculty job.

Hydrogel electronics enables smart antiseizure management by a closed-loop therapeutic system.

This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do