Mart Krupovìč | Lightnews

Mart Krupovic

@mkrupovic.bsky.social

2.5K followers 440 following 85 posts

Virus origins/diversity/evolution; mobilome; Archaea.
Head of the Cell Biology and Virology of Archaea Unit at Institut Pasteur:
https://research.pasteur.fr/en/team/archaeal-virology/

Videos

Biology 41%

Environmental science 29%

Posts Replies Media Videos

Reposted by Mart Krupovìč

Thelonevirologist @thelonevirologist.bsky.social · 3d

Endogenized polinton-like viruses in the dinoflagellate Oxyrrhis marina uncover novel PolB fusion

www.microbiologyresearch.org/content/jour...

Endogenized polinton-like viruses in the dinoflagellate Oxyrrhis marina uncover novel PolB fusion

Marine viruses are ubiquitous entities that impact the biology of a large fraction of prokaryotic and eukaryotic diversity. Dinoflagellates are heterotrophic, mixotrophic and photosynthetic eukaryotes...

www.microbiologyresearch.org

Reposted by Mart Krupovìč, Brett J. Baker

Buzz Baum @buzzbaum.bsky.social · 10d

Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?

Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.

Sign up: meetings.embo.org/event/26-arc...

We look forward to seeing you in Cambridge, UK.

Please repost!

Molecular Biology of Archaea: Life Through the Prism of Archaea

In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…

meetings.embo.org

Reposted by Simon Roux, Mart Krupovìč

Nature Reviews Genetics @natrevgenet.nature.com · 11d

Review: Viromics approaches for the study of viral diversity and ecology in microbiomes by @simrouxvirus.bsky.social & Clement Coclet @jgi.doe.gov
rdcu.be/excHt

Viromics approaches for the study of viral diversity and ecology in microbiomes

Nature Reviews Genetics - In this Review, Roux and Coclet outline current viromics approaches and discuss how they have contributed to our growing understanding of viral genomic diversity, focusing...

rdcu.be

Reposted by Mart Krupovìč

DEEMteam_Orsay @deemteam.bsky.social · 11d

With our old friends Sergey, Luis and Guifré, we have published a minireview in @currentbiology.bsky.social about aphelids, the sister group to fungi, including why we think they are not fungi but, nevertheless, key to understand early fungal evolution.

authors.elsevier.com/a/1mH793QW8S...

Reposted by Mart Krupovìč

Vikram Alva @vikramalva.bsky.social · 13d

Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉

In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.

www.nature.com/articles/s41...

Reposted by Mart Krupovìč

Kurianlab @kurianlab.bsky.social · 14d

www.nature.com/articles/s41...

An RNA splicing system that excises DNA transposons from animal mRNAs - Nature

A new type of mRNA splicing mechanism discovered in Caenorhabditis elegans that detects and removes inverted repeats also occurs in human cells, thereby providing another strategy to protect against t...

www.nature.com

Reposted by Mart Krupovìč

Escalante Lab @crescalante.bsky.social · 14d

I am happy to share our new preprint about the #cryoEM #structure of the AAV2 Rep-Capsid complex. Congratulations to the team. A great collaboration with the Kaelber Lab at Rutgers.
www.biorxiv.org/content/10.6...

Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex

The Adeno-associated virus (AAV) has become the most used viral vector for gene therapy applications to treat monogenic diseases, with over 250 clinical trials and six FDA-approved biologics. AAV has ...

www.biorxiv.org

Reposted by Mart Krupovìč

Tamara Basta @tamarabasta.bsky.social · 15d

Delighted to share our new preprint: www.biorxiv.org/content/10.6...
We address a longstanding question about the role of the topoisomerase reverse gyrase in hyperthermophiles. Great collaboration with Baranello and @tobiaswarnecke.bsky.social groups. #Archaeasky #Microsky

Localised activity of reverse gyrase at gene regulatory elements

DNA topoisomerases are essential enzymes found in all cells, where they regulate DNA supercoiling. Reverse gyrase (RG) is a unique type of topoisomerase that introduces positive supercoils into DNA an...

www.biorxiv.org

Reposted by Mart Krupovìč

smallthingslab.bsky.social @smallthingslab.bsky.social · 16d

Heterotrophic nanoflagellates in lakes ingest 10–20 bacteria/hour, removing roughly 1/3 of all prokaryotes daily but most remain uncultured and unsequenced. We devised a new cultivation strategy to describe one such predator here 🦖🔬
t.co/TU1fq4eVg2 #MicrobialEcology

https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf271/8373286

t.co

Reposted by Mart Krupovìč

Karolin Luger @nucleosomepolice.bsky.social · 17d

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

Reposted by Elena Litchman, Mart Krupovìč, Wolfgang Huber , and 1 more Elena Litchman, Mart Krupovìč, Wolfgang Huber, Jean-Yves Tinévez

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 18d

🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research

Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research

The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

research.pasteur.fr

Reposted by Mart Krupovìč

Emmanuele Severi @emmseveri.bsky.social · 18d

#microsky #phagesky #phage defence

The different roles of the two glucosyltransferases of phage T4 in overcoming antiphage functions

www.biorxiv.org/content/10.6...

A Pair of DNA Glucosyltransferases Elevate Counter-defense in Bacteriophage T4

Bacteriophages encode diverse pathways to modify their nucleobases. These modifications help phages to evade the host defense systems such as restriction-modification (RM), and type II and type V CRIS...

www.biorxiv.org

Reposted by Mart Krupovìč

Evgenii Protasov @evgenii-protasov.bsky.social · 19d

The latest and most detailed review on a fundamental biochemical pathway: #glycolysis
#microbiology #biochemistry
onlinelibrary.wiley.com/doi/full/10....

Reposted by Mart Krupovìč

Archaea Biology Vienna @archaea-vienna.bsky.social · 21d

Fresh from our group, a new role for oxygen production in ammonia-oxidizing archaea:

Oxygen production as an electron overflow pathway in ammonia-oxidizing archaea

Congrats to Thomas Pribasnig for this great work!

Check it out here:
www.biorxiv.org/content/10.6...

Reposted by Mart Krupovìč

Sorek Lab @soreklab.bsky.social · 22d

Preprint: Systematic discovery of TIR-based immune signaling systems in bacteria

Conservation of TIR-derived signals accross the tree of life! We found bacterial TIR immune systems that signal via canonical cADPR (like in humans) and 2'cADPR (a plant immune signal).

Documented 11 Thoeris types

Reposted by Mart Krupovìč

Simon Roux @simrouxvirus.bsky.social · 23d

🦠🧪🧬🚨 New paper and database alert: the new IMG/VR release is now MetaVR ! We have a new website - meta-virome.org - with quick search capabilities for the >24M viruses, >12M vOTUs, and >42M protein clusters (including >790k with predicted structures !). academic.oup.com/nar/advance-...

Meta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomes

Abstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st

academic.oup.com

Reposted by Mart Krupovìč

Javier Espadas @javierespadas.bsky.social · 25d

New preprint from the lab!!🎉
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...

Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism

The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...

www.biorxiv.org

Mart Krupovic @mkrupovic.bsky.social · 27d

Explicit description of viral capsid subunit shapes by unfolding dihedrons by Ryuya Toyooka et al. www.nature.com/articles/s42...

Explicit description of viral capsid subunit shapes by unfolding dihedrons - Communications Biology

A proposed geometric framework describes and classifies all possible protein subunit shapes in viral capsids through spherical tiling theory, revealing different interaction patterns based on subunit ...

www.nature.com

Reposted by Mart Krupovìč

The Banfield Lab @banfieldlab.bsky.social · 27d

Out now in Nature Communications: Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses

www.nature.com/articles/s41...

@luisvalentin.bsky.social @lingdong-shi.bsky.social @martianmicrobe.bsky.social @mschoelmerich.bsky.social

Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses - Nature Communications

Borgs are large extrachromosomal elements of anaerobic methane-oxidizing archaea. Here, via in silico protein structure prediction of ~10,000 Borg proteins, the authors reveal that Borgs share numerou...

www.nature.com

Mart Krupovic @mkrupovic.bsky.social · 28d

Congrats to all coauthors, @sonaida.bsky.social, Ulysse Guyet, @tomdelmont.bsky.social, Eugene Koonin, et al. @pasteur.fr @cnrs.fr

Reposted by Simon Roux

Mart Krupovic @mkrupovic.bsky.social · 28d

Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

www.nature.com

Reposted by Mart Krupovìč

Sofia Medvedeva @sonaida.bsky.social · 28d

www.nature.com/articles/s41...

Thrilled to share our new study! We show that mirusviruses include lineages packed with spliceosomal introns and likely replicating in the nucleus of unicellular eukaryotes—a sharp contrast to most large and giant eukaryotic viruses that replicate in the cytoplasm.

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

www.nature.com

Reposted by Mart Krupovìč

Osterman Ilya @ostermanilya.bsky.social · 28d

Intron-rich viruses - WOW!
rdcu.be/eSfG2

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

www.nature.com

Reposted by Mart Krupovìč

BejaLab @bejalab.bsky.social · Nov 25

Arbitrium systems control lysis/lysogeny through the regulation of small antirepressor proteins www.biorxiv.org/content/10.1...

Reposted by Mart Krupovìč

Satoshi Kawato 川戸智 @kawatosatoshi.bsky.social · Nov 24

New update for the gbdraw web app!🚀
You can now display gene labels ONLY on the first genome in the linear diagram. Just select "First" in the "Label layout" option.
Try it out here👉: gbdraw.streamlit.app
#gbdraw #bioinformatics #genomics #visualization #virology #microbiology #streamlit

Reposted by Mart Krupovìč

Tominaga K. (tomiken) @pacyc184.bsky.social · Nov 24

Evolutionary Flexibility of Ribosome Biogenesis in Bacteria | Molecular Biology and Evolution | Oxford Academic https://academic.oup.com/mbe/article/42/11/msaf288/8340222?login=false

Evolutionary Flexibility of Ribosome Biogenesis in Bacteria

Abstract. Ribosomes are essential for protein synthesis and require ribosome biogenesis factors for assembly. To uncover the evolutionary diversity of ribo

dx.doi.org

Reposted by Mart Krupovìč, Jean-Yves Tinévez

Christophe Zimmer @chzimmer.bsky.social · Nov 23

Recently out: “Uniform dynamics of cohesin-mediated loop extrusion in living human cells”. In this study led by brilliant former PhD student Thomas Sabaté we use live cell microscopy and polymer simulations to characterize how DNA loops and TADs form in human cells by cohesin-driven extrusion. (1/4)

Reposted by Simon Roux, Mart Krupovìč, Mya Breitbart , and 2 more Simon Roux, Mart Krupovìč, Mya Breitbart, José R. Penadés, Alan McNally

Alexander Harms @aharms485.bsky.social · Nov 20

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.

Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.

A thread 1/8

Reposted by Mart Krupovìč

Daniela Barillà @danielabarilla.bsky.social · Nov 20

Let’s wrap things up: my commentary on the Asgard hypernucleosomes.

Congratulations to all the authors of the paper 🍾!

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...

Cryo-EM reveals open and closed Asgard chromatin assemblies

Ranawat et al. show the cryo-EM structures of Asgard archaeal chromatin assemblies, revealing that the histone HHoB assembles into both compact closed and extended open hypernucleosomes. The closed co...

www.cell.com

Reposted by Mart Krupovìč

roop-dhillon.bsky.social @roop-dhillon.bsky.social · Nov 17

New video on Nested Symbiosis in extreme environments out on my YouTube Channel. Give it a watch if you can, a great paper by @mkrupovic.bsky.social

Original Paper: doi.org/10.1038/s415...

youtu.be/OQR5obtf7-4

Nested Symbiosis in Extreme Environments

YouTube video by Archaeal Adventures

youtu.be

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