Davide Angeletti
@angelettilab.bsky.social
Viral Immunology | B cells | Antibodies | Influenza | Mucosal Immunity | Associate Professor Univ. Gothenburg, Sweden
www.angelettilab.com
www.angelettilab.com
Pinned
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS
The nasal mucosa is the first immunologically active site that respiratory viruses
encounter and establishing immunity at the initial point of path...
www.pnas.org
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Reposted by Davide Angeletti
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Davide Angeletti
Mucosal delivery of influenza antigens using a replication deficient adenovirus supports broadly reactive antibody responses and heterologous viral immunity in the respiratory tract of animals https://www.biorxiv.org/content/10.1101/2025.10.13.682194v1
October 14, 2025 at 11:16 PM
Mucosal delivery of influenza antigens using a replication deficient adenovirus supports broadly reactive antibody responses and heterologous viral immunity in the respiratory tract of animals https://www.biorxiv.org/content/10.1101/2025.10.13.682194v1
Reposted by Davide Angeletti
I am really excited to see this article on basic experimental design principles published. Definitely will be mandatory reading for incoming graduate students in my lab. Maggie Wagner who led this article did an amazing job with the illustrations of basic principles www.nature.com/articles/s41...
How thoughtful experimental design can empower biologists in the omics era - Nature Communications
Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...
www.nature.com
August 7, 2025 at 7:43 PM
I am really excited to see this article on basic experimental design principles published. Definitely will be mandatory reading for incoming graduate students in my lab. Maggie Wagner who led this article did an amazing job with the illustrations of basic principles www.nature.com/articles/s41...
Reposted by Davide Angeletti
New review paper from the influenza group
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
Virion motility of sialoglycan-cleaving respiratory viruses - npj Viruses
npj Viruses - Virion motility of sialoglycan-cleaving respiratory viruses
doi.org
July 29, 2025 at 3:24 PM
New review paper from the influenza group
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
Reposted by Davide Angeletti
Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 19, 2025 at 9:00 PM
Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Davide Angeletti
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
June 5, 2025 at 2:28 PM
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Davide Angeletti
Last chance TODAY - to register and submit abstracts for #EMBObarrierTissues in Basel 🇨🇭🇨🇭🇨🇭! We've hit our registration goal 🥳, but there's always room for more. Join @maurogaya.bsky.social and me to explore the latest in lymphocyte and mucosal immunology. Details: meetings.embo.org/event/25-bar...
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…
meetings.embo.org
May 30, 2025 at 8:08 AM
Last chance TODAY - to register and submit abstracts for #EMBObarrierTissues in Basel 🇨🇭🇨🇭🇨🇭! We've hit our registration goal 🥳, but there's always room for more. Join @maurogaya.bsky.social and me to explore the latest in lymphocyte and mucosal immunology. Details: meetings.embo.org/event/25-bar...
Very proud of Danica Besavilla, PhD student in the lab, receiving the Poster award at the #Antibodies & Complement meeting, taking place in Catania.
She presented her paper on mAbs to #Influenza #Neuraminidase , just published in @natureportfolio.nature.com #npjViruses
www.nature.com/articles/s44...
She presented her paper on mAbs to #Influenza #Neuraminidase , just published in @natureportfolio.nature.com #npjViruses
www.nature.com/articles/s44...
Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase - npj Viruses
npj Viruses - Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase
www.nature.com
May 29, 2025 at 5:13 PM
Very proud of Danica Besavilla, PhD student in the lab, receiving the Poster award at the #Antibodies & Complement meeting, taking place in Catania.
She presented her paper on mAbs to #Influenza #Neuraminidase , just published in @natureportfolio.nature.com #npjViruses
www.nature.com/articles/s44...
She presented her paper on mAbs to #Influenza #Neuraminidase , just published in @natureportfolio.nature.com #npjViruses
www.nature.com/articles/s44...
Reposted by Davide Angeletti
Proud to announce our new technique for tracking relative B cell clonality in situ with B Cell Receptor MERFISH (BCR-MERFISH)! Congratulations to Evan Yang and our colleagues in the Carroll laboratory! Check out our bioRxiv: www.biorxiv.org/content/10.1... 1/9
May 28, 2025 at 3:40 PM
Proud to announce our new technique for tracking relative B cell clonality in situ with B Cell Receptor MERFISH (BCR-MERFISH)! Congratulations to Evan Yang and our colleagues in the Carroll laboratory! Check out our bioRxiv: www.biorxiv.org/content/10.1... 1/9
Reposted by Davide Angeletti
Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function a...
doi.org
May 22, 2025 at 12:13 AM
Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...
Reposted by Davide Angeletti
Postdoctoral position in Computational Biology open !
Our Lab is trying to understand the molecular and cellular mechanisms involved in establishing intestinal immune homeostasis and how a breakdown of these mechanisms may lead to diseases
More info 👇 :
lnkd.in/dQZq55nv
lnkd.in/d6sbw59P
Our Lab is trying to understand the molecular and cellular mechanisms involved in establishing intestinal immune homeostasis and how a breakdown of these mechanisms may lead to diseases
More info 👇 :
lnkd.in/dQZq55nv
lnkd.in/d6sbw59P
May 9, 2025 at 8:00 AM
Postdoctoral position in Computational Biology open !
Our Lab is trying to understand the molecular and cellular mechanisms involved in establishing intestinal immune homeostasis and how a breakdown of these mechanisms may lead to diseases
More info 👇 :
lnkd.in/dQZq55nv
lnkd.in/d6sbw59P
Our Lab is trying to understand the molecular and cellular mechanisms involved in establishing intestinal immune homeostasis and how a breakdown of these mechanisms may lead to diseases
More info 👇 :
lnkd.in/dQZq55nv
lnkd.in/d6sbw59P
Reposted by Davide Angeletti
The American Society for Microbiology is committed to ensuring that scientific research is conducted adhering to strict standards for biosafety and biosecurity, but pausing research is not the path forward. Read our statement: asm.org/press-releas...
Pausing Research Not a Path to Better Biosafety & Biosecurity
The American Society for Microbiology is committed to ensuring that scientific research is conducted adhering to strict standards for biosafety and biosecurity.
asm.org
May 6, 2025 at 9:08 PM
The American Society for Microbiology is committed to ensuring that scientific research is conducted adhering to strict standards for biosafety and biosecurity, but pausing research is not the path forward. Read our statement: asm.org/press-releas...
Reposted by Davide Angeletti
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…
meetings.embo.org
April 30, 2025 at 3:04 PM
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
Reposted by Davide Angeletti
In @jem.org, Conlon, Huang, and Gerner show that immunization generates concentration gradients of antigens and #inflammation across interconnected chains of lymph nodes that regulate the magnitude and heterogeneity of adaptive immunity. rupress.org/jem/article/...
April 30, 2025 at 6:04 PM
In @jem.org, Conlon, Huang, and Gerner show that immunization generates concentration gradients of antigens and #inflammation across interconnected chains of lymph nodes that regulate the magnitude and heterogeneity of adaptive immunity. rupress.org/jem/article/...
Reposted by Davide Angeletti
Neat @pnas.org paper from @angelettilab.bsky.social & @matsbemark.bsky.social on ectopic germinal centres in the nasal turbinates of mice and humans. doi.org/10.1073/pnas...
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS
The nasal mucosa is the first immunologically active site that respiratory viruses
encounter and establishing immunity at the initial point of path...
doi.org
April 27, 2025 at 11:14 PM
Neat @pnas.org paper from @angelettilab.bsky.social & @matsbemark.bsky.social on ectopic germinal centres in the nasal turbinates of mice and humans. doi.org/10.1073/pnas...
Reposted by Davide Angeletti
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination @angelettilab.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
March 27, 2025 at 3:45 AM
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination @angelettilab.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS
The nasal mucosa is the first immunologically active site that respiratory viruses
encounter and establishing immunity at the initial point of path...
www.pnas.org
March 25, 2025 at 10:28 AM
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Reposted by Davide Angeletti
Reposted by Davide Angeletti
Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Intrinsic OASL expression licenses interferon induction during influenza A virus infection
Effective control of viral infection requires rapid induction of the innate immune response, especially the type I and type III interferon (IFN) systems. Despite the critical role of IFN induction in ...
www.biorxiv.org
March 18, 2025 at 6:47 PM
Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Davide Angeletti
Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune history shapes human antibody responses to H5N1 influenza viruses - Nature Medicine
H5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 v...
www.nature.com
March 13, 2025 at 5:39 PM
Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Davide Angeletti
Very excited to share our new review in @embomolmed.org @embopress.org on human tonsil/adenoid-based immune organoid cultures for drug and vaccine testing in a human-first approach! With @maximilianmoll.bsky.social at @immunosens.bsky.social and @unibonn.bsky.social www.embopress.org/doi/full/10....
Boosting human immunology: harnessing the potential of immune organoids | EMBO Molecular Medicine
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
January 28, 2025 at 7:26 AM
Very excited to share our new review in @embomolmed.org @embopress.org on human tonsil/adenoid-based immune organoid cultures for drug and vaccine testing in a human-first approach! With @maximilianmoll.bsky.social at @immunosens.bsky.social and @unibonn.bsky.social www.embopress.org/doi/full/10....
Reposted by Davide Angeletti
This is bad news. It suggests reassortment of circulating H5N1 viruses with viruses containing N9 NA.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
1st U.S. case of H5N9 bird flu (different from H5N1) reported on California duck farm
1st U.S. case of H5N9 bird flu reported on California duck farm - National | Globalnews.ca
The United States has reported its first outbreak of H5N9 bird flu in poultry on a duck farm in California, the World Organization for Animal Health (WOAH) said on Monday.
globalnews.ca
January 27, 2025 at 10:43 PM
This is bad news. It suggests reassortment of circulating H5N1 viruses with viruses containing N9 NA.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
Reposted by Davide Angeletti
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 22, 2025 at 5:37 PM
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Reposted by Davide Angeletti
Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection - Nature Communications
H7N9 influenza A virus circulates in poultry but can also infect humans with often fatal outcome. Here, Chen et al. identify a novel nanobody that cross-reacts between H7N9 and human viruses H1N1 and ...
www.nature.com
January 9, 2025 at 5:16 PM
Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our first paper of 2025, just published in @naturecomms.bsky.social 🧪🦠
Fantastic work by first author Zhao-Shan Chen and great collaboration with Qiyun Zhu and colleagues at Lanzhou Veterinary Research Institute.
Short thread below 🧵
rdcu.be/d5JEL
#ViroSky
Fantastic work by first author Zhao-Shan Chen and great collaboration with Qiyun Zhu and colleagues at Lanzhou Veterinary Research Institute.
Short thread below 🧵
rdcu.be/d5JEL
#ViroSky
Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection
Nature Communications - H7N9 influenza A virus circulates in poultry but can also infect humans with often fatal outcome. Here, Chen et al. identify a novel nanobody that cross-reacts between H7N9...
rdcu.be
January 9, 2025 at 2:58 PM
Excited to share our first paper of 2025, just published in @naturecomms.bsky.social 🧪🦠
Fantastic work by first author Zhao-Shan Chen and great collaboration with Qiyun Zhu and colleagues at Lanzhou Veterinary Research Institute.
Short thread below 🧵
rdcu.be/d5JEL
#ViroSky
Fantastic work by first author Zhao-Shan Chen and great collaboration with Qiyun Zhu and colleagues at Lanzhou Veterinary Research Institute.
Short thread below 🧵
rdcu.be/d5JEL
#ViroSky